Cardiac glycoside is digitoxin. Medical search. Frequent questions

Cardiac glycosides are found in several plants, including the leaves of the foxglove plant. (medlineplus.gov)
Besides the foxglove plant, cardiac glycosides also occur naturally in plants such as Lily-of-the-Valley and oleander , among several others. (medlineplus.gov)
A cardiac glycoside extracted from foxglove leaves (Digitalis sps. (pharmanotes.org)
The cardiac glycosides digitoxin and digoxin are found in foxglove (Digitalis purpurea) and are used to treat heart problems in humans in modest doses. (uochemists.com)
3. Foxglove (Digitalis purpurea) - Characterized by tall spikes with multiple bell-shaped pink and purple flowers with interesting black and white spots inside their cup, parts of Foxglove contain cardiac glycoside, a digitoxin which affects the heart. (garden-lovers.net)
Foxglove contains about 35 cardioactive glycosides, which include digitoxin, gitoxin, digoxin, gitaloxin and digitalin as well as the saponin digitonin. (thepharmacognosy.com)

Uses/Indications - Like digoxin, digitoxin is indicated for heart failure or atrial arrhythmias, but because it is metabolized by the liver to a greater extent, some clinicians feel that it should be used instead of digoxin in patients with diminished renal function. (elephantcare.org)
It contains lycorine , a toxic crystalline alkaloid, which causes vomiting, stomach cramps, convulsions and even cardiac arrhythmias. (garden-lovers.net)
Ouabain, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. (pharmacycode.com)
Even apparently stable patients can rapidly develop fatal arrhythmias and cardiac arrest during treatment. (doczz.net)
Digoxin is one of the most prescribed drugs in treatment of patients with diagnosis of cardiac heart failure and certain types of cardiac arrhythmias. (biochemia-medica.com)

Like digoxin, this apparent interpatient variability suggests that digitoxin serum levels must be monitored to optimize therapy and reduce the chance for toxicity. (elephantcare.org)
The early signs of toxicity from the cardiac glycosides can mimic the heart problem it is meant to treat, making diagnosis difficult. (wagwalking.com)
Kanji S, Maclean RD. Cardiac glycoside toxicity: More than 200 years and counting. (cdc.gov)

A growing body of evidence indicates that digitoxin cardiac glycoside is a promising anticancer agent when used at therapeutic concentrations. (cdc.gov)
Two cardiac glycosides, digoxin and digitoxin, had a great therapeutic efficacy in OCCC cells in vitro and in vivo . (oncotarget.com)
Taken together, our results demonstrate that FXYD2 is functionally upregulated in OCCC and may serve as a promising prognostic biomarker and therapeutic target of cardiac glycosides in OCCC. (oncotarget.com)
The therapeutic approach for digitalis glycoside poisoning has been radically modified since the introduction of digoxin-specific antibody fragments (Fab)2. (doczz.net)

However, digitoxin, digoxin and several other cardiac glycosides, such as ouabain, are known to have steep dose-response curves, i.e. minute increases in the dosage of these drugs can make the difference between an ineffective dose and a fatal one. (blogspot.com)
Seeds of Strophanthus gratus provide two Active glycoside - STROPHANTHUS-G and OUABAIN, While seeds of strophanthus kombe yield primarily STROPHANTHIN-K. (pharmanotes.org)

Like other cardiac glycosides, these toxins exert their effects by inhibiting the ATPase activity of a complex of transmembrane proteins that form the sodium potassium ATPase pump, (Na+/K+-ATPase). (blogspot.com)

Furthermore, up-regulation of FXYD2 expression significantly increased the sensitivity of OCCC cells to cardiac glycosides, the Na + /K + -ATPase inhibitors. (oncotarget.com)

The leaves of Digitalis Purpurea are the source of Digitoxin and Digoxin, which are cardiac glycosides. (howmed.net)
Leaves of Digitalis lanata provide two - DIGOXIN and DIGITOXIN, while leaves of Digitalis Purpurea (Fox glove) are the major source of digitoxin. (pharmanotes.org)
In 1957, it was possible to isolate the most important active ingredient from Digitalis purpurea , digoxin considered as a cardiac glucoside. (reconnectivehealingpractitioners.com)
Both digitoxin and digoxin present in the leaves, flowers, and seeds of Digitalis purpurea , are considered a cumulative poison in the body and are potentially toxic to animals and humans. (reconnectivehealingpractitioners.com)
One of the best-known medicines based on the extracts of Digitalis purpurea is Lanoxin, with Digitoxin . (reconnectivehealingpractitioners.com)
The cardiac glycosides of Digitalis purpurea they have direct effects on the heart muscle, causing it to shrink. (reconnectivehealingpractitioners.com)
In trying to dig deeper into the effect of Digitalis purpurea, in vitro studies have been conducted to evaluate the cytotoxic properties of glycosides and flavonoids. (reconnectivehealingpractitioners.com)

It is a cardiac glucoside (a type of glycoside). (wikipedia.org)

Due to the presence of the cardiac glycoside digitoxin, the leaves, flowers and seeds of this plant are all poisonous to humans and some animals and can be fatal if eaten. (blogspot.com)
Although the highest concentration of the active substances of pharmacological uses is found in the leaves, the seeds harbor digitalis glycosides , steroid saponins, flavones (chrysoeriol), anthraquinone, and organic acids. (reconnectivehealingpractitioners.com)

Cardiac glycosides, usually in the form of digoxin, are often used in the treatment of congestive heart failure. (wagwalking.com)
Digitalis and its glycosides are used as cardiotonic in the treatment of congestive heart failure. (thepharmacognosy.com)

Since intracellular calcium plays a key role in cardiac automaticity, conductivity and contractility, intoxication from these drugs leads to an inhibition of sinus and atrio-ventricular (AV) node depolarization and to a depression of myocardial cell contractility5. (doczz.net)

Toxic triterpenoids like cardiac glycosides may induce heart attacks in humans and other vertebrate herbivores. (uochemists.com)

It is sometimes used for hypertension and cardiac arrhythmia. (mountainmausremedies.com)
Mga kasingkahulugan na cardiac glycosides Drugs Cardiac arrhythmia Digitoxin Digoxin ay isang aktibong sangkap na kabilang sa pangkat ng mga cardiac glycosides. (paggaling.com)
Pangunahin itong ginagamit upang gamutin ang dalawang magkakaibang mga klinikal na larawan: epilepsy at cardiac arrhythmia. (paggaling.com)
US Patent Application Number: 20030199813 information expected: April 22, 2002 pressure: The place is used to products for initiating the enzyme of a form, metabolic as a eye signaling critical regulator boy, and well responding the spirochetal's acceleration role as a arrhythmia of a ability in the patient's drug, similar as the insensitive cardiac level emergent stimulation. (siriuspixels.com)

New scientific avenues have shown that manipulating the chemical structure of the saccharide moiety of digitoxin leads to synthetic analogs with increased cytotoxic activity. (cdc.gov)

Cardiac glycoside overdose occurs when someone takes more than the normal or recommended amount of this medicine. (medlineplus.gov)
Chemistry - A cardiac glycoside, digitoxin occurs as a bitter tasting, odorless, white to pale buff colored, microcrystalline powder. (elephantcare.org)

Symptoms of Digitalis poisoning include a low pulse rate, nausea, vomiting, and uncoordinated contractions of different parts of the heart, leading to cardiac arrest and finally death. (blogspot.com)
If someone were to eat it, it would cause low pulse rate, vomiting, nausea and heart contractions that could ultimately cause them to go into cardiac arrest. (garden-lovers.net)

Vomiting is generally not induced in cases of cardiac glycoside poisoning due to the rapid absorption of the compound. (wagwalking.com)

cardiovascular system affected by cardiac glycosides. (poultryhelp.com)

If you catch your pet consuming the either digitalis-based heart medication or cardiac glycoside laden plant, identification may be all that is required to determine the cause of your pet's reactions. (wagwalking.com)

Clinically patients with CCB or BB poisoning present profound bradycardia, possible AV block, severe ventricular dysfunction leading to acute impairment of cardiac output and cardiac arrest1. (doczz.net)

Long-term (chronic) poisoning can occur in people who take cardiac glycosides every day. (medlineplus.gov)
Older people are especially likely to suffer from problems of long-term (chronic) cardiac glycoside poisoning. (medlineplus.gov)
In patients in whom fatigue due to low left ven-tricular output is a primary symptom, an arteriolar dilator such as hydralazine may be helpful in increasing forward cardiac output.In most patients with severe chronic failure that responds poorly to other therapy, the problem usually involves both elevated filling pressures and reduced cardiac output. (brainkart.com)

It increases the contractility and improves the tone of the cardiac muscle. (thepharmacognosy.com)

Digitalis strengthens the force of contractions of weakened hearts, but it is not a cardiac vitamin that can make a strong heart stronger. (medscape.com)

Digoxin is a cardiac glycoside that is FDA approved for the treatment of atrial fibrillation , atrial flutter , and heart failure . (wikidoc.org)

There are blood tests available to detect the cardiac glycosides, as well as to monitor the levels of glycosides in the system, however the cost of these methods generally limits their accessibility for veterinary diagnosis. (wagwalking.com)

with effects similar to digitoxin. (wikipedia.org)
are the two chemically similar cardiac glycosides: digitoxin and digoxin. (blogspot.com)

In weakness to cardiac resistance treating to the Frank-Starling plan, a efficient membrane is first to pulmonary cell, retinal as corpus by the ventricular saponin-permeabilized supply to prevent Sediment. (siriuspixels.com)

Supportive measures and the use of digoxin-specific antibody fragments are first line treatment for digitalis glycoside poisoning. (doczz.net)

Activation by hydrolysis of licorice glycoside (GL) to aglycone (GA) depends on bowel flora. (interactionsguide.com)
Blockade of efflux of sodium increases calcium in myocytes resulting in increased activation of contractile proteins in the cardiac muscle. (medscape.com)

This compound has been used for centuries both as a healing agent for those who already suffer from cardiac disorders as well as a poison. (wagwalking.com)

Digitoxin is highly protein bound (97% in humans, 70-90% in dogs) and values generally are the same in uremic patients. (elephantcare.org)

Serum concentrations might be detectable after an exposure to plant-derived cardiac glycosides, some of which can cross-react with the various hospital laboratory assays used. (cdc.gov)

Cardiac glycoside is a chemical that has effects on the heart, stomach, intestines, and nervous system. (medlineplus.gov)

Drugs such as beta-blockers, steroids, and some chemotherapy agents may interact negatively with cardiac glycoside. (wagwalking.com)

It has been found to have up to 38 different cardiac glycosides, which if consumed in minute amounts can cause a reduced heart rate, abdominal pain, blurred vision and skin rash. (garden-lovers.net)

Pakikipag-ugnay Maraming mga kadahilanan at parallel na pangangasiwa ng iba pang mga gamot ay maaaring maka-impluwensya sa digitoxin effect, samakatuwid isang tumpak na anamnesis (sistematikong pagtatanong ng pasyente tungkol sa mga nakaraang sakit, paggamit ng gamot, atbp. (paggaling.com)

Cardiac glycosides are organic compounds that can disrupt regular heart rhythm by acting on the force of the cardiac muscle itself. (wagwalking.com)

Digitoxin is extensively metabolized and the elimination half-life usually remains unchanged in renal failure patients. (elephantcare.org)

Cardiac glycosides are naturally occurring compounds formed in several plants. (wagwalking.com)

Digitoxin has a prolonged half-life and a well-established clinical profile. (cdc.gov)

If the deci-sion is made to use a cardiac glycoside, digoxin is the one chosen in most cases (and the only one available in the USA). (brainkart.com)

Angiotensin-converting enzyme inhibitor or an angiotensin II receptor blocker if you have coronary artery disease, diabetes, high blood pressure, or other vascular or cardiac conditions. (healthyheartworld.com)

Digoxin and digitoxin are the main digitalis products. (medscape.com)

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