Cardiac bone marrow mesenchymal stem cells. Medical search. Frequent questions

And for a final bit of dèja vu to start the new year, here is yet another trial showing that you can safely put transendocardial stem cells with autologous mesenchymal stem cells (MSCs) and bone marrow mononuclear cells (BMCs) into patients with ischaemic cardiomyopathy. (jwatch.org)
Senescence of mesenchymal stem cells (MSCs) and the related functional decline of osteogenesis have emerged as the critical pathogenesis of osteoporosis in aging. (thno.org)
Here, we intend to investigate whether RESV counteracts senescence-associated bone loss via osteogenic improvement of MSCs and the underlying mechanism. (thno.org)
MSCs derived from bone marrow (BMMSCs) and the bone-specific, senescence-accelerated, osteoblastogenesis/osteogenesis-defective mice (the SAMP6 strain) were used as experimental models. (thno.org)
Although mesenchymal stem cells (MSCs) can change into different cell types, including cardiomyocytes and endothelial cells, this is not their primary mechanism of action in cardiovascular regeneration[2]. (rehealth.com)
MSCs release an antiinflammatory microenvironment around them that influences the behavior of neighboring cells[3,4], such as endogenous stem cell recruitment, proliferation, and cell change and most importantly neovascularization (increase blood flow)[5-15]. (rehealth.com)
MSCs secrete various molecules that induce cardioprotection by stopping cell death and increasing angiogenesis, a process that significantly increases blood flow to vital tissues [16-19,25]. (rehealth.com)
Also, MSCs stimulate the proliferation and change of endogenous cardiac stem cells, thus contributing to muscle regeneration[20]. (rehealth.com)
Fibronectin (FN) is commonly used in the development of serum-free media for the expansion of mesenchymal stem cells (MSCs). (biomedcentral.com)
This study was aimed to observe if thrombin could stimulate FN secretion by human bone marrow MSCs and investigate the potential underlying mechanisms. (biomedcentral.com)
PCR analysis showed that human bone marrow MSCs expressed two subtypes of PARs, PAR-1 and PAR-2. (biomedcentral.com)
Mesenchymal stem cells (MSCs) are adult multipotent cells that were initially isolated from bone marrow[ 1 ] and characterized by the fibroblast-like appearance in culture and the capacities to form bone, adipose and cartilage. (biomedcentral.com)
However, the quantity of MSCs is very low in bone marrow (about 0.001 to 0.01% of the mononuclear cells) and in vitro expansion is the prerequisite for their clinical application. (biomedcentral.com)
Bone marrow derivedmesenchymal stem cells (MSCs) are a promising approach to the treatment of cardiac injury after myocardial infarction (MI). (biomedcentral.com)
However, little is known about the underlying mechanisms and the fate of the transplanted cells.Our aim was to in vivo monitoring the magnetically labeled MSCs after transplantation into infarcted rat hearts and determining the effects on cardiac function using a 7.0 T magnetic resonance imaging (MRI) scanner. (biomedcentral.com)
Seven days after MI, rats (syngeneic females) were randomized to injections of labeled MSCs (2×10 6 cells/50μL) or saline (50μL) into the border zone of infarcted myocardium. (biomedcentral.com)
The survival of injected MPIO-labeled MSCs is poor at 4 weeks after transplantation, and the MR hypointensities mainly arise from cardiac macrophage that engulfed the MPIO particles. (biomedcentral.com)
However, MSCs attenuate left ventricular dilatation and dysfunction after MI, which may attribute to enhanced angiogenesis, inhibition of host cell apoptosis and fibrosis. (biomedcentral.com)
Mesenchymal stem cells (MSCs) are multipotent cells with the potential to differentiate into bone, cartilage, fat and muscle cells and are being investigated for their utility in cell-based transplantation therapy. (biomedcentral.com)
A dose-response to QDs in rat bone marrow MSCs was assessed in Control (no-QDs), Low concentration (LC, 5 nmol/L) and High concentration (HC, 20 nmol/L) groups. (biomedcentral.com)
Finally, in a cardiomyocyte co-culture QD labeled MSCs were easy to locate and formed functional cell-to-cell couplings, assessed by dye diffusion. (biomedcentral.com)
Transplanted MSCs are expected to engraft, differentiate and remodel in response to the surrounding cardiac microenvironment resulting in tissue regeneration and functional repair. (biomedcentral.com)
In part, this is due to limited methods to track MSCs in vivo , precluding long-term functional studies of transplanted cells. (biomedcentral.com)
In the present study, rat bone marrow MSCs were used to evaluate QD exposure on labeled MSC yield, QD retention and proliferation. (biomedcentral.com)
The clinical use of human bone marrow-derived mesenchymal stem cells (BM-MSCs) has been expanded but failure of the transplanted stem cells in the heart still remains a problem. (medicaldesignbriefs.com)
The research team mixed genetically engineered stem cells (genetically engineered hepatocyte growth factor-expressing MSCs, HGF-eMSCs) developed by SL Bigen Co., Ltd. to make bioink in the form of a patch and introduced a new therapy by transplanting it to a damaged heart. (medicaldesignbriefs.com)
The joint research team first genetically engineered the existing BM-MSCs to produce hepatocyte growth factor consistently to improve the therapeutic potential of stem cells. (medicaldesignbriefs.com)
The engineered stem cells (HGF-eMSCs) were then mixed with BM-MSCs to make the bioink. (medicaldesignbriefs.com)
Implanted cells in a patch survived longer in vivo and had more myocardiocytes survive than the experimental group of BM-MSCs transplanted. (medicaldesignbriefs.com)
As the field of cell-based treatment develops, it has become obvious that different cell types - mesenchyme immature microorganisms (MSCs) being the model - have adequate capacity to dodge or potentially smother the invulnerable framework to the degree that they might be utilized as allografts without requiring corresponding immunosuppression [ 2 ]. (alliedacademies.org)
Clinical preliminaries have shown that allogeneic bone marrow-inferred MSCs might be securely managed to people without evoking clinically applicable insusceptible responses. (alliedacademies.org)
Ensuing to this intense MI preliminary, we played out a randomized clinical preliminary in patients with ongoing ischemic cardiomyopathy, which had as its fundamental objective the examination of transendocardial infusion of autologous and allogeneic bone marrow-determined MSCs. (alliedacademies.org)
Transplantation of mesenchymal stem cells (MSCs) derived from adult bone marrow has been proposed as a potential therapeutic approach for post-infarction left ventricular (LV) dysfunction. (uni-hannover.de)
Introduction The advantage of transplantation of bone tissue marrow-derived mesenchymal stem cells (MSCs) after cardiac infarction continues to be evaluated in lots of preclinical and scientific research [1,2]. (mycareerpeer.com)
Potential systems of MSC-mediated safety from ischemic damage will be the differentiation of MSCs into cardiomyocytes, the excitement of cardiac stem cell proliferation, and/or cells that enhance vascularization [3]. (mycareerpeer.com)
Nevertheless, the reduced retention price of MSCs after transplantation and their low propensity to differentiate right into a cardiac phenotype [4] make it improbable that cell alternative is the major mechanism of great benefit. (mycareerpeer.com)
However, a postconditioning benefit of MSCs was also demonstrated when cells were injected 2?h after ischemic injury [21]. (mycareerpeer.com)
We have previously demonstrated [22] that conditioned tyrode (ConT) obtained from MSCs enhances cardiac excitationCcontraction coupling (ECC) by Akt-mediated activation of endothelial nitric oxide synthase (eNOS) and a subsequent increase in L-type Ca2+ current (ICa,L) and enhances Ca2+ uptake through the sarcoplasmic reticulum Ca2+ ATPase (SERCA). (mycareerpeer.com)
There are many studies involving autologous therapies and some allogenic therapies, based on the recovery of mobilized bone marrow cells, including mesenchymal stem cells (MSCs) and adipose derived stem cells that also include the stromal or adherent cell type that has an MSC phenotype. (biomedcentral.com)
This includes bone and cartilage repair, cell types into which MSCs readily differentiate, and immune conditions such as graft versus host disease and autoimmune conditions that utilize the MSC's immune suppressive properties. (biomedcentral.com)
The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)
Mesenchymal stem cells (MSCs) are the most commonly used cells in tissue engineering and regenerative medicine. (frontiersin.org)
MSCs can promote host tissue repair through several different mechanisms including donor cell engraftment, release of cell signaling factors, and the transfer of healthy organelles to the host. (frontiersin.org)
Employing in vitro cell culture of inherited mitochondrial disease and an in vivo animal experimental model of low-grade inflammation (high fat feeding), we show human-derived MSCs to alter mitochondrial function. (frontiersin.org)
Mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) were derived from syngenic mouse bone marrow. (vinastemcelllab.com)
Mesenchymal stem/stromal cells (MSCs) are increasingly used as an intravenously applied cellular therapeutic. (stemcellslab.net)
Later, Arnold Caplan's group described mesenchymal stem/stromal cells (MSCs) as multipotent mesenchymal cell populations which can differentiate into several tissue types, and demonstrated roles for MSCs in the regeneration of bone, cartilage or ligaments in animal and clinical studies [2-4]. (stemcellslab.net)
Pivotal studies by the group of Horwitz in children with osteogenesis imperfecta, an inherited enzyme deficiency of collagen synthesis by mesenchymal cells in bone, opened the field for intravenous use of MSCs. (stemcellslab.net)
This implies homing of transplanted MSCs to sites in bone marrow and/or bone. (stemcellslab.net)
In a second study [6], these authors showed that autologous, enzyme-deficient MSCs transduced with a copy of the intact gene resulted in normal collagen production in bone cavities. (stemcellslab.net)
The tissue source of the MSCs was in most cases not decisive, and cells from various tissue sources were explored. (stemcellslab.net)
and signals from the injected cells were found early after administration of the MSCs at the highest frequencies in the lungs, followed by liver and spleen. (stemcellslab.net)

The administration of bone marrow-derived mesenchymal stem cells (BMSCs) is emerging as a promising approach for I/R injury-induced myocardial infarction due to its multiple differentiation potential(7, 8). (researchsquare.com)
Recently, single cell RNA sequencing (scRNA-seq) analysis has been used to examine cellular fate and function during cellular differentiation and has contributed to elucidating the mechanisms of various diseases. (hindawi.com)
Analysis of dynamic gene expression revealed that Gpx3 was significantly upregulated during cell differentiation into protective cells. (hindawi.com)
Finally, we found that transcription factors Jun , Fos , Atf3 , and Egr1 were upregulated in protective cells, especially Egr1 was predicted to be involved in the regulation of genes related to antioxidant stress and angiogenesis, suggesting a role in promoting differentiation into this cell phenotype. (hindawi.com)
The scRNA-seq analysis was used to characterize the dynamic changes associated with fibroblast differentiation and identified Gpx3 as a factor that might be involved in the regulation of myocardial fibrosis under cardiac pressure overload. (hindawi.com)
Despite growing experience and knowledge concerning human MSC and their use in cell-based strategies, the molecular mechanisms that govern MSC self-renewal, expansion and multilineage differentiation are not well understood and remain an active area of investigation. (biomedcentral.com)
We monitored these cells during their expansion ex vivo with respect to proliferation kinetics, surface marker profile and differentiation potential. (biomedcentral.com)
Progenitors are obtained by so-called direct reprogramming or directed differentiation and are also called induced somatic stem cells. (wikipedia.org)
This meant that the cells can change their differentiation pathway. (wikipedia.org)
In Drosophila imaginal discs, cells have to choose from a limited number of standard discrete differentiation states. (wikipedia.org)
The fact that transdetermination (change of the path of differentiation) often occurs for a group of cells rather than single cells shows that it is induced rather than part of maturation. (wikipedia.org)
Bone mass, bone formation rates and osteogenic differentiation of BMMSCs were primarily evaluated. (thno.org)
Chronic intermittent application of RESV enhances bone formation and counteracts accelerated bone loss, with RESV improving osteogenic differentiation of senescent BMMSCs. (thno.org)
Moreover, it seems that paracrine action of skeletal myoblasts facilitate neighboring cardiomyocytes to maintain their replicative potential and/or stimulate differentiation of native cardiac stem cells (8,9). (escardio.org)
Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
Hart, D. (2014) Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? (scirp.org)
Ando, W., Heard, B., Nakamura, N., Frank, C.B. and Hart, D.A. (2012) Ovine Synovial Membrane-Derived Mescenchymal Progenitor Cells Retain the Phenotype of the Original Tissue That Was Exposed to in Vivo Inflammation: Evidence for a Suppressed Chondrogenic Differentiation Potential of the Cells. (scirp.org)
Valproic acid can enhance the differentiation of stem cells into oligodendrocytes, making it a potential candidate for MS treatment. (bvsalud.org)
Further predicated on the evaluation of transcription elements we activated the cells to endure cardiac differentiation. (bibf1120.com)
Here, we investigate the cytotoxic effects of in vitro QD labeling on MSC proliferation and differentiation and use as a cell label in a cardiomyocyte co-culture. (biomedcentral.com)
In this way, it will provide a scaffold for stem cells and will both 1) allow for cell differentiation into organized, contractile tissue over time, and 2) nourish cellular environments via its retained native vascular conduits - together enabling the bioengineering of functional, human-sized whole heart in vitro. (savingtinyhearts.org)
Until recently, differentiation was thought to be the primary function of regenerative cells. (vetstem.com)
Within the normal BM and in pathological conditions, areas of hypoxia may have a role in maintaining stem cell fate or determining the fine equilibrium between their proliferation and differentiation. (ox.ac.uk)
In this study, the transcriptional profiles and proliferation and differentiation potential of UCB CD133(+) cells and BM mesenchymal cells (BMMC) exposed to normoxia and hypoxia were analyzed and compared. (ox.ac.uk)
The differentiation potential of UCB CD133(+) clonogenic myeloid cells was unaltered by short exposures to hypoxia. (ox.ac.uk)
1 Neural stem/progenitor cell proliferation and differentiation: role of sonic hedgehog and wingless/int-1 proteins. (vinastemcelllab.com)
5 Differentiation of periodontal stem/progenitor cells: roles of tgf-β1. (vinastemcelllab.com)
7 Smooth muscle cell differentiation from embryonic stem cells: role of hdac7 and pdgf-bb. (vinastemcelllab.com)
9 Tendon injury: role of differentiation of aduilt and embryonic derived stem cells. (vinastemcelllab.com)
At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)

Stem cell scientists have capitalised on the electrical properties of a widely used nanomaterial to develop cells which may allow the regeneration of cardiac cells. (phys.org)
BACKGROUND AND OBJECTIVES: Most studies in cardiac regeneration have explored bone marrow mesenchymal stem cells (BM-MSC) with variable therapeutic effects. (koreamed.org)
At a start-up in Maryland, she used stem cells from bone marrow (culture-expanded mesenchymal stem cells) for meniscus regeneration. (consciouslifenews.com)
There, her work revolved around using bone marrow mesenchymal stem cells for spinal cord regeneration. (consciouslifenews.com)
One example is the transformation of iris cells to lens cells in the process of maturation and transformation of retinal pigment epithelium cells into the neural retina during regeneration in adult newt eyes. (wikipedia.org)
The idea of myocardial regeneration with stem cell transplantation after myocardial infarction receives tremendous interest. (escardio.org)
Stem cells release an antiinflammatory microenvironment around them that influences the behavior of neighboring cells, promoting tissue regeneration and improving muscle function. (rehealth.com)
1. Majka M, Sulkowski M, Badyra B, Musialek P. Concise review: mesenchymal stem cells in cardiovascular regeneration: emerging research directions and clinical applications. (rehealth.com)
Individual exfoliated deciduous teeth (SHED) and adipose stem cells (ASC) were suggested seeing that substitute cell choice for cardiac regeneration. (bibf1120.com)
Keystone Symposium, Molecular Biology of Cardiac Diseases and Regeneration, April 3-8. (anl.gov)
Keystone Symposium, Molecular Mechanisms of Cardiac Disease and Regeneration, February 19-24. (anl.gov)
This was because the secretion of cytokine, which helps formation of blood vessels and cell growth, was maximized and delivered nutrients that promoted vascular regeneration and enhanced survival of the myocardiocytes. (medicaldesignbriefs.com)
The research team anticipated that this new method could be a breakthrough treatment of myocardial infarction as the implanted stem cells through HGF-eMSCs ultimately enhanced vascular regeneration and improved the myocardial infarction affected area. (medicaldesignbriefs.com)
Exosomes, a new tool in regenerative research, have implications for cardiac and tendon regeneration, wound healing, and incontinence, as well as many other applications. (mayoclinic.org)
The team manipulated the mesenchymal stem cells to create a heart regeneration cell, called cardiopoietic stem cells , and studied this cell through preclinical and human clinical trials. (mayoclinic.org)
This study was designed to improve our understanding of genetic modification of human bone marrow derived mesenchymal stem cells (hMSCs) by polyethylenimine (PEI, branched with Mw 25 kD), one of non-viral vectors that show promise in stem cell genetic modification, in the context of cardiac regeneration for patients. (uni-hannover.de)
Umbilical cord blood (UCB) and bone marrow (BM)-derived stem and progenitor cells possess two characteristics required for successful tissue regeneration: extensive proliferative capacity and the ability to differentiate into multiple cell lineages. (ox.ac.uk)
Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)

These findings indicated that cell transplantation therapy for the patients with heart failure might possibly be achieved using the regenerated cardiomyocytes from autologous bone marrow cells in the near future. (elsevierpure.com)
The transplantation of bone marrow-derived mesenchymal stem cells (BMMSCs) alleviates neuropathology and improves cognitive deficits in animal models with Alzheimer's disease. (biomedcentral.com)
Several preliminary reports have demonstrated that local stem cell transplantation in patients with acute myocardial infarction is safe and may lead to improved myocardial function and perfusion. (escardio.org)
In experimental and clinical studies unselected mononuclear bone marrow cells as well as specific subpopulations have been used for transplantation. (escardio.org)
MRI was used to evaluate stem cell migration, signal intensity changes and cardiac function at baseline (1 day before transplantation), 3 days, 2 weeks and 4 weeks after transplantation, respectively. (biomedcentral.com)
However, age-related functional decline of stem cells has restricted their clinical benefits after transplantation into the infarcted myocardium. (uni-hannover.de)
Likewise, many children are now surviving hematopoietic stem-cell transplantation (HSCT) (see related histology slide below) and require structured long-term follow-up care. (medscape.com)
In a study from the United States, long-term survivors of pediatric bone marrow transplantation followed in the Bone Marrow Transplant Survivors Study were compared with survivors of childhood cancer treated without bone marrow transplant from the Childhood Cancer Survivor Study. (medscape.com)
[ 2 , 8 ] Survivors of bone marrow transplantation were more likely to have a severe or life threatening condition (relative risk [RR] = 3.9), more than one chronic condition (RR = 2.6), functional impairment (RR=3.5), and activity limitations (RR = 5.8) than conventionally treated patients. (medscape.com)
These data reinforce the need for marked vigilance in ensuring proper screening and management of long-term survivors of bone marrow transplantation. (medscape.com)
To stimulate and facilitate further research, the NCI and NHLBI held the First International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation on April 28 and 29, 2011. (medscape.com)
25 Severe combined immunodefieciency patients: immune recovery after stem cell transplantation. (vinastemcelllab.com)
In these studies, however, transplanted cells were followed, if at all, at the site of transplantation, and biodistribution was not an issue. (stemcellslab.net)
This concept started from the observation that bone marrow transplantation can provide stromal cells able to synthesize intact collagen type I, replacing deficient patient cell function and ameliorating disease symptoms [5]. (stemcellslab.net)
The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
Central venous catheter placement is required before the administration of hematopoietic cell transplantation. (medscape.com)

Various cell types have been tested experimentally for cardiac repair so far, but only those of autologous origin have yet undergone clinical testing due to immune competency. (escardio.org)
To determine the safety and efficacy of intramyocardial autologous blood stem cell injection for cardiomyopathy. (tci-thaijo.org)
Nevertheless invasive techniques in isolating and culturing the cells in conjunction with escalating creation cost because of autologous configurations may hamper the reproducibility of such a trial in the foreseeable future. (bibf1120.com)
uses a concentrated form of autologous adipose-derived adult stem cells to treat traumatic and degenerative diseases, including bowed tendons, ligament injuries, osteoarthritis, and osteochondral defects in horses, dogs, and cats. (vetstem.com)

Bone marrow mesenchymal stem cells (BMSCs) have been reported to attenuate myocardial I/R injury via their paracrine effects, which can be enhanced by hypoxic preconditioning. (researchsquare.com)
However these therapies are of limited value for restoration of cardiac functions after myocardial infarction. (escardio.org)
Interestingly, contradictory data exist for transformation of bone marrow derived progenitor cells (BMPC) into new cardiomyocytes and alternative mechanisms as enhanced neovascularization, enhanced scar tissue formation due to augmented inflammatory response and decreased apoptosis have been suggested for the benefical effects of these cells on myocardial function after myocardial infarction (4). (escardio.org)
A typical human myocardial infarct involves the loss of approximately 1 billion cardiomyocytes and 2-3 billion other (mostly endothelial) myocardial cells, leading to a significant negative impact on the length and quality of life[1,21,22]. (rehealth.com)
Chen, X. Mesenchymal stem cells improve cardiac function after myocardial infarction in rats without long-term survival: a serial 7.0T MRI study. (biomedcentral.com)
Intravenous administration of mesenchymal stem cells ( MSC ) following myocardial infarction prevents contractile dysfunction. (anl.gov)
Recently, an international joint research team of POSTECH, Seoul St. Mary's Hospital, and City University of Hong Kong developed a cardiac patch with bioink that enhanced the functionality of stem cells to regenerate blood vessels, which in turn improved the myocardial infarction affected area. (medicaldesignbriefs.com)
They transplanted the cardiac patch with this bioink to the heart muscles affected by myocardial infarction. (medicaldesignbriefs.com)
Zhang J, Wu M, Zhang X, Yang M, Xiong T, Zhi W. Adult Bone Marrow-Derived Mesenchymal Stem Cells Seeded on Tissue-Engineered Cardiac Patch Contribute to Myocardial Scar Remodeling and Enhance Revascularization in a Rabbit Model of Chronic Myocardial Infarction. (hsforum.com)

The main purpose of this study was to characterize the fate of cardiac fibroblasts (CFs) and the dynamic gene expression patterns in a model of cardiac pressure overload using scRNA-seq analysis. (hindawi.com)
In vitro studies confirmed that the conditioned media of BMPC inhibited miR-155 expression and profibrotic signaling in mouse cardiac fibroblasts under diabetic conditions. (indexindex.com)
Furthermore, miR-155 over-expression in mouse cardiac fibroblasts inhibited antifibrotic Sloan-Kettering Institute proto-oncogene (Ski) and Ski-related novel gene, non-Alu-containing (SnoN) signaling and abrogated antifibrogenic response of HGF. (indexindex.com)
hESCs can be generated by SCNT using dermal fibroblasts nuclei from both a middle-aged 35-year-old male and an elderly, 75-year-old male, suggesting that age-associated changes are not necessarily an impediment to SCNT-based nuclear reprogramming of human cells. (wikipedia.org)
A past research shows that overexpression of TBX5 GATA4 and MEF2C transcription elements in cardiac fibroblasts could create cardiomyocytes [17]. (bibf1120.com)
MSC co-culture with skin fibroblasts from mitochondrial disease patients rescued aberrant mitochondrial morphology from a fission state to a more fused appearance indicating an effect of MSC co-culture on host cell mitochondrial network formation. (frontiersin.org)
Early enzymologic studies showed that cultured fibroblasts from patients with I-cell disease were deficient in numerous lysosomal enzymes. (medscape.com)
I-cell disease fibroblasts were subsequently discovered to be able to internalize and use lysosomal enzymes produced by normal cells, whereas normal or other lysosomal disease fibroblasts were incapable of internalizing lysosomal enzymes secreted by the I-cell disease fibroblasts. (medscape.com)
These are observed in cells of mesenchymal origin, especially fibroblasts. (medscape.com)
Other sites of abnormal cell vacuolization include the renal glomerular podocytes and in the fibroblasts of the liver's periportal spaces. (medscape.com)

They then used these nanomaterials to create cells with the characteristics of cardiac progenitors, a special type of cell found in the heart, from adult stem cells . (phys.org)
The electrical properties of the nanomaterial triggered a response in the mesenchymal (adult) stem cells, which we sourced from human bone marrow. (phys.org)
Some types of mature, specialized adult cells can naturally revert to stem cells. (wikipedia.org)
For instance, multilineage-differentiating stress-enduring (Muse) cells are stress-tolerant adult human stem cells that can self-renew. (wikipedia.org)
The bone morrow contains several stem cell types including hematopoetic stem cells, endothelial progenitor cells, mesenchymal (stromal) stem cells and multipotent adult progenitor cells. (escardio.org)
This starts up an avenue for using adult stem cells in dealing with cardiovascular diseases. (bibf1120.com)
We can augment the function of adult stem cells approved by Ministry of Food and Drug Safety and FDA using this newly developed and promising 3D bioprinting technology with the engineered stem cells. (medicaldesignbriefs.com)
More research teams are accelerating the use of other types of adult stem cells, in particular neural stem cells for diseases where beneficial outcome could result from either in-lineage cell replacement or extracellular factors. (biomedcentral.com)
These results, therefore, provide a global view of the signaling and regulatory network that controls oxygen sensing in human adult stem/progenitor cells derived from hematopoietic tissues. (ox.ac.uk)
Some adult stem cell niches have already been described, but the majority of them remain unclear, including the dental pulp stem cell niches. (bvsalud.org)

2 Sensitivity of hematopoietic and leukemic stem cells to hoxa gene levels. (vinastemcelllab.com)
The clinical presentation of patients with aplastic anemia includes symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
Low power, H and E showing a hypocellular bone marrow with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)

We optimized the PEI-mediated reporter gene transfection into hMSCs, evaluated whether transfection efficiency is associated with gender or age of the cell donors, analysed the influence of cell cycle on transfection and investigated the transfer of therapeutic vascular endothelial growth factor gene (VEGF). (uni-hannover.de)

Such cells from different sources can proliferate and differentiate into different lineages (e.g. osteogenic, chondrogenic and adipogenic) after suitable stimulation. (scirp.org)
Distinct mesenchymal lineages and niches promote epithelial self-renewal and myofibrogenesis in the lung. (nature.com)

Fukuda, K 2002, ' Reprogramming of bone marrow mesenchymal stem cells into cardiomyocytes ', Comptes Rendus - Biologies , vol. 325, no. 10, pp. 1027-1038. (elsevierpure.com)
Cell therapy is currently emerging as a potential new treatment for post MI patients with the assumption that recolonization of the areas of scarred myocardium with exogenously supplied surrogates or precursors of cardiomyocytes can restore function and ultimately affect clinical outcomes. (escardio.org)
There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)

Our in vitro studies included scratch wound-healing migration assays and transwell assays to examine PPI's effect on HCC cell migration and invasion. (bvsalud.org)
The results of these experiments demonstrated that PPI increased the susceptibility of HCC to sorafenib while inhibiting SR-HCC cell growth, migration, and invasion. (bvsalud.org)
Interference with and overproduction of GRP78 in vitro impacted the proliferation, migration, invasion, and metastasis of HCC cells. (bvsalud.org)
Further examination revealed that PPI hindered the expression of GRP78 protein, resulting in a suppressive effect on SR-HCC cell migration and invasion. (bvsalud.org)
Borlongan, C.V., Glover, L.E., Tajiri, N., Kaneko, Y. and Freeman, T.B. (2011) The Great Migration of Bone Marrow-Derived Stem Cells towards the Ischemic Brain: Therapeutic Implications for Stroke and Other Neurological Disorders. (scirp.org)
Li, L. and Jiang, J. (2011) Regulatory Factors of Mesenchymal Stem Cell Migration into Injured Tissues and Their Signal Transduction Mechanisms. (scirp.org)
PZR promotes cell migration on the extracellular matrix (ECM) molecule, fibronectin, by interacting with SHP-2 (Src homology-2 domain-containing protein tyrosine phosphatase-2), a molecule essential for skeletal development and often mutated in Noonan and Leopard syndrome patients sharing overlapping musculoskeletal abnormalities and cardiac defects. (ox.ac.uk)
To further explore the role of PZR, we assessed the expression of PZR and its ITIM-less isoform, PZRb, in human bone marrow mesenchymal stromal cells (hBM MSC), and its ability to facilitate adhesion to and spreading and migration on various ECM molecules. (ox.ac.uk)

These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)
The resistant state of skeletal myoblasts to ischemia renders these cells suitable candidates for repair of chronically infracted and failing heart (5). (escardio.org)
It has been noted that in humans and preclinical animal models that exposure to microgravity/space flight or prolonged bed rest (a surrogate for microgravity) can lead to infiltration of skeletal muscle and bone marrow with fat. (scirp.org)
The most severely affected system is the skeletal system, in which trabeculation of bone and cartilage structures are abnormal. (medscape.com)

With a variety of assays we could show that MSC represent a cell population which can be expanded for therapeutic applications. (biomedcentral.com)
In recent years mesenchymal stem cells (MSC) have generated a great deal of interest as a potential source for cell-based therapeutic strategies. (biomedcentral.com)
Polyphyllin I (PPI), a promising pharmaceutical candidate, has shown potential therapeutic advantages in the treatment of sorafenib-resistant hepatocellular carcinoma (SR-HCC cells). (bvsalud.org)
Your bone marrow actually has very low amounts of mesenchymal stem cells, which are now believed to be the most important, from a therapeutic perspective. (consciouslifenews.com)
As such, stem cell therapy cannot be regarded as a valid therapeutic option for patients with cardiovascular disease in the present era of evidenced-based medicine, yet it holds great hope for the future. (escardio.org)
Valproic acid (VPA), a neuroprotective agent and inhibitor of GSK3-ß, along with human Adipose-Derived Stem Cells (hADSCs) have been proposed to be potential therapeutic agents for neurodegenerative disorders. (bvsalud.org)
Even so a electric battery of pitfalls restricts using this cell series in therapeutic program namely ethical problems involving devastation of embryo challenging isolation methods as well as the tendency to create tumours [6]. (bibf1120.com)
14 Pluripotent cell-derived glial precursor cells for the delivery of therapeutic proteins to the central nervous system. (vinastemcelllab.com)

Bone marrow-derived progenitor cell (BMPC) therapy has been shown to promote neovascularization, decrease infarct area and attenuate left ventricular (LV) dysfunction after MI. (indexindex.com)
They are classified as either totipotent (iTC), pluripotent (iPSC) or progenitor (multipotent - iMSC, also called an induced multipotent progenitor cell - iMPC) or unipotent - (iUSC) according to their developmental potential and degree of dedifferentiation. (wikipedia.org)
Hart, D.A. (2014) Why Mesenchymal Stem Cell/Progenitor Cell Heterogeneity in Specific Environments? (scirp.org)
Both progenitor cell populations responded to hypoxic stimuli by stabilizing the hypoxia inducible factor (HIF)-1alpha protein. (ox.ac.uk)

These protective effects may be associated with the inhibition of apoptosis and inflammation, as reflected by less TUNEL-positive cells and lower levels of serum proinflammatory cytokines (Interleukin-1β, Interleukin-6, tumor necrosis factor-α) and cardiac troponin I in the N-CM group compared with the vehicle group. (researchsquare.com)
There is a signal crosstalk between autophagy and apoptosis, which may be regulated to produce synergistic effect on the preconditioning of stem cells. (biomedcentral.com)
Mesenchymal stem cells secrete factors that inhibit apoptosis in H9c2 cardiac myoblasts. (anl.gov)

Once damaged by heart attack, cardiac muscle has very little capacity for self-repair and at present there are no clinical treatments available to repair damaged cardiac muscle tissue. (phys.org)
Since the use of a patient's own heart cells is not a viable clinical option, many researchers are working to try to find an alternative source of cells that could be used for cardiac tissue repair. (phys.org)
This is a totally new approach and provides a ready-source of tailored cells , which have the potential to be used as a new clinical therapy. (phys.org)
BACKGROUND: Bone marrow oedema (BMO) in children/adolescents is a rare clinical condition without an etiologic cause. (koreamed.org)
However, their low frequency in bone marrow necessitate ex vivo expansion for further clinical application. (biomedcentral.com)
Preclinical and some small-scaled clinical trials have suggested feasibility and safety of cardiac stem cell therapy. (escardio.org)
Clinical studies with stem cells have shown an improved ventricular remodeling and cardiac metabolism, which translates into a better quality of life conditions. (rehealth.com)
Clinical applications of mesenchymal stem cells. (rehealth.com)
Gimble, J.M., Bunnell, B.A. and Guilak, F. (2012) Human Adipose-Derived Cells: An Update on the Transition to Clinical Translation. (scirp.org)
Batsali, A.K., Kastrinaki, M.C., Papadaki, H.A. and Pontikoglou, C. (2013) Mesenchymal Stem Cells Derived from Wharton's Jelly of the Umbilical Cord: Biological Properties and Emerging Clinical Applications. (scirp.org)
Human stem cells are used in the clinical therapies of a dead heart, which happens when a blood vessel is clogged or whole or a part of heart muscle is damaged. (medicaldesignbriefs.com)
While a vast storehouse of knowledge on stem cells exists, clinical indications remain elusive. (mayoclinic.org)
Cell based treatment is at the front of clinical examination for cardiovascular infection, upheld by more than 10 years of thorough pre-clinical investigation of cell science, mechanism(s) of activity, immunology, and phenotypic adequacy. (alliedacademies.org)
Critically, making an interpretation of cell treatment into standard clinical practice requires the capacity to direct a protected and strong item at the ideal measurements promptly. (alliedacademies.org)
Likewise, in another clinical preliminary where allogeneic mesenchyme antecedent cells (MPCs) were conveyed to patients with left ventricular help gadgets, contributor explicit HLA refinement created after randomization in two MPC and three control patients, which were all settled by 1 year. (alliedacademies.org)
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. (biomedcentral.com)
The rapid advance of stem cell clinical trials for a broad spectrum of conditions warrants an update of the review by Trounson (2009) [ 1 ]. (biomedcentral.com)
There has been a rapid surge in clinical trials involving stem cell therapies over the last two to three years and those trials are establishing the clinical pathways for an emergent new medicine. (biomedcentral.com)
Placenta-derived stem cells are being considered for similar uses and are in Phase III clinical trial for critical limb ischemia by Israel's Pluristem Therapeutics. (biomedcentral.com)
A significant proportion of clinical studies that are underway involve bone marrow and cord blood stem cells for blood and immune disorders [ 3 ] and cancers. (biomedcentral.com)
We have chosen to concentrate on the emerging therapeutics that broadly involves a wide range of cell types in clinical trials registered on the National Institutes of Health's clinical trials web site. (biomedcentral.com)
Success in numerous animal models of disease and emerging success in human clinical trials for Crohn's fistulas 1 and stroke, 2 along with hundreds of ongoing clinical trials (see sidebar) support the rationale for stem cell use, and now success, in veterinary medicine. (vetstem.com)
VetStem Regenerative Cell Therapy is based on a clinical technology licensed from Artecel Inc. Original patents are from the University of Pittsburgh and Duke University. (vetstem.com)

Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. (biomedcentral.com)
After injury, mature terminally differentiated kidney cells dedifferentiate into more primordial versions of themselves and then differentiate into the cell types needing replacement in the damaged tissue Macrophages can self-renew by local proliferation of mature differentiated cells. (wikipedia.org)
They form characteristic cell clusters in suspension culture that express a set of genes associated with pluripotency and can differentiate into endodermal, ectodermal and mesodermal cells both in vitro and in vivo. (wikipedia.org)
Dental pulp stem cells have been isolated from deciduous and permanent teeth and have the potential to self-renew and differentiate. (bvsalud.org)

Over the last 10 years, there has been tremendous interest in developing a cell-based therapy to address this problem. (phys.org)
In this interview, she discusses the enormous regenerative potential of stem cell therapy. (consciouslifenews.com)
While it's easy to think of stem cell therapy as a magic bullet, it would be wise to implement strategies that nourish and thereby help optimize the stem cells you already have in your body. (consciouslifenews.com)
The other thing we've discovered over the years is that [stem cell therapy] is not the type of thing where you take one dose and you're cured forever. (consciouslifenews.com)
Together, our data demonstrates that paracrine regulation of cardiac miRNAs by transplanted BMPCs contributes to the antifibrotic effects of BMPC therapy. (indexindex.com)
These data suggest that targeting miR-155 might serve as a potential therapy against cardiac fibrosis in the diabetic heart. (indexindex.com)
Cell therapy is a potential new treatment for post MI patients, but the main challenges are : the necessity to preserve immune competency and to gain adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
Repair of scar tissue constitutes a challenge for cardiac stem cell therapy due to lack of adequate nutrition and homing signals necessary for stem cells' engraftment and survival. (escardio.org)
Could extracellular vesicles derived from mesenchymal stem cells be a potential therapy for acute pancreatitis-induced cardiac injury? (wjgnet.com)
Conditions with poor vascularization may benefit from stem cell therapy by promoting the creation of a more developed circulatory network. (rehealth.com)
These properties have been shown by the improvement of the left ventricular remodeling[23] and cardiac metabolism[24] following MSC therapy. (rehealth.com)
Mesenchymal stem cells: emerging mechanisms of immunomodulation and therapy. (rehealth.com)
Because of this stem cell therapy provides emerged alternatively choice with potential benefits for sufferers with end-stage cardiovascular disease. (bibf1120.com)
Stem cells are expensive, difficult to transport, and stem cell therapy results are unpredictable. (mayoclinic.org)
A brief note on allogeneic cell therapy. (alliedacademies.org)
Jager M. A brief note on allogeneic cell therapy. (alliedacademies.org)
Current treatment options for children with severe cardiac defects and those with CHF include medical therapy, cardiac pacing, mechanical ventricular assist device implantation (VAD), and heart replacement. (savingtinyhearts.org)
3-6 The first peer-reviewed double-blinded multicenter study for adipose-derived stem cell therapy use in canine osteoarthritis of the hip showed significant improvement in all post treatment evaluation times for lameness, pain, and range of motion. (vetstem.com)
VetStem Regenerative Cell (VSRC™) therapy delivers a functionally diverse cell population able to communicate with other cells in their local environment. (vetstem.com)
high-risk patients included male subjects, recipients of stem cells from female donors, patients younger than 10 years, those with nonidentical donors, and those who received radiation therapy in the transplant preparative regimen. (medscape.com)
Trang chủ Công trình KHCN Sách/Chương sách Improving the Efficacy of Diabetes Mellitus Treatment by Combining Cell Replacement Therapy. (vinastemcelllab.com)
Stem cell therapy has the potential to overcome these limitations and may offer the best outcomes for treating diabetes mellitus. (vinastemcelllab.com)
Based on the pathophysiology of diabetes mellitus, stem cell therapy targets two mechanisms, namely cell replacement and immune correction. (vinastemcelllab.com)
The aim of this series of studies was to evaluate the efficiency of diabetic treatment by combining cell replacement therapy with immune correction therapy. (vinastemcelllab.com)
These findings provide hope for a new strategy that can improve the outcomes of stem cell-based therapy for diabetes in humans. (vinastemcelllab.com)
18 Adipose-derived stem cells: therapy through paracrine actions. (vinastemcelllab.com)

Differentiated airway epithelial cells can revert into stable and functional stem cells in vivo. (wikipedia.org)
and NF-?B signaling play a critical role in cigarette smoke-induced epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy. (rochester.edu)
Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis. (nature.com)

Considering the limited amount of cells that could be transferred, they used heart-derived extracellular matrix bioink to make a cardiac patch. (medicaldesignbriefs.com)
These early trials are showing roles for stem cells both in replacing damaged tissue as well as in providing extracellular factors that can promote endogenous cellular salvage and replenishment. (biomedcentral.com)

16 Microencapsulation procedures for the immunoisolation of wharton's jelly mesenchymal stem cells: a review. (vinastemcelllab.com)

Although many studies indicate a better still left ventricular ejection, an evaluation between studies is normally difficult because of variants in (1) cell selection, (2) variety of cells transplanted, (3) period of treatment, (4) approach to cell delivery, and (5) period of follow-up. (mycareerpeer.com)

They showed that opposing gradients of bone morphogenetic protein (BMP) and Nodal, two transforming growth factor family members that act as morphogens, are sufficient to induce molecular and cellular mechanisms required to organize, in vivo or in vitro, uncommitted cells of the zebrafish blastula animal pole into a well-developed embryo. (wikipedia.org)
The mechanisms underlying MSC engraftment and electrical and mechanical integration with host cardiac tissue are not understood. (biomedcentral.com)
26 Transplanted mesenchymal stem cells aid the injured brain through trophic support mechanisms.Index. (vinastemcelllab.com)

Why Use Adipose-Derived Stem Cells? (vetstem.com)

Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trinileage differenciation capacity. (rehealth.com)
An open door that extraordinarily upgrades the capacity to foster such an item is the utilization of allogeneic treatment, which offers a proficient method for accomplishing both quick accessibility of item and the proper number of cells [ 1 ]. (alliedacademies.org)
Stream kilometric crosscoordinate with serum from the second understanding to new contributor T cells showed a powerless positive response, demonstrating low titer, once more allogeneic refinement with class I benefactor antigens. (alliedacademies.org)
Moreover, children who received transplants approached growth curves similar to the children transplanted with allogeneic complete bone marrow [6]. (stemcellslab.net)

To improve the quality of liver grafts from extended-criteria donors donated after circulatory death (DCD), this study explored whether bone marrow mesenchymal stem cells (BMMSCs) combined with normothermic machine perfusion (NMP) have protective effects on DCD donor livers and the effects of ferroptosis in this procedure. (medscimonit.com)
Hydrogen peroxide was used to induce an oxidative stress model of hepatocyte IAR-20 cells to evaluate the protective effects of BMMSCs in vitro. (medscimonit.com)
BMMSCs showed significant protective effects on the ultrastructure of DCD donor livers and ROS-induced injury to IAR-20 cells under electron microscopy. (medscimonit.com)
BMMSCs also significantly improved the expression level of microtubule-associated protein 1 light chain 3 (LC3)-II in both DCD donor livers and ROS-induced injured IAR-20 cells, including upregulating the expression of ferritin. (medscimonit.com)
Moreover, Mitofilin is revealed to be indispensable for mitochondrial homeostasis and osteogenesis of BMMSCs, and that insufficiency of Mitofilin leads to BMMSC senescence and bone loss. (thno.org)

Transendocardial Mesenchymal Stem Cells and Mononuclear Bone Marrow Cells for Ischemic Cardiomyopathy (pg. (jwatch.org)

In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)

Ischemia in the cardiac muscle results in the loss of energy production and changes in the intracellular ion homeostasis [10]. (mycareerpeer.com)
MSC-mediated cardioprotection from ischemia/reperfusion (I/R) injury has been demonstrated through preconditioning of the cardiac tissue [17]. (mycareerpeer.com)

Quantum Dots (QDs) offer an alternative to organic dyes and fluorescent proteins to label and track cells in vitro and in vivo . (biomedcentral.com)
Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)
Aplastic anemia: evidence for dysfunctional bone marrow progenitor cells and the corrective effect of granulocyte colony-stimulating factor in vitro. (medscape.com)

Single-cell deconvolution of fibroblast heterogeneity in mouse pulmonary fibrosis. (nature.com)

Pseudotime analysis showed that CFs differentiated into two distinct cell fates, one of which produced activated myofibroblasts, and the other which produced protective cells that were associated with reduced fibrosis levels, increased antioxidative stress responses, and the ability to promote angiogenesis. (hindawi.com)
Furthermore, inhibition of paracrine factor hepatocyte growth factor (HGF) signaling in vivo suppressed the BMPC-mediated inhibition of miR-155 expression and the associated protective effect on cardiac fibrosis and function. (indexindex.com)
BMPCs release HGF, which inhibits miR-155-mediated profibrosis signaling, thereby preventing cardiac fibrosis. (indexindex.com)
Fig. 1: Deconvolving fibrosis using multi-modal single-cell approaches. (nature.com)
Defining the activated fibroblast population in lung fibrosis using single-cell sequencing. (nature.com)
Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis. (nature.com)
Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis. (nature.com)
Atherosclerotic plaque rupture is the leading cause of cardiovascular death resulting from acute coronary syndrome (ACS) and leads to cardiac remodeling and fibrosis following ACS. (archivesofmedicalscience.com)

He has taught anatomy, physiology, and cell biology at Trinity Christian College for 34 years, and he still teaches there in addition to his work at Argonne. (anl.gov)
However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)

The theoretical basis for marrow failure includes primary defects in or damage to the stem cell or the marrow microenvironment. (medscape.com)

The primary purpose of stem cells is to maintain, heal and regenerate tissues wherever they reside in your body. (consciouslifenews.com)
Your tissues are constantly getting damaged … You're going to have to repeat-dose and use those stem cells to your advantage. (consciouslifenews.com)
Mesenchymal stem/progenitor cells (MSC/MPC) are found in many tissues and fluids including bone marrow, adipose tissues, muscle, synovial membranes, synovial fluid, and blood. (scirp.org)
POT1 mutation carriers had a range of benign and malignant neoplasms involving epithelial, mesenchymal, and neuronal tissues in addition to B- and T-cell lymphoma and myeloid cancers. (cdc.gov)

Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery. (rehealth.com)

The stem cells are isolated from the patient's own blood and cultured. (tci-thaijo.org)

3. Maintenance of neural stem cells in the brain: role of notch signaling. (vinastemcelllab.com)
20 Malignant gliomas: treatment using genetically-modified neural stem cells. (vinastemcelllab.com)

Hayflick, L. & Moorhead, P. S. The serial cultivation of human diploid cell strains. (nature.com)
Human MSC are easy to isolate from small aspirate of bone marrow via their adherence ability. (biomedcentral.com)
In this study we asked if human MSC are developing in an aberrant or unwanted way during ex vivo long-term cultivation and if cultivation conditions exert any influence on their stem cell maintenance. (biomedcentral.com)
We investigated the presence of aluminium (Al) in human colon cancer samples and its potential association with biological processes involved in cancer progression, such as epithelial to mesenchymal transition (EMT) and cell death. (bvsalud.org)
The Human Lung Cell Atlas: a high-resolution reference map of the human lung in health and disease. (nature.com)
Transcriptional profiling of human cord blood CD133+ and cultured bone marrow mesenchymal stem cells in response to hypoxia. (ox.ac.uk)
6 Induced pluripotent stem cells from human extra-embryonic amnion cells: role of dna methylation in mainting stemness. (vinastemcelllab.com)
13 Proliferation of bone marrow-derived human mesenchymal stem cells: role of enamel matrix proteins. (vinastemcelllab.com)
17 Human hair follical stem cells: markers, selection and perspective clinic application. (vinastemcelllab.com)

We have isolated a cardiomyogenic cell line (CMG cell) from murine bone marrow mesenchymal stem cells. (elsevierpure.com)

Stem cells secrete angiogenic factors, which promote the formation of new blood vessels from pre-existing ones in a very similar way to a sprout and splitting behavior. (rehealth.com)
Bone marrow mesenchymal stem cells secrete factors that exert anti-apoptotic and pro-apoptotic effects on H9c2 cardiac myoblasts. (anl.gov)

4 Maintenance of hematopoiesis: role of early b cell factor 2 matthias kieslinger. (vinastemcelllab.com)
In the 1970s, Friedenstein and colleagues [1] first reported that locally applied culture-expanded populations of bone marrow stroma-derived fibroblastic cells remained at their injection sites under the kidney capsule, where an ectopic hematopoiesis was initiated. (stemcellslab.net)
Hematopoiesis support of mesenchymal stem cells in children with aplastic anemia]. (medscape.com)

The limitations imposed on patient cells could be addressed by genetic modification of stem cells. (uni-hannover.de)
Rejuvenation therapies aim to reverse or repair age-related cellular changes such as molecular waste, calcification , tissue stiffening , loss of stem cell function , genetic alterations, and impaired energy production . (fightaging.org)

We will use a perfusion bioreactor to simulate physiological conditions in the ECM, onto which we will seed uncommitted progenitors, cardiac precursors, and/or bone marrow-derived mesenchymal stem cells. (savingtinyhearts.org)

Senescent cells are characterized by an upregulation of proinflammatory cytokines, which is termed the senescence-associated secretory phenotype (SASP). (nature.com)

Induced stem cells (iSC) are stem cells derived from somatic, reproductive, pluripotent or other cell types by deliberate epigenetic reprogramming. (wikipedia.org)
The researchers were able to identify the minimal conditions and factors that would be sufficient for starting the cascade of molecular and cellular processes to instruct pluripotent cells to organize the embryo. (wikipedia.org)
At the same time, the first three trials using cells derived from pluripotent cells have begun. (biomedcentral.com)
12 Induced pluripotent stem cell production and characterization: an overview of somatic cell reprogramming. (vinastemcelllab.com)

Double staining for iron and CD68 (resident macrophage marker) showed that most of the iron-positive cells were cardiac macrophages at 4 weeks. (biomedcentral.com)

Anatomy49

Organisms20

Diseases19

Chemicals and Drugs48

Analytical, Diagnostic and Therapeutic Techniques and Equipment52

Phenomena and Processes45

Disciplines and Occupations3

Technology, Industry, Agriculture8

Information Science1

Named Groups1

Health Care1

MSCs52

Differentiation30

Regeneration19

Transplantation16

Autologous4

Myocardial9

Fibroblasts10

Adult10

Hematopoietic3

Endothelial1

Lineages2

Cardiomyocytes3

Migration8

Skeletal4

Therapeutic8

Progenitor cell4

Apoptosis3

Clinical23

Differentiate4

Therapy26

Epithelial cells3

Extracellular2

Wharton's Jelly1

Left ventricular1

Mechanisms3

Adipose derived stem1

Allogeneic4

BMMSCs5

Ischemic Cardiomyopathy1

Cardiomyocyte1

Ischemia2

Vitro3

Heterogeneity1

Fibrosis8

Biology2

Microenvironment1

Tissues4

Exosomes1

Patient's1

Neural stem2

Human9

Murine1

Secrete2

Hematopoiesis3

Genetic2

Progenitors1

Phenotype1

Pluripotent4

Macrophages1