Human cardiacMyocytesMyocardialMobile cardiac telemetryAbstractFetalMitigated cardiac fibrosisMitochondrial functionMillions of cardiac patientsPostnatal developmentLeft ventricularFibrosisDifferentiationLoss of proliferative capacitySurgeryArrhythmiasRole in cardiacModel of cardiacSarcoplasmic reticulumRehabilitationImplantableHeartPulmonaryArrestAutonomicConductionPatientsSignificantlyTransverse aorticTissueSkeletal muscleElectrophysiologyRisk stratificationTranscriptionalGenesPacemakersDefibrillatorsDisordersFunctionSymptomsCentersDefectivePathwayToxicityCentreMolecularTherapiesMaturationTherapyAdvisory CommitteeAnomalous developmentMethodsProteinsStagesTherapeuticMonitoring DevicesTranscriptionHealthcare2021
Human cardiac3
- This study uncovers distinct layers of epigenetic regulation not only during prenatal development and postnatal maturation but also in diseased human cardiac myocytes. (nature.com)
- Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency. (bvsalud.org)
- It is unknown how NOTCH1 regulates human cardiac cell lineage determination and cardiomyocyte proliferation. (bvsalud.org)
Myocytes3
- Epigenetic mechanisms and transcription factor networks essential for differentiation of cardiac myocytes have been uncovered. (nature.com)
- Notably, cis -regulatory regions in cardiac myocytes are significantly enriched for cardiovascular disease-associated variants. (nature.com)
- Separately, the incubation of cardiac myocytes isolated from naïve adult rat hearts in vitro with UFTiO2 did not alter the phosphorylation status of the same cardiac proteins. (cdc.gov)
Myocardial7
- Cardiac hypertrophy is typified by enlargement of myocardial wall mass and changes in the gross anatomical dimensions of the ventricles. (europeanpharmaceuticalreview.com)
- These cardiac techniques are otherwise referred to as echocardiography , Cardiac MRI , Cardiac CT , Cardiac PET and Cardiac SPECT including myocardial perfusion imaging . (wikipedia.org)
- Myocardial fibrosis, characterized as interstitial fibroblast proliferation and excessive collagen deposition, is the structural basis of myocardial stiffness and the key process of cardiac function transformation from the compensatory phase to heart failure. (dovepress.com)
- Recently, EndMT has been increasingly recognized as a vital process that contributes to various cardiovascular pathologies in adults, which include atherosclerosis, valvular heart disease, cardiac fibrosis, and myocardial infarction. (dovepress.com)
- Furthermore, myocardial infarction surgery-induced cardiac fibrosis and dysfunction were attenuated by systemic delivery of miR-409-3p antagomir. (hindawi.com)
- Cardiac fibrosis is a pathological manifestation of myocardial remodeling, which is characterized by increased fibroblast-to-myofibroblast conversion and excessive extracellular matrix (ECM) deposition within the myocardial interstitium, leading to myocardial stiffness, ventricular dilation, arrhythmias, and heart failure [ 1 , 2 ]. (hindawi.com)
- Accumulating studies have revealed that miRNAs that participate in the myocardial fibrotic program, such as miR-18a-5p, attenuate cardiac fibrosis via regulating the Notch2 pathway [ 13 ], and miR-24-3p alleviates myocardial fibrosis through PHB2 [ 14 ]. (hindawi.com)
Mobile cardiac telemetry5
- The Asia Pacific Mobile Cardiac Telemetry Systems Market is expected to witness market growth of 12.7% CAGR during the forecast period (2020-2026). (researchandmarkets.com)
- Mobile Cardiac Telemetry (MCT) is becoming more and more common as the device is far less labor-intensive than the traditional event monitor for the patient. (researchandmarkets.com)
- Mobile Cardiac Telemetry tracking is a wave of the future as there are too many technical benefits relative to other long-term monitoring options. (researchandmarkets.com)
- Increasing the prevalence of cardiovascular diseases and related mortality has raised an understanding of the advantages of mobile cardiac telemetry (MCT) technology and has stimulated market development. (researchandmarkets.com)
- Based on cardiac monitoring devices, the market is segmented into ECG devices, implantable loop recorders, mobile cardiac telemetry devices, cardiac output monitoring devices, and others. (researchandmarkets.com)
Abstract2
- abstract = "It is well recognised that dialysis patients suffer excess morbidity and mortality and that this is mainly due to cardiac failure and sudden cardiac death rather than conventional risk factors. (manchester.ac.uk)
- ABSTRACT Acute kidney injury is a serious complication after cardiac surgery. (who.int)
Fetal5
- However, reshaping of the epigenome of these terminally differentiated cells during fetal development, postnatal maturation, and in disease remains unknown. (nature.com)
- However, the detailed epigenetic processes involved in maturation from fetal to adult CMs and in cardiac disease leading to terminal heart failure have not been fully uncovered, yet. (nature.com)
- Cardiac tissues are first detectable on the 18th or 19th day of fetal life. (medscape.com)
- Disturbed fetal limb muscle development has also been reported and may underlie the bony malformations. (medscape.com)
- The defect results from incomplete septation of the truncus arteriosus during fetal cardiac development. (msdmanuals.com)
Mitigated cardiac fibrosis1
- TMZ treatment mitigated cardiac fibrosis, ameliorated left ventricular dysfunction, and reduced NOX activity. (dovepress.com)
Mitochondrial function2
- Cardiac mitochondrial function is altered in a variety of inherited and acquired cardiovascular diseases. (jci.org)
- Objectives: The purpose of this study is the development of a porcine model of carbon monoxide (CO) poisoning to investigate alterations in brain and heart mitochondrial function. (lu.se)
Millions of cardiac patients2
- Prevencio president and chief executive officer Rhonda Rhyne said: "Prevencio is honoured to work with Massachusetts General Hospital's talented team of dedicated researchers to find safer, more accurate and more affordable ways to identify and treat millions of cardiac patients. (medicaldevice-network.com)
- We are very proud of Dr. Small-Howard and her team, and we expect results from this effort that will enable the company to do well by doing good for literally millions of cardiac patients around the world. (rdworldonline.com)
Postnatal development1
- Gene expression profiling (RNA-seq) and genome-wide sequencing of methylated DNA (MBD-seq) identified dynamic changes in the cardiac methylome during postnatal development [2545 differentially methylated regions (DMRs) from P1 to P14 in the mouse]. (nih.gov)
Left ventricular1
- Rats injected with ISO exhibited severe interstitial cardiac fibrosis and perivascular fibrosis, decreased left ventricular ejection fraction, and increased NOX activity. (dovepress.com)
Fibrosis16
- Endothelial-to-mesenchymal transition (EndMT) is an important mechanism underlying cardiac fibrosis. (dovepress.com)
- This study aimed to investigate the possible effect of TMZ on cardiac fibrosis exerted via the inhibition of NOX2-mediated EndMT. (dovepress.com)
- A cardiac fibrosis model was established in Sprague-Dawley rats through a subcutaneous injection of isoproterenol (ISO, 5 mg/kg/d). (dovepress.com)
- TMZ may ameliorate EndMT and ISO-induced cardiac fibrosis through the NOX2/NF-κB/Snail pathway. (dovepress.com)
- The findings of the study may provide new insights into the potential role of TMZ in the pathophysiology of cardiac fibrosis. (dovepress.com)
- Cardiac fibroblasts are generally the primary effector cells of fibrosis and have been reported to be partly derived from cardiac endothelial cells through the endothelial to mesenchymal transition (EndMT) process. (dovepress.com)
- Cardiac fibrosis is a hallmark of numerous chronic cardiovascular diseases that leads to heart failure. (hindawi.com)
- Dysregulation of microRNAs has been confirmed to be involved in cardiac fibrosis development. (hindawi.com)
- This study was the first to highlight the role and molecular mechanism of miR-409-3p in cardiac fibrosis. (hindawi.com)
- Gpd1 siRNA abolished the antifibrotic effect of miR-409-3p inhibitor in neonatal rat cardiac fibroblasts, suggesting that miR-409-3p promotes cardiac fibrosis at least partially through Gpd1. (hindawi.com)
- Moreover, GATA2 was identified as a cardiac fibrosis-associated upstream positive transcription factor of miR-409-3p. (hindawi.com)
- Finally, these findings suggest that modulating miR-409-3p could be a potential therapeutic method for cardiac fibrosis. (hindawi.com)
- Understanding the molecular mechanisms underlying cardiac fibrosis is beneficial to the development of novel strategies for therapeutic intervention. (hindawi.com)
- Inflammation, oxidative stress, and aging have been proven to contribute to cardiac fibrosis, which is regulated by multiple factors [ 7 - 9 ]. (hindawi.com)
- These observations demonstrated that miRNAs might be promising therapeutic targets for alleviating cardiac fibrosis. (hindawi.com)
- For instance, miR-409-3p promotes epithelial to mesenchymal transition and tumor growth in prostate cancer and also accelerates osteoblastic differentiation through the Wnt/ β -catenin pathway [ 17 , 18 ], a crucial pathway in regulating cardiac fibrosis. (hindawi.com)
Differentiation8
- Cardiac differentiation was carried out by sequential modulation of WNT signaling , and NOTCH1 knockout and wild-type differentiating cells were collected at day 0, 2, 5, 10, 14, and 30 for single-cell RNA-seq . (bvsalud.org)
- Human NOTCH1 knockout induced pluripotent stem cells are able to generate functional cardiomyocytes and endothelial cells , suggesting that NOTCH1 is not required for mesoderm differentiation and cardiovascular development in vitro . (bvsalud.org)
- Single- cell transcriptomic analysis reveals abnormal cell lineage determination of cardiac mesoderm , which is manifested by the biased differentiation toward epicardial and second heart field progenitors at the expense of first heart field progenitors in NOTCH1 knockout cell populations . (bvsalud.org)
- NOTCH1 is essential for human ventricular-like cardiomyocyte differentiation and proliferation through balancing cell fate determination of cardiac mesoderm and modulating cell cycle progression. (bvsalud.org)
- Notably, transfection with miR-409-3p mimics promoted the proliferation of cardiac fibroblasts and fibroblast-to-myofibroblast differentiation, accompanied by upregulated expression of Col1a1, Col3a1, and α -SMA. (hindawi.com)
- These functional characteristics are in accordance with the expression of α- and β-cardiac myosin heavy chain at early differentiation stages and the additional expression of ventricular-specific MLC-2V and atrial-specific ANF genes at terminal stages demonstrated by reverse transcription polymerase chain reaction (RT-PCR) analysis. (uni-luebeck.de)
- For testing the influence of exogenous compounds on cardiac differentiation the teratogenic compound retinoic acid (RA) was applied during distinct stages of embryoid body development. (uni-luebeck.de)
- A temporally controlled influence of RA on cardiac differentiation and expression of cardiac-specific genes was found. (uni-luebeck.de)
Loss of proliferative capacity2
- The goal of this study was to determine whether DNA methylation plays an important role in guiding transcriptional changes during the first 2 wk of mouse heart development, which is an important period for cardiomyocyte maturation, loss of proliferative capacity and loss of regenerative potential. (nih.gov)
- Permanent cultures of cardiac cells described so far have limited value for studying cell biology and pharmacology of the developing heart because of the loss of proliferative capacity and cardiac-specific properties of cardiomyocytes during long-term cultivation. (uni-luebeck.de)
Surgery8
- The new facility gives residents in Surry County and nearby areas the ability to attend a closer outpatient cardiac rehab program after a heart attack, a heart-related surgery or heart disease, according to the two medical centers. (surryedp.com)
- The Salam Centre for Cardiac Surgery is a 63-bed cardiac surgery hospital located on the outskirts of Khartoum, Sudan. (wikipedia.org)
- Medical specialty professional organizations discourage the use of routine cardiac imaging during pre-operative assessment for patients about to undergo low or mid-risk non-cardiac surgery because the procedure carries risks and is unlikely to result in the change of a patient's management. (wikipedia.org)
- It can also be used during cardiac surgery to monitor the patient and assess the success of surgical interventions. (wikipedia.org)
- Connecticut Children's closely tracks our congenital cardiac surgery outcomes and reports them to the Society of Thoracic Surgeons (STS) National Database , which is the leading patient safety and quality improvement registry among cardiothoracic surgeons. (connecticutchildrens.org)
- This study was conducted to determine the frequency of acute kidney injury and the associated risk factors following cardiac surgery at Dhahran health centre in eastern Saudi Arabia. (who.int)
- All patients who underwent cardiac surgery between June 2005 and December 2008 were included. (who.int)
- Acute kidney injury following cardiac surgery is a serious problem among patients in eastern Saudi Arabia. (who.int)
Arrhythmias4
- Evidence-based recommendations on implantable cardioverter defibrillators and cardiac resynchronisation therapy for people with ventricular arrhythmias or heart failure. (nice.org.uk)
- This guidance replaces NICE technology appraisal guidance on implantable cardioverter defibrillators for arrhythmias (TA95) and NICE technology appraisal guidance on cardiac resynchronisation therapy for the treatment of heart failure (TA120). (nice.org.uk)
- This raises the possibility that exposure to environmental PAHs in many animals -- including humans -- could lead to cardiac arrhythmias and bradycardia, or slowing of the heart. (ibtimes.com)
- In response, international regulatory agreements were developed that mandate testing of all new drugs, both cardiac and non-cardiac, for cardiac liability, including drug-induced long QT interval (LQT) and risk for development of life-threatening arrhythmias, such as Torsade de Pointes (TdP) 5 . (nature.com)
Role in cardiac1
- NF-κB is a major transcription factor regulating cell survival, organ development and inflammation, but its role in cardiac development has been inadequately explored. (elsevierpure.com)
Model of cardiac1
- According to the classic model of cardiac development, the process begins when a thin crescent-shaped membrane (septum primum) begins to form along the dorsal and cranial walls of the atrium. (medscape.com)
Sarcoplasmic reticulum2
- We hypothesized that pathological sarcoplasmic reticulum Ca2+ leak through defective cardiac intracellular Ca2+ release channels/ryanodine receptors (RyR2) accelerates heart failure development by stimulating Ca2+-dependent hypertrophic signaling. (maastrichtuniversity.nl)
- The HRC gene encodes the histidine-rich calcium-binding protein, which is found in the lumen of the junctional sarcoplasmic reticulum (SR) of cardiac and skeletal muscle and within calciosomes of arterial smooth muscle. (ox.ac.uk)
Rehabilitation8
- Wake Forest Baptist Medical Center has partnered with Northern Hospital of Surry County to provide cardiac rehabilitation services at a new facility in Mount Airy. (surryedp.com)
- The cardiac rehabilitation facility is on the third floor of Northern Hospital, which is located at 830 Rockford St. (surryedp.com)
- The new facility, which construction finished on in April, is about 3,000-square-feet and can accommodate up to 15 patients per day, said Connie Paladenech, manager of cardiac and pulmonary rehabilitation at Wake Forest Baptist, in an email. (surryedp.com)
- The first patients were admitted to the Cardiac Rehabilitation program earlier this month. (surryedp.com)
- Thirty adults aged 49 to 85 years with CVD were recruited from a local exercise-based cardiac rehabilitation clinic in Auckland, New Zealand. (jmir.org)
- A decision support system can contribute to the efficiency of eHealth in cardiac rehabilitation. (utwente.nl)
- Home-based cardiac rehabilitation: Development, implementation and out" by Adnan Yaqoob, Rubina Barolia et al. (aku.edu)
- Cardiac rehabilitation (CR) is an important strategy to bring cardiac patients back to a normal life after a cardiac event. (aku.edu)
Implantable1
- This document specifies requirements that are applicable to those active implantable medical devices intended to treat bradyarrhythmias and devices that provide therapies for cardiac resynchronization. (iso.org)
Heart29
- Here, we investigate the dynamics of the cardiac myocyte epigenome during development and in chronic heart failure. (nature.com)
- Purification of CM nuclei by fluorescence-assisted sorting has led to the identification of cell-type-specific mCpG and histone modification signatures in CMs during mouse heart development and maturation 11 . (nature.com)
- Based on this method 13 , 14 , we used a nuclear staining strategy to isolate CM nuclei from intact prenatal and postnatal human heart tissue and subjected these nuclei to comprehensive analysis of the epigenome during prenatal development, postnatal maturation, and in heart failure. (nature.com)
- Here we describe the human CM epigenome during prenatal development and postnatal maturation of the heart from infant to adult age and in terminal failure. (nature.com)
- The secondary heart field (SHF) is a conserved developmental domain in avian and mammalian embryos that contributes myocardium and smooth muscle to the cardiac arterial pole. (duke.edu)
- Some molecular pathways required for SHF development in birds and mammals are conserved in teleosts, as Nkx2.5 and Nkx2.7 as well as Fgf8 regulate Bmp signaling in the zebrafish heart fields. (duke.edu)
- Although these in vivo models have provided a useful means of studying the factors involved in this cardiac condition in the whole heart. (europeanpharmaceuticalreview.com)
- The cardiac conduction system (CCS) (also called the electrical conduction system of the heart ) [1] transmits the signals generated by the sinoatrial node - the heart 's pacemaker , to cause the heart muscle to contract , and pump blood through the body's circulatory system . (wikipedia.org)
- A new study has found that a chemical found in crude oil slows the fish's heart rates, reduces cardiac contractility and causes irregular heartbeats. (ibtimes.com)
- The research, which was conducted on the tuna population, found that the mixture of chemicals found in the oil slows the fish's heart rates, reduces cardiac contractility and causes irregular heartbeats. (ibtimes.com)
- What we found was that oil blocked key processes in the cardiac cells involved with linking excitation to contraction, which means that beat to beat, we slowed the heart cells down and we also decreased their contractility," Block told BBC. (ibtimes.com)
- The protein ion channels we observe in the tuna heart cells are similar to what we would find in any vertebrate heart and provide evidence as to how petroleum products may be negatively impacting cardiac function in a wide variety of animals," Block said. (ibtimes.com)
- We explore what an SCA is versus a heart attack, ways we can all respond to save lives, a rapid response checklist and the ongoing vision for the Sudden Cardiac Arrest Association as we look to 2020 and beyond. (associationdatabase.com)
- SCAA is partnering with the Children's Cardiomyopathy Foundation this September to raise awareness of pediatric cardiomyopathy, the number one cause of sudden cardiac arrest and heart transplants among young people. (associationdatabase.com)
- In this way, haemodialysis itself may contribute to the development of heart failure and the risk of sudden death. (manchester.ac.uk)
- The research team led by Professor Jakovljevic developed an easy-to-use, non-invasive, patient friendly Cardiac Output Response to Stress (CORS) test to enhance risk stratification and early diagnosis of heart failure (HF) in primary care. (jobs.ac.uk)
- The CORS test measures haemodynamic function (cardiac output, stroke volume, heart rate, and blood pressure) at rest- (supine), challenge- (standing), and stress-(step-exercise) phases. (jobs.ac.uk)
- Ventricular chamber growth and development during perinatal circulatory transition is critical for functional adaptation of the heart. (jci.org)
- Morpholino knock-down of Kind2 in zebrafish has a pleiotropic effect on development that includes the heart. (ed.ac.uk)
- Heart development was assessed in adult flies by immunological methods and videomicroscopy. (ed.ac.uk)
- To relate cardiac autonomic function measured by heart rate variability (HRV) with prevalent and incident hypertension at the population level, the authors examined a stratified random sample of 2,061 examinees from the biracial Atherosclerosis Risk in Communities (ARIC) cohort. (psu.edu)
- Cardiac imaging refers to minimally invasive imaging of the heart using ultrasound , magnetic resonance imaging (MRI), computed tomography (CT), or nuclear medicine (NM) imaging with PET or SPECT . (wikipedia.org)
- A physician may recommend cardiac imaging to support a diagnosis of a heart condition. (wikipedia.org)
- With the introduction of the matrix TEE probe, 3D TEE can collect real-time 3D images that provide a comprehensive view of the heart structures, leading to better understanding and decision making during cardiac procedures. (wikipedia.org)
- It was found that the test predicted with 97% accuracy (negative predictive value) that a low-risk patient would not have a heart attack or major cardiac event within one year. (medicaldevice-network.com)
- We found that miR-409-3p was consistently increased in three fibrotic models, including heart tissues of postmyocardial infarction (MI) mice and neonatal rat cardiac fibroblasts treated with angiotensin II (Ang II) or transforming growth factor- β (TGF- β ). (hindawi.com)
- Patients urgently need new drugs that can prevent or reverse the stages of cardiac disease and heart failure , according to Stokes. (rdworldonline.com)
- Pulmonary exposure of rats to UFTiO2 increased the phosphorylation levels of p38 mitogen-activated protein kinase and cardiac troponin I, but not Akt, in the heart and substance P synthesis in nodose ganglia. (cdc.gov)
- His son presented with cardiac conduction disturbance with no congenital heart or skeletal defect. (medscape.com)
Pulmonary2
- Pulmonary exposure of rats to ultrafine titanium dioxide enhances cardiac protein phosphorylation and substance P synthesis in nodose ganglia. (cdc.gov)
- To identify factors associated with the development of Pulmonary embolism, a multivariable Binary Logistic Regres- sion model with sensitivity analysis was run. (who.int)
Arrest11
- Cardiac arrest frequently happens at home, and victims don't always have someone around to call for help. (engadget.com)
- University of Washington researchers have crafted a proof-of-concept AI that can detect the audio cues of cardiac arrest and respond accordingly. (engadget.com)
- The system is trained on 911 call samples to listen for the telltale sounds of agonal breathing (that is, distinctive gasps for air) that come with cardiac arrest. (engadget.com)
- In the new series, SCAA will continue to drive awareness for sudden cardiac arrest and give listeners a broader level of expertise as we join forces with our medical partners, survivors and industry specialists to build an unparalleled advocacy ecosystem to increase survivor rates for the world's leading cause of death. (associationdatabase.com)
- However, if someone collapses from a sudden cardiac arrest, why can't I use the same technology to find the closest AED? (associationdatabase.com)
- When his wife Julie had a cardiac arrest, it took 45 seconds to get CPR started. (associationdatabase.com)
- To assist high school and college athletic programs prepare for and respond to a sudden cardiac arrest (SCA). (nih.gov)
- Sudden cardiac arrest is the leading cause of death in young athletes. (nih.gov)
- The increasing number of people living in high-rise buildings presents unique challenges to care and may cause delays for 911-initiated first responders (including paramedics and fire department personnel) responding to calls for out-of-hospital cardiac arrest. (cmaj.ca)
- We examined the relation between floor of patient contact and survival after cardiac arrest in residential buildings. (cmaj.ca)
- We included all adult patients (≥ 18 yr) with out-of-hospital cardiac arrest of no obvious cause who were treated in private residences. (cmaj.ca)
Autonomic6
- In this study, we performed a literature review in order to investigate the relationship between auditory mechanisms and cardiac autonomic regulation. (bvsalud.org)
- It was hypothesized that dopamine release in the striatal system induced by pleasure songs are involved in the cardiac autonomic regulation. (bvsalud.org)
- Association of cardiac autonomic function and the development of hypertension. (psu.edu)
- High frequency (HF, 0.15 to 0.35 Hz), low frequency (LF, 0.025 to 0.15 Hz) spectral powers, and LF/HF ratio, estimated from spectral analysis, and standard deviation of all normal RR intervals (SDNN), calculated from time domain analysis, were used as the conventional indices of cardiac autonomic function. (psu.edu)
- These results suggest that cardiac autonomic function is associated with prevalent hypertension, and that reduced vagal function and the imbalance of sympatho-vagal function are associated with the risk of developing hypertension. (psu.edu)
- Dive into the research topics of 'Association of cardiac autonomic function and the development of hypertension. (psu.edu)
Conduction1
- Embryologic evidence of generation of the cardiac conduction system illuminates the respective roles of this specialized set of cells. (wikipedia.org)
Patients7
- Numerous residents of Mount Airy and surrounding communities are already traveling to Winston-Salem for their cardiac rehab services, and these patients can now be served right here at home," said Brian Beasley, vice president of clinic operations at Northern Hospital, in a prepared statement. (surryedp.com)
- Beta-blockers are a beneficial treatment for post MI patients because they decrease the incidence of recurrent cardiac events by blunting the effects of adrenaline in the body. (cms.gov)
- It has 63 cardiac beds, three operating theatres, diagnostic laboratories, a staff accommodation unit for 150 staff, and a free guest house for patients' families. (wikipedia.org)
- The researchers will invite 15-20 cardiac patients and 12-15 healthcare providers for semi-structured interviews in the qualitative phase of the study. (aku.edu)
- [1] Stress cardiac imaging is discouraged in the evaluation of patients without cardiac symptoms or in routine follow-ups. (wikipedia.org)
- Because symptoms frequently occur relatively late during the course of valvular incompetence, the prevalence of valve lesions was assessed for patients who were exposed to these drugs but who had no obvious history of cardiac disease or cardiac symptoms. (cdc.gov)
- However, in a subsequent regression analysis, only chest pain was found to be significantly associated with the development of PE in COVID-19 patients (AOR= 3.24, 95% CI= 1.10, 9.54, p-value=0.033). (who.int)
Significantly2
- Cardiac function was significantly lower, and cardiac dimensions were larger at 8 weeks after transverse aortic constriction in R176Q/+ compared with wild-type mice. (maastrichtuniversity.nl)
- In exploring the mechanism, we found that the expression of bone morphogenetic protein 10 (BMP10) and T-box transcription factor 20 (Tbx20), major regulators of cardiac development, was significantly downregulated and upregulated, respectively, in the SM22αCre-CAIKKβ flox/flox mice. (elsevierpure.com)
Transverse aortic1
- Quantitative PCR revealed increased transcriptional activation of cardiac stress genes in R176Q/+ mice after transverse aortic constriction. (maastrichtuniversity.nl)
Tissue1
- By using this platform, time and efforts will be reduced and both cardiac and alveolar models will be studied for tissue repairing assays. (dim-elicit.fr)
Skeletal muscle1
- Cardiac muscle has some similarities to neurons and skeletal muscle, as well as important unique properties. (wikipedia.org)
Electrophysiology1
- Here we show, computationally and experimentally, the limits of all-optical electrophysiology when applied to drug testing, then implement and validate OptoDyCE, a fully automated system for all-optical cardiac electrophysiology. (nature.com)
Risk stratification1
- An integrated cardiac support network incorporating standardised risk stratification, point-of-care troponin testing and cardiologist-supported decision making was progressively implemented in non-metropolitan areas of South Australia from 2001 to 2008. (mja.com.au)
Transcriptional2
- HRC is a direct transcriptional target of MEF2 during cardiac, skeletal, and arterial smooth muscle development in vivo. (ox.ac.uk)
- The expression of HRC in cardiac, skeletal, and smooth muscle raises the possibility of a common transcriptional mechanism governing its expression in all three muscle cell types. (ox.ac.uk)
Genes1
- The T-box gene family is a group of related genes that play a critical role in human embryonic development. (medscape.com)
Pacemakers2
- Pacemakers are generally implanted to alleviate symptoms of decreased cardiac output related to rate or arrhythmia. (cms.gov)
- Based on cardiac rhythm management devices, the market is divided into defibrillators and pacemakers. (researchandmarkets.com)
Defibrillators1
- The increasing presence of and timely access to automated external defibrillators (AEDs) at sporting events provides a means of early defibrillation and the potential for effective secondary prevention of sudden cardiac death. (nih.gov)
Disorders2
- A study conducted to validate the test showed that it accurately identifies the risk of these cardiac disorders compared to commonly-used risk factors. (medicaldevice-network.com)
- Although screening for these disorders has not been widely implemented, the potential to treat these disorders is likely to drive further efforts at development. (medscape.com)
Function3
- This function influences the chamber-specific development and pathogenesis in response to hypoxia and cyanotic CHDs. (jci.org)
- It therefore remains unclear whether cardiomyocyte Kind2 expression is required for cardiomyocyte junction formation and the development of normal cardiac function. (ed.ac.uk)
- The inhalation of engineered nanoparticle s stimulates the development of atherosclerosis and impairs vascular function. (cdc.gov)
Symptoms1
- Children's Cardiomyopathy Awareness Month urges families to #KnowYourHeart to learn the signs, symptoms and risk factors of cardiomyopathy, which will help identify at-risk children and get them the appropriate medical attention to prevent sudden cardiac death. (associationdatabase.com)
Centers1
- Based on End User, the market is segmented into Hospitals, Cardiac centers and Other End-user. (researchandmarkets.com)
Defective1
- Defective development of the embryonic radial ray (eg, aplasia, hypoplasia, fusion, other anomalous development) results in a wide spectrum of phenotypes, including triphalangeal or absent thumbs, foreshortened arms, and phocomelia. (medscape.com)
Pathway1
Toxicity1
- In the last 40 years, over 20% of drugs discontinued at all phases of development, including discovery, preclinical and clinical evaluation, and post-market surveillance has been due to cardiac toxicity, where unintended interactions with cardiac ion channels result in pro-arrhythmic effects 4 . (nature.com)
Centre1
- All researchers at Coventry University (from PhD to Professor) are part of the Doctoral College and Centre for Research Capability and Development, which provides support with high-quality training and career development activities. (jobs.ac.uk)
Molecular1
- The general principles of cardiac development have been studied in great detail on a morphological and molecular basis. (nature.com)
Therapies1
- Odudu, A & McIntyre, C 2010, ' Influence of dialysis therapies in the development of cardiac disease in CKD ', Journal of Renal Care , vol. 36, no. 1, pp. 47-53. (manchester.ac.uk)
Maturation1
- We find that prenatal development and postnatal maturation are characterized by a cooperation of active CpG methylation and histone marks at cis -regulatory and genic regions to shape the cardiac myocyte transcriptome. (nature.com)
Therapy2
- An article by Hjalmarson (1997) claims that there is no other therapy that has such a well-documented effect on sudden cardiac death. (cms.gov)
- Pharmaceutical development company GrowBlox Life Sciences L.L.C., a wholly owned subsidiary of GB Sciences Inc., obtained the license for Stokes' intellectual therapy last December from Makai Biotechnology L.L.C., a Hawaiʻi-based cardiovascular therapy company founded by Stokes. (rdworldonline.com)
Advisory Committee1
- New Framework (GRADE) for Development of Evidence-Based Recommendations by the Advisory Committee on Immunization Practices. (cdc.gov)
Anomalous development1
- Although the hemodynamic consequences of a common arterial outflow may predispose to the development of the fourth or the sixth arch (but not both), anomalous development of the arch system is likely a fundamental aspect of the morphogenetic anomalies that produce truncus arteriosus. (medscape.com)
Methods1
- Further development of the model and methods will permit personalized assessment of patient BF status. (frontiersin.org)
Proteins1
- In conclusion, the inhalation of UFTiO2 enhanced the phosphorylation levels of cardiac proteins. (cdc.gov)
Stages1
- Ultimately, developing tools for improved failure prediction of a drug in earlier stages of the development process is necessary to reverse current trends. (nature.com)
Therapeutic1
- The development of new therapeutic tools for the treatment of this condition has in many cases been hampered by the lack of biologically relevant experimental models on which new treatments can be tested. (europeanpharmaceuticalreview.com)
Monitoring Devices2
- The global cardiac monitoring & cardiac rhythm management devices market is segmented into cardiac monitoring devices, cardiac rhythm management devices, end user, company, and regional distribution. (researchandmarkets.com)
- To classify and forecast global cardiac monitoring & cardiac rhythm management devices market based on cardiac monitoring devices, cardiac rhythm management devices, end user, company, and regional distribution. (researchandmarkets.com)
Transcription1
- Consequent abnormal expression of the cardiac and limb-specific T-box transcription factors lead to the malformations described in HOS. (medscape.com)
Healthcare1
- The purpose of this professional development module is to refresh and enhance the knowledge of healthcare practitioners who conduct student-athlete pre-participation physical examinations. (njafp.org)
20212
- Global Cardiac Safety Services market 2021-2031 is segmented on the basis of Type, End Users and Geography. (visiongain.com)
- To analyze historical growth in market size of global cardiac monitoring & cardiac rhythm management devices market from 2017 to 2021. (researchandmarkets.com)