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CarcinomaCarcinoma, Squamous CellCarcinoma, HepatocellularCarcinoma in SituCarcinoma, PapillaryLiver NeoplasmsCarcinoma, Ductal, BreastCarcinoma, Basal CellImmunohistochemistryCarcinoma, Transitional CellCarcinoma, BronchogenicCarcinoma, Intraductal, NoninfiltratingCarcinoma, Adenoid CysticCarcinoma, Small CellTumor Markers, BiologicalCarcinoma, MedullaryAdenocarcinomaCarcinoma, LobularCarcinoma, NeuroendocrineNeoplasm InvasivenessNasopharyngeal NeoplasmsCell Line, TumorPrognosisThyroid NeoplasmsBreast NeoplasmsNeoplasm StagingGene Expression Regulation, NeoplasticTumor Cells, CulturedLung NeoplasmsCarcinoma, MucoepidermoidCarcinoma, AdenosquamousCarcinoma, EndometrioidHead and Neck NeoplasmsCarcinoma, EmbryonalEsophageal NeoplasmsMouth NeoplasmsCarcinoma, Merkel CellCarcinoma, DuctalLymphatic MetastasisOvarian NeoplasmsAdrenocortical CarcinomaColonic NeoplasmsCarcinoma, VerrucousCarcinoma, Signet Ring CellNeoplasm MetastasisUrinary Bladder NeoplasmsStomach NeoplasmsNeoplasm ProteinsSkin NeoplasmsNeoplasm Recurrence, LocalMice, NudeCarcinoma, Large CellDNA, NeoplasmLaryngeal NeoplasmsAntineoplastic AgentsRetrospective StudiesUterine Cervical NeoplasmsImmunoenzyme TechniquesRNA, MessengerNeoplasm TransplantationNeoplasms, Multiple PrimarySurvival RateAdenocarcinoma, FollicularSurvival AnalysisAdenocarcinoma, MucinousTreatment OutcomeAntigens, NeoplasmEmbryonal Carcinoma Stem CellsReverse Transcriptase Polymerase Chain ReactionPrecancerous ConditionsCarcinoma, Papillary, FollicularGallbladder NeoplasmsCarcinoma, Non-Small-Cell LungTumor Suppressor Protein p53Endometrial NeoplasmsAdenocarcinoma, Clear CellDisease ProgressionColorectal NeoplasmsCell Proliferationalpha-FetoproteinsTongue NeoplasmsApoptosisPancreatic NeoplasmsCystadenocarcinoma, SerousCarcinoma, Lewis LungCombined Modality TherapyBronchial NeoplasmsCell DivisionSalivary Gland NeoplasmsTissue Array AnalysisDisease-Free SurvivalKeratinsCisplatinTime FactorsRNA, NeoplasmFollow-Up StudiesMutationCell Transformation, NeoplasticTransplantation, HeterologousBiopsy
SituCuniculatumInvasive squamous cell carcTreatment of verrucous carcinomaTumorLesionMelanomaTumorsExophyticCase of verrucousBasaloidLesionsProliferativePenileRecurrentLeukoplakiaOralBiopsySubtypesSebaceous carcinomaHuman papillomavirus type 16Buccal mucosaRecurrenceCancersNonmetastasising well differentiatedHead and neckOccur1948GenitalVariantPatient underwentVulvarInfectionDiagnosisAnalIncidenceBladderHistopathology
Situ4
Cuniculatum3
  • Epithelioma cuniculatum (also known as Carcinoma cuniculatum,: 654 and Ackerman tumor) is a subtype of verrucous carcinoma, characterized by well-differentiated epithelial cells which lack cytological atypia, but display a blunt papillary/pebbly surface and keratin-filled crypts extending deep into the connective tissue. (wikipedia.org)
  • Epithelioma cuniculatum: a variety of squamous carcinoma peculiar to the foot. (medscape.com)
  • Whether the carcinoma occur in the upper aerodigestive tract (verrucous carcinoma), on the genitalia (condyloma acuminatum), or on extremities (carcinoma cuniculatum), they are essentially the same neoplasm with slow growing, locally invasive and nonmetastasizing behavior 3 . (ispub.com)
Invasive squamous cell carc1
Treatment of verrucous carcinoma1
Tumor7
  • Although most verrucous carcinomas are nonmetastatic, staging is still based on the tumor, nodes, metastases (TNM) staging system. (medscape.com)
  • In 1948, Lauren V. Ackermann first described this neoplasm of the oral mucous membrane, which is now also know as Verrucous Carcinoma of Ackermann or Ackermann's tumor. (ispub.com)
  • The development of verrucous carcinoma from proliferative lesions makes it likely that the tumor develops from a benign precursor. (ispub.com)
  • Increased expression of immunoreactive tumor growth factor-alpha has been noted in lesions of both proliferative verrucous leukoplakia and oral squamous cell cancer, but not in healthy oral mucosa. (medscape.com)
  • Carcinoma of cervix is classified as per the WHO classification into primary tumors which are predominantly epithelial tumors, mesenchymal tumors and tumor like lesions, mixed epithelial stromal tumors, melanocytic, germ cell, and lymphoid tumors. (cytojournal.com)
  • Verrucous carcinoma of the anus or Buschke-Lowenstein tumor of the anus: staging and treatment. (unito.it)
  • A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane. (bvsalud.org)
Lesion6
  • Verrucous carcinoma (VC) was first described in 1948 as a slow-growing exophytic and papillary lesion [ 1 ]. (jwmr.org)
  • The fully developed carcinoma in an exophytic gray to red bulky lesion with a rough, shaggy, papillomatous surface 3 . (ispub.com)
  • Two weeks before presentation, a biopsy of the lesion, performed at another institution, had indicated a probable verrucous carcinoma. (japmaonline.org)
  • A recurrent lesion was noted during a follow-up visit, and a second biopsy revealed a hyperkeratotic papillomatous verrucous lesion, type unclassified. (japmaonline.org)
  • Homogeneous leukoplakia (arrow), with a proliferative growth in the center of the lesion (red arrow) that revealed verrucous carcinoma on biopsy. (iarc.fr)
  • Note the 2x1 cm red velvety lesion (yellow arrow) on the left side of the lower labial mucosa with an area of crust formation extending to the vermilion border (red arrow), which on histopathological examination revealed well-differentiated squamous cell carcinoma. (iarc.fr)
Melanoma2
  • Other primary anal malignancies are rarer and include basal cell carcinoma, primary anal adenocarcinoma, Paget disease (primary and secondary), neuroendocrine carcinoma, and malignant melanoma. (webpathology.com)
  • Cancers from distant sites that metastasize to the vagina through the blood or lymphatic system also occur, including colon cancer, renal cell carcinoma, melanoma , and breast cancer. (medscape.com)
Tumors7
  • Verrucous carcinoma is an uncommon but distinct variety of well differentiated squamous cell carcinoma first delineated by Ackerman in 1948 3 .The term verrucous carcinoma refers to those exophytic mucosal or cutaneous squamous tumors that are heaped above the epithelial surface with a papillary micronodular surface and pushing margins 4 .Predominantly being a squamous mucosal lession, verrucous carcinoma may also be found on cutaneous surfaces. (ispub.com)
  • [ 1 ] Furthermore, because multiple cancers occur in proliferative verrucous leukoplakia-afflicted patients (ie, field-cancerization phenomenon), this suggests an infectious agent is responsible for the tumors. (medscape.com)
  • Objective: Laryngeal verrucous carcinoma (LVC) comprises 1% to 4% of all laryngeal tumors. (researchgate.net)
  • Squamous cell carcinoma (SCC) in various morphological forms needs to be separated from other epithelial tumors for treatment modality selection. (cytojournal.com)
  • Primary vaginal carcinoma is rare, constituting only 1-2% of all malignant gynecologic tumors. (medscape.com)
  • More than 9 in 10 oral cavity tumors are squamous cell carcinoma. (ucihealth.org)
  • Other much less common types of oral cancer include salivary gland tumors, including adenoid cystic carcinoma and adenocarcinoma, and lymphoma. (ucihealth.org)
Exophytic2
  • Oral submucous fibrosis with an exophytic, proliferative growth on the right buccal mucosa which proved to be squamous cell carcinoma on histopathological examination. (iarc.fr)
  • Verrucous carcinomas an exophytic, well differentiated form of oral cancer. (experts.com)
Case of verrucous3
  • A case of male patient is being presented who was diagnosed as a case of verrucous carcinoma. (ispub.com)
  • The histopathological examination of the tissue biopsied revealed it to be case of verrucous carcinoma with numerous dysplastic features. (ispub.com)
  • Waltz KM, Helm KF, Billingsley EM: The spectrum of epidermal nevi: a case of verrucous epidermal nevus contiguous with nevus sebaceus. (karger.com)
Basaloid1
  • About 75% to 100% of basaloid and warty carcinomas harbor HPV infection. (cancer.gov)
Lesions6
  • Furthermore, the cell cycle regulatory genes p16 INK4a and p14 ARF are noted to be altered in lesions of proliferative verrucous leukoplakia. (medscape.com)
  • Flow cytometric analysis of archived lesions of proliferative verrucous leukoplakia has shown evidence of aneuploid cell lines, with DNA indexes remaining constant throughout the course of disease in most cases. (medscape.com)
  • Thus, flow cytometry has been proposed as a tool to help identify lesions of proliferative verrucous leukoplakia early in the course of the disease. (medscape.com)
  • Epidermal nevi(EN)represent a heterogeneous group of mosaic skin lesions frequently following the lines of Blaschko. (karger.com)
  • Clinically, all of them showed aggressive and multifocal lesions, varying from homogenous to non homogenous aspect with verrucous surface and erythematous areas. (bvsalud.org)
  • It was suggested that PVL diagnostic criteria should include the presence of multifocal white lesions with aggressive behavior, long-term evolution, recurrences after any type of treatment, excluding the obligation of verrucous aspect on the time of diagnosis. (bvsalud.org)
Proliferative15
  • Proliferative verrucous leukoplakia (PVL) is an uncommon form of progressive multifocal leukoplakia with a high rate of malignant transformation to either squamous cell cancer or verrucous carcinoma and a high probability of recurrence. (medscape.com)
  • The etiology of proliferative verrucous leukoplakia (PVL) is unknown. (medscape.com)
  • [ 6 ] However, a role for the TP53 gene mutation or inactivation has not been found in the pathogenesis of proliferative verrucous leukoplakia. (medscape.com)
  • Proliferative verrucous leukoplakia (PVL) is an uncommon variant of oral leukoplakia, occurring in less than 1% of adults. (medscape.com)
  • No data on the worldwide incidence of proliferative verrucous leukoplakia are reported. (medscape.com)
  • Although most studies of proliferative verrucous leukoplakia have been reported from western populations in the United States, Great Britain, Spain, and Italy, cases of possible proliferative verrucous leukoplakia have been reported in people of Indian and Chinese origin living in Malaysia. (medscape.com)
  • Proliferative verrucous leukoplakia is usually seen in adults older than 40 years. (medscape.com)
  • Nearly all cases of proliferative verrucous leukoplakia (PVL) develop into malignancy. (medscape.com)
  • Patients with proliferative verrucous leukoplakia (PVL) should avoid other known factors associated with development of oral squamous cell carcinoma, such as tobacco, alcohol, and betel. (medscape.com)
  • Association between proliferative verrucous leukoplakia and infection with human papillomavirus type 16. (medscape.com)
  • Proliferative verrucous vs conventional leukoplakia: no significantly increased risk of HPV infection. (medscape.com)
  • Epstein-Barr virus in oral proliferative verrucous leukoplakia and squamous cell carcinoma: A preliminary study. (medscape.com)
  • Proliferative multifocal leukoplakia better name that proliferative verrucous leukoplakia. (medscape.com)
  • The proliferative verrucous leukoplakia (PVL) is a rare entity, with a high malignancy potential, classified as a subtype of oral leukoplakia (OL). (bvsalud.org)
  • Frequent alterations of p16INK4a and p14ARF in oral proliferative verrucous leukoplakia. (medscape.com)
Penile2
Recurrent1
  • Hassan, M , Qureshi, A & Nasir, H 2016, ' Recurrent verrucous carcinoma of the urinary bladder after transurethral resection followed by intravesical mitomycin, and a review of the literature ', BMJ Case Reports , vol. 2016, 216146. (elsevierpure.com)
Leukoplakia2
  • Ulcerated leukoplakia on left lateral border of the tongue with nodular areas that showed squamous cell carcinoma on histopathological examination. (iarc.fr)
  • Verrucous leukoplakia with malignant transformation. (iarc.fr)
Oral11
  • Patients with oral verrucous carcinoma may be at greater risk of a second oral squamous cell carcinoma, for which the prognosis is worse. (wikipedia.org)
  • Verrucous-squamous carcinomas of the oral cavity. (wikipedia.org)
  • Gene profiling analysis for patients with oral verrucous carcinoma and oral squamous cell carcinoma. (medscape.com)
  • Verrucous carcinoma of the oral cavity: A clinical and pathological study of 101 cases. (medscape.com)
  • Grinspan D, Abulafia J. Oral florid papillomatosis (verrucous carcinoma). (medscape.com)
  • Depprich RA, Handschel JG, Fritzemeier CU, Engers R, Kubler NR. Hybrid verrucous carcinoma of the oral cavity: A challenge for the clinician and the pathologist. (medscape.com)
  • With respect to the upper aero digestive tract, where the verrucous carcinoma most often arises, the oral cavity, particularly the cheek mucosa, gingivae and retromolar areas, remains the most common site of origin 4 . (ispub.com)
  • Bethel nut chewing, poor dental hygiene and Human Papilloma Virus (HPV) infection have been implicated in the development of oral verrucous carcinoma 4 . (ispub.com)
  • Squamous cell carcinoma, which means the cancer develops in the squamous cells that line the inside of the mouth or throat, is by far the most common type of oral cancer. (msdmanuals.com)
  • Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers. (cdc.gov)
  • Role of functional polymorphism of matrix metalloproteinase-2 (-1306 C/T and -168 G/T) and MMP-9 (-1562 C/T) promoter in oral submucous fibrosis and head and neck squamous cell carcinoma in an Indian population. (cdc.gov)
Biopsy1
Subtypes2
  • List of cutaneous conditions List of verrucous carcinoma subtypes Ridge JA, Glisson BS, Lango MN, Feigenberg S, Horwitz EM (2008). (wikipedia.org)
  • Vast majority of them are squamous cell carcinomas (SCC) which include conventional, verrucous, and spindle cell (sarcomatoid) subtypes. (webpathology.com)
Sebaceous carcinoma1
Human papillomavirus type 161
Buccal mucosa1
  • The most common location for verrucous carcinomas is the buccal mucosa and gingiva. (experts.com)
Recurrence1
  • Squamous cell carcinomas (SCCs) at high risk for local recurrence or metastasis are best treated with Mohs surgery. (medscape.com)
Cancers2
Nonmetastasising well differentiated1
Head and neck3
  • Verrucous carcinoma may occur in various head and neck locations, as well as in the genitalia or sole of the foot. (wikipedia.org)
  • Patel KR, Chernock RD, Zhang TR, Wang X, El-Mofty SK, Lewis JS Jr. Verrucous carcinomas of the head and neck, including those with associated squamous cell carcinoma, lack transcriptionally active high-risk human papillomavirus. (medscape.com)
  • Odar K, Kocjan BJ, Hošnjak L, Gale N, Poljak M, Zidar N. Verrucous carcinoma of the head and neck - not a human papillomavirus-related tumour? (medscape.com)
Occur1
  • It is important to monitor such cysts because they may occur in the form of carcinomas. (deepdyve.com)
19481
Genital3
  • 1 This was the genital form of verrucous carcinoma. (ispub.com)
  • The prevailing evidence favors HPV infection as a causative factor in many genital tract carcinomas. (cancer.gov)
  • Verrucous carcinoma, in which the cancer resembles a large benign genital wart. (prostate.net)
Variant3
Patient underwent1
  • Since the diagnosis changed to VC, and the resection margin was involved by the carcinoma, the patient underwent an amputation procedure at the proximal phalangeal base. (jwmr.org)
Vulvar4
Infection1
  • Rhinocladiella aquaspersa , proven agent of verrucous skin infection and a novel type of chromoblastomycosis. (cdc.gov)
Diagnosis1
  • Some authors make the diagnosis after a long-term follow-up, observing initial stages until the development of verrucous areas or carcinomas. (bvsalud.org)
Anal2
  • Anal carcinomas account for less than 5% of malignancies of large bowel . (webpathology.com)
  • A novel biomarker-based analysis reliably predicts nodal metastases in anal carcinoma: preliminary evidence of therapeutic impact. (unito.it)
Incidence1
Bladder1
Histopathology1
  • Invasive verrucous carcinoma: a temporal bone histopathology report. (medscape.com)