• Lobular carcinoma in situ (LCIS) is noninvasive breast cancer that arises from the lobule at the terminal end of the duct and shows a rather diffuse distribution throughout the breast, which explains its presentation as a nonpalpable mass in most cases (see the images below). (medscape.com)
  • It is generally ER positive (ER+) and often associated with lobular carcinoma in situ (LCIS). (ox.ac.uk)
  • Women with low-grade DCIS are at higher risk of developing invasive breast cancer than women without DCIS, but are less likely to have a recurrence of the breast carcinoma or to develop new cancers than women with higher-grade DCIS. (medscape.com)
  • Unlike invasive or infiltrative carcinomas, which invade the tissue around the area of origin or other parts of the body, carcinoma in situ exists solely where it began. (beatcancer.eu)
  • Genetic predisposition to in situ and invasive lobular carcinoma of the breast. (ox.ac.uk)
  • Invasive lobular breast cancer (ILC) accounts for 10-15% of all invasive breast carcinomas. (ox.ac.uk)
  • The treatment of non-muscle-invasive bladder cancer (Ta, T1, carcinoma in situ [CIS]) begins with transurethral resection of bladder tumor (TURBT). (medscape.com)
  • A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (bvsalud.org)
  • Squamous Cell Carcinoma Squamous cell carcinoma is cancer that begins in the squamous cells of the skin. (msdmanuals.com)
  • Squamous cell carcinoma in situ (formerly called Bowen disease) most commonly occurs on sun-exposed areas of the skin but may occur anywhere. (msdmanuals.com)
  • Other types include squamous cell carcinoma (see the image below) and adenocarcinomas. (medscape.com)
  • Cross-section through the bladder, uterus, and vagina with squamous cell carcinoma of the bladder infiltrating through the bladder wall into the vaginal wall. (medscape.com)
  • Garneski KM , Warcola AH , Feng Q , Kiviat NB , Leonard JH , Nghiem P . Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors. (cdc.gov)
  • Genome-wide association studies have identified more than 70 common polymorphisms that predispose to breast cancer, but these studies included predominantly ductal (IDC) carcinomas. (ox.ac.uk)
  • It will detail its meaning, differentiate it from other carcinomas, and explore its causes, risk factors, and types. (beatcancer.eu)
  • Age, lifestyle habits such as smoking and excessive alcohol consumption, family history, and exposure to certain types of human papillomavirus (HPV) can amplify the chances of developing carcinoma in situ. (beatcancer.eu)
  • There are several other types of carcinoma in situ, including cervical intraepithelial neoplasia (CIN), which pertains to the cervix, and melanoma in situ residing within the skin. (beatcancer.eu)
  • In order to accentuate the significance and complexity of carcinoma in situ, this article offers an in-depth overview of this type of cancer. (beatcancer.eu)
  • Within the broad spectrum of cancer classifications, carcinoma in situ (CIS) takes its unique spot. (beatcancer.eu)
  • Kassem A , Schopflin A , Diaz C , Weyers W , Stickeler E , Werner M , Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene. (cdc.gov)
  • Becker JC , Houben R , Ugurel S , Trefzer U , Pfohler C , Schrama D . MC polyomavirus Is frequently present in Merkel cell carcinoma of European patients. (cdc.gov)
  • Carcinoma in situ" is a medical term referring to a group of abnormal cells that remain in their original location. (beatcancer.eu)
  • Ductal carcinoma in situ (DCIS) is noninvasive breast cancer that is limited to the inside of the ducts of the breast. (medscape.com)
  • Women with low-grade DCIS are at higher risk of developing invasive breast cancer than women without DCIS, but are less likely to have a recurrence of the breast carcinoma or to develop new cancers than women with higher-grade DCIS. (medscape.com)
  • To our knowledge, the hormone receptor status of noncontiguous ductal carcinoma in situ (DCIS) occurring concurrently in ER/PgR-negative invasive cancer has not been studied. (hindawi.com)
  • Ductal carcinoma in situ (DCIS) is probably a continuum of successive steps of the same process, with increasing malignant potential as the disease progresses from papillary to comedo forms. (hindawi.com)
  • Expression of ER in DCIS alone compared to contiguous DCIS associated with invasive carcinoma has been investigated in the past. (hindawi.com)
  • One study showed that intraductal carcinoma associated with invasive cancer was more frequently ER-positive compared to DCIS without associated invasion [ 15 ]. (hindawi.com)
  • In this article, we describe a matched-pair analysis of ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) of nine breast ductal carcinomas to identify novel molecular markers characterizing the transition from DCIS to IDC. (aacrjournals.org)
  • Synchronous Ductal Carcinoma in situ (DCIS-IDC) is an early stage breast cancer invasion in which it is possible to delineate genomic evolution during invasion because of the presence of both in situ and invasive regions within the same sample. (tmc.edu)
  • While laser capture microdissection studies of DCIS-IDC examined the relationship between the paired in situ (DCIS) and invasive (IDC) regions, these studies were either confounded by bulk tissue or limited to a small set of genes or markers. (tmc.edu)
  • We also applied deep-exome sequencing to the in situ, invasive and normal tissues for the DCIS-IDC patients. (tmc.edu)
  • The association between family history and risk of triple negative breast cancer and ductal carcinoma in situ (DCIS) has not been well investigated, especially in Asian populations. (biomedcentral.com)
  • Lobular carcinoma in situ (LCIS) is noninvasive breast cancer that arises from the lobule at the terminal end of the duct and shows a rather diffuse distribution throughout the breast, which explains its presentation as a nonpalpable mass in most cases (see the images below). (medscape.com)
  • Breast cancer evolves from normal epithelium of the terminal duct or lobular unit through a series of increasingly abnormal proliferative lesions beginning with atypical hyperplasia, to premalignant in situ disease, to malignant and increasingly invasive neoplasia [ 1 - 3 ]. (hindawi.com)
  • According to histopathological diagnosis, cases were classified as follows: 14 comedo, 8 solid, 5 micropapillary, 6 lobular, 3 papillary, 1 apocrine and 12 mixed in situ carcinomas. (unife.it)
  • 3. Risk of invasive breast carcinoma among women diagnosed with ductal carcinoma in situ and lobular carcinoma in situ, 1988-2001. (nih.gov)
  • 4. Lobular carcinoma in situ or atypical lobular hyperplasia at core-needle biopsy: is excisional biopsy necessary? (nih.gov)
  • 6. Lobular carcinoma in situ on core biopsy-what is the clinical significance? (nih.gov)
  • We sought to evaluate differences between those ductal carcinomas in situ presenting as large versus small lesions while controlling for high-grade, to determine whether there exist phenotypic and genetic differences between the 2 groups. (duke.edu)
  • Nearly all breast cancers are carcinomas. (cancer.org)
  • In 50 in situ breast cancers an immunohistochemical study, evaluating estrogen (ER) and progesterone (PR) receptors, Proliferation Index (PI), c-erbB-2/Neu and p53 expression was performed. (unife.it)
  • 7. Age-specific incidence rates of in situ breast carcinomas by histologic type, 1980 to 2001. (nih.gov)
  • However, the in situ phenotype identification of the two main cells of the immune system cannot be reliably done on morphological grounds as they are morphologically identical [8]. (who.int)
  • In order to gain more insight into the tumour-host relationship, the present study was conducted to characterize the in situ phenotype of the lymphocytic infiltrate surrounding tumour tissue of BCC through the use of monoclonal antibodies against B and T cell populations. (who.int)
  • Scholars@Duke publication: Genomic alterations and phenotype of large compared to small high-grade ductal carcinoma in situ. (duke.edu)
  • Basal cell carcinoma (BCC) is a malignant epithelial neoplasm and is the most common cancer in the head and neck region. (who.int)
  • In situ carcinoma is characteristically contained within the epithelium, with the basement membrane intact, and without any signs of invasion [ 4 ]. (hindawi.com)
  • Our data support a multiclonal invasion model, in which genome evolution occurs within the ducts and gives rise to multiple subclones that escape the ducts into the adjacent tissues to establish the invasive carcinomas. (tmc.edu)
  • A clinically distinct subgroup of pure ductal carcinoma in situ presents as an extensive, high-grade lesion, which nevertheless lacks invasion. (duke.edu)
  • A more thorough evaluation of these differences could help identify the likelihood of recurrence or progression for in situ lesions. (duke.edu)
  • In summary, we have developed a novel method for single cell DNA sequencing, which preserves spatial context, and applied this method to understand clonal evolution during the transition between carcinoma in situ to invasive ductal carcinoma. (tmc.edu)
  • Clonal integration of a polyomavirus in human Merkel cell carcinoma. (cdc.gov)
  • The origin of the oral cases is still uncertain, but the carcinoma is thought to arise from pluripotential cells in the basal layer or from heterotropic sebaceous glands [2]. (who.int)
  • 12. Feasibility of breast-conserving surgery for patients with breast carcinoma associated with nipple discharge. (nih.gov)
  • 15. Mammographically detected, clinically occult ductal carcinoma in situ treated with breast-conserving surgery and definitive breast irradiation. (nih.gov)
  • Twenty cases of basal cell carcinoma (BCC) of the head and neck region were examined immunohistochemically for the detection of T- and Blymphocytes. (who.int)
  • 13. Results of 23,810 cases of ductal carcinoma-in-situ. (nih.gov)
  • The results obtained identify the different biophenotypes of in situ carcinomas, suggesting the possibility of multiple cancerogenetic ways with a different weight of biological events. (unife.it)
  • Becker JC , Houben R , Ugurel S , Trefzer U , Pfohler C , Schrama D . MC polyomavirus Is frequently present in Merkel cell carcinoma of European patients. (cdc.gov)
  • Foulongne V , Kluger N , Dereure O , Brieu N , Guillot B , Segondy M . Merkel cell polyomavirus and Merkel cell carcinoma, France. (cdc.gov)
  • Kassem A , Schopflin A , Diaz C , Weyers W , Stickeler E , Werner M , Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene. (cdc.gov)
  • 14. [In situ carcinomas of the breast: clinical features and therapeutic strategies]. (nih.gov)