Cardiac carcinoid tumor. Medical search. Frequent questions

Overview of Carcinoid Tumors Carcinoid tumors develop from neuroendocrine cells in the gastrointestinal tract (90%), pancreas, pulmonary bronchi, and rarely the genitourinary tract. (msdmanuals.com)
A neuroendocrine tumor (NET) can develop anywhere in the body, but is mainly found in the pancreas, gastrointestinal tract, and lungs. (biomedcentral.com)

Carcinoid tumors can be "nonfunctioning" presenting as a tumor mass or "functioning" i.e. producing several biopeptides causing carcinoid syndrome. (medscape.com)
Therefore, findings range from no tumor-related symptoms (most carcinoid tumors) to full symptoms of carcinoid syndrome (primarily in adults). (medscape.com)
Treatment focuses on control of the underlying carcinoid syndrome, targeting subsequent valvular heart disease and managing consequent heart failure. (karger.com)
Malignant Carcinoid Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Malignant Carcinoid Syndrome" by people in Harvard Catalyst Profiles by year, and whether "Malignant Carcinoid Syndrome" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Malignant Carcinoid Syndrome" by people in Profiles. (harvard.edu)
Assessment of change in quality of life, carcinoid syndrome symptoms and healthcare resource utilization in patients with carcinoid syndrome. (harvard.edu)
Impact of carcinoid syndrome symptoms and long-term use of somatostatin analogs on quality of life in patients with carcinoid syndrome: A survey study. (harvard.edu)
Changes in Weight Associated With Telotristat Ethyl in the Treatment of Carcinoid Syndrome. (harvard.edu)
Telotristat ethyl in carcinoid syndrome: safety and efficacy in the TELECAST phase 3 trial. (harvard.edu)
Understanding the Patient Experience with Carcinoid Syndrome: Exit Interviews from a Randomized, Placebo-controlled Study of Telotristat Ethyl. (harvard.edu)
Cost reduction from resolution/improvement of carcinoid syndrome symptoms following treatment with above-standard dose of octreotide LAR. (harvard.edu)
Advances in the management of patients with carcinoid syndrome. (harvard.edu)
Retrospective review of serotonergic medication tolerability in patients with neuroendocrine tumors with biochemically proven carcinoid syndrome. (harvard.edu)
Carcinoid syndrome is a group of symptoms associated with carcinoid tumors - tumors of the small intestine, colon, appendix, and bronchial tubes in the lungs. (health32.com)
Carcinoid syndrome is the pattern of symptoms sometimes seen in people with carcinoid tumors. (health32.com)
Carcinoid syndrome occurs only 10% of the time, usually after the tumor has spread to the liver or lung. (health32.com)
Carcinoid syndrome is the pattern of symptoms that typically are exhibited by people with carcinoid tumors. (health32.com)
Carcinoid-syndrome: recent advances, current status and controversies. (nih.gov)
The syndrome results from vasoactive substances (including serotonin , bradykinin, histamine, prostaglandins, polypeptide hormones) secreted by the tumor, which is typically a metastatic intestinal carcinoid. (msdmanuals.com)
Endocrinologically active tumors of the diffuse peripheral endocrine or paracrine system (neuroendocrine tumors) produce various amines and polypeptides with corresponding symptoms and signs, including carcinoid syndrome. (msdmanuals.com)
An intestinal carcinoid does not usually cause carcinoid syndrome unless hepatic metastases have occurred because metabolic products released by the tumor are rapidly destroyed by blood and liver enzymes in the portal circulation (eg, serotonin by hepatic monoamine oxidase). (msdmanuals.com)
Carcinoid syndrome develops in about 50% of the population with neuroendocrine tumors ( 1 ). (snmjournals.org)
Carcinoid heart disease manifests in many patients with carcinoid syndrome ( 2 ), but the prevalence dropped to approximately 20% after the introduction of newer therapies such as somatostatin analogs and 177 Lu-DOTATATE, along with everolimus, sunitinib, and the combination of capecitabine and temozolomide ( 3 ). (snmjournals.org)
The patient was thus considered for PRRT as a potential way to control the functioning carcinoid syndrome. (snmjournals.org)
In patients with carcinoid syndrome and VIPomas, the effect of Sandostatin Injection and SANDOSTATIN LAR DEPOT on tumor size, rate of growth and development of metastases, has not been determined. (guidelinecentral.com)
Xermelo, or telotristat ethyl, is the only approved oral therapy for carcinoid syndrome diarrhea, a debilitating condition caused by metastatic neuroendocrine tumors. (chicagobusiness.com)
Carney Complex, also known as Carney syndrome or NAME syndrome is a rare genetic disorder characterized by the development of multiple tumors in various parts of the body. (medtigo.com)
Malignant carcinoid syndrome occurs in fewer than 10% of patients with a carcinoid tumor. (medscape.com)
Carcinoids do not produce the malignant carcinoid syndrome until they are no longer confined to the small bowel or mesentery, perhaps because the liver breaks down the secretory products of tumors restricted to those locations. (medscape.com)
If a patient is thought to have carcinoid syndrome, blood and urine tests must be performed to determine levels of bioactive substances secreted by carcinoid tumors. (medscape.com)

The pathophysiology of CHD is related to vasoactive substances secreted by the tumor, of which serotonin is most prominent in the pathophysiology of CHD. (karger.com)
Serotonin stimulates fibroblast growth and fibrogenesis, which can lead to cardiac valvular fibrosis. (karger.com)
Symptoms are caused by tumor secretion of serotonin, prostaglandins, and other biologically active substances. (harvard.edu)
These tumors release too much of the hormone serotonin, as well as several other chemicals that cause the blood vessels to open (dilate). (health32.com)
Carcinoid tumors secrete excessive amounts of the hormone serotonin. (health32.com)
Serotonin , the primary hormone produced by carcinoid tumors, acts on smooth muscle to cause diarrhea, colic, and malabsorption. (msdmanuals.com)
a small tumor that secretes serotonin, found esp. (wordsmyth.net)
The name was chosen to separate these tumors from ordinary malignancies (carcinomas), but by the 1950s, the fact that carcinoids could be malignant was obvious, thanks to Erspamer and Asero (1952), who identified serotonin production by carcinoid tumors. (medscape.com)

The sign and symptoms of a "nonfunctioning" tumor depend on the tumor location and size as well as on the presence of metastases. (medscape.com)
Signs and symptoms of carcinoid tumors vary greatly and depend on the tumor location and size as well as on the presence of metastases. (medscape.com)
and asthma attacks-caused by vasoactive hormones secreted by metastases from carcinoid tumors. (medscape.com)
Imaging studies also must be performed to detect the sites of either primary tumors or metastases. (medscape.com)

A carcinoid tumor that shows atypical characteristics and has borderline malignant potential. (nih.gov)
In the huge spectrum of lung neuroendocrine neoplasms, typical and atypical carcinoids should be considered as a separate biological entity from poorly differentiated forms, harboring peculiar molecular alterations. (springeropen.com)
The first group includes typical carcinoids (TCs) and atypical carcinoids (ACs), characterized by a low mitotic count with absence of necrosis. (springeropen.com)

The etiology of carcinoid tumors is not known, but genetic abnormalities are suspected. (medscape.com)

chemotherapy may be used for malignant tumors. (msdmanuals.com)

Analysis of Real-World Treatment Patterns, Healthcare Resource Utilization, and Costs Between Octreotide and Lanreotide Among Patients With Neuroendocrine Tumors. (harvard.edu)
A study found that levels of chromogranin-A (CgA) and N-terminal pro-brain natriuretic peptide (NT-proBNP) were associated with the presence and severity of tricuspid regurgitation as a manifestation of carcinoid heart disease among patients with neuroendocrine tumors. (acc.org)

The surgical technique may vary according to the type or location of the tumor. (medscape.com)

Patients with poorly differentiated neuroendocrine carcinoma, high-grade neuroendocrine carcinoma without specification of differentiation status, adenocarcinoid tumor, or goblet cell carcinoid tumor are not eligible. (stanford.edu)
The terms related to NETs, including "carcinoid", "endocrine", "neuroendocrine", "small cell carcinoma" and "large cell neuroendocrine carcinoma (LCNEC)", were searched among histopathological diagnoses of all neoplasm specimens obtained during surgical procedures at Tokyo Medical University Hospital during the 6 years between January 2008 and December 2013. (biomedcentral.com)

While carcinoid tumors have a tendency to grow slowly, they have a potential for metastasis. (medscape.com)
Carcinoid tumors have high potential for metastasis. (medscape.com)
A section of a rare lymph node metastasis from adenocarcinoid tumor (250 X). Image courtesy of Professor Pantaleo Bufo, University of Foggia, Italy. (medscape.com)

Over 50% of diagnosed neuroendocrine neoplasms (NENs) are carcinoid tumors, secreting mainly serotonine. (umk.pl)
Neuroendocrine neoplasms (NENs) include all tumors derived from the diffuse endocrine system. (springeropen.com)
sequenced the whole exome of 69 pulmonary carcinoids reporting the most frequently DNA alterations found in these neoplasms. (springeropen.com)

Characterization, Prognosis, and Treatment of Patients With Metastatic Lung Carcinoid Tumors. (nih.gov)
Despite their indolent behavior, lung carcinoids correlate with a worse survival. (springeropen.com)
Further studies are necessary to identify new potential "druggable" molecular targets in the selected subset of low-grade lung carcinoids. (springeropen.com)
Most of these tumors produce 5-hydroxytryptamine, which, in physiologic conditions, is taken up and stored in the platelets while the excesses are inactivated in the liver and lung and transformed into 5-hydroxyindoleacetic acid (5-HIAA). (medscape.com)

1] This article focuses on cutaneous paraneoplastic syndromes caused by solid tumors. (medscape.com)
Perspectives on the current pharmacotherapeutic strategies for management of functional neuroendocrine tumor syndromes. (nih.gov)
Carcinoid tumors and related syndromes may be a part of multiple endocrine neoplasia . (medscape.com)

The North American Neuroendocrine Tumor Society Consensus Guidelines for Surveillance and Medical Management of Midgut Neuroendocrine Tumors. (nih.gov)
Carcinoid heart diseases affect in more than half percent of the patients with the carcinoid tumors, got from the midgut neuroendocrine tissue. (mnheart.com)
Typically, 90% of carcinoid tumors originate from the distal ileum or appendix (the embryologic midgut. (medscape.com)

Carcinoid heart disease (CHD) is a rare and potentially lethal manifestation of an advanced carcinoid (neuroendocrine) tumor. (karger.com)
Cardiac manifestations constitute CARCINOID HEART DISEASE. (harvard.edu)
Peptide Receptor Radionuclide Therapy with 177Lu-DOTATATE in Carcinoid Heart Disease: A Contraindication or a Promising Treatment Approach Bettering Chances for Corrective Surgery? (snmjournals.org)
We report the gratifying response of functioning metastatic neuroendocrine tumor with carcinoid heart disease (uncontrolled by long-acting octreotide) to treatment with 177 Lu-DOTATATE. (snmjournals.org)
Considering the significantly shortened overall survival of patients with carcinoid heart disease, the relative paucity of available treatment options, and the risk of complications during corrective surgery on poorly controlled functioning disease, 177 Lu-DOTATATE can emerge as a potent option in this group of patients. (snmjournals.org)
We report a case of carcinoid heart disease that was managed successfully by such therapy ( 177 Lu-DOTATATE), with a documented objective and symptomatic response that enabled the patient to be considered for corrective surgery. (snmjournals.org)
A 30-y-old man who had been diagnosed with a grade II jejunal neuroendocrine tumor metastatic to the liver and abdomen was found clinically and on 2-dimensional (2D) echocardiography to have the complication of carcinoid heart disease. (snmjournals.org)
The echocardiogram above shows severe tricuspid regurgitation due to leaflet malcoaptation, typical for carcinoid heart disease. (acc.org)
2 Characteristic echocardiographic features of advanced carcinoid heart disease include thickening and retraction of immobile tricuspid valve leaflets with associated tricuspid regurgitation, which is severe in 90 percent of patients. (acc.org)
However, given the patient's history of metastatic neuroendocrine tumor, as well as an elevated pro-BNP with echocardiographic evidence of severe tricuspid regurgitation, carcinoid heart disease is the most likely cause. (acc.org)
This is a feature consistent with carcinoid heart disease. (acc.org)
7 In carcinoid heart disease, the tricuspid valve is not displaced, and the anterior leaflet is not elongated. (acc.org)
Surgical management of left-sided carcinoid heart disease. (acc.org)

3 The morphology of the valve leaflet is not disrupted and the carcinoid plaque generally affects the ventricular aspect of the tricuspid valve leaflets and the arterial aspect of the pulmonic valve cusps. (acc.org)

Signs and symptoms of carcinoid tumors vary greatly. (medscape.com)
[ 14 ] Due to their vague and intermittent symptoms, diagnosis of carcinoid tumors may be delayed, especially in children, in whom the tumor is rare and the diagnosis is unexpected. (medscape.com)
Metabolic products released by primary pulmonary and ovarian carcinoids bypass the portal route and may similarly induce symptoms. (msdmanuals.com)
Rare intestinal carcinoids with only intra-abdominal spread can drain directly into the systemic circulation or the lymphatics and cause symptoms. (msdmanuals.com)
Endocarditis would be an unlikely cause of this presentation in the absence of symptoms of infection and no evidence of vegetations or intra-cardiac abscess on echocardiogram. (acc.org)
These tumors can affect the heart's function and may lead to various symptoms, such as heart murmurs, palpitations, and in severe cases, cardiac obstruction. (medtigo.com)
Symptoms related to cardiac myxomas may include heart murmurs, palpitations, shortness of breath, and fatigue. (medtigo.com)

She had a benign lump in her breast 15 years ago that had to be removed, and in 2015 she was hit with a double whammy when she had to have cardiac catheterization for an 80 percent coronary artery blockage, followed close on by the discovery of a slow-growing carcinoid tumor in her colon that required chemotherapy. (gazettejournal.net)
Cabozantinib is a chemotherapy drug known as a tyrosine kinase inhibitor, and it targets specific tyrosine kinase receptors, that when blocked, may slow tumor growth. (stanford.edu)

[ 6 ] In its 2015 consensus statement on best practices for pulmonary neuroendocrine tumors, the ENETS noted that tumor grading based on a combination of KI-67, mitotic rate, and necrosis may be of clinical importance but lacks validation. (medscape.com)
Pulmonary Neuroendocrine Tumors. (nih.gov)
Mutation or loss of this gene can be found in 13% of sporadic pulmonary carcinoids and seem to be associated to shorter survival [ 13 ]. (springeropen.com)

A section (on the right) of an intestinal carcinoid mass arising from the mucosa (150 X). Image courtesy of Professor Pantaleo Bufo, University of Foggia, Italy. (medscape.com)

That, he continued, was the "forerunner of designer, targeted therapies," and the subsequent "explosion" in the availability of modern cancer therapies has included many that confer cardiac issues. (fitness-gear-pro.com)
She explained that cytotoxic cancer therapies are associated with an increased risk for cardiac toxicity that is most acute during the treatment phase, but is not entirely diminished once it is over, and then typically accumulates during long-term follow-up. (fitness-gear-pro.com)
There are nevertheless a number of potential strategies to reduce the risk for cardiac toxicity, including primary and secondary prevention prior to the start of cancer therapy and early CVR-CVT management during treatment, as well as cardiovascular risk assessment in the first year after treatment completion and cancer-survivorship programs. (fitness-gear-pro.com)
It is also in a Phase 2 clinical study to be used to treat biliary tract cancer tumors, the statement said. (chicagobusiness.com)

Cardiac myxomas are one of the most common and significant manifestations of Carney Complex. (medtigo.com)

Laboratory diagnosis of carcinoid tumors depends on the identification of the characteristic biomarkers of the disease. (medscape.com)

with epigastric pain being the most common presenting symptom in duodenal carcinoids and jaundice the most common clinical finding in ampullary carcinoids. (amjcaserep.com)
Although duodenal and ampullary carcinoid tumors may have different clinical presentations, as well as histochemistry characteristics and metastatic potential, they appear to benefit from the same surgical treatment. (amjcaserep.com)

This phase III trial studies cabozantinib to see how well it works compared with placebo in treating patients with neuroendocrine or carcinoid tumors that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). (stanford.edu)
The final reason for the greater interest in cardio-oncology, Lyon added, is the increasing awareness in oncology and hematology teams of the potential for cardiac problems among their patients. (fitness-gear-pro.com)
Chromogranin-A and N-terminal pro-brain natriuretic peptide: an excellent pair of biomarkers for diagnostics in patients with neuroendocrine tumor. (acc.org)
Metastatic carcinoid tumor to the heart: echocardiographic-pathologic study of 11 patients. (acc.org)
At last follow-up, local tumor progression occurred in 11.9% of patients in the SC compared with 8.1% of patients in the non-SC cohort (P = .27). (bvsalud.org)
The term "carcinoid" was used for a long time because patients with a primary lesion in the gastrointestinal tract were mainly examined and the course was relatively favorable [ 1 ]. (biomedcentral.com)

A neuroendocrine tumor (NET) is characterized by production and secretion of peptide hormones, amines, or the presence of secretory granules. (biomedcentral.com)

In 1928, Masson established characterization of carcinoids as argentaffin cell tumors. (medscape.com)

If feasible, the treatment of choice for carcinoid tumors is surgical excision. (medscape.com)
Complete surgical removal of all tumor tissues, when feasible, is the best treatment. (medscape.com)

Carcinoid crisis can be the most serious symptom of carcinoid tumors and can be life-threatening. (medscape.com)
A symptom complex associated with CARCINOID TUMOR and characterized by attacks of severe flushing of the skin, diarrheal watery stools, bronchoconstriction, sudden drops in blood pressure, edema, and ascites. (harvard.edu)

Carcinoid tumors are of neuroendocrine origin and derived from primitive stem cells in the gut wall, especially the appendix. (medscape.com)

The tumors associated with Carney Complex are primarily benign but can still cause significant health issues due to their size and location. (medtigo.com)
The tumors associated with Carney Complex are predominantly benign myxomas, which do not spread to other parts of the body. (medtigo.com)
[ 4 ] but Oberndorfer called a group of small, benign-appearing tumors karzinoide tumoren (carcinoid) for the first time in 1907. (medscape.com)

however, tumors can originate from any cell of the amine precursor uptake and decarboxylation system and, therefore, produce several intestinal hormones. (medscape.com)

This is especially true for carcinoids, even because there is a small core of well differentiated NENs with a relatively high proliferative index showing the ability to metastasize as poorly differentiated forms [ 5 ]. (springeropen.com)

The carcinoid tumors are usually located in the gastrointestinal tract and metastasize to the liver. (harvard.edu)

In 1980, the World Health Organization (WHO) applied the term carcinoid to all tumors of the diffuse endocrine system (synonymous with amine precursor uptake and decarboxylation [APUD] and neuroendocrine cell system). (medscape.com)

Long-term treatment of the severe diarrhea and flushing episodes associated with metastatic carcinoid tumors. (guidelinecentral.com)
Long-term treatment of the profuse watery diarrhea associated with VIP-secreting tumors. (guidelinecentral.com)

The World Health Organization (WHO) and the European Neuroendocrine Tumor Society (ENETS) both incorporate mitotic count and Ki-67 proliferation for the classification of gastroenteropancreatic NETs (GEP-NETs). (medscape.com)

Duodenal and ampullary carcinoids are very rare tumors accounting respectively for 2% and 0.03% of all carcinoid tumors. (amjcaserep.com)
He was diagnosed with duodenal periampullary carcinoid tumor and treated with local excision. (amjcaserep.com)

The Problem of Appendiceal Carcinoids. (nih.gov)
[ 9 ] ) Carcinoid tumors represent 90% of appendiceal tumors. (medscape.com)

BACKGROUND AND OBJECTIVES: There is conflicting evidence on the significance of adrenocorticotrophic hormone (ACTH) staining in the prognosis of nonfunctioning pituitary neuroendocrine tumors (NFpitNETs). (bvsalud.org)

Surgery with complete removal of the tumor tissue is the ideal treatment. (health32.com)

Anatomy8

Organisms1

Diseases40

Chemicals and Drugs15

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes2

Disciplines and Occupations1

Health Care2

Pancreas2

Syndrome31

Serotonin8

Metastases4

Atypical3

Etiology1

Malignant1

Among Patients With Neuroendocrine Tumors2

Location of the tumor1

Carcinoma2

Metastasis3

Neoplasms3

Lung4

Syndromes3

Midgut3

Heart disease13

Tricuspid valve1

Symptoms7

Chemotherapy2

Pulmonary3

Intestinal carcinoid1

Cancer4

Manifestations1

Diagnosis1

Clinical2

Patients6

Secretion1

Argentaffin1

Surgical2

Symptom2

Appendix1

Benign3

Originate1

NENs1

Gastrointestinal tract1

Diffuse1

Diarrhea2

Mitotic count1

Duodenal2

Appendiceal2

Hormone1

Surgery1