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Carcinoma, Pancreatic DuctalCarcinomaPancreatic NeoplasmsPancreatic DuctsCarcinoma, Ductal, BreastCarcinoma, Squamous CellCarcinoma, HepatocellularCarcinoma in SituCarcinoma, PapillaryImmunohistochemistryAdenocarcinomaCarcinoma, Intraductal, NoninfiltratingCarcinoma, DuctalTumor Markers, BiologicalLiver NeoplasmsCell Line, TumorNeoplasm InvasivenessPancreasCarcinoma, Basal CellGene Expression Regulation, NeoplasticPrognosisBreast NeoplasmsAdenocarcinoma, MucinousPancreatitis, ChronicNeoplasm StagingCarcinoma, Transitional CellTumor Cells, CulturedCarcinoma, BronchogenicPancreatectomyCarcinoma, Adenoid CysticCarcinoma, MedullaryCarcinoma, Small CellCarcinoma, Acinar CellPancreatitisCarcinoma, LobularLymphatic MetastasisMice, NudePrecancerous ConditionsTissue Array AnalysisCarcinoma, NeuroendocrineReverse Transcriptase Polymerase Chain ReactionNeoplasm ProteinsNasopharyngeal NeoplasmsNeoplasm MetastasisPancreaticoduodenectomyThyroid NeoplasmsCell ProliferationAdenocarcinoma, PapillaryLung NeoplasmsRNA, MessengerCarcinoma, AdenosquamousDisease ProgressionCarcinoma, MucoepidermoidNeoplasms, Multiple PrimaryNeoplasm Recurrence, LocalPancreatic JuiceCarcinoma, EndometrioidSurvival AnalysisHead and Neck NeoplasmsNeoplasm TransplantationSurvival RateDNA, NeoplasmRetrospective StudiesImmunoenzyme TechniquesGenes, rasCell Transformation, NeoplasticAntineoplastic AgentsCarcinoma, EmbryonalEsophageal NeoplasmsMouth NeoplasmsCarcinoma, Merkel CellKaplan-Meier EstimateTreatment OutcomeTumor Suppressor Protein p53Ovarian NeoplasmsColonic NeoplasmsSmad4 ProteinGene Expression ProfilingAdrenocortical CarcinomaProto-Oncogene Proteins p21(ras)Carcinoma, VerrucousCarcinoma, Signet Ring CellAmpulla of VaterApoptosisAntigens, NeoplasmAcinar CellsMutationUrinary Bladder NeoplasmsStomach NeoplasmsMetaplasiaSkin NeoplasmsKeratinsBreastSignal TransductionRNA, NeoplasmCarcinoma, Large CellCadherinsGenes, Tumor SuppressorEpithelial CellsLaryngeal Neoplasms
AdenocarcinomaJunction CarcinomasSquamous cell carcCholangiocarcinomaGallbladderTumoursCancersTumorGastricTumorsMalignanciesPatientsTissueAlterationsHttpsCancerBreastCellsMolecular genetics of pancreaticHepatocellular carcinomaMalignant pancreaticExocrinePDACRenal cell carcPancreasNeoplasmsPrognosisGeneticDiabetesIncludeExpression
Adenocarcinoma6
  • The most common cause of malignant biliary obstruction is pancreatic adenocarcinoma . (medscape.com)
  • Pancreatic ductal adenocarcinoma has a poor clinical outcome and responses to immunotherapy are suboptimal. (elifesciences.org)
  • The plasticity and heterogeneity of fibroblasts in the tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) has emerged as a key factor in determining tumor growth and therapeutic response. (elifesciences.org)
  • Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, is used for maintenance therapy in pancreatic adenocarcinoma. (medscape.com)
  • Olaparib has US Food and Drug Administration (FDA) approval for adults with germline BRCA -mutated metastatic pancreatic adenocarcinoma whose disease has not progressed on at least 16 weeks of a first-line platinum-based chemotherapy regimen. (medscape.com)
  • It is indicated for maintenance treatment of adults with deleterious or suspected deleterious gBRCAm metastatic pancreatic adenocarcinoma whose disease has not progressed on at least 16 weeks of a first-line platinum-based chemotherapy regimen. (medscape.com)
Junction Carcinomas2
  • Durvalumab is under clinical development by AstraZeneca and currently in Phase III for Gastroesophageal (GE) Junction Carcinomas. (pharmaceutical-technology.com)
  • According to GlobalData, Phase III drugs for Gastroesophageal (GE) Junction Carcinomas have a 100% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. (pharmaceutical-technology.com)
Squamous cell carc1
  • We also provide an in-depth protocol for the generation of head and neck squamous cell carcinoma organoids and their subsequent use in semi-automated therapy screens. (nature.com)
Cholangiocarcinoma1
  • however, the association of gallstones with cholangiocarcinoma is less marked than with carcinoma of the gallbladder. (medscape.com)
Gallbladder1
Tumours8
  • Not only do these wrap pancreatic tumours in a dense, protective layer, they also foster complex relationships with the cancerous cells: some fibroblasts may fuel tumour growth, while other may help to contain its spread. (elifesciences.org)
  • Our purpose was to employ this novel technique to observe microvessels in pancreatic tumours. (bmj.com)
  • Sixty five patients with suspicious pancreatic tumours received contrast enhanced coded phase inversion harmonic ultrasonography, contrast enhanced computed tomography, and endosonography. (bmj.com)
  • Final diagnoses based on histological findings were pancreatic ductal carcinomas in 49 patients, inflammatory pseudotumours with chronic pancreatitis in seven, and endocrine tumours in nine. (bmj.com)
  • Sensitivities for depicting pancreatic tumours were compared between three examinations. (bmj.com)
  • Values for sensitivity in depicting pancreatic tumours of 2 cm or less in size were 68% for contrast enhanced computed tomography, 95% for endosonography, and 95% for contrast enhanced ultrasonography. (bmj.com)
  • Contrast enhanced coded phase inversion harmonic ultrasonography successfully visualised fine vessels in pancreatic tumours and may play a pivotal role in the depiction and differential diagnosis of pancreatic tumours. (bmj.com)
  • Contrast enhanced Doppler sonography has been proposed as a valuable technique for the diagnosis of hepatic and pancreatic tumours. (bmj.com)
Cancers5
  • Pancreatic cancer is one of the deadliest and most difficult cancers to treat. (elifesciences.org)
  • The diagnosis of pancreatic cancers, particularly their differential diagnosis from chronic pancreatitis, has often been difficult, even when a combination of various imaging modalities such as ultrasonography (US), magnetic resonance cholangiopancreatography (MRCP), endoscopic retrograde cholangiopancreatography (ERCP), endosonography (EUS), contrast enhanced computed tomography (CT), and catheterised angiography are employed. (bmj.com)
  • Aberrant (upregulated) expression of the MUC1 mucin has been seen in breast carcinomas and other neoplasms, such as colon and pancreatic cancers. (bmj.com)
  • Approximately 90 percent of pancreatic cancers start in the ducts of the pancreas. (dkfz.de)
  • For very rare cancers such as acinar cell carcinoma of the pancreas, it is difficult to test the effectiveness of novel drugs in classic clinical trials. (dkfz.de)
Tumor4
  • Scientists think that the various types of pancreatic cancer differ considerably in their tumor biology. (dkfz.de)
  • In their analysis of acinar cell carcinomas, the DKFZ researchers found no recurrent cancer-promoting point mutations in tumor-relevant genes, which are characteristic for pancreatic ductal carcinomas. (dkfz.de)
  • The results confirm that acinar cell carcinoma of the pancreas has a completely different tumor biology and, hence, a different development history than tumors of the pancreatic duct," Schmezer said. (dkfz.de)
  • Biliary ductal dilatation is easily demonstrated with US, but the tumor mass is seldom localized with it. (medscape.com)
Gastric4
  • Several studies have reported conflicting and inconclusive results concerning the clinical relevance of mucin expression in gastric carcinoma. (bmj.com)
  • This study investigated the correlations between aberrant expression of mucins in gastric carcinoma and patient clinicopathological features. (bmj.com)
  • The expression of MUC1, MUC2, MUC3, MUC5AC, and MUC6 was investigated immunohistochemically in gastric carcinoma (n = 46) in relation to patient clinicopathological features. (bmj.com)
  • Membrane bound mucins MUC1 and MUC3 appear to be associated with the development of gastric carcinoma. (bmj.com)
Tumors3
  • Extrahepatic tumors are divided into proximal, middle, and distal ductal tumors. (medscape.com)
  • Solitary well-demarcated tumors are difficult to differentiate from primary hepatocellular carcinomas (HCCs). (medscape.com)
  • Compared with other tumors, they are less cellular and have relatively few well-differentiated carcinoma cells in a dense connective tissue stroma. (medscape.com)
Malignancies1
  • The neurotensin receptor ligand 111 In/ 177 Lu-3B-227 has demonstrated high potential in imaging and therapy for several malignancies (e.g., pancreatic adenocarcinomas). (snmjournals.org)
Patients1
  • relied on tumour samples obtained from pancreatic cancer patients. (elifesciences.org)
Tissue1
  • The investigators performed comprehensive molecular analyses of tissue samples from 74 cases of acinar cell carcinoma. (dkfz.de)
Alterations1
  • The good news is that for many of the frequent alterations that we found in acinar cell carcinoma, targeted agents are already available and some of them are even already approved for therapy. (dkfz.de)
Https1
  • Her work is supported by the Pancreatic Cancer Research Fund (https://www.pcrf.org.uk), Science Foundation Ireland, through the Precision Oncology Ireland Consortium and the EU Horizon 2020 Marie Sklodowska-Curie Programme. (tcd.ie)
Cancer6
  • Scientists from the German Cancer Research Center (DKFZ) have conducted comprehensive molecular analyses of a rare type of pancreatic cancer. (dkfz.de)
  • In addition, there are a number of much less common cancer types, including acinar cell carcinoma, that develop from specific exocrine cells of the pancreas. (dkfz.de)
  • Since this type of cancer is extremely rare and accounts for only about two percent of all cases of pancreatic cancer, very little is known about this disease. (dkfz.de)
  • The most active agents for pancreatic cancer have been 5-fluorouracil (5-FU) and gemcitabine. (medscape.com)
  • Response rates are typically less than 20% in pancreatic cancer. (medscape.com)
  • Erlotinib has been approved by the FDA for use, in combination with gemcitabine, as a first-line treatment for locally advanced, unresectable, or metastatic pancreatic cancer. (medscape.com)
Breast1
  • 1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)
Cells1
  • In approximately 70 percent of the acinar cell carcinomas under investigation, the researchers discovered defective DNA repair genes that can result in the failure of cells to repair defects in the genetic material. (dkfz.de)
Molecular genetics of pancreatic1
Hepatocellular carcinoma4
Malignant pancreatic1
  • About 85% of malignant pancreatic cancer arises as ductal adenocarcinomas. (medscape.com)
Exocrine2
PDAC1
  • Purpose: The identification of pancreatic ductal adenocarcino-ma (PDAC) dysregulated genes may unveil novel molecular targets entering inhibitory strategies. (unav.edu)
Renal cell carc2
  • Renal cell carcinoma (RCC) is one of the most lethal genitourinary malignancies with poor prognoses, since it is largely resistant to chemotherapy, radiotherapy, and targeted therapy. (nature.com)
  • 36. DNA mismatch repair genes in renal cell carcinoma. (nih.gov)
Pancreas1
  • [ 4 ] Chronic pancreatitis or long-term inflammation of the pancreas can be caused by greater alcohol consumption, leading to a risk for pancreatic cancer that is increased up to 16-fold. (medscape.com)
Neoplasms1
  • the other 95%-98% of pancreatic neoplasms Neoplasms New abnormal growth of tissue. (lecturio.com)
Prognosis2
Genetic1
  • 26. Clinicopathologic and genetic features of nonfamilial colorectal carcinomas with DNA replication errors. (nih.gov)
Diabetes2
  • Diabetes mellitus can be both a symptom of and a risk factor for pancreatic cancer. (medscape.com)
  • Studies show that 1% of patients who are diagnosed with diabetes after 50 years of age develop pancreatic cancer within 3 years of being diagnosed with diabetes. (medscape.com)
Include2
  • Pathognomonic features of carcinoma include circumferential perineural invasion, glomerulations, mucinous fibroplasia, and glands infiltrating adipose tissue. (cap.org)
  • [ 7 ] Other nonhereditary factors shown to increase risk for pancreatic cancer include peptic ulcer surgery or partial gastrectomy, smoking, obesity , and physical inactivity. (medscape.com)
Expression3
  • 23. Loss of hMSH2 and hMSH6 expression is frequent in sporadic endometrial carcinomas with microsatellite instability: a population-based study. (nih.gov)
  • In the present study, the clinical significance of SOX9 expression in oesophageal squamous cell carcinoma was examined. (iiarjournals.org)
  • utilizing transgenic animals that express TVA in the ductal or endocrine compartments of the pancrease to identify the effects of oncogene expression in the cell lineages. (umassmed.edu)