Carrier ProteinsInflammasomePathwaysCytoskeletal ProteinsTransducingApoptosisPyrin domainInteractsMYD88InflammasomesCytosolicIntracellularCytokinesPathwayPHOSPHORYLATIONMoleculeTransductionFADDAnti-fungalComplexesImmuneType I transmembrane proteinMediatesApoptoticKinaseReceptorsMeSHHomotypicMyeloidCard9InfectionTRIFMechanismsInducesAlveolarDomainEnzymeDomainsEndogenousDifferentiationViralTranscriptionActivationDrugsInteractionCellMolecular
Carrier Proteins1
- A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. (childrensmercy.org)
Inflammasome16
- Oligomerisation of initiating proteins such as AIM2 (absent in melanoma-2) and NLRP3 (NOD-like receptor family, pyrin domain-containing-3) recruits procaspase-1 via the inflammasome adapter molecule ASC (apoptosis-associated speck-like protein containing a CARD). (nih.gov)
- The NLRP3 inflammasome is activated in response to various signals, including pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs). (spandidos-publications.com)
- The NLRP3 inflammasome consists of the NLRP3 scaffold, the apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD) (ASC) adaptor and caspase-1 ( 5 , 6 ). (spandidos-publications.com)
- The NLRP3 inflammasome is activated in response to a variety of signals that include pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs) ( 6 ). (spandidos-publications.com)
- Extracellular ATP, one of the DAMPs, serves as the second signal for NLRP3 inflammasome activation ( 11 ). (spandidos-publications.com)
- ASC ( apoptosis-associated speck-like protein containing a CARD domai n, also known as PYCARD) is a protein adaptor important in canonical inflammasome responses [1,2]. (invivogen.com)
- ASC's bipartite composition, consisting of one PYD and one CARD domain, allows the recruitment of the CARD-containing pro-caspase-1 to canonical inflammasome sensors that do not contain a CARD domain, such as NLRP3, AIM2, and Pyrin [1]. (invivogen.com)
- 2017 . Molecular mechanisms of inflammasome signaling. (invivogen.com)
- The inflammasome is a cytosolic multimeric signalling complex that coordinates the activation of an immune response against invading pathogens. (immunochemistry.com)
- Recently, two inflammasome-forming proteins, CARD8 and NLRP1, have emerged as innate immune sensors for the enzymatic activity of virus-encoded proteases. (bvsalud.org)
- One neuroinflammatory pathway activated following TBI is the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome, composed of three components: NLRP3, adapter protein apoptosis-associated speck-like protein containing a CARD (ASC), and caspase-1 10,13 . (tamhsc.edu)
- The term "inflammasome" was first used in 2002 by researchers in Switzerland (1) to refer to a caspase-activating protein complex. (promegaconnections.com)
- Inflammasome complexes are made up of scaffolding sensor proteins (NLR, AIM2, ALR), and an adaptor protein containing a caspase activation and retention domain (CARD) and inactive procaspase-1. (promegaconnections.com)
- The NLRC4 inflammasome (also referred to as IPAF) is activated by bacterial type III secretion system (T3SS) components and flagellin (in mice), but unlike other inflammasomes, NLRC4 activation requires a second NLR protein, NAIP, which functions as a receptor for the T3SS triggers. (promegaconnections.com)
- The NLRC4 inflammasome also has a differential requirement for the adaptor protein. (promegaconnections.com)
- However, it can induce expression of proinflammatory cytokines by activating NF-κB signaling and NLRP3 inflammasome, resulting in cytokine storms. (ijbs.com)
Pathways6
- Card9 mediates signals from so called pattern recognition receptors (Dectin-1) to downstream signalling pathways such as NF-κB and by this activates pro-inflammatory cytokines (TNF, IL-23, IL-6, IL-2) and an anti-inflammatory cytokine (IL-10) and subsequently an appropriate innate and adaptive immune response to clear an infection. (wikipedia.org)
- Although some aspects of the signaling pathways downstream of p75 have been elucidated recently, mechanisms of receptor activation and proximal signaling events are unknown. (embl-heidelberg.de)
- Hyperactivation by interleukins of downstream inflammatory pathways, including p38/MAPK signaling, can be detrimental to brain function 10,13 . (tamhsc.edu)
- It is a signal transducing adaptor protein that undergoes tyrosine PHOSPHORYLATION in signaling pathways that regulate CELL MIGRATION and CELL PROLIFERATION. (ucdenver.edu)
- Weyant MJ, Carothers AM, Bertagnolli ME, Bertagnolli MM. Colon cancer chemopreventive drugs modulate integrin-mediated signaling pathways. (ucdenver.edu)
- Moreover, autoinflammatory and autoimmune diseases are dependent upon the activation of innate immune signaling pathways. (mhmedical.com)
Cytoskeletal Proteins1
- Intracellular signaling adaptor proteins that play a role in the coupling of SYNDECANS to CYTOSKELETAL PROTEINS . (nih.gov)
Transducing5
- Adaptor Proteins, Signal Transducing" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
- This graph shows the total number of publications written about "Adaptor Proteins, Signal Transducing" by people in this website by year, and whether "Adaptor Proteins, Signal Transducing" was a major or minor topic of these publications. (childrensmercy.org)
- Below are the most recent publications written about "Adaptor Proteins, Signal Transducing" by people in Profiles. (childrensmercy.org)
- A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. (uchicago.edu)
- signal transducing adaptor family membe. (gsea-msigdb.org)
Apoptosis5
- Apoptosis-associated speck-like protein containing a caspase recruitment domain inflammasomes mediate IL-1? (umassmed.edu)
- These studies identified PYCARD a cytoplasmatic adaptor protein consisting of a pyrin domain name (PYD) and a caspase recruitment domain name (CARD)12-16 as a central factor in myeloid cells that decided apoptosis in response to signals such as TNF-α and TRAIL. (researchtoactionforum.org)
- DEATH domain, found in proteins involved in cell death (apoptosis). (embl-heidelberg.de)
- The DD mediates self-association of these receptors, thus giving the signal to downstream events that lead to apoptosis. (embl-heidelberg.de)
- TRAIL, also called Apo2L, is a cytotoxic protein that induces apoptosis of many transformed cell lines but not of normal tissues, even though its death domain-containing receptor, DR4, is expressed on both cell types. (embl-heidelberg.de)
Pyrin domain1
- The pyrin domain (PYD) and CARD-containing adaptor, ACS is required necessary for caspase-1 activation but not needed for NLRCP-mediated pyroptosis (2). (promegaconnections.com)
Interacts5
- CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B". J. Biol. (wikipedia.org)
- It signals via an N-terminal caspase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. (nih.gov)
- Cytoplasmic dsRNA is also recognized by the RLH system, which interacts with MAVS via caspase recruitment domains (CARDs). (jci.org)
- Adaptor protein TNFR2 interacts with CD40 and functions as a mediator of the signal transduction. (neuromics.com)
- Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells. (ucdenver.edu)
MYD883
- The interaction between DDX54 and myeloid differentiation factor-88 adapter protein (MYD88) was verified. (bvsalud.org)
- Menden H, Xia S, Mabry SM, Noel-MacDonnell J, Rajasingh J, Ye SQ, Sampath V. Histone deacetylase 6 regulates endothelial MyD88-dependent canonical TLR signaling, lung inflammation, and alveolar remodeling in the developing lung. (childrensmercy.org)
- Other DD-containing proteins, such as ankyrin, MyD88 and pelle, are probably not directly involved in cell death signalling. (embl-heidelberg.de)
Inflammasomes8
- Inflammasomes are protein complexes assembled upon recognition of infection or cell damage signals, and serve as platforms for clustering and activation of procaspase-1. (nih.gov)
- These cells do not express the ASC protein and display a complete abrogation of mature IL-1β secretion upon activation of the canonical and non-canonical inflammasomes. (invivogen.com)
- A key player in the inflammation process is a group of protein complexes call inflammasomes. (promegaconnections.com)
- We now know that inflammasomes are cytosolic multiprotein platforms that assemble in response to pathogens and other signals. (promegaconnections.com)
- However, non-NLR proteins such as AIM2 (absent in melanoma 2) and pyrin can also form inflammasomes. (promegaconnections.com)
- The different sensor proteins are activated by different types of outside stimuli, and inflammasomes are loosely sorted into families based on the protein forming these sensors. (promegaconnections.com)
- These NLR inflammasomes are activated when the scaffold protein senses or binds its activating stimuli. (promegaconnections.com)
- These inflammasomes do not contain CARD domains and so must recruit ASC using their PYD for activation. (promegaconnections.com)
Cytosolic1
- Cytosolic signaling adaptor proteins that were initially discovered by their role in the innate immunity (IMMUNITY, INNATE) response of organisms that lack an adaptive immune system. (uchicago.edu)
Intracellular3
- Cells can use a broad range of intracellular and extracellular mechanisms for detecting different "danger" signals generated or released during infection or injury. (immunochemistry.com)
- They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. (childrensmercy.org)
- TRID is a distinct gene product with an extracellular TRAIL-binding domain and a transmembrane domain but no intracellular signaling domain. (embl-heidelberg.de)
Cytokines5
- It mediates signals from pattern recognition receptors to activate pro-inflammatory and anti-inflammatory cytokines, regulating inflammation. (wikipedia.org)
- PRRs initiate a signalling cascade that leads to activation and production of inflammatory cytokines upon recognition of conserved microbial signatures or danger signals (commonly referred to as pathogen associated molecular patterns or PAMPs, or danger associated molecular patterns or DAMPS, respectively). (immunochemistry.com)
- DEGs mainly focus on pattern recognition receptors (PRRs) and the adaptor proteins, cytokines, and cell adhesion molecules. (bvsalud.org)
- In the NOD-like receptor signaling pathway, multiple NOD-like receptor family CARD domains containing 3-like (NLRC3-like) were significantly downregulated, and pro-inflammatory cytokines were upregulated. (bvsalud.org)
- Multiple proinflammatory cytokines are involved in the disease development and clinical presentation of GPP and the interleukin (IL)-36-mediated signaling pathway play a central role. (bvsalud.org)
Pathway1
- In innate immune system, N protein inhibits IFN-β production and RNAi pathway for virus survival. (ijbs.com)
PHOSPHORYLATION1
- Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression. (uchicago.edu)
Molecule1
- For instance Fas-associated death domains (FADD) proteins an adaptor molecule for Fas signaling includes both a DD and a DED. (healthyconnectionsinc.com)
Transduction1
- A family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. (nih.gov)
FADD4
- MAVS also activates NF-κB through Fas-associated death domain-containing protein (FADD) and RIP1 interaction. (jci.org)
- Fas-associated death domain (DD) adaptor (FADD) an associate from the DD superfamily contains both a DD and a death effector domain (DED) that are essential in mediating FAS ligand-induced apoptotic signaling. (healthyconnectionsinc.com)
- The DED over the FADD after that recruits the caspase-8 through a DED-DED connections leading to the forming of the death-inducing signaling complicated (Disk). (healthyconnectionsinc.com)
- Right here we present that p45 forms a complicated using the FADD adaptor. (healthyconnectionsinc.com)
Anti-fungal1
- CARD9 is a central component of anti-fungal innate immune signaling via C-type lectin receptors, and several immune-related disorders are associated with CARD9 alterations. (broadinstitute.org)
Complexes2
- Members of this family of proteins are often found associated with histone-modifying enzymes and protein complexes that regulate gene expression. (bvsalud.org)
- The primary roles of N protein are to assemble with genomic RNA into the viral RNA-protein (vRNP) complex and to localize to the replication transcription complexes (RTCs) to enhance viral replication and transcription. (ijbs.com)
Immune2
- In this work, we have revealed that early viral protein UBCv1, the only known conjugating enzyme encoded by a virus, modulates innate immune and inflammatory signaling. (mdpi.com)
- Susceptibility to infection in humans is strongly heritable, and among the many loci that influence it, those that encode proteins vital to the innate immune response are of central importance. (mhmedical.com)
Type I transmembrane protein2
- TREM-1 (Triggering Receptor Expressed on Myeloid cells) is a type I transmembrane protein having a single Ig-like domain. (rndsystems.com)
- SIRP beta 1 is a type I transmembrane protein belonging to the SIRP family within the Ig superfamily. (rndsystems.com)
Mediates1
- Hexon and penton structures form the capsid of AdV, and fiber protein mediates the binding of the virion to the cell surface and is a major determinant of viral tropism. (genemedi.com)
Apoptotic2
- For instance FasL performing through Fas is normally capable of concurrently eliciting apoptotic signaling via the activation of caspase-8 and anti-apoptotic signaling via the activation of NF-κB and Erk1/2 [5]. (healthyconnectionsinc.com)
- Alpha-helical domain present in a variety of proteins with apoptotic functions. (embl-heidelberg.de)
Kinase4
- It plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM . (nih.gov)
- Activation of TLR3 by viral dsRNA leads to the recruitment of Toll/IL-1R homology domain-containing adaptor-inducing IFN-γ (TRIF), which activates TNF receptor-associated factor 6 (TRAF6), TANK-binding kinase 1/IκB kinase i (TBK1/IKKi), and receptor-interacting protein 1 (RIP1). (jci.org)
- DMH-1 is a selective inhibitor of bone morphogenic protein (BMP) type-I receptor activin receptor-like kinase 2 (ALK2) receptor (IC 50 = 108 nM or 12.6 nM in in vitro kinase assays). (tocris.com)
- protein kinase C delta [Source:HGNC Sym. (gsea-msigdb.org)
Receptors1
- several of these TNF receptors use caspase activation as a signalling mechanism. (embl-heidelberg.de)
MeSH2
- Nod Signaling Adaptor Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
- Crk-Associated Substrate Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
Homotypic1
- The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. (embl-heidelberg.de)
Myeloid1
- In a murine model the genetic deletion of IκBα and the ensuing activation of NFκB resulted in a fatal myelodysplastic/myeloproliferative disorder.8 However strikingly hematopoietic cells isolated from IκBα knockout mice did not develop myeloid abnormalities when cultured on wild-type supportive layers 9 suggesting that this microenvironment provided a relevant signal for the development or propagation of MDS. (researchtoactionforum.org)
Card93
- Caspase recruitment domain-containing protein 9 is an adaptor protein of the CARD-CC protein family, which in humans is encoded by the CARD9 gene. (wikipedia.org)
- CARD9 is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). (wikipedia.org)
- We showed that the protective variant of CARD9, which is C-terminally truncated, acted in a dominant-negative manner for CARD9-mediated cytokine production, indicating an important role for the C terminus in CARD9 signaling. (broadinstitute.org)
Infection1
- Thus, mice genetically deficient in IL-1β, IL-1α, or IL-1 receptor signaling are extremely susceptible to Mtb infection ( 1 , 2 , 4 , 7 ) while in vitro stimulation of Mtb-infected macrophages with IL-1β results in reduced mycobacterial burdens ( 7 ). (frontiersin.org)
TRIF1
- In contrast, activation of IRF3 and ISRE signaling upon stimulation with TRIFΔRIP, cGAS/STING or RIG-I-CARD remained unaltered. (mdpi.com)
Mechanisms1
- In this review article, we are focusing on the signaling mechanisms of SARS-CoV-2 N protein in viral replication, cell death and inflammation. (ijbs.com)
Induces1
- Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth. (uchicago.edu)
Alveolar1
- 5 ), cigarette smoke may (as reflected by dashed arrows) affect lung cell responses to RNA viruses by enhancing MAVS-PKR signaling and therefore trigger alveolar cell death. (jci.org)
Domain7
- This protein was identified by its selective association with the CARD domain of BCL10, a positive regulator and NF-κB activation. (wikipedia.org)
- A NOD-signaling adaptor protein that contains a C-terminal leucine-rich domain which recognizes bacterial PEPTIDOGLYCAN . (nih.gov)
- This class of proteins contains three domains, a C-terminal ligand recognition domain, an N-terminal effector-binding domain, and a centrally located nuclear-binding oligomerization domain. (uchicago.edu)
- A family of endogenous regulatory proteins that associate with RETINOBLASTOMA PROTEIN via a specific high-affinity binding domain. (bvsalud.org)
- Taxonomic distribution of proteins containing DEATH domain. (embl-heidelberg.de)
- The complete taxonomic breakdown of all proteins with DEATH domain is also avaliable . (embl-heidelberg.de)
- Click on the protein counts, or double click on taxonomic names to display all proteins containing DEATH domain in the selected taxonomic class. (embl-heidelberg.de)
Enzyme1
- Of them, SARS-CoV-2 S protein binds to its cellular receptor, angiotensin-converting enzyme 2 (ACE2) [ 8 , 9 ], to enter the cells. (ijbs.com)
Domains5
- subfamily the caspase recruitment domains (Credit card) subfamily as well as the pyrin domains (PYD) subfamily [1]. (healthyconnectionsinc.com)
- These domains Biopterin provide to mediate connections among members from the DD superfamily to start signaling cascades. (healthyconnectionsinc.com)
- There are 10756 DEATH domains in 10503 proteins in SMART's nrdb database. (embl-heidelberg.de)
- Unlike the death domains involved in signaling by the TNF receptor and Fas, p75ICD does not self-associate in solution. (embl-heidelberg.de)
- Unlike SIRP alpha that has cytoplasmic ITIM domains, SIRP beta 1 possesses positively charged residues that allow association with ITAM motif containing adaptor molecules. (rndsystems.com)
Endogenous1
- Although it is unclear whether PKR may be directly stimulated by the interaction of MAVS and dsRNA (as indicated by the dashed arrow), the endogenous protein PACT/RAX can also activate PKR independently of dsRNA. (jci.org)
Differentiation1
- Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation. (uchicago.edu)
Viral6
- Then the endosome acidifies, resulting in disassociation of capsid proteins and transportation of viral DNA into nucleus. (genemedi.com)
- SARS-CoV-2 Nucleocapsid (N) protein plays a critical role in multiple steps of the viral life cycle and participates in viral replication, transcription, and assembly. (ijbs.com)
- N protein can also undergo liquid-liquid phase separation (LLPS) with viral genome RNA and inhibit stress granules to facilitate viral replication and assembly. (ijbs.com)
- Besides the function in viral life cycle, N protein can bind GSDMD to antagonize pyroptosis but promotes cell death via the Smad3-dependent G1 cell cycle arrest mechanism. (ijbs.com)
- Many host proteins can also function as cofactors for viral entry, such as heparin sulfate proteoglycans, C-type lectins, neuropilin-1 and furin [ 10 - 13 ]. (ijbs.com)
- After being entry, the viral and host membranes can fuse together and then release the positive sense, single-stranded RNA genome of SARS-CoV-2 that directly translates into the structural and nonstructural proteins [ 9 ]. (ijbs.com)
Transcription1
- Mutations of the signal transducer and activator of transcription 3 (STAT3) gene were shown to cause the AD HIES by 2 groups independently. (medscape.com)
Activation1
- MAVS recruits IKK and TBK1, and this converges with TLR3 signaling and leads to NF-κB activation and the induction of type I IFNs (e.g. (jci.org)
Drugs1
Interaction2
- Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis. (childrensmercy.org)
- A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling. (uchicago.edu)
Cell5
- To foster research on the ASC adaptor, InvivoGen provides cellular tools that have been generated from the human monocytic THP1 cell line. (invivogen.com)
- In vitro functional assays demonstrated that this variant leads to a subtle increase in baseline NF-κB signaling and impaired proliferative responses following T cell receptor and mitogenic stimulation. (ox.ac.uk)
- however, she has broad, sustained responses to protein-polysaccharide conjugate vaccines and displays normal proliferative responses to ex vivo T cell stimulation. (ox.ac.uk)
- I am also interested in the application of biochemical, molecular, genetic, and bioinformatic techniques to the characterization of proteins involved in cell wall synthesis and degradation. (rtrn.net)
- Receptor-facilitated antigen presentation requires the recruitment of B cell linker protein to Igalpha. (uchicago.edu)
Molecular1
- It is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-κB. (wikipedia.org)