Cardiac cells cells into cardiomyocytes. Medical search. Frequent questions

The manipulation of endothelial cells to secrete protective factors could enhance cardioprotection. (mdpi.com)
Another change associated with aging involves the dysfunction of endothelial cells , which form the inner lining of blood vessels and the heart. (medicalnewstoday.com)
Endothelial cells regulate the blood flow as well as the exchange of fluids and molecules between the blood and the tissue. (medicalnewstoday.com)
The dysfunction of endothelial cells results in the narrowing of arteries and can increase the risk of cardiovascular diseases. (medicalnewstoday.com)
Endothelial cells also play an important role in angiogenesis, the process of formation of new blood vessels from preexisting ones. (medicalnewstoday.com)
Pericytes or perivascular cells are cells that are embedded at intervals along the walls of capillaries and wrap around endothelial cells. (medicalnewstoday.com)
Pericytes interact with endothelial cells to play an important role in the formation of new blood vessels and the maintenance of blood vessels. (medicalnewstoday.com)
Whilst the evidence is mixed, some studies have suggested that aging is associated with a decline in the coverage of endothelial cells by pericytes, resulting in increased permeability of blood vessels. (medicalnewstoday.com)
Thus, in addition to endothelial cells, impaired pericyte function may contribute to cardiovascular diseases. (medicalnewstoday.com)
They include endothelial cells, fibroblasts, and keratinocytes. (frontiersin.org)
We were interested in the developmental potential of single cardiac progenitor cell into cardiomyocytes, smooth muscle cells, and endothelial cells. (stanford.edu)
However it remains unknown which endocytic pathways are active in brain endothelial cells. (helsinki.fi)
In present study we characterized human brain endothelial cells, hCMEC/D3, which are widely utilized as BBB in vitro model. (helsinki.fi)
As brain endothelial cells are polarized in vivo, the aim of the study was to demonstrate the cell polarization of hCMEC/D3 cells and to study the activity and functionality of different endocytic pathways as a function of cell polarization. (helsinki.fi)

Epigenetic mechanisms and transcription factor networks essential for differentiation of cardiac myocytes have been uncovered. (nature.com)
By performing promoter capture Hi-C (PCHi-C) on human embryonic stem cell-derived cardiomyocytes (hESC-CMs), we show that such promoter interactions are a key mechanism by which enhancers contact their target genes after hESC-CM differentiation from hESCs. (manchester.ac.uk)
During cardiogenesis, the differentiation into working muscle cells and the conduction system remains a matter of discussion. (medscape.com)
Likewise, they have the ability to activate the angiogenesis, proliferation, migration, and differentiation of the main cell types involved in skin regeneration. (frontiersin.org)
1. Development of a ML/AI pipeline for the prediction of subtypes and differentiation stage of developing mouse cardiac cells from mesoderm to birth and from in vitro differentiation of human induced pluripotent stem cells (hiPSCs). (stanford.edu)
Recent Accomplishments - Starting in 2013, we incorporated Fluidigm-based multiplex single cell PCR equipment HD Biomark to analyze the differentiation of single cardiac progenitor cells in vitro and found that Nkx2.5 expression marks a subpopulation of committed endocardial precursor cells in the mouse heart (Li et al, Development 2015). (stanford.edu)
Moreover, it seems that paracrine action of skeletal myoblasts facilitate neighboring cardiomyocytes to maintain their replicative potential and/or stimulate differentiation of native cardiac stem cells (8,9). (escardio.org)
the EST, which assesses the effects of compounds on the differentiation of mouse embryonic stem cells into contracting cardiomyocytes, can be used to rank the potency of chemicals within a series of alkoxyacetic acid metabolites formed from The implementation of the European REACH (Registration, glycol ethers. (cdc.gov)

We investigated the in vivo relationship between the incidence of apoptotic cell death and left ventricular function serially from the beginning of hypertension to decompensated heart failure in Dahl salt-sensitive rats. (portlandpress.com)
To understand why, we will compare the function of individual human right atrial and left ventricular cardiac cells (cardiomyocytes) from coronary bypass patients who have diabetes and those who do not. (otago.ac.nz)
The left ventricular myocardium slices of both groups were semi-quantitatively analyzed using immunohistochemical staining of 8-oxidized guanine riboside (8-oxo-G) and 8-oxidized guanine deoxyriboside (8-oxo-dG) to evaluate the oxidation of RNA and DNA in cardiomyocytes. (bvsalud.org)

Cardiomyocyte apoptosis was detected by the TUNEL (terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling) method. (portlandpress.com)
In conclusion, these data suggest that cardiomyocyte apoptosis is a terminal event, and plays a role as an aggravating factor in the vicious cycle of heart failure. (portlandpress.com)
The aim of this study was to investigate whether resveratrol (RSV) could ameliorate ischemia- and hypoxia-associated cardiomyocyte apoptosis and injury via inhibiting senescence signaling and inflammasome activation. (hindawi.com)
RSV inhibited the expression of senescence markers (p53, p16, and p19), inflammasome markers (NLRP3 and Cas1 p20), and nuclear translocation of NF- κ B, hence alleviating infarction area, fibrosis, and cell apoptosis. (hindawi.com)
Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
MI/RI modeled mice were exposed to Sevo or injected with miR-99a or BRD4-related vectors to identify their functions in cardiac function, pathological injury, cardiomyocyte apoptosis, inflammation, and oxidative stress in MI/RI mice. (bvsalud.org)
Sevo improved cardiac function, relieved myocardial injury, repressed cardiomyocyte apoptosis, and alleviated inflammation and oxidative stress in mice with MI/RI. (bvsalud.org)
A study by Hashem et al using induced pluripotent stem cell-derived cardiomyocytes indicated that LAMP2 protein deficiency in Danon disease results in autophagic flux impairment, which in turn causes excessive oxidative stress and, subsequently, cardiomyocyte apoptosis. (medscape.com)

The basement membrane of myocytes is the boundary that separates the intracellular part of the cell from the extracellular environment. (microscopemaster.com)
Notably, cis -regulatory regions in cardiac myocytes are significantly enriched for cardiovascular disease-associated variants. (nature.com)
This study uncovers distinct layers of epigenetic regulation not only during prenatal development and postnatal maturation but also in diseased human cardiac myocytes. (nature.com)
Depression of calcium dynamics in cardiac myocytes - a common mechanism of halogenated hydrocarbon anesthetics and solvents. (cdc.gov)
To elucidate the therapeutic potential of cardiac cell therapy, (cardio-)myocytes and non-myocytes were transplanted in different murine infarction models. (uni-bonn.de)
Transplantation of pluripotent stem cell-derived cardiomyocytes represents one regenerative therapeutic concept that aims at adding new myocytes to the injured heart. (cnic.es)
Myocarditis is inflammation of the myocardium with necrosis of cardiac myocytes. (msdmanuals.com)
The tips of the Purkinje fibers are electrically coupled to muscle cells and the working myocytes are longitudinally connected via gap junctions, thereby initiating a coordinated, efficient contraction of the ventricles. (medscape.com)

In some cases, the first sign of the disorder is sudden cardiac death. (medlineplus.gov)
Ventricular arrhythmias account for the large majority of the 300,000 cases of sudden cardiac death annually in the United States. (sciencedaily.com)
Techniques of Prediction of Arrhythmia Occurrence and Stratification for Sudden Cardiac Death. (heartandcoeur.com)
BrS is associated with an increased risk of syncope, palpitations, chest pain, convulsions, difficulty in breathing (nocturnal agonal breathing) and/or Sudden Cardiac Death (SCD) secondary to PVT/VF, unexplained cardiac arrest or documented PVT/VF or Paroxysmal atrial fibrillation (AF) in the absence of apparent macroscopic or structural heart disease, electrolyte disturbance, use of certain medications or coronary heart disease and fever. (bvsalud.org)
Focal involvement is less likely to cause heart failure but can lead to arrhythmias and sudden cardiac death. (msdmanuals.com)

The transcription factor family E2F are also thought to be very important in regulating cardiomyocyte proliferation. (wikipedia.org)

In addition, neonatal rat cardiomyocytes (NRCMs), cardiac fibroblasts (CFs), and macrophages were isolated for in vitro experiments. (hindawi.com)

Notably, the iPSC-derived cardiomyocytes were then used to develop a therapy that was ultimately used to treat the patient. (ca.gov)
Human iPSC-derived cardiomyocytes resemble the phenotypes and functionality of primary cardiac cells and circumvent the variability presented by using primary cells. (moleculardevices.com)
iPSC-derived cardiomyocytes demonstrate synchronous spontaneous contractions that can be modified by drugs and chemical compounds, making them a biologically-relevant model. (moleculardevices.com)
5,6 The method to record and analyze calcium oscillations using time-lapse imaging and the ImageXpress® Micro High-Content Imaging System in iPSC-derived cardiomyocytes has been previously described. (moleculardevices.com)
Filmstrips of time-lapse images of spheroid and 2D iPSC derived cardiomyocytes stained with the Calcium 6 dye. (moleculardevices.com)
Human iPSC-derived cardiomyocytes were cultured according to the manufacturer's protocols in either 2D or 3D assay formats. (moleculardevices.com)

Also, cardiomyocyte proliferation and regeneration has been demonstrated to occur in various neonatal mammals in response to injury in the first week of life. (wikipedia.org)
After cardiomyocyte proliferation and regeneration was demonstrated to occur in zebrafish after resection, various animal models were utilized in order to explore whether mammals also have this innate ability. (wikipedia.org)
Since 2011, many other research groups have explored cardiomyocyte regeneration. (wikipedia.org)
Wnt/β-catenin signaling acts cell-autonomously to promote cardiomyocyte regeneration in the zebrafish heart. (uni-ulm.de)
As reported in a recent paper in npj Regenerative Medicine , however, axolotl with depleted macrophages (immune cells vital for clearing away dead cells as well as pathogens) showed a modified response to heart injury and impaired regeneration. (jax.org)
Prior studies have focused on driving cardiomyocyte proliferation to improve cardiac regeneration in mice. (jax.org)
The axolotl studies suggest that focusing instead on the role of macrophages in early ECM structure and repair events that repress fibrotic activation may provide molecular targets that better promote mammalian cardiac regeneration. (jax.org)
For this we utilise cardiac tissue engineering and animal models and combine these with chemo- and optogenetic tools to dissect out mechanisms in cardiac regeneration. (cnic.es)
The idea of myocardial regeneration with stem cell transplantation after myocardial infarction receives tremendous interest. (escardio.org)
There are limited numbers of publications about ES cells in pulp regeneration, due to the restricted policies regarding ES cell research over the past few years. (bvsalud.org)

Many other proteins associated with familial dilated cardiomyopathy make up the structural framework (the cytoskeleton) of cardiomyocytes. (medlineplus.gov)
In 80 to 90 percent of cases, familial dilated cardiomyopathy is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. (medlineplus.gov)
One of the long-standing goals of scientists is to repair heart tissue damaged by various forms of CVD such as cardiac hypertrophy, dilated cardiomyopathy, myocardial infarction, heart fibrosis, and genetic and developmental heart defects such as heart valve deformities. (bvsalud.org)

The study indicates that inducing the expression of LAV-BPIFB4 in aged mice improved cardiac function and regulation of blood flow to the heart. (medicalnewstoday.com)

iPSCs show significant potential for cardiac regenerative medicine, as researchers can use biochemical cues to "program" them into a cardiomyocyte-like cell, which shows regenerative efficacy in damaged cardiac muscle. (medgadget.com)
Cells from the blood samples are reprogrammed into clinical-grade human induced pluripotent stem cells, which can be distributed to recipients for regenerative medicine. (wjgnet.com)
The mesenchymal stromal cells (MSC) have immunomodulatory properties and a high regenerative capacity. (frontiersin.org)
Therefore, research on exosomes produced by MSC has been intensified for use in cell-free regenerative medicine. (frontiersin.org)
Cardiac events such as myocardial infarction (MI), in which tissue is damaged, leading to fibrosis and possibly heart failure, offer a particularly compelling area for implementing regenerative medicine. (jax.org)
Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)
Regenerative endodontic procedures can be defined as biologically based procedures designed to replace damaged structures, including dentin and root structures, as well as cells of the pulp-dentin complex. (bvsalud.org)
The major areas of research that might have application in the development of regenerative endodontic techniques are (a) postnatal stem cells, (b) scaffold materials, (c) morphogen/growth factors, (d) implantation. (bvsalud.org)
The most valuable cells for regenerative endodontics are postnatal or adult stem cells. (bvsalud.org)

In addition, it contributes to the excitation and contraction coupling through the transverse tubules (invaginations of the sarcolemma into the cytoplasm of cardiac cells). (microscopemaster.com)
These structures allow the depolarizing current to flow through the cardiac muscle cells from one to another and thus contribute to the contraction and relaxation of the cells. (microscopemaster.com)
This prevents the cells of the cardiac muscles from pulling apart during contraction. (microscopemaster.com)
The ability of eight widely used halogenated hydrocarbons (HC) to depress calcium (Ca) ion dynamics in rat cardiomyocytes during excitation/contraction coupling was examined. (cdc.gov)
Each cell typically contains 1 nucleus (some are multinucleated) and numerous mitochondria so that it has ample energy for contraction. (giantmicrobes.com)
The cells also contain myofibrils with are responsible for contraction. (giantmicrobes.com)
6 The cardiomyocytes were then stained with the EarlyTox ™ Cardiotoxicity Kit or Calcium 6 dye, both of which measure changes in cytoplasmic calcium levels, a kinetic indicator of the cardiomyocyte contraction. (moleculardevices.com)
Myoblasts retain skeletal muscle properties and couple only sporadically to resident cardiomyocytes precluding synchronized contraction as mechanism of benefit (8). (escardio.org)
The heart achieves the coordinated contraction of the atrial and ventricular chambers due to the precise timing of the cardiac conduction system (CCS), a specialized complex and heterogeneous network of cells that initiate and allow propagation of action potentials through the heart. (medscape.com)

The cardiomyocytes of neonatal rats and piglets are also able to undergo proliferation in response to injury during the first week of life. (wikipedia.org)
One research group demonstrated that neonatal transgenic mice deficient in fatty acids had a longer time span in which their cardiomyocytes were able proliferate in response to injury. (wikipedia.org)
Transgenic rac1 protein was expressed at levels comparable to endogenous rac levels, with activation of the rac1 signaling pathway resulting in two distinct cardiomyopathic phenotypes: a lethal dilated phenotype associated with neonatal activation of the transgene and a transient cardiac hypertrophy seen among juvenile mice that resolved with age. (jci.org)

The authors' findings, published online this week by the peer-reviewed journal Nature Medicine , suggest that mutations of either of two gene products -- proteins called KCNE2 and KCNQ1 -- already known to be involved in human cardiac arrhythmias, could also cause thyroid dysfunction. (sciencedaily.com)
It has long been known that the thyroid influences cardiac function and cardiac arrhythmias," says study senior author Dr. Geoffrey W. Abbott, associate professor of pharmacology in medicine at Weill Cornell Medical College, "but our findings demonstrate a novel genetic link between inherited cardiac arrhythmia and thyroid dysfunction. (sciencedaily.com)
Additionally, it is the authors' suggestion that assessment of the thyroid status of patients with KCNE2- and KCNQ1-linked cardiac arrhythmias could in some cases reveal a potential endocrine component to their cardiac arrhythmias that may not have been previously determined. (sciencedaily.com)
Inherited mutations in KCNQ1 and KCNE2 cause ventricular and atrial cardiac arrhythmias, previously presumed to be due entirely to the role of these proteins in cardiac muscle. (sciencedaily.com)
When the thyroid does not produce enough TH, a person may experience symptoms such as fatigue and a lowered heart rate, but there is also a more complex interplay between thyroid function, cardiac structure and cardiac arrhythmias. (sciencedaily.com)
Cardiac arrhythmias affect up to three million people in the United States. (sciencedaily.com)
Beside my clinical function as a consultant in cardiac surgery, scientifically I am interested in new biological approaches to improve the pump function of the infarcted heart and to prevent ventricular arrhythmias. (uni-bonn.de)
Furthermore we aim to improve the electrophysiological properties of the myocardial scar by cell- or gene-therapeutic based (over-)expression of the gap junction protein Connexin43 within the lesion area in order to reduce post-infarct ventricular arrhythmias. (uni-bonn.de)
Overexpression of Cx43 in cells of the myocardial scar: Correction of post-infarct arrhythmias through heterotypic cell-cell coupling. (uni-bonn.de)
Our group is specifically focusing on two aspects: i) low cell engraftment and ii) engraftment-induced arrhythmias. (cnic.es)

The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
Although there is no definitive evidence, combinations of progenitor cells seem to be more benefical than specific stem cell type for cardiac repair (3). (escardio.org)

Schlossarek, S., Mearini, G. and Carrier, L. (2011) Cardiac myosin-binding protein c in hypertrophic cardiomyopathy: Mechanisms and therapeutic opportunities. (scirp.org)
Epigenetic mechanisms are highly cell-type-specific requiring cell separation techniques to determine epigenomic features in a specific cell type, especially when keeping in mind that the cellular composition of the human heart is highly dynamic. (nature.com)
This simplified approach towards understanding the essence of the mechanisms, underlying the processes determining life and death of a cell has undoubtedly provided scientists with enormous amount of knowledge. (intechopen.com)
The molecular mechanisms of cardiac remodeling during IHD are complex [ 2 - 4 ]. (hindawi.com)
Presentations documented the impact of stem cell research on the understanding of human biological mechanisms, amelioration of human health, and treatment of disease and trauma. (ca.gov)
Both exercise-induced molecular mechanisms and physiological cardiac remodeling have been previously studied on a whole heart level. (researchgate.net)
This 'Molecular Perspectives' will highlight several diverse mechanisms of isolated conduction system disease as well as conduction system degeneration associated with other cardiac and non-cardiac disorders. (medscape.com)
Understanding of the molecular and ionic mechanisms underlying cardiac conduction is essential for the appreciation of the pathogenesis of conduction abnormalities in structurally normal and altered hearts. (medscape.com)

Knowledge of the anatomy and electrophysiology of the cardiac conduction system from the atrioventricular (AV) junction to the distal Purkinje fibers is essential to understanding the pathophysiology of left bundle branch (LBB) block (LBBB). (medscape.com)
The components of the cardiac pacemaker and conduction system are not uniform with respect to the function, morphology, and molecular phenotype. (medscape.com)
The four-ring theory describes four conduction system rings within the cardiac tube that differentiate into components of the pacemaker and conduction system. (medscape.com)
The recruitment model assumes some cardiomyocytes are committed early on to the conduction system. (medscape.com)
The specification model postulates that the primary myocardial cells express either conduction system or working myocyte genes. (medscape.com)
The specialized conduction system of the heart is composed of cells that conduct electrical impulses faster than the surrounding myocardium. (medscape.com)
Li et al, Development 2019) as well as the developing cardiac conduction system at embryonic day 16.5 of mouse development (Goodyer et al, Circulation Research 2019). (stanford.edu)
The cardiac conduction system can be anatomically, developmentally, and molecularly distinguished from the working myocardium. (medscape.com)
Abnormalities in cardiac conduction can occur due to a variety of factors, including developmental and congenital defects, acquired injury or ischemia of portions of the conduction system, or less commonly due to inherited diseases that alter cardiac conduction system function. (medscape.com)
Human genetic studies have identified mutations in the sodium channel SCN5A gene causing tachyarrhythmia disorders, as well as progressive cardiac conduction system diseases, or overlapping syndromes. (medscape.com)

Thus, endothelial cell dysfunction can lead to a reduction in the blood supply to the heart muscle by coronary arteries, thus increasing the risk of a heart attack or myocardial infarction. (medicalnewstoday.com)
However these therapies are of limited value for restoration of cardiac functions after myocardial infarction. (escardio.org)
Several preliminary reports have demonstrated that local stem cell transplantation in patients with acute myocardial infarction is safe and may lead to improved myocardial function and perfusion. (escardio.org)

However, reshaping of the epigenome of these terminally differentiated cells during fetal development, postnatal maturation, and in disease remains unknown. (nature.com)
However, the detailed epigenetic processes involved in maturation from fetal to adult CMs and in cardiac disease leading to terminal heart failure have not been fully uncovered, yet. (nature.com)

Researchers at Michigan Tech and Harvard Medical School have developed a new way to create cardiomyocytes from induced pluripotent stem cells (iPSCs), for improved cardiac cell therapy. (medgadget.com)
Programming induced pluripotent stem cells into heart muscle cells requires biochemical and biomechanical cues. (medgadget.com)
Induced pluripotent stem cell-derived cardiomyocytes beating in substrate. (medgadget.com)
Dr. Robert Kass (Columbia University), gave further examples of the power of pluripotent stem cells to ameliorate a bad situation. (ca.gov)
Cardiac Toxicity From Ethanol Exposure in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. (stembook.org)
ES cells are pluripotent cells, which mean that they can give rise to all differentiated cell types derived from all three germ layers. (bvsalud.org)

Cytoskeletal proteins - Proteins that help maintain the shape of the cell, stabilize proteins of the sarcomere and maintain mechanical integrity as well as resistance. (microscopemaster.com)
Cardiac myosin binding protein-C (cMyBP-C) is one of the proteins that make up the contractile apparatus of cardiomyocytes. (scirp.org)
These genes provide instructions for making proteins that are found in cardiac muscle cells called cardiomyocytes. (medlineplus.gov)
The remaining proteins play various roles within cardiomyocytes to ensure their proper functioning. (medlineplus.gov)
We also demonstrate that the benefit is related to the ability of the gene to reprogram cardiac cells to become more resistant to stress and build up the machinery ( ribosomes ) that make proteins. (medicalnewstoday.com)
The ras family of small GTP-binding proteins exerts powerful effects upon cell structure and function. (jci.org)
Since rate of autophagy in cells was not detected, it is impossible to determine, if there were changes in autophagy that were not reflected as changes in colocalization of these two proteins. (helsinki.fi)
To characterize hCMEC/D3 cells for the presence of specific endocytic pathways, proteins involved into each pathway were selected. (helsinki.fi)
There are a myriad of mutations identified in genes encoding cardiac transcription factors, ion channels, gap junctions, energy metabolism regulators, lamins and other structural proteins. (medscape.com)

Cardiomyocyte proliferation refers to the ability of cardiac muscle cells to progress through the cell cycle and continue to divide. (wikipedia.org)
Current research aims to further understand the biological mechanism underlying cardiomyocyte proliferation in hopes to turn this capability back on in adults in order to combat heart disease. (wikipedia.org)
The complete biological mechanism underlying cardiomyocyte proliferation has not been fully elucidated. (wikipedia.org)
Many of the signals that a cell receives during phase G1 determine whether the cell will undergo proliferation. (wikipedia.org)
One gene, jumonji (jmj), has been shown to start increasing in its expression in embryonic day 10.5 mice and is proposed to help cease the proliferation of cardiomyocytes by repressing the expression of cyclin D1. (wikipedia.org)
Knockout experiments demonstrated that the length of cardiomyocyte proliferation can be extended when Meis1 is deleted in mice. (wikipedia.org)

Cardiac function in vivo was evaluated by echocardiography and cardiac catheterization. (portlandpress.com)
Our findings revealed that RSV protected against ischemia-induced mouse heart injury in vivo and hypoxia-induced NRCM injury in vitro via regulating Sirt1/p53-mediated cell senescence and inhibiting NLRP3-mediated inflammasome activation. (hindawi.com)
The panels were Stem Cells and Aging, Drug Discovery and Endogenous Stem Cells, Tracking Stem Cells Using In Vivo Imaging, and Disease Modeling. (ca.gov)
This study, the first examination of rac1-mediated cardiac effects in vivo, demonstrates that dilation and hypertrophy can share a common molecular origin and presents evidence that both timing and concurrent signaling from multiple pathways can influence cardiac remodeling. (jci.org)
Gene therapy displacement of endogenous MCUb with a dominant-negative MCUb transgene (MCUb W246R/V251E ) in vivo rescued T2D cardiomyocytes from metabolic inflexibility and stimulated cardiac contractile function and adrenergic responsiveness by enhancing phospholamban phosphorylation via protein kinase A. We conclude that MCUb represents one newly discovered molecular effector at the interface of metabolism and cardiac function, and its repression improves the outcome of the chronically stressed diabetic heart. (diabetesjournals.org)

As the chief cell type of the heart, cardiac cells are primarily involved in the contractile function of the heart that enables the pumping of blood around the body. (microscopemaster.com)
Although cardiomyocytes contain many of the organelles found in other animal cells, they also contain others (e.g. myofibrils) that allow them to effectively perform their function. (microscopemaster.com)
Phosphorylation of cMyBP-C is essential for normal cardiac function, since dephosphorylation of this protein leads to its degradation and has been associated with cardiomyopathy. (scirp.org)
Barefield, D. and Sadayappan, S. (2010) Phosphorylation and function of cardiac myosin-binding protein c in health and disease. (scirp.org)
In silico prediction analysis with IPA predicted that upregulation of mitochondria depolarization, ROS generation, cardiomyopathy, suppression of Ca 2+ homeostasis, mitochondrial function, and ATP synthesis occurred in PM 2.5 -treated HL-1 cells. (nih.gov)
In conclusion, our results assessed the harmful effects of PM 2.5 on mitochondrial function and analyzed the biological changes related to cardiac movement, which is potentially associated with cardiovascular diseases. (nih.gov)
It is likely that the changes impair cardiomyocyte function and reduce the ability of these cells to contract, weakening and thinning cardiac muscle. (medlineplus.gov)
A recent study published in Cardiovascular Research suggests that LAV-BPIFB4 , a gene variant that previous research ha shown to be highly expressed by individuals with an exceptionally long lifespan, could also protect cardiac and vascular function in old age. (medicalnewstoday.com)
In the new study, inducing the expression of LAV-BPIFB4 in aged mice led to improvements in cardiac function that, translated to the human context, would be equivalent to a reduction in the heart's biological age by 10 years. (medicalnewstoday.com)
Image-Driven Modeling of Nanoscopic Cardiac Function: Where Have We Come From, and Where Are We Going? (simula.no)
The term inflammatory cardiomyopathy (ICM) refers to a group of disorders for which an acute or chronic myocardial inflammation is the central cause of abnormal cardiac structure or impaired cardiac function. (intechopen.com)
This, in turn, could indicate treatment of the thyroid condition, with potentially beneficial effects on cardiac function. (sciencedaily.com)
To examine the effect of rac1 activation upon cardiac structure and function, transgenic mice were created that express constitutively activated rac1 specifically in the myocardium. (jci.org)
Combining tissue engineering and stem cell biology allows us to generate three-dimensional human tissue constructs (engineered heart tissue) with organotypic function that structurally resemble native myocardium. (cnic.es)
We are using cardiac ultrasound during exercise to determine whether high intensity interval training exercise can improve the function of the diabetic left ventricle and 'normalise' the response of the diabetic heart to vigorous exercise. (otago.ac.nz)
By isolating these individual cell preparations, our study will examine the function of heart cells without the influence of the nervous system, heart rate, or pumping conditions. (otago.ac.nz)
This study will determine whether exercise training 'normalizes' the cardiac cell function of diabetic rat hearts. (otago.ac.nz)
Diabetes results in a cardiomyopathy characterized by decreased cardiomyocyte function, increased myocardial fatty acid utilization, decreased glucose utilization, increased myocardial oxygen consumption, and decreased cardiac efficiency ( 4 , 5 ), primarily as the result of changes in metabolism and Ca 2+ handling within the myocyte ( 3 , 6 , 7 ). (diabetesjournals.org)
Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
The syndrome is caused by changes in the structure and function of certain cardiac ion channels and reduced expression of Connexin 43 (Cx43) in the Right Ventricle (RV), predominantly in the Right Ventricular Outflow Tract (VSVD), causing electromechanical abnormalities. (bvsalud.org)

In human beings, as well as many other animals, cardiomyocytes are the first cells to terminally differentiate thus making the heart one of the first organs to form in a developing fetus. (microscopemaster.com)
Although other types of cells, such as gastrointestinal epithelial cells, can proliferate and differentiate throughout life, cardiac tissue contains little intrinsic ability to proliferate, as adult human cells arrest in the cell cycle. (wikipedia.org)
Lineage-restricted cardiomyocytes proliferate to pre-injury numbers but some fail to differentiate in fibrotic hearts. (uni-ulm.de)
He wanted a compound that might differentiate the early versions of the cells that create the myelin sheath to protect the nerve ("OPCs)" to mature myelinating oligodendrocytes. (ca.gov)
A stem cell is commonly defined as a cell that has the ability to continuously divide and produce progeny cells that differentiate (develop) into various other types of cells or tissues. (bvsalud.org)

Injury stimulates a subset of cardiomyocytes in the zebrafish heart that are able to proliferate and dedifferentiate. (wikipedia.org)

It is essential for cell homeostasis and survival and has been related to various diseases and pathophysiology. (helsinki.fi)

Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia. (uni-bonn.de)
Embryonic stem cell-derived cardiomyocytes as a model for arrhythmia. (heartandcoeur.com)

A defined synthetic mixture of amino acids, salts, carbohydrates, vitamins and serum was shown to support cells in vitro[ 3 ], thus unifying a major variable in cell culturing experiments and providing a possibility for rapid development of this novel method. (intechopen.com)
In vitro toxicity data of these metabolites derived in the development of validated and accepted in vitro and in silico embryonic stem cell test were used as input in the PBK model to extrapolate in vitro concentration-response curves to predicted approaches is urgently needed. (cdc.gov)

There have also been case reports that suggest that the cardiomyocytes of newborns are able to proliferate in response to ischemia. (wikipedia.org)
Persistent myocardial ischemia and hypoxia will cause malignant cardiac remodeling and subsequent heart failure. (hindawi.com)
Acute or chronic inflammation induced by ischemia has also been suggested to play an important role in the process of malignant cardiac remodeling [ 3 ]. (hindawi.com)
The resistant state of skeletal myoblasts to ischemia renders these cells suitable candidates for repair of chronically infracted and failing heart (5). (escardio.org)

Rare causes of specific inflammatory cardiomyopathies include cardiac sarcoidosis, giant cell myocarditis and eosinophilic myocarditis. (intechopen.com)
In patients with cardiac sarcoidosis, giant cell myocarditis or eosinophilic myocarditis the use of immunosuppressive treatment is recommended, as is the case in myocarditis associated with autoimmune disorders. (intechopen.com)
Immunosuppression is of use in certain types of myocarditis (eg, hypersensitivity myocarditis, giant cell myocarditis, myocarditis caused by sarcoidosis). (msdmanuals.com)

Co-emergence of cardiac and gut tissues promotes cardiomyocyte maturation within human iPSC-derived organoids. (nih.gov)
We also use human stem cells as a test-tube model to study the process of heart formation and to create new human heart tissues and organs from these stem cells. (stanford.edu)
Smooth muscle cells seeded into ring-shaped agarose wells aggregate and contract to form robust three-dimensional (3D) tissues within 7 days. (jove.com)
All tissues originate from stem cells. (bvsalud.org)
Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)

This leads to oxidative stress and death of the cells. (mitacs.ca)

Gene and Cell Therapy for Sinus and AV Nodal Dysfunction. (heartandcoeur.com)

Here, we investigate the dynamics of the cardiac myocyte epigenome during development and in chronic heart failure. (nature.com)
We find that prenatal development and postnatal maturation are characterized by a cooperation of active CpG methylation and histone marks at cis -regulatory and genic regions to shape the cardiac myocyte transcriptome. (nature.com)

These lab-fabricated, fluorescently stained cardiomyocytes-heart muscle cells-exhibit the maturation and functionality of heart cells grown within a heart. (medgadget.com)
Purification of CM nuclei by fluorescence-assisted sorting has led to the identification of cell-type-specific mCpG and histone modification signatures in CMs during mouse heart development and maturation 11 . (nature.com)

Unfortunately stem cell therapeutics don't have high success rates partly because the cells are not mature and fully functional. (medgadget.com)
Among these is the isolation of the first line of murine stem cells [ 5 , 6 ] in 1981, followed by establishment of the first human embryonic stem cell lines by Thompson [ 7 ]. (intechopen.com)
During her Master's thesis, she contributed to the development of a physical model for integrating optoelectronic scaffolds with optogenetics to investigate their effects on human stem cell-derived cardiomyocyte functionality. (uniklinik-freiburg.de)
Cell Stem Cell. (nih.gov)
The Scientific Symposium at Stem Cell Meeting on the Mesa (SCMOM) aims to advance scientific progress through the collaboration of over 16 researchers and academic leaders who were selected to present at the 8th annual conference in 2013. (ca.gov)
Our aim is to develop (stem-cell based) strategies to remuscularize the failing heart. (cnic.es)
As such, stem cell therapy cannot be regarded as a valid therapeutic option for patients with cardiovascular disease in the present era of evidenced-based medicine, yet it holds great hope for the future. (escardio.org)
Preclinical and some small-scaled clinical trials have suggested feasibility and safety of cardiac stem cell therapy. (escardio.org)
Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
This explains why researchers are now focusing attention on developing stem cell therapies using postnatal stem cells donated by the patients themselves or their close relatives. (bvsalud.org)
This approach could therefore micromass test, and the embryonic stem cell test (EST) provide a means to reduce the need for animal testing in human risk assessment practices. (cdc.gov)
physiologically based animals because a mouse embryonic stem cell line is used. (cdc.gov)

Rather than focusing on biochemical cues, these researchers looked at modifying the 3D environment of the cells, with a view to creating an environment more like that found in the heart. (medgadget.com)
Growing the cells in a three-dimensional substrate that mimics the natural heart environment produces better cells. (medgadget.com)
The mechanical properties of substrates play an important role in the cell behavior because the mechanical cues that cells sense in the actual (heart) environment is unique," said Abadi. (medgadget.com)
Using photolithography to shape a polydimethylsiloxane substrate and micropatterning to alter the substrate surface, the researchers developed 3D molds that mimic the natural forces and pressures that cardiomyocytes experience in the heart. (medgadget.com)
The researchers plan to test the cells in an animal model of cardiac disease, and also investigate the potential of enhancing electrical conductivity between the cells, to facilitate the cell-cell communication that occurs in the heart. (medgadget.com)
Also known as myocardiocytes, cardiomyocytes are cells that make up the heart muscle/cardiac muscle. (microscopemaster.com)
Cardiac muscle cells poster, cardiology print cardiomyocytes, heart anatomy medical clinic wall decor watercolor. (mimiwatercolorprints.com)
There are similar genes in zebrafish and humans that control the development of the heart and the phenomenal ability of zebrafish cardiomyocytes to proliferate in response to injury has made it a popular research model. (wikipedia.org)
Owing to technical restrictions, these studies were performed in heart tissue and therefore the affected cell type(s) could not be identified. (nature.com)
To compensate, the heart attempts to increase the amount of blood being pumped through the heart, leading to further thinning and weakening of the cardiac muscle. (medlineplus.gov)
FACTS: The heart is made of muscle cells which pump the body's blood throughout our lives from dawn to dusk and then from dusk to dawn. (giantmicrobes.com)
But in a normal healthy beating heart the cells are active once a second or a hundred thousand times a day, two billion times a life or more - the blood that's pumped could make a river red. (giantmicrobes.com)
Cardiomyocytes are interlaced in order to form the heart muscle. (giantmicrobes.com)
Cardiomyocyte comes from the parts: Cardio=heart and Myo= muscle Cyte= cell. (giantmicrobes.com)
Heart cells do not reproduce rapidly like other cells in the body. (giantmicrobes.com)
Cell division in the heart is immensely slow after birth. (giantmicrobes.com)
However, scientists are using hormones to manipulate cell growth so that the body can replace lost muscle after a heart attack. (giantmicrobes.com)
Inhibiting malignant cardiac remodeling has been considered an efficient strategy for preventing the occurrence and development of heart failure. (hindawi.com)
Intriguingly, the cardiomyocyte cells responsible for heart muscle repair continued to be activated and proliferate. (jax.org)
We subsequently became interested in developing a developing heart expression atlas in order to identify the cell type, developmental stage, and anatomical location of each single cardiac cells during mouse heart development using a random forest-based computational algorithm that we termed ATLAS-seq. (stanford.edu)
We have determined that heart cells from diabetic rats generate less force, and are less responsive to adrenaline than cells from non-diabetic hearts. (otago.ac.nz)
Using a recombinant endonuclease-deficient Cas9-based gene promoter pulldown approach coupled with mass spectrometry, we found that MCUb is upregulated in the T2D heart due to loss of glucose homeostasis regulator nuclear receptor corepressor 2 repression, and chromatin immunoprecipitation assays identified peroxisome proliferator-activated receptor α as a mediator of MCUb gene expression in T2D cardiomyocytes. (diabetesjournals.org)
Investigation of Genetic Causes in Patients with Congenital Heart Disease in Qatar: Findings from the Sidra Cardiac Registry. (cdc.gov)
The normal cardiac impulse of the vertebrate heart originates in the pacemaker cells of the sinoatrial node, located in the right atrium. (medscape.com)

Traditionally, cardiomyocytes were believed to have little to no ability to proliferate and regenerate after birth. (wikipedia.org)
Recent research has demonstrated that human cardiomyocytes do proliferate to a small extent for the first two decades of life. (wikipedia.org)
In 2009, Dr. Jonas Frisén's research group used a technique implementing carbon-dating of cardiomyocytes to propose that human adult cardiomyocytes do proliferate, but at a very slow rate. (wikipedia.org)

The focus of the department of cardiology is on Cardiac Failure, Stem Cells and Genetics. (umcutrecht.nl)

This study demonstrates that it is also possible to make human cardiac cells younger and older mice hearts by transferring a gene expressed by centenarians. (medicalnewstoday.com)

When the team tested the molds, they found that the cells matured more quickly and showed enhanced functionality, compared with traditional 2D culture. (medgadget.com)

Teresa received her BSc degree in Biomedical Engineering in 2018 from Padova University (Italy) and her MSc degree in Cell and Tissue Engineering in 2020 from Keele University (UK). (uniklinik-freiburg.de)
The key elements of tissue engineering are stem cells, morphogen, and a scaffold of extracellular matrix. (bvsalud.org)

In all 3 BSE-challenged macaques and none cardiac symptoms from prion-amyloid cardiomyopathy. (cdc.gov)
The death of the neurons and cardiomyocytes are responsible for progressive severe neurological and cardiac symptoms. (mitacs.ca)
Variant Creutzfeldt-Jakob disease, caused by transmission of bovine spongiform encephalopathy to humans, may manifest with cardiac symptoms from prion-amyloid cardiomyopathy. (cdc.gov)
Diagnosis is based on symptoms and clinical findings of abnormal electrocardiography (ECG), cardiac biomarkers, and cardiac imaging in the absence of cardiovascular risk factors. (msdmanuals.com)

Screening and evaluation of TBX20 and CITED2 mutations in children with congenital cardiac septal defects: Correlation with cardiac troponin T and caspase-3. (cdc.gov)

The team developed a culture mold that mimics the physiological conditions under which cardiomyocytes grow. (medgadget.com)
The EV composition depends on the producer cell type and its physiological conditions. (frontiersin.org)

One member of this family, rac, induces actin cytoskeletal reorganization in nonmuscle cells and hypertrophic changes in cultured cardiomyocytes. (jci.org)
Hypertrophic cardiomyopathy (HCM) is a well-recognized cardiac muscle disorder that has been known by various names, including idiopathic hypertrophic subaortic stenosis (IHSS). (medscape.com)

While cardiomyocytes are muscle cells, they are different from other muscle cells in a number of ways. (microscopemaster.com)
Unlike other muscle cells in the body, cardiomyocytes are highly resistant to fatigue and therefore always contracting and relaxing to ensure proper circulation of blood around the body. (microscopemaster.com)
The TTN gene provides instructions for making a protein called titin, which is found in the sarcomeres of many types of muscle cells, including cardiomyocytes. (medlineplus.gov)
In collaboration with the child's cardiologists, iPSC from the patient were converted to cardiomyocytes (cardiac muscle cells). (ca.gov)

Yet, even with first clinical trials underway hurdles to a successful clinical application of a cardiomyocyte transplantation approach remain. (cnic.es)
We are currently working on strategies to improve engraftment and suppress engraftment-induced arrythmias after cardiomyocyte transplantation. (cnic.es)
In experimental and clinical studies unselected mononuclear bone marrow cells as well as specific subpopulations have been used for transplantation. (escardio.org)

This is particularly interesting because cardiomyocytes undergo a shift in their metabolism during development: cardiomyocytes rely on glycolytic metabolism but switch to relying on oxidative phosphorylation. (wikipedia.org)

For example, Larry Goldstein discussed how using iPS cells from patients can better help understand the genetic risk of neurodegenerative diseases like Alzheimer's. (ca.gov)
The iPS cells from the patient allowed the doctors and researchers to understand the specific genetic background of this patient that caused the bad, off-target effects of the drugs usually used to treat Long QT Syndrome. (ca.gov)

The cessation of the cardiomyocyte cell cycle is believed to be regulated by transcription factors and cyclin dependent kinase inhibitors, although the exact mechanism remains unclear. (wikipedia.org)
Зупинка серця Cardiac arrest is the cessation of cardiac mechanical activity resulting in the absence of circulating blood flow. (msdmanuals.com)

Current knowledge of cellular behavior is mainly acquired by studies concerning homogenous populations of cells cultured as monolayers. (intechopen.com)
Through them, the cells modify their microenvironment and the behavior of neighboring cells. (frontiersin.org)

iCell Cardiomyocytes 2 (FUJIFILM Cellular Dynamics Inc. (moleculardevices.com)
This article outlines a versatile method to create cell-derived tissue rings by cellular self-assembly. (jove.com)

As the analysis of these data is computationally intensive, we have expanded our technology platform to incorporate biocomputational work including machine learning/artificial intelligence (ML/AI) to enhance our understand of the biological meaning from our single cell RNA seq data. (stanford.edu)

As the cells mature, they begin to beat, and more closely resemble mature, native cardiomyocytes. (medgadget.com)

The micropatterning alters the cell cytoskeleton and nuclear shape of cells cultured in the molds, causing changes in gene expression. (medgadget.com)

Conn Hastings received a PhD from the Royal College of Surgeons in Ireland for his work in drug delivery, investigating the potential of injectable hydrogels to deliver cells, drugs and nanoparticles in the treatment of cancer and cardiovascular diseases. (medgadget.com)

The cells are specially made to pump without a rest: abundant mitochondria and myoglobins help the cells to breathe, and coronary arteries bring lots of blood to feed the cells themselves (veins carry off the cells' digested waste) - unless, of course, the arteries are blocked and then the cells can die! (giantmicrobes.com)

The authors conclude that changes of Ca+2 dynamics in cardiomyocytes may be a common mechanism of HC cardiotoxicity. (cdc.gov)
The characterization of BBB cells would help light on the exact mechanism of nanoparticle delivery into the brain, which would enable the design of targeted nanoparticles to deliver drugs to the CNS. (helsinki.fi)

The general principles of cardiac development have been studied in great detail on a morphological and molecular basis. (nature.com)
Taken together, CITED4 expression is necessary for exercise-induced regional remodeling of the heart's microstructural helicity revealing how a key molecular regulator of cardiac remodeling manifests into downstream local tissue-level changes. (researchgate.net)
Expression of transcription factor CITED4 is necessary for exercise-induced regional remodeling of the heart's microstructural helicity, revealing how a key molecular regulator of cardiac remodeling mediates local tissue-level changes. (researchgate.net)

However, creating fully functional cardiac cells can be a challenge. (medgadget.com)
This results in more robust, mature and functional cardiomyocyte-like cells. (medgadget.com)
The study of promoter interactions in other hESC-derived cell types may be of utility in functional investigation of GWAS-associated regions. (manchester.ac.uk)

In particular, the cardiac movement of HL-1 was significantly reduced after PM 2.5 treatment. (nih.gov)
Proportion of patients with moderate and severe cardiac amyloid deposition was significantly higher in the high-absorbance group than in the low-absorbance group ((85.0%, 17/20) vs. (31.6%, 6/19), P=0.001). (bvsalud.org)

Anatomy33

Organisms11

Diseases30

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment42

Phenomena and Processes55

Disciplines and Occupations3

Technology, Industry, Agriculture2

Information Science3

Health Care4

Endothelial cells14

Differentiation8

Left ventricular3

Apoptosis8

Myocytes8

Sudden cardi5

Regulating cardiomyocyte proliferation1

Fibroblasts1

IPSC-derived cardiomyocytes6

Regeneration10

Dilated cardiomyopathy3

Improved cardiac function1

Regenerative9

Contraction9

Neonatal3

Arrhythmias10

Progenitor2

Mechanisms8

Conduction system10

Myocardial infarction3

Fetal2

Pluripotent6

Proteins9

Proliferation6

Vivo5

Function20

Differentiate5

Zebrafish heart1

Pathophysiology1

Arrhythmia2

Vitro2

Ischemia4

Giant cell myocarditis3

Tissues5

Oxidative stress1

Dysfunction1

Myocyte2

Maturation2

Stem cell12

Heart24

Proliferate3

Cardiology1

Mice1

Functionality1

Tissue Engineering2

Symptoms4

Mutations1

Physiological conditions2

Hypertrophic2

Muscle cells4

Transplantation3

Metabolism1

Genetic2

Cessation2

Behavior2

Cellular2

Biological1

Resemble1

Cytoskeleton1

Cardiovascular diseases1

Coronary1

Mechanism2

Molecular3

Functional3

Significantly2