Cardiac beta. Medical search. Frequent questions

Multicenter, Prospective, Randomized Controlled Trial of High-Sensitivity Cardiac Troponin I-Guided Combination Angiotensin Receptor Blockade and Beta-Blocker Therapy to Prevent Anthracycline Cardiotoxicity: The Cardiac CARE Trial. (ox.ac.uk)
BACKGROUND: Anthracycline-induced cardiotoxicity has a variable incidence, and the development of left ventricular dysfunction is preceded by elevations in cardiac troponin concentrations. (ox.ac.uk)
METHODS: In a multicenter, prospective, randomized, open-label, blinded end-point trial, patients with breast cancer and non-Hodgkin lymphoma receiving anthracycline chemotherapy underwent serial high-sensitivity cardiac troponin testing and cardiac magnetic resonance imaging before and 6 months after anthracycline treatment. (ox.ac.uk)
Patients at high risk of cardiotoxicity (cardiac troponin I concentrations in the upper tertile during chemotherapy) were randomized to standard care plus cardioprotection (combination carvedilol and candesartan therapy) or standard care alone. (ox.ac.uk)
CONCLUSIONS: Combination candesartan and carvedilol therapy had no demonstrable cardioprotective effect in patients receiving anthracycline-based chemotherapy with high-risk on-treatment cardiac troponin I concentrations. (ox.ac.uk)
Low-risk nonrandomized patients had similar declines in left ventricular ejection fraction, bringing into question the utility of routine cardiac troponin monitoring. (ox.ac.uk)
These protective effects may be associated with the inhibition of apoptosis and inflammation, as reflected by less TUNEL-positive cells and lower levels of serum proinflammatory cytokines (Interleukin-1β, Interleukin-6, tumor necrosis factor-α) and cardiac troponin I in the N-CM group compared with the vehicle group. (researchsquare.com)

5 Further, beta-blockers reduce infarct size in patients with acute MI and decrease the risk of sudden death due to ventricular arrhythmias. (cms.gov)
In conclusion, decreased or increased protein expression of several TRPM4 variants linked to cardiac conduction disorders or ventricular arrhythmias were found to be caused by altered TRPM4 half-life compared to the WT form. (frontiersin.org)
In response, international regulatory agreements were developed that mandate testing of all new drugs, both cardiac and non-cardiac, for cardiac liability, including drug-induced long QT interval (LQT) and risk for development of life-threatening arrhythmias, such as Torsade de Pointes (TdP) 5 . (nature.com)
The main inherited cardiac arrhythmias are long QT syndrome, short QT syndrome, catecholaminergic polymorphic ventricular tachycardia and Brugada syndrome. (cdc.gov)

Differential Effects of Beta-Hydroxybutyrate Enantiomers on Induced Pluripotent Stem Derived Cardiac Myocyte Electrophysiology. (bvsalud.org)
In this study, we compared the effects of two commercial ßOHB formulations an enantiomer R ßOHB and a racemic mixture ±ßOHB on induced pluripotent stem cell cardiac myocytes (iPS-CMs) electrophysiology . (bvsalud.org)
I am the director of electrophysiology research and I'm a cardiac electrophysiologist. (medscape.com)
Here we show, computationally and experimentally, the limits of all-optical electrophysiology when applied to drug testing, then implement and validate OptoDyCE, a fully automated system for all-optical cardiac electrophysiology. (nature.com)

Initiate beta-blockers only in patients whose condition is stable, without CHF symptoms, and titrate slowly. (medscape.com)
DOB-GBP can be used to predict improved cardiac sympathetic nerve activity, cardiac function, and symptoms after treatment in patients with DCM. (nih.gov)
Pacemakers are generally implanted to alleviate symptoms of decreased cardiac output related to rate or arrhythmia. (cms.gov)
In these cases, there are no concerning symptoms or underlying cardiac diseases, and these patients can just be provided with reassurance. (medscape.com)
Beta-Lactoglobulin allergy is a type of allergy in which an individual is allergic to the beta-lactoglobulin and may suffer from symptoms such as redness and itching on the skin, facial swelling, dermatitis, diarrhea, constipation, nausea, vomiting, delayed growth in infants, shortness of breath, etc. (practo.com)

Beta-blockers slow an individual's heart rate, decrease myocardial contractility, and lower blood pressure, thus lessening the heart's overall workload and decreasing its demand for oxygen. (cms.gov)
There appear to be multiple affinity states of the β1-adrenoceptor, which may explain the distinct pharmacology of a β-adrenoceptor mediating cardiac contractility. (sigmaaldrich.com)

An article by Hjalmarson (1997) claims that there is no other therapy that has such a well-documented effect on sudden cardiac death. (cms.gov)
This drug-induced heart condition, which is known as acquired long QT syndrome, increases the risk of cardiac arrest and sudden death. (medlineplus.gov)
Case report of familial sudden cardiac death caused by a DSG2 p.F531C mutation as genetic background when carrying with heterozygous KCNE5 p.D92E/E93X mutation. (nih.gov)
These rare diseases are often the underlying cause of sudden cardiac death in young individuals and result from mutations in several genes encoding ion channels or proteins involved in their regulation. (cdc.gov)

Frequently, the rate can be slowed safely with administration of calcium channel blockers (class IV) or beta-adrenergic blockers (class II). (medscape.com)
Medications include antibiotic prophylaxis for procedures or dental work and standard therapy for heart failure (diuretic drugs, digitalis, beta-blockers, and ACE inhibitors). (medscape.com)
Beta-blockers have mortality benefits in the general heart failure population and must be considered in the population of patients with complex congenital heart disease. (medscape.com)
Medicare will not cover pacemaker implantation for either post MI patients with asymptomatic bradycardia who otherwise would be precluded from beta-blocker long-term drug therapy or post MI patients who are treated with beta-blockers and later develop asymptomatic bradycardia as a result of the treatment. (cms.gov)
3 Several medications are effective in reducing the risk of reinfarction in post MI patients, such as aspirin, beta-blockers and lipid lowering agents. (cms.gov)
Beta-blockers are a beneficial treatment for post MI patients because they decrease the incidence of recurrent cardiac events by blunting the effects of adrenaline in the body. (cms.gov)
Clinicians increasingly understand that beta-blockers are an important treatment for patients post MI. (cms.gov)
Who should receive beta-blockers in the surgical setting? (todayshospitalist.com)
One hypothesis is that beta-blockers improve the energetic balance of the heart and act, at least in part, by preserving high-energy phosphate metabolism. (ox.ac.uk)
Clinical evidence on energetic effects of beta-blockers is still only anecdotal. (ox.ac.uk)
Currently, a larger systematic placebo-controlled clinical trial of the functional and energetic effects of bisoprolol in dilated cardiomyopathy, followed sequentially by MR imaging and spectroscopy, is underway, which, when completed, should reveal whether beta-blockers in fact preserve high-energy phosphate metabolism in human heart failure. (ox.ac.uk)
beta blockers in non-cardiac surgery: haemodynamic data needed. (wustl.edu)
While some drugs can effectively treat this condition, many drugs, including beta-blockers, can sometimes cause the problem. (healthline.com)
Your doctor should look at the drugs you take to find possible causes of ED. Drugs for lowering blood pressure - like beta-blockers - are among the most common drug-related causes of ED. (healthline.com)
What are beta-blockers? (healthline.com)
Beta-adrenergic blocking agents ( beta-blockers ) are a common type of heart medication. (healthline.com)
Overall, beta-blockers block certain nervous system receptors. (healthline.com)
It's thought that by blocking these receptors, beta-blockers may interfere with the part of your nervous system responsible for causing an erection. (healthline.com)
How common is erectile dysfunction with beta-blockers? (healthline.com)
ED and sexual dysfunction may also occur in some people who take beta-blockers. (healthline.com)
This suggests that people who take beta-blockers for high blood pressure may already be experiencing ED before starting their medication. (healthline.com)
Calcium channel blockers and angiotensin-converting enzyme (ACE) inhibitors may be as effective as beta-blockers at reducing high blood pressure. (healthline.com)
The side effects of these drugs are similar, and none of them interacts with beta-blockers. (healthline.com)
Overall, the majority of those in the registry were prescribed aspirin, beta blockers, ACE inhibitors and statins during their hospitalization, consistent with treatment protocol for patients with acute coronary syndrome. (news-medical.net)
Women at high risk for CVD and without contraindications should receive aspirin, beta blockers, and an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker in addition to pharmacologic therapy for hyperlipidemia, hypertension, and diabetes. (aafp.org)
cardiac medications such as: ACE inhibitors, blood pressure medications, alpha blockers, and beta blockers, and finally central nervous system medications such as pain medications. (cdc.gov)
Medication classes significantly associated with an increased risk for agricultur al injury included taking two different types of heart medications: beta blockers ( OR 2.30, 95% CI: 1.07-4.97) and ACE inhibitors (OR 2.72, 95% CI: 1.15-6.46). (cdc.gov)

Hypertension and PAF can affect cardiac diastolic function. (hindawi.com)
The study aimed to evaluate the effect of RDN on cardiac diastolic function in patients with refractory hypertension and PAF. (hindawi.com)
Before RDN, the indices about cardiac diastolic function were out of the normal range. (hindawi.com)
AF could lead to the loss of atrial systolic function and ventricular irregular contraction and then promote the decline of cardiac diastolic function. (hindawi.com)
Similar to persistent AF, paroxysmal atrial fibrillation (PAF) could also have a significant impact on cardiac diastolic function. (hindawi.com)
Theoretically, the RDN also has a certain effect on cardiac diastolic function in these patients. (hindawi.com)
cardiac output, ejection fraction, and left ventricular end diastolic pressure have not been affected. (nih.gov)

Acts directly on cardiac muscle, increasing myocardial systolic contractions through intracellular calcium release. (medscape.com)
Beta-blocker therapy after myocardial infarction guided by left ventricular ejection fraction : Is 50 the new 40? (lu.se)
Chemotherapeutic agents may cause adverse cardiac effects either directly, by compromising myocardial structure and function, or indirectly, by impairing vascular hemodynamics or other organ systems such as the endocrine glands, which may result in endocrinopathies. (ajmc.com)

We demonstrate that in differentiating myoblasts, the mRNAs encoding two actin isoforms, beta-cytoplasmic, and alpha-cardiac, can occupy different cytoplasmic compartments within the same cytoplasm. (umassmed.edu)

Because of those similarities, patients underwent emergency cardiac catheterization. (news-medical.net)

Currently there are three iron chelating agents available for continuous use in patients with thalassemia on regular transfusions (desferrioxamine, deferiprone, and deferasirox) providing good results in reducing cardiac, hepatic and endocrine toxicity. (scielo.br)

Cardiac myocytes were cultured in R ßOHB or ±ßOHB for at least ten days after lactate selection. (bvsalud.org)

Despite recent findings regarding the functional implications of TRPM4 in cardiac diseases, the molecular and cellular mechanisms leading to altered conduction are poorly understood. (frontiersin.org)

In the last 40 years, over 20% of drugs discontinued at all phases of development, including discovery, preclinical and clinical evaluation, and post-market surveillance has been due to cardiac toxicity, where unintended interactions with cardiac ion channels result in pro-arrhythmic effects 4 . (nature.com)

In this genetic association study of 413 adults who had unexplained SCD, nearly one-fifth of individuals had pathogenic or likely pathogenic genetic variants consistent with inherited cardiomyopathies or arrhythmia syndromes, despite having normal cardiac findings. (cdc.gov)

The therapeutic effects of diltiazem are believed to be related to its ability to inhibit the cellular influx of calcium ions during membrane depolarization of cardiac and vascular smooth muscle. (nih.gov)

Efforts to improve cardiac shock outcomes through percutaneous mechanical circulatory support devices have been hindered by the fact that CS patients are heterogeneous, and prognosis may depend on a range of factors. (the-hospitalist.org)
Finally, it seems appropriate to consider the "sodium channel syndrome" (mutations in the gene of the α subunit of the sodium channel, SCN5A gene) as a single clinical entity that may manifest in a wide range of phenotypes, to thus have a better insight on these cardiac syndromes and potential outcomes for their clinical treatment. (bvsalud.org)

Зупинка серця Cardiac arrest is the cessation of cardiac mechanical activity resulting in the absence of circulating blood flow. (msdmanuals.com)
Cardiac arrest stops blood from flowing to vital organs, depriving them of. (msdmanuals.com)

Cardiac glycoside with direct inotropic effects in addition to indirect effects on cardiovascular system. (medscape.com)

We evaluated whether dobutamine gated blood pool scintigraphy (DOB-GBP) can predict improvement in cardiac sympathetic nerve activity and cardiac function after beta-blocker therapy in patients with dilated cardiomyopathy (DCM). (nih.gov)
This score shows the percentage of heart attack patients who were prescribed a beta blocker at discharge. (upmc.com)
In experimental heart failure caused by chronic coronary ligation in the rat, the beta-blocker bisoprolol significantly improves cardiac function in parallel to preservation of phosphocreatine stores and intracellular ATP transfer rates, suggesting improved cardiac energetics as one mechanism of action. (ox.ac.uk)
Beta-adrenergic receptor blocker and renin-angiotensin system inhibitor therapies have been associated with modest cardioprotective effects in unselected patients receiving anthracycline chemotherapy. (ox.ac.uk)
While the exact rate is unknown, a 2020 review suggests the rate of ED associated with beta-blocker usage may be more common than previously thought. (healthline.com)
However, the same study also noted that one type of beta-blocker, nebivolol (Bystolic), was found to improve erectile function in study participants who had both ED and high blood pressure. (healthline.com)
If your doctor thinks that your ED may be related to your beta-blocker and you can't take other blood pressure drugs, you may still have options. (healthline.com)
If ED seems to be a side effect of your beta-blocker, talk with a doctor. (healthline.com)
You can also ask your doctor about possibly switching to the beta-blocker nebivolol. (healthline.com)
Only about one patient in three was taking a beta blocker after infarction. (bmj.com)

Cardiac muscle (like skeletal muscle) is characterized by striations - the stripes of dark and light bands resulting from the organised arrangement of myofilaments and myofibrils in the sarcomere along the length of the cell. (wikipedia.org)
Important physiological consequences of β-adrenoceptor activation include stimulation of cardiac rate and force, relaxation of vascular, urogenital and bronchial smooth muscle, stimulation of renin secretion from the juxta-glomerular apparatus, stimulation of insulin and glucagon secretion from the endocrine pancreas, stimulation of glycogenolysis in liver and skeletal muscle and stimulation of lipolysis in the adipocyte. (sigmaaldrich.com)

Pathological variants in TRPM4 gene have been linked to several cardiac phenotypes such as complete heart block (CHB), ventricular tachycardia, and Brugada syndrome (BrS). (frontiersin.org)

For me, this topic is near and dear to my heart because, one, I'm a cardiac electrophysiologist, and two, I am currently expecting my second child. (medscape.com)
During 2003-2015, 1,509 patients with ICDs (629 patients) and pacemakers (880 patients) were enrolled and underwent 2,103 MRI examinations supervised by either an electrophysiologist or a registered nurse with cardiac device programming experience. (the-hospitalist.org)

We therefore tested whether sildenafil blunts dobutamine-stimulated cardiac function in humans. (erowid.org)

Cases of pulmonary arterial hypertension (PAH) have been reported in patients treated with interferon beta products, including BETASERON. (nih.gov)

beta-actin mRNA is localized to the leading lamellae and alpha-actin mRNA is associated with a perinuclear compartment. (umassmed.edu)
beta-actin peripheral and alpha-actin perinuclear. (umassmed.edu)

Although its influence on rest heart function has appeared minimal, recent animal studies suggest that sildenafil can have potent effects on hearts stimulated by beta-adrenergic or pressure overloads. (erowid.org)
People with congestive heart failure may also need a reduced transfusion volume and rate, depending on their cardiac function. (cdc.gov)
However, the physiological role for this channel in cardiac function remains unclear. (frontiersin.org)

Takotsubo cardiomyopathy patients with cardiac rupture do not differ significantly from those without rupture. (nih.gov)
They occur in patients with preexisting cardiac disease or additional risk factors, such as congenital heart disease. (medscape.com)
Addition of echocardiogram measurement of biventricular dysfunction improved the accuracy of prognosis among patients with cardiac shock (CS) in the cardiac intensive care unit. (the-hospitalist.org)
In patients in the cardiac ICU with CS, biventricular dysfunction (BVD), as assessed using transthoracic echocardiography, improves clinical risk stratification when combined with the Society for Cardiovascular Angiography and Interventions shock stage. (the-hospitalist.org)
Ventricular systolic dysfunction is commonly seen in patients who have suffered cardiac shock, most often on the left side. (the-hospitalist.org)
Although echocardiography is often performed on these patients during diagnosis, previous studies looking at ventricular dysfunction used invasive hemodynamic parameters, which made it challenging to incorporate their findings into general cardiac ICU practice. (the-hospitalist.org)
The researchers analyzed data from 3,158 patients admitted to the cardiac ICU at the Mayo Clinic Hospital St. Mary's Campus in Rochester, Minn., 51.8% of whom had acute coronary syndromes. (the-hospitalist.org)
The majority of patients with implantable cardiac devices have a clinical indication for MRI within 10 years. (the-hospitalist.org)
Safety of magnetic resonance imaging in patients with cardiac devices. (the-hospitalist.org)
Similarly, most patients left the hospital on a cardiac regimen very similar to that prescribed for heart attack patients. (news-medical.net)
Looking at long-term prognosis, researchers say patients tended to do well from a cardiac standpoint, with only two patients experiencing a recurrence of broken heart syndrome, while the remaining patients did not appear to have any other cardiac issues during the four-year follow-up. (news-medical.net)
In the absence of an iron chelating agent, patients with beta-thalassemia on regular transfusions present complications of transfusion-related iron overload. (scielo.br)
Survival in medically treated patients with homozygous beta-thalassemia. (scielo.br)
We're very effective in the [cardiac care unit] CCU dealing with patients with MI. (medscape.com)
The present study examined the association of type-D personality (and its components) with quality of life in cardiac patients compared with healthy people. (who.int)
La présente étude a examiné l'association de la personnalité de type D (et ses composantes) à la qualité de vie des patients atteints de troubles cardiaques comparativement à la qualité de vie des personnes en bonne santé. (who.int)

In heart failure, chronic therapy with beta-receptor blocking agents improves cardiac performance and prolongs survival, but the exact mechanisms whereby these compounds exert such beneficial effects remain unclear. (ox.ac.uk)

These mutations increase the Ca2+ sensitivity of cardiac myofilaments. (genome.jp)

The transfusion management of beta thalassemia in the United States. (cdc.gov)
Complications of beta-thalassemia major in North America. (scielo.br)
Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major. (scielo.br)

Takotsubo cardiomyopathy (TSC) and its complications, such as cardiac rupture (CR), are increasingly being reported in the literature. (nih.gov)

Improvements in survival have been achieved over the last 40 years due to iron chelation therapy and iron assessment by serum ferritin, and liver/cardiac magnetic resonance imaging (MRI) techniques ( 3 3. (scielo.br)

P =.008) and age (beta=-.48, P =.002) were significantly associated with Acc_CPM (adjusted R 2 =.40). (jmir.org)

Cardiac muscle tissue has autorhythmicity, the unique ability to initiate a cardiac action potential at a fixed rate - spreading the impulse rapidly from cell to cell to trigger the contraction of the entire heart. (wikipedia.org)
These channels are active in the inner ear and in heart (cardiac) muscle, where they transport potassium ions out of cells. (medlineplus.gov)
In the heart, the channels are involved in recharging the cardiac muscle after each heartbeat to maintain a regular rhythm. (medlineplus.gov)

The mechanisms of cellular excitability and propagation of electrical signals in the cardiac muscle are very important functionally and pathologically. (bvsalud.org)

The odds of nonfatal agricultur al injury were lower with the use of more than one cardiac medication (OR: 0.35, 95% CI: 0.13-.0.94) compared to a farm er taking no cardiac medications. (cdc.gov)

KCNE4 and KCNE5: K(+) channel regulation and cardiac arrhythmogenesis. (nih.gov)
Functional states of the sodium channel (closed, open, and inactivated) and their structure help to understand the cardiac regulation processes. (bvsalud.org)

Effects include beta-blockade, alpha1-blockade, and antioxidant properties. (medscape.com)

BETASERON is an interferon beta indicated for the treatment of relapsing forms of multiple sclerosis, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults. (nih.gov)

One beta subunit, produced from the KCNE1 gene, binds to the channel and regulates its activity. (medlineplus.gov)

There are two types of cardiac muscle cell: cardiomyocytes which have the ability to contract easily, and modified cardiomyocytes the pacemaker cells of the conducting system. (wikipedia.org)
In cardiac muscle the T-tubules are only found at the Z-lines. (wikipedia.org)
Cardiac muscle cells branch freely and are connected by junctions known as intercalated discs which help the synchronized contraction of the muscle. (wikipedia.org)
An altered KCNE1 protein cannot regulate the flow of potassium ions through channels in the inner ear and cardiac muscle. (medlineplus.gov)
There are areas in the cardiac muscle with anatomical and functional differentiation that present automatism, thus subjecting the rest of the fibers to their own rhythm. (bvsalud.org)

A British Cardiac Society survey of the potential for the secondary prevention of coronary disease: ASPIRE (Action on Secondary Prevention through Intervention to Reduce Events). (bmj.com)

Beta-hydroxybutyrate (ßOHB), along with acetoacetate and acetone , are liver -produced ketone bodies that are increased after fasting or prolonged exercise as an alternative fuel source to glucose . (bvsalud.org)

Anatomy26

Organisms12

Diseases38

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes46

Disciplines and Occupations4

Information Science3

Health Care11

Troponin7

Arrhythmias4

Electrophysiology4

Symptoms5

Contractility2

Sudden4

Blockers27

Diastolic7

Myocardial3

Alpha-cardiac1

Catheterization1

Hepatic1

Myocytes1

Conduction1

Toxicity1

Arrhythmia1

Depolarization1

Outcomes2

Arrest2

Inotropic1

Blocker10

Skeletal2

Phenotypes1

Electrophysiologist2

Blunts1

Hypertension1

Actin2

Function3

Patients16

Improves1

Mutations1

Thalassemia3

Complications1

Magnetic1

Significantly1

Heart3

Mechanisms1

Medication1

Regulation2

Effects1

Treatment1

Subunit1

Muscle5

Disease1

Liver1