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  • tumor
  • Renal cell carcinoma, or RCC, develops in the lining of the kidney's tubes and grows into a mass or tumor. (novartis.com)
  • A triphasic renal CT with IV contrast ordered nine months later to confirm the angiomyolipoma revealed a fat-poor, hypovascular tumor that enhanced from 34 to 70 Hounsfield units. (empr.com)
  • This 64-year-old female patient, was referred to our clinic with an enlarging right renal tumor. (empr.com)
  • Receptors for leptin, a protein hormone, may be associated with tumor recurrence in patients with renal cell carcinoma (RCC), providing further understanding about molecular links between obesity and RCC tumor formation and prognosis, according to a study. (medworm.com)
  • Tumor suppressors help control the growth and division of cells. (wikipedia.org)
  • In BHD-associated kidney tumors, the inherited FLCN gene with a germline mutation is present in all cells, but the remaining wild type copy is inactivated in the tumor cells through somatic mutation or loss of heterozygosity. (wikipedia.org)
  • Additionally, injection of kidney tumor cells from the adenocarcinoma cell line ACHN with FLCN inactivation into immunocompromised mice resulted in the growth of significantly larger tumors, further underscoring a tumor suppressor role for FLCN. (wikipedia.org)
  • effective in curin
  • Although chemotherapy and radiation treatments are generally not effective in curing renal cell carcinoma, they may be used in conjunction with surgery or in cases where, because of generally poor health , surgery is not indicated. (britannica.com)
  • ccRCC
  • VHL loss activates the HIF-2 transcription factor, and constitutive HIF-2 activity restores tumorigenesis in VHL-reconstituted ccRCC cells. (nih.gov)
  • PT2399 dissociated HIF-2 (an obligatory heterodimer of HIF-2α-HIF-1β) in human ccRCC cells and suppressed tumorigenesis in 56% (10 out of 18) of such lines. (nih.gov)
  • subset
  • Pedram Argani, Victor E. Reuter, Lei Zhang, Yun-Shao Sung, Yi Ning, Jonathan I. Epstein, George J. Netto, and Cristina R. Antonescu: TFEB-amplified Renal Cell Carcinomas: An Aggressive Molecular Subset Demonstrating Variable Melanocytic Marker Expression and Morphologic Heterogeneity. (wikipedia.org)
  • epithelial cells
  • Amphophils are epithelial cells found in the anterior and intermediate lobes of the pituitary. (wikipedia.org)
  • Together, these epithelial cells are responsible for producing the hormones of the anterior pituitary and releasing them into the bloodstream. (wikipedia.org)
  • therapy
  • The renal cell carcinoma market is segmented according to type of therapy into the following divisions: surgery, chemotherapy, biological therapy, hormone therapy, targeted agents, and radiation therapy. (sbwire.com)
  • Vitro
  • Coimmunoprecipitation experiments with FNIP1 and FLCN expressed in HEK293 cells and in vitro binding assays have shown that the C-terminus of FLCN and amino acids 300 to 1166 of FNIP1 are required for optimal FLCN-FNIP1 binding. (wikipedia.org)
  • Urology
  • Renal & Urology News publishes timely news coverage of scientific developments of interest to nephrologists and urologists, including in-depth coverage of all relevant medical conferences. (renalandurologynews.com)
  • computed tomography
  • A renal mass of indeterminate etiology should be monitored periodically by imaging study such as intravenous pyelography (IVP), ultrasonography, or computed tomography (CT) scanning. (medscape.com)
  • morbidity
  • Treating RCC with renal ablation reduces morbidity, better preserves renal parenchymal volume (which correlates with overall renal function), reduces recovery time, and can result in shorter or no inpatient hospitalization. (prweb.com)
  • thus
  • Thus, countries with dense African population display potential for the development of renal cell carcinoma market. (sbwire.com)
  • Thus, for protein production, and therefore mTORC1 activation, cells must have adequate energy resources, nutrient availability, oxygen abundance, and proper growth factors in order for mRNA translation to begin. (wikipedia.org)