TumorsMyoepithelial carcinomaColorectal adenomasAdenocarcinomaPathologyParotid glandSquamousPolypsDysplasiaIncidenceRarelyPleomorphic adenomasHepatocellularTumorTumorigenesisResidualAdenomatousNeoplasmsDiagnosisSequenceCarcinogenesisMalignancyPatientsHepaticAdrenocorticalDiagnosesSpecimensPathwaysMetastaticParathyroid hormoneArisesPoorlyPrevalentFocalBiomarkersHistopathologicalTumourBiopsyHistologicMiceAdrenalPrimarySignificantlyMolecular
Tumors16
- Relative incidence of parotid tumors, showing carcinoma ex pleomorphic adenoma at right. (wikipedia.org)
- Transplanted cells in nude mice formed subcutaneous tumors, which had histological features of squamous cell carcinoma with apparent keratinizing tendencies. (biomedcentral.com)
- This study demonstrates in vitro that certain cell types from pleomorphic adenoma are able to clone and survive over a long term and develop subcutaneous tumors in nude mice. (biomedcentral.com)
- Carcinoma ex-pleomorphic adenoma (CxPA) is an uncommon malignancy, accounting for roughly 11% of primary tumors of the salivary gland. (scirp.org)
- Almost all of these tumors are benign (pituitary adenomas). (cancer.org)
- Very few pituitary tumors are cancers (pituitary carcinomas). (cancer.org)
- Epithelial myoepithelial carcinoma (EMC) is a rare malignant salivary gland tumor with biphasic pattern accounting for nearly 2% of malignant salivary gland tumors and less than 1% of all salivary gland epithelial neoplasm. (ijhnp.org)
- Salivary gland tumors with myoepithelial differentiation such as adenoid cystic carcinoma (ACC), PA, myoepithelioma, basal cell adenoma (BCA), basal cell adenocarcinoma (BCAC), and myoepithelial carcinoma are to be considered in the differential diagnoses. (ijhnp.org)
- Most tumors that affect the adrenal cortex are adenomas. (medicalnewstoday.com)
- Adrenocortical tumors encompass a spectrum of diseases with often seamless transition from benign (adenoma) to malignant (carcinoma) behavior. (oncolink.org)
- The tumors are usually noncancerous (benign), in which case they are called adenomas. (medlineplus.gov)
- Objective: Laryngeal verrucous carcinoma (LVC) comprises 1% to 4% of all laryngeal tumors. (researchgate.net)
- Most pituitary tumors are adenomas. (msdmanuals.com)
- Most tumors of the pituitary and suprasellar region are pituitary adenomas. (msdmanuals.com)
- Rarely, pituitary tumors are carcinomas. (msdmanuals.com)
- Skin malignancies, Merkel cell carcinoma and rare appendageal tumors. (medscape.com)
Myoepithelial carcinoma6
- [ 2 ] In most instances the luminal epithelial cells undergo malignant change, though a combination of epithelial and myoepithelial malignancy or purely myoepithelial carcinoma may also occur. (medscape.com)
- High-grade adenocarcinoma (not otherwise specified), myoepithelial carcinoma, and epithelial-myoepithelial carcinomas are other common tumor types arising in this setting. (medscape.com)
- What is myoepithelial carcinoma? (mypathologyreport.ca)
- Myoepithelial carcinoma is a type of salivary gland cancer made up almost entirely of myoepithelial cells. (mypathologyreport.ca)
- Where is myoepithelial carcinoma found in the body? (mypathologyreport.ca)
- Epithelial-myoepithelial carcinoma (EMC) is a rare and low-grade malignant tumor of the salivary gland. (ijhnp.org)
Colorectal adenomas1
- The etiopathogenesis of most colorectal carcinomas (CRC) follows the conventional adenoma-carcinoma sequence (ACS), in which colorectal adenomas with low-grade dysplasia (LGD) and/or high-grade dysplasia (HGD) evolve to invasive adenocarcinoma (ADC), through a stepwise accumulation of genetic and epigenetic alterations. (encyclopedia.pub)
Adenocarcinoma4
- Scholars@Duke publication: Adenoma-like adenocarcinoma: a subtype of colorectal carcinoma with good prognosis, deceptive appearance on biopsy and frequent KRAS mutation. (duke.edu)
- METHODS AND RESULTS: For 35 carcinomas with adenomatous-like areas (cytological and surface architectural appearance that would be insufficient to warrant a diagnosis of adenocarcinoma if evaluated on biopsy), we recorded staging information, molecular data, clinical outcome, whether precursor adenoma was present and whether previous biopsy had been diagnosed as malignant. (duke.edu)
- CONCLUSIONS: Adenoma-like adenocarcinoma is an uncommon variant of CRC with a low rate of metastasis and good prognosis. (duke.edu)
- he has published findings on adenoma-like adenocarcinoma and micropapillary carcinoma. (rochester.edu)
Pathology2
- Although pathologists in their daily services of surgical pathology had recognized such singular atypical cells in pleomorphic adenomas, these atypical cells were not always regarded as evidence or the source for malignant transformation [ 4 - 6 ]. (biomedcentral.com)
- Final pathology revealed high grade mucoepidermoid carcinoma arising from a pleomorphic adenoma. (scirp.org)
Parotid gland5
- Carcinoma ex pleomorphic adenoma (ca ex PA) is a type of cancer typically found in the parotid gland. (wikipedia.org)
- We have established five cell systems from a benign pleomorphic adenoma of the parotid gland of a 61-year-old woman. (biomedcentral.com)
- We established and characterized five cell systems (designated as SM-AP1 to SM-AP5) from a benign pleomorphic adenoma of the parotid gland. (biomedcentral.com)
- Most myoepithelial carcinomas are found in the parotid gland, however, any of the salivary glands including the minor salivary glands in the oral cavity can be involved. (mypathologyreport.ca)
- Herein, we report a case of a high-grade mucoepidermoid carcinoma ex-pleomorphic adenoma within the deep lobe of the parotid gland. (scirp.org)
Squamous5
- The histological features of squamous cell carcinoma from the transplanted cell systems in nude mice might suggest a secondary onset of malignancy from a pre-existing benign adenoma. (biomedcentral.com)
- Fine needle aspiration (FNA) of the neck mass was consistent with poorly differentiated metastatic carcinoma, likely of squamous origin. (scirp.org)
- Carcinoma in situ is the earliest type of squamous cell cancer. (medicalnewstoday.com)
- Nasopharyngeal carcinomas (NPC) are non-keratinizing squamous cell carcinomas of the nasopharynx associated with Epstein-Barr virus (EBV). (researchgate.net)
- Tumor types included squamous cell carcinomas, bronchoalveolar adenomas, bronchoalveolar carcinomas and scirrhous carcinomas. (cdc.gov)
Polyps2
- Colorectal cancer (CRC), a commonly diagnosed cancer often develops slowly from benign polyps called adenoma to carcinoma. (biomedcentral.com)
- To study the roles of tyrosine kinases in colon cancer, we developed a tyrosine-kinase- expression profile for each of the four different stages of colon carcinogenesis, using normal colon mucosa, adenomatous polyps, primary carcinoma and hepatic metastases collected from the same patient. (tmu.edu.tw)
Dysplasia6
- Authors report their experience in the treatment of adenomas with severe dysplasia and early cancer of the colon-rectum confirming that the endoscopic resection of these lesions is safe and curative when completely removed and no submucosal invasion is found. (unboundmedicine.com)
- Severe dysplasia was found in 15 adenomas. (unboundmedicine.com)
- The Authors focused on 12 patient with early carcinoma and 15 with severe dysplasia. (unboundmedicine.com)
- Adenomas, differentiated by size, villous architecture and degree of dysplasia were compared to both early and advanced carcinomas. (unboundmedicine.com)
- A diagnosis model consisting of four effect indexes was constructed based on the markers, the sensitivities of the Adenoma Effect Index 1 for AA, Adenoma Effect Index 2 for high-grade dysplasia (HGD) adenoma were 71.3% and 76.5%, the specificities were 90.5% and 90.3%, respectively. (biomedcentral.com)
- In most cases, the disease begins as a benign adenomatous polyp, which develops into advanced adenoma with high-grade dysplasia and then progresses to invasive cancer [ 12 ]. (biomedcentral.com)
Incidence2
- Its phenotype is changing from single lesions to multiple lesions owing to the reduction in estrogen exposure and increasing incidence of obesity and metabolic syndrome as driving factors in the formation of hepatic adenoma. (medscape.com)
- These patients can be particularly challenging for the imager because of distortion of normal anatomic landmarks and an increasing incidence of ectopic adenomas. (medscape.com)
Rarely5
- [ 9 ] Not surprisingly, carcinoma ex pleomorphic adenoma is rarely encountered in children or in patients younger than 30 years. (medscape.com)
- however, the presence of mucoepidermoid carcinoma (MEC) arising from pleomorphic adenoma (PA) has been rarely reported, with a total of nine cases in the literature. (scirp.org)
- Rarely, people with familial isolated hyperparathyroidism develop a cancerous tumor called parathyroid carcinoma. (medlineplus.gov)
- The loss of parafibromin's tumor suppressor function can lead to the development of parathyroid adenoma or, rarely, parathyroid carcinoma. (medlineplus.gov)
- [ 4 ] Rarely, patients develop hyperparathyroidism secondary to a parathyroid carcinoma . (medscape.com)
Pleomorphic adenomas3
- Carcinoma ex pleomorphic adenoma represents the most common malignant change to occur in pleomorphic adenomas. (medscape.com)
- however, exposure to radiation is thought to be a factor (as it is with pleomorphic adenomas). (medscape.com)
- Pleomorphic adenomas have been often subjected to cytogenetic and molecular analyses. (biomedcentral.com)
Hepatocellular2
- Hepatocellular adenoma (HCA), also called hepatic adenoma, is an uncommon benign solid liver tumor. (medscape.com)
- Hepatocellular adenomas (HCAs) are also known as hepatic adenomas, telangiectatic focal nodular hyperplasia (FNH) or, less commonly, liver cell adenomas. (medscape.com)
Tumor12
- Other malignant neoplasms to arise in the setting of a pleomorphic adenoma include carcinosarcoma (true malignant mixed tumor) and metastasizing pleomorphic adenoma. (medscape.com)
- The gross appearance of carcinoma ex pleomorphic adenoma varies, though the majority (approximately 64%) are infiltrative with poorly defined tumor margins. (medscape.com)
- The carcinoma tumor type must be specified and, if applicable, graded. (medscape.com)
- The most common tumor type seen in carcinoma ex pleomorphic adenoma is salivary duct carcinoma. (medscape.com)
- In addition, they had ductal arrangements or plasmacytoid appearances of tumor cells and myxoid or hyaline stromata, indicating some characteristics of pleomorphic adenoma. (biomedcentral.com)
- En España representa el tumor más frecuente si se consideran hombres y mujeres en conjunto, y constituye la segunda causa de fallecimiento por cáncer. (ucm.es)
- However CRC is a perfectly preventable tumor because most of them develop from adenomas and we have effective techniques, as endoscopic polypectomy, for their detection and treatment. (ucm.es)
- Among these kinases, arg kinase appears to be expressed at a higher level in primary carcinoma and metastatic tumor than in adjacent normal mucosa or adenomatous polyp. (tmu.edu.tw)
- Periphery of the tumor showed chondroid and myxomatous stroma and tubular structures reminiscent of pleomorphic adenoma (PA). (ijhnp.org)
- A multiplex ligation-dependent probe amplification method was used to compare differences in copy number in 39 common tumor-associated genes among 7 patients with parathyroid carcinoma and 14 age- and sex-matched subjects with parathyroid adenoma. (nih.gov)
- Using three-dimensional live-cell imaging of patient-derived tumor organoids (tumor PDOs), we show that CIN is widespread in colorectal carcinomas regardless of background genetic alterations, including microsatellite instability. (nature.com)
- A parathyroid adenoma is a benign tumor on a parathyroid gland. (medscape.com)
Tumorigenesis4
- The adenoma carcinoma sequence: an indoctrinated model for tumorigenesis, but is it always a clinical reality? (unboundmedicine.com)
- TY - JOUR T1 - The adenoma carcinoma sequence: an indoctrinated model for tumorigenesis, but is it always a clinical reality? (unboundmedicine.com)
- These translocations have been regarded as one of the major responsible genetic events for the tumorigenesis of pleomorphic adenoma. (biomedcentral.com)
- Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. (nature.com)
Residual1
Adenomatous1
Neoplasms1
- Berstein L, Gurney JG: Carcinomas and other malignant epithelial neoplasms. (oncolink.org)
Diagnosis7
- In the other approximately 25% of cases the individual had a pleomorphic adenoma excised previously and the diagnosis is made based on (1) the presence of a carcinoma, and (2) the history of a pleomorphic adenoma at that location. (wikipedia.org)
- Carcinoma ex pleomorphic adenoma is not a specific diagnosis, as it only indicates a malignant carcinoma arising from an antecedent pleomorphic adenoma. (medscape.com)
- This study reports the successful diagnosis model establishment and cross-region validation for colorectal advanced adenoma and carcinoma based on the progressive gut microbiota gene markers. (biomedcentral.com)
- The results suggested that the novel diagnosis model can significantly improve the diagnostic performance for advanced adenoma. (biomedcentral.com)
- A novel bacterial marker m3 for the non-invasive diagnosis of colorectal adenoma has been identified and evaluated [ 11 ]. (biomedcentral.com)
- The final pathologic diagnosis was metastatic high-grade mucoepidermoid carcinoma ex-pleomorphic adenoma. (scirp.org)
- Imaging studies to detect parathyroid adenomas should be performed only after the diagnosis of primary HPT is established on the basis of biochemical findings. (medscape.com)
Sequence4
- Evidence exists to support alternative pathways to the adenoma carcinoma sequence. (unboundmedicine.com)
- Gullo, I. Adaptive Immune Landscape of Colorectal Adenoma-Carcinoma Sequence. (encyclopedia.pub)
- Adaptive Immune Landscape of Colorectal Adenoma-Carcinoma Sequence" Encyclopedia , https://encyclopedia.pub/entry/14853 (accessed December 03, 2023). (encyclopedia.pub)
- Dynamic stromal cellular reaction throughout human colorectal adenoma-carcinoma sequence: A role of TH17/IL-17A. (nord.no)
Carcinogenesis1
- This study identifies a possible role for arg tyrosine kinase in colon carcinogenesis, especially in the transition from adenoma to carcinoma. (tmu.edu.tw)
Malignancy3
- Carcinoma ex pleomorphic adenoma is defined as an epithelial and/or myoepithelial malignancy arising from a primary or recurrent pleomorphic adenoma . (medscape.com)
- Malignancy may be not be apparent on gross examination, especially in cases of noninvasive or minimally invasive carcinoma. (medscape.com)
- Background: Mucoepidermoid carcinoma ex-pleomorphic adenoma (MECxPA) is an extremely rare salivary gland malignancy. (scirp.org)
Patients6
- Patients with carcinoma ex pleomorphic adenoma classically present with recent and rapid enlargement of a previously longstanding and slow-growing mass. (medscape.com)
- Further another study showed that Fusobacterium species could serve as biomarkers to differentiate patients with CRC and advanced adenoma (AA) from controls [ 10 ]. (biomedcentral.com)
- Here, we performed a metagenomic analysis of samples from colorectal advanced adenoma and carcinoma patients with different stages and control subjects and identified the progressive microbiota biomarkers. (biomedcentral.com)
- The study participants comprised 20 patients with gastric carcinoma, 20 patients with positive H. pylori - associated gastritis and 20 individuals as the control group. (who.int)
- L'étude portait sur 20 patients atteints d'un carcinome gastrique, 20 patients souffrant d'une gastrite à H. pylori et 20 personnes en tant que groupe témoin. (who.int)
- Fields et al reviewed 500 patients with Merkel cell carcinoma in a single-institution study. (medscape.com)
Hepatic2
- Prior to this, a study by Edmonson reported finding only two hepatic adenomas among 50,000 autopsy specimens at Los Angeles County Hospital between 1907 and 1958. (medscape.com)
- [ 4 ] In 1973, Baum et al first suggested an association between hepatic adenomas and OCPs. (medscape.com)
Adrenocortical2
- Systemic treatment of adrenocortical carcinoma in children: data from the German GPOH-MET 97 trial. (oncolink.org)
- Factors associated with survival in pediatric adrenocortical carcinoma: An analysis of the National Cancer Data Base (NCDB). (oncolink.org)
Diagnoses1
- Histopathological diagnoses of the specimen were renal cell carcinoma and renal tubulopapillary adenoma respectively. (elsevierpure.com)
Specimens1
Metastatic1
Parathyroid hormone1
- In primary hyperparathyroidism due to adenomas, the normal feedback on parathyroid hormone production by extracellular calcium seems to be lost, resulting in a change in the set point. (medscape.com)
Arises2
- It arises from the benign tumour pleomorphic adenoma. (wikipedia.org)
- Among the salivary gland carcinomas, carcinoma in pleomorphic adenoma has been regarded as a representative carcinoma type which arises secondarily in the background of a pre-existent benign pleomorphic adenoma. (biomedcentral.com)
Poorly1
- It is still poorly understood how and which benign pleomorphic adenoma cells transform into its malignant form, carcinoma ex pleomorphic adenoma. (biomedcentral.com)
Prevalent1
- It was shown that amplification of CCND1, a gene encoding cyclin D1, was more prevalent in parathyroid carcinomas than in adenomas (71 vs. 21 %, p = 0.056). (nih.gov)
Focal1
- In our previous study, we proposed a concept of focal carcinomas in pleomorphic adenoma which is an advanced stage of accumulated atypical cells with P53 over-expressions as an initial stage or a latent form of apparent carcinomas secondarily arising in pleomorphic adenoma [ 3 ]. (biomedcentral.com)
Biomarkers3
- Recently, it is shown that the fecal microbiome could be a source of targeted non-invasive biomarkers for colorectal adenoma and cancer. (biomedcentral.com)
- Therefore, it is clinically valuable to find non-invasive progressive fecal microbiota biomarkers that can reflect the dynamic changes of the disease from normal to adenoma and CRC by continuously increasing or decreasing. (biomedcentral.com)
- In this study, we identified potential early biomarkers of colorectal cancer (CRC) development by genome-wide DNA methylation assay (Illumina infinium450, 450 K) of normal ( N = 20) and pre-colorectal cancer samples including 18 low-grade adenoma (LGA) and 22 high-grade adenoma (HGA), integrated with GEO and ArrayExpress datasets ( N = 833). (biomedcentral.com)
Histopathological1
- Therefore, we aimed to look for an association between the histopathological features of adenomas and their anatomical location as compared with the distribution of cancers. (unboundmedicine.com)
Tumour2
- In approximately 75% of cases ca ex PAs arise in a pleomorphic adenoma that is apparent when the tumour is excised. (wikipedia.org)
- Carcinoma ex pleomorphic adenoma is a type of salivary gland cancer that develops from within a previously noncancerous tumour called pleomorphic adenoma. (mypathologyreport.ca)
Histologic1
Mice1
- For DCA 63% of the mice had carcinomas and 43% had adenomas. (epa.gov)
Adrenal1
- Wooten MD, King DK: Adrenal cortical carcinoma. (oncolink.org)
Primary3
- The molecular bases for parathyroid carcinomas present in conjunction with sporadic primary hyperparathyroidism are not fully elucidated. (nih.gov)
- In the present report, we describe a rare case of primary signet ring cell carcinoma of the appendix with ovarian metastasesand unresectable peritoneal dissemination occurring in a 45-year-old female patient. (wjgnet.com)
- In approximately 85-90% of cases, primary hyperparathyroidism is caused by a single adenoma. (medscape.com)
Significantly2
- Pathway analysis identified nervous system-related methylation changes that are significantly associated with early adenoma development. (biomedcentral.com)
- Expression of CCND1 mRNA level was significantly higher in carcinomas than in adenomas (p = 0.003). (nih.gov)