AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth Care
Heart TransplantationGraft RejectionTransplantation, HomologousTransplantation, HeterotopicRats, Inbred WFGraft SurvivalSkin TransplantationRats, Inbred LewTransplantation ToleranceRats, Inbred ACIGraft Enhancement, ImmunologicIsoantibodiesAllograftsIsoantigensMyocytes, CardiacTransplantation, IsogeneicMice, Inbred C57BLMyocardiumMice, Inbred BALB CTransplantation ImmunologyRats, Inbred BNCardiac OutputLymphocyte Culture Test, MixedTissue DonorsImmune ToleranceTime FactorsHeartImmunosuppressionMice, Inbred CBAT-LymphocytesImmunoconjugatesKidney TransplantationArrhythmias, CardiacCardiac Surgical ProceduresImmunosuppressive AgentsCoronary VesselsMice, Inbred C3HMice, KnockoutDeath, Sudden, CardiacCorneal TransplantationHistocompatibilityBone TransplantationArteriosclerosisCD40 LigandRats, Inbred F344Histocompatibility TestingRNA, MessengerMice, Inbred ASpleenCyclosporineLymphocyte TransfusionCD8-Positive T-LymphocytesCD4-Positive T-LymphocytesAcute DiseaseAdoptive TransferLymphocyte DepletionMice, Inbred StrainsAntibodies, MonoclonalHistocompatibility Antigens Class IIReceptors, CXCR3Lymphocyte ActivationPostoperative ComplicationsMajor Histocompatibility ComplexCytokinesBone BanksImmunohistochemistryRats, Inbred StrainsInterferon-gammaCardiomegalyCardiac TamponadeCardiac Pacing, ArtificialBiopsyHeart DiseasesFibroblast Growth Factor 1T-Lymphocytes, RegulatoryChronic DiseaseMice, Inbred DBAMice, TransgenicCells, CulturedCardiac CatheterizationGene ExpressionCoronary Artery DiseaseCTLA-4 AntigenMyocardial ContractionReverse Transcriptase Polymerase Chain ReactionHeart ArrestEndothelium, VascularHeart VentriclesT-Lymphocyte SubsetsTissue PreservationIslets of Langerhans TransplantationCell MovementAntigens, DifferentiationFlow CytometryHistocompatibility Antigens Class ILeukocytesInterleukin-4Coronary DiseaseImmunoenzyme TechniquesUp-Regulation
RejectionVasculopathyTransplantationRecipientsCongenital Cardiac SurgeryTransplantSurgeryAortic Heart ValveTissueMyocardial infarctionMalignancySurvivalEchocardiographicOrganExperimentalSarcomaSurgeonsPulmonaryEffectorMechanismMiceGraftsRatsInvestigateDysfunctionArrestUndergoneRelationClinicalPatientsTraumaSurgicalDiagnosticFunctionRoleTreatmentRESULTSUniqueEarlyCellsLeftMedicine
Rejection15
  • The purpose of this study was to quantify T cell receptor excision circles (TRECs) in blood mononuclear cells of cardiac transplant recipients and to investigate a possible relationship between TREC levels and rejection episodes. (unifesp.br)
  • The concept of rejection is not unique to cardiac allograft transplantation and, to a varying extent, occurs in all forms of solid organ transplantation. (medscape.com)
  • Cardiac transplant rejection manifests in one or more of the following three ways: acute cell-mediated rejection, antibody-mediated rejection (AMR), and allograft vasculopathy. (medscape.com)
  • Acute cell-mediated rejection is primarily a host T-lymphocyte-mediated response mounted against the allograft tissue. (medscape.com)
  • Long term survival of heart transplant recipients is limited by chronic rejection, cardiac allograft vasculopathy (CAV), and malignancy. (lidsen.com)
  • Acute rejection of allografts remains a significant problem in clinical transplantation, and the fundamental mechanism underlying this rejection are as yet only poorly elucidated. (elsevierpure.com)
  • IFN-γ-inducible genes are specifically up-regulated in murine cardiac allografts, suggesting that signaling mediated by IFN-γ may play an important role in the late phase of acute rejection in vivo. (elsevierpure.com)
  • by cardiac myocyte-targeted overexpression of GTPCH would diminish acute cardiac allograft rejection. (ox.ac.uk)
  • Visualization of the in vivo generation of donor antigen-specific effector CD8+ T cells during mouse cardiac allograft rejection: in vivo effector CD8+ T cell generation during allograft rejection. (ox.ac.uk)
  • The focus of the Streblow laboratory is on defining the role of human cytomegalovirus (HCMV) in the development of vascular disease and chronic rejection of organ allografts. (ohsu.edu)
  • Determine viral and host gene expression during the development of atherosclerosis and transplant vascular sclerosis, the vascular lesion associated with chronic allograft rejection. (ohsu.edu)
  • Determining the mechanisms of viral acceleration of chronic allograft rejection from latently infected donor, which is the most common cause of HCMV-associated disease in transplant patients associated with expression during the different stages of viremia associated with CMV including. (ohsu.edu)
  • Dr. Solomon's research interests include endothelial cell dysfunction and inflammation in pulmonary arterial hypertension, methods of detection of cardiac allograft cellular rejection, and organizational structures and outcomes in the delivery of critical care cardiology. (nih.gov)
  • Mycophenolate mofetil has also been shown to reverse ongoing acute rejection in the canine renal and rat cardiac allograft models. (nih.gov)
  • Deep learning-enabled assessment of cardiac allograft rejection from endomyocardial biopsies. (cdc.gov)
Vasculopathy8
  • Cardiac allograft vasculopathy (CAV) is a progressive type of coronary artery disease in people who have had a heart transplant. (wikipedia.org)
  • Cardiac allograft vasculopathy (CAV) , also called accelerated graft arteriosclerosis, generally refers to concentric luminal narrowing of the epicardial and intramural coronary arteries. (medscape.com)
  • Cardiac allograft vasculopathy (CAV) inevitably occurs in most heart transplant recipients over a variable time course. (medscape.com)
  • Munagala M, Phancao A. Cardiac Allograft Vasculopathy: A Review of Risk Factors and Pathogenesis. (lidsen.com)
  • This application note demonstrates the successful use of Enzo Life Sciences' MULTIVIEW® (mouse-HRP/rabbit-AP) IHC kit to observe and characterize immune cell infiltrates in human cardiac allograft vasculopathy. (enzolifesciences.com)
  • one investigated CGM as a screening tool for cardiac allograft vasculopathy in heart transplant patients and seven investigated specific CGM parameters without commenting on diagnostic accuracy. (bmj.com)
  • The diagnostic accuracy reported for CGM to detect cardiac allograft vasculopathy was 100% and 88% respectively for sensitivity and specificity. (bmj.com)
  • At age 10, Lexi's first heart transplant brought a glimmer of hope, but the specter of severe cardiac allograft vasculopathy persisted. (syncardia.com)
Transplantation5
  • This process generally occurs months to years following transplantation and is currently the limiting factor in long-term allograft survival. (medscape.com)
  • METHODS: A trace population of 2.0x10(6) CD8+DES+ T cells were adoptively transferred into syngeneic CBA.Ca (H-2k) mice 24 hr before transplantation of an H-2Kb+ or H-2Kb- cardiac allograft. (ox.ac.uk)
  • His clinical research has primarily been directed toward surgical issues in complex congenital heart care and cardiac transplantation (focusing on advances with operative techniques, outcomes research and transplantation for congenital heart disease), with a particular emphasis on the development of mechanical ventricular assist devices for children, as well as stem-cell based valved conduits for pediatric application. (chop.edu)
  • Cardiac transplantation is a standard therapy for many end-stage heart diseases and returns patients to normal life. (rotrf.org)
  • The patients were evaluated by echocardiography before and after transplantation, and the relation between allograft function and echocardiographic changes was evaluated. (ima.org.il)
Recipients2
  • and (4) lower TREC levels in cardiac recipients than in age-matched healthy controls. (unifesp.br)
  • Our results show that in kidney transplant recipients, allograft function significantly affects cardiac structure and function. (ima.org.il)
Congenital Cardiac Surgery1
  • Dr. Chen served as the Chief of Congenital Cardiac Surgery, Co-Director of the Heart Center, Professor of Surgery at the University of Washington School of Medicine, and holder of the Sam and Althea Stroum Endowed Chair in Pediatric Cardiovascular Surgery. (chop.edu)
Transplant3
  • Cardiac transplant is a widely accepted therapy for select patients with end stage cardiovascular disease. (lidsen.com)
  • Only physicians experienced in immunosuppressive therapy and management of renal, cardiac or hepatic transplant patients should prescribe mycophenolate mofetil. (nih.gov)
  • To investigate the relationship between post-transplant kidney function and echocardiographic measures in patients with normal/preserved pre-transplant cardiac structure and function. (ima.org.il)
Surgery7
  • 1 Department of Regenerative Medicine and Advanced Cardiac Therapeutics, 2 Cardiology Division, Department of Internal Medicine, 3 Department of Cardiovascular Surgery, 4 Division of Diagnostic Pathology, 5 Department of Pathology, Keio University School of Medicine, Tokyo, Japan. (jci.org)
  • Jonathan M. Chen, MD, is the Co-Director of the Cardiac Center and holds the Mortimer J. Buckley Jr., MD, Endowed Chair in Cardiac Surgery at Children's Hospital of Philadelphia. (chop.edu)
  • Dr. Chen is the Co-Director of the Cardiac Center and holds the Mortimer J. Buckley Jr., MD, Endowed Chair in Cardiac Surgery at Children's Hospital of Philadelphia. (chop.edu)
  • Dr. Chen holds important leadership positions in cardiac surgery organizations and currently serves on the editorial board of the Journal of Thoracic and Cardiovascular Surgery. (chop.edu)
  • Patients with cardiac sarcoma having surgery had a median survival of 12 months, whereas those who did not have surgery had a median survival of 1 month. (acc.org)
  • Journal of Cardiac Surgery. (doximity.com)
  • Peter J. Gruber, MD, PhD, is the chief of Pediatric Cardiac Surgery for Yale Medicine and Yale New Haven Children's Hospital, and a pediatric cardiothoracic surgeon who treats patients from infancy-in some cases before they are born-to adults. (yalemedicine.org)
Aortic Heart Valve2
  • The company's products include Aortic Heart Valve, Mitral Heart Valve, Aortic Allograft, Pulmonary Human Heart Valve, Pulmonary Patch, and Surgical Adhesive among others. (plunkettresearch.com)
  • Our surgical aortic valve replacement solutions include the On-X® Aortic Heart Valve and CryoValve® SG Pulmonary Valve Allograft for the Ross procedure. (artivion.com)
Tissue5
  • AMR refers to allograft injury resulting from activation of the complement system, typically by recipient-generated antibodies directed against the allograft tissue. (medscape.com)
  • 2 In a 17-year retrospective study of primary cardiac and non-cardiac soft tissue sarcomas in the SEER (Surveillance, Epidemiology, and End Results) database, Hamidi et al. (acc.org)
  • found 210 primary cardiac sarcomas and 24,404 non-cardiac soft tissue sarcomas. (acc.org)
  • 3 The median overall survival for patients with cardiac sarcoma was 6 months and for non-cardiac soft tissue sarcoma was 96 months. (acc.org)
  • With the unwavering quality and standards of our allograft tissue processing technology, our cryopreserved cardiac and vascular allograft tissues have played a vital role in life-restoring surgeries for adults and pediatric patients for over 30 years. (artivion.com)
Myocardial infarction1
  • Recently, EndMT has been increasingly recognized as a vital process that contributes to various cardiovascular pathologies in adults, which include atherosclerosis, valvular heart disease, cardiac fibrosis, and myocardial infarction. (dovepress.com)
Malignancy1
  • 1 Most cardiac surgeons and cardiologists will have minimal experience with primary cardiac malignancy. (acc.org)
Survival1
  • Oral delivery of alloantigen combined with non-depleting anti-CD4 monoclonal antibody induces indefinite survival of cardiac allografts and generates CD4(+) regulatory T cells. (ox.ac.uk)
Echocardiographic1
  • Echocardiographic assessment of allograft function in conjunction with coronary angiographic findings are used in assessing the severity of CAV. (lidsen.com)
Organ1
  • Inflammation and endothelial injury can be triggered by the donor arrest, organ procurement, and allograft ischaemia and reperfusion. (wikipedia.org)
Experimental2
  • Mycophenolate mofetil also inhibited proliferative arteriopathy in experimental models of aortic and cardiac allografts in rats, as well as in primate cardiac xenografts. (nih.gov)
  • We aim to investigate the role of HIF-1 in cardiac allografts using experimental, pharmacological, gene vector and transgene-based strategies. (rotrf.org)
Sarcoma1
  • We divide primary cardiac sarcoma into three clinical groups based on their site of presentation: right heart sarcomas, left heart sarcomas, and pulmonary artery (PA) sarcomas. (acc.org)
Surgeons2
  • Artivion Inc offers cardiac and vascular surgeons a suite of aortic-centric solutions. (plunkettresearch.com)
  • Our intentional focus on the aorta and collaboration with the world's foremost cardiac and vascular surgeons allow us to leverage our combined expertise in the development of new, innovative, life-changing aortic-centric technologies. (artivion.com)
Pulmonary2
Effector1
  • Cardiac fibroblasts are generally the primary effector cells of fibrosis and have been reported to be partly derived from cardiac endothelial cells through the endothelial to mesenchymal transition (EndMT) process. (dovepress.com)
Mechanism1
  • Endothelial-to-mesenchymal transition (EndMT) is an important mechanism underlying cardiac fibrosis. (dovepress.com)
Mice2
  • We compared mRNA profiles in murine cardiac allografts with isografts using DNA microarrays with probe sets corresponding to more than 11,000 mice genes. (elsevierpure.com)
  • We screened for gene expression changes in murine cardiac allografts between fully incompatible mice strains (BALB/c H2 d to C3H/He H2 k ) using a DNA microarray. (elsevierpure.com)
Grafts1
  • These pump systems more recently have allowed the use of cardiac grafts retrieved from donors after cardiac arrest. (msdmanuals.com)
Rats2
  • A cardiac fibrosis model was established in Sprague-Dawley rats through a subcutaneous injection of isoproterenol (ISO, 5 mg/kg/d). (dovepress.com)
  • Rats injected with ISO exhibited severe interstitial cardiac fibrosis and perivascular fibrosis, decreased left ventricular ejection fraction, and increased NOX activity. (dovepress.com)
Investigate1
  • This study aimed to investigate the possible effect of TMZ on cardiac fibrosis exerted via the inhibition of NOX2-mediated EndMT. (dovepress.com)
Dysfunction2
  • In patients with significant allograft dysfunction (eGFR ≤ 45 ml/min), LV hypertrophy worsened, with no improvement in LV dimensions. (ima.org.il)
  • TMZ treatment mitigated cardiac fibrosis, ameliorated left ventricular dysfunction, and reduced NOX activity. (dovepress.com)
Arrest1
  • Steve faced the overwhelming battle of left ventricular hypertrophy and cardiomyopathy, making every breath a struggle until he suffered from cardiac arrest and fell into a coma. (syncardia.com)
Undergone1
  • 45% had undergone previous cardiac operations. (uzh.ch)
Relation1
  • however, data on cardiac adaptation and its relation to kidney allograft function remain sparse. (ima.org.il)
Clinical1
  • 1 The clinical incidence of these tumors is about 1 in every 500 cardiac surgical cases in large centers. (acc.org)
Patients3
  • Chaque année, des milliers de volontaires, pour la plupart des patients, mais aussi des personnes en bonne santé, participent à nos études. (ottawaheart.ca)
  • Primary malignant cardiac tumors tend to occur in young patients with a mean age of 44 years and are evenly divided between the sexes. (acc.org)
  • We perform cardiac magnetic resonance angiography, chest and abdominal computed tomography, as well as a whole body positron emission tomography on all patients suspected of primary malignant cardiac tumors. (acc.org)
Trauma1
Surgical2
  • We recently reviewed our experience with the surgical treatment of 96 primary cardiac sarcomas over a 25-year period for the Houston Methodist Hospital/MD Anderson Cancer Center combined multidisciplinary cardiac tumor group. (acc.org)
  • Our Cardiac and Vascular Ancillary Solutions provide complementary support for your cardiac and vascular surgical procedures. (artivion.com)
Diagnostic1
Function1
  • Myocardial fibrosis, characterized as interstitial fibroblast proliferation and excessive collagen deposition, is the structural basis of myocardial stiffness and the key process of cardiac function transformation from the compensatory phase to heart failure. (dovepress.com)
Role1
  • The findings of the study may provide new insights into the potential role of TMZ in the pathophysiology of cardiac fibrosis. (dovepress.com)
Treatment1
  • The purpose of this paper is to summarize our experience with the evaluation and treatment of primary malignant cardiac tumors. (acc.org)
RESULTS2
  • RESULTS: H-2Kb specific T cells proliferated and produced interleukin-2 and interferon-gamma in response to H-2Kb+, but not H-2Kb- cardiac allografts. (ox.ac.uk)
  • CONCLUSIONS: These results demonstrate that alloantigen-specific T cells can be monitored in vivo during the immune response to an allograft and that the fate of CD8+ T cells specific for the allogeneic class I molecules expressed by the graft is different between cells in the periphery and those that infiltrate the graft. (ox.ac.uk)
Unique1
  • Explore our complete offering of cryopreserved allografts and learn about our unique SynerGraft® technology and autologous pericardium program. (artivion.com)
Early1
  • Hence, regular follow-up and monitoring of the allograft for early signs of disease is advocated. (wikipedia.org)
Cells1
  • CD8+DES+ T cells that infiltrated the H-2Kb+ cardiac allografts developed a distinct cell surface and cytokine phenotype compared with the CD8+DES+ T cells that remained in the periphery. (ox.ac.uk)
Left1
  • Coronary sinus, normally located between the LEFT ATRIUM and LEFT VENTRICLE on the posterior surface of the heart, can serve as an anatomical reference for cardiac procedures. (bvsalud.org)
Medicine1
  • Address correspondence to: Keiichi Fukuda, Department of Regenerative Medicine and Advanced Cardiac Therapeutics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. (jci.org)