Carcinoma promote malignant cell proliferation. Medical search. Frequent questions

In addition, it is also involved in the proliferation and migration of many kinds of cells and plays a key role in the invasion and metastasis of various types of tumors. (biomedcentral.com)
It is reported that FOXC1 plays an important role in the occurrence, development, and migration of malignant tumors [ 12 ]. (hindawi.com)
Ovarian carcinoma ranks fifth in the leading causes of cancer-relevant deaths among the female, with the highest fatality rate in all gynecological malignant tumors and the rising incidence worldwide. (iospress.com)
The CTNNB1 gene mutations that cause desmoid tumors are somatic, which means they are acquired during a person's lifetime and are present only in tumor cells. (medlineplus.gov)
Excess beta-catenin promotes the uncontrolled proliferation of cells, allowing the formation of desmoid tumors. (medlineplus.gov)
HNSCC is currently one of the most common malignant tumors worldwide, with morbidity and mortality accounting for 3.6 and 3.4% of all malignant tumors in 2020, respectively ( 2 ). (frontiersin.org)
This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. (cancerindex.org)
Cell adhesion molecule-1 (CADM1) is a member of the immunoglobulin superfamily that functions as a tumor suppressor of lung tumors. (cancerindex.org)
The complex interplay between them is essential in promoting malignant phenotype, poor prognosis, and drug resistance in GI tumors (including esophageal, gastric, colorectal, liver, and pancreatic cancers). (ijbs.com)
A variety of evidence suggests that spontaneous immune responses to autologous tumor-associated antigens affect the cure of malignant tumors, and that some antibodies in sera could influence cancer cells. (okayama-u.ac.jp)
Based on the results of these studies, anti-RPL29 antibody could be a first-in-class molecular-targeted drug for the treatment of malignant tumors. (okayama-u.ac.jp)
In addition, the concentration of the anti-RPL29 antibody in sera can be a new diagnostic biomarker for the treatment of malignant tumors. (okayama-u.ac.jp)
Esophageal cancer is one of the most common malignant tumors. (spandidos-publications.com)
A leading contributing factor to metastasis and treatment resistance is the heterogeneity and plasticity of the cells within tumors 6 . (nature.com)
Abstract Ionizing radiation is frequently used to treat solid tumors, as it causes DNA damage and kill cancer cells. (techscience.com)
Neoplasms of the pancreas encompass a wide spectrum of benign and malignant tumors. (proteinlounge.com)
Pancreatic adenocarcinoma, the malignant neoplasm of the exocrine duct cells, accounts for more than ninety percent of all pancreatic tumors (Ref.1). (proteinlounge.com)
Gliomas are the most common intracranial malignant tumors in humans, and high-grade Gliomas in particular pose a unique challenge due to their propensity for proliferation and tissue invasion. (proteinlounge.com)
CONTEXT: Gastric neuroendocrine tumors are rare neoplasms that originate from gastric enterochromaffin-like (ECL) cells in the oxyntic mucosa. (tum.de)
OBJECTIVE: In this study we investigated the histopathological and molecular findings in the gastrointestinal wall of a patient with multiple endocrine neoplasia type 1 with malignant duodenal gastrinoma and multiple gastric ECL cell tumors, who additionally developed a signet-ring cell carcinoma of the stomach. (tum.de)
RESULTS: Immunohistochemical studies of gastric ECL cell tumors showed a largely diminished E-cadherin expression in comparison to gastric surface mucosa cells and a loss of E-cadherin expression in the cells of the signet-ring carcinoma. (tum.de)
The SEs consist of critical epigenetic regulatory elements, which modulate the biological characteristics of digestive system tumors including tumor cell identity and differentiation, tumorigenesis, environmental response, immune response, and chemotherapeutic resistance. (ijbs.com)
Digestive system tumors including esophageal cancer, colorectal cancer, gastric cancer, pancreatic cancer, hepatic cancer, cholangiocarcinoma, and gallbladder carcinoma are associated with significantly high mortality and morbidity rates [ 1 ]. (ijbs.com)
Hepatocellular carcinoma (HCC) one of the most common digestive system tumors, threatens the tens of thousands of people with high morbidity and mortality world widely. (biomedcentral.com)
Furthermore, we found that EphrinA2 dramatically enhanced the capability of 7404 cells to develop tumors in distant organs (Fig. 2E). (gabasignaling.com)
Oral cancer refers to malignant tumors, of which 90% are squamous cell carcinomas (OSCCs). (oulu.fi)

SCARA5 promoted cell proliferation and migration but inhibited apoptosis in ESCC. (hindawi.com)
miRNA-149 was underexpressed in gastric cancer tissues and cells, while overexpression of miRNA-149 promoted cell apoptosis, retarded cell cycle, and inhibited proliferation and migration in AGS and MKN28 cells. (hindawi.com)
The present study certified that inhibition of SNHG8 executed suppressive activities in ovarian carcinoma by obstructing cell proliferation, migration, EMT process and stemness as well as driving cell apoptosis. (iospress.com)
The Hippo pathway plays a critical role in organ size control by regulating cell growth, proliferation, and apoptosis [ 6 - 9 ]. (oncotarget.com)
Silencing RPL29 by RNA interference in cancer cells induces the cell cycle arrest at G0/G1 phase and promotes its apoptosis. (okayama-u.ac.jp)
The TP53 gene plays an important role in regulating the cell cycle, apoptosis and DNA damage repair ( 8 , 9 ). (spandidos-publications.com)
Wild-type TP53 can inhibit the cell cycle and activate apoptosis-related genes that induce apoptosis and regulate cell proliferation ( 10 ). (spandidos-publications.com)
Some lncRNAs affect the growth and development of breast cancer by regulating cell proliferation and apoptosis, and others are involved in invasion and metastasis and drug resistance of breast cancer [ 6 ]. (jcancer.org)
In addition, it can stimulate apoptosis of cells containing damaged DNA. (medscape.com)
Twenty-nine of these genes were significantly regulated in UC-in-remission subjects compared with non-IBD controls, including a large number of epithelial cell-expressed genes such as REG4, S100P, SERPINB5, SLC16A1, DEFB1, AQP3 and AQP8, which modulate epithelial cell growth, sensitivity to apoptosis and immune function. (bmj.com)
Among the genes that remain deregulated during remission, we identify several that are expressed by epithelial cells and are involved in epithelial cell proliferation, resistance to apoptosis and response to stress. (bmj.com)
They can inhibit apoptosis, activate cell proliferation , promote cellular invasion, induce chronic inflammation, and directly produce carcinogens. (igenbiolabgroup.com)
With the induction of such proteins the TGFβ signaling pathway influences cellular proliferation differentiation motility survival and apoptosis in tumor cells. (researchatlanta.org)
To disclose the underlying mechanism responsible for the tumorigenetic promotion in nude mice, we examined the influence of EphrinA2 on cell proliferation and apoptosis in vivo, respectively. (gabasignaling.com)
PL treatment successfully impaired cell cycling and proliferation, migration, and invasion, enhanced apoptosis, and modulated macrophage polarization associated with the tumoral immune-inflammatory response of tongue cancer cell lines (TSCC). (oulu.fi)

Our previous works have demonstrated that 8-bromo-7-methoxychrysin suppressed stemness of human hepatocellular carcinoma (HCC) cell line SMMC-7721 induced by condition medium from hepatic stellate cell line LX-2 that was activated by liver cancer stem-like cells (LCSCs). (biomedcentral.com)
We have previously demonstrated that hepatocellular carcinoma (HCC) stemness was induced by condition mediumfrom hepatic stellate cellline LX-2(HSC-CM) that was activated by liver cancer stem-like cells (LCSLCs) derived from SMMC-7721 cell line (SMMC-7721-derived LCSLCs) [ 5 ]. (biomedcentral.com)
Anti-RPL29 antibody also showed the suppressive effects on the proliferation of other cancer cells such as lung adenocarcinoma, breast cancer, and hepatocellular carcinoma. (okayama-u.ac.jp)
Recent studies demonstrated that high serum levels of soluble ST2 (sST2) are a worse prognostic factor in hepatocellular carcinoma ( 9 ), and that serum IL-33 is a diagnostic and prognostic marker in non-small cell lung cancer, independent of the therapeutic intervention ( 10 ). (frontiersin.org)
TGFβ signaling is present in most malignancies (11-14) such as hepatocellular carcinoma (15) pancreatic malignancy (16) and myelodysplastic syndromes (17). (researchatlanta.org)
For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)

Of the 31 genes, the 21 upregulated genes were primarily associated with cell paracrine and intracellular signaling, transcription regulation and cell adhesion and migration, and their transcriptional products included transforming growth factor-β2 (TGF-β2), insulin-like growth factor-binding protein 2 and transcriptional factor AP-2α/γ ( 11 ). (spandidos-publications.com)
Hepatocyte growth factor (HGF) is a polypeptide growth factor that acts on the growth, migration and morphogenesis of many cell types. (biomedcentral.com)
It possesses a unique forkhead domain combined with a fragment of the target gene to initiate transcription [ 10 ] and regulates various biological processes such as tumor cell differentiation, cell proliferation, and migration [ 11 ]. (hindawi.com)
Metastatic recurrence is a leading cause of cancer-associated death, and cancer cell migration is the initial step among the metastatic process. (aging-us.com)
The migration of these cells also increased as demonstrated by wound healing and transwell assays. (jcancer.org)
In contrast, silencing of UASR1 suppressed cell proliferation and migration. (jcancer.org)
Then the survival cells were collected to investigate their potential of colony formation, attachment, invasion, and migration. (scielo.br)
Furthermore, lactate production induced by PKM2 significantly promotes migration and invasion. (researchsquare.com)
Conclusively, ApoE over-expression promotes cancer proliferation and migration and contributes to an aggressive clinical course in patients with lung adenocarcinoma and MPE. (ncku.edu.tw)
On the other hand, if germ cells are forced to remain attached to the seminiferous epithelium for a period of time longer than necessary to complete their development, they will degenerate and eventually be phagocytosed by Sertoli cells and for this, proper regulation of germ cell migration in the seminiferous epithelium and at blood-testes barrier (abbreviated as BTB) is essential (Ref.1). (proteinlounge.com)
and potent inhibition of NHK proliferation and migration by two Src family kinase inhibitors PP1 and PD173952. (aspetjournals.org)
The ErbB inhibitor PD158780 and the mitogen-activated protein kinase kinase inhibitor U0126 also markedly inhibited NHK proliferation, migration, and amphiregulin production. (aspetjournals.org)
Gastrin and its derivates have been reported to regulate epithelial cell proliferation, migration, and differentiation. (tum.de)

CAFs provide cancer cells with nutrition and promote the proliferation, invasion and metastasis of cells ( 6 - 9 ). (spandidos-publications.com)
The anti-cancer impact of propofol on cervical cancer cells growth in vivo was determined by means of xenograft tumor model and lung metastasis model. (aging-us.com)
Prior studies have suggested that propofol (2, 6-diisopropylphenol), one of the most extensively used intravenous anesthetic agents during cancer surgical excision, influences the biological behaviors of cancer cell, including growth, invasiveness, and metastasis [ 10 , 11 ]. (aging-us.com)
In colorectal cancer, propofol inhibits cancer cells proliferation and metastasis by regulating miR-124-3p.1/AKT3 [ 13 ]. (aging-us.com)
Then, can it repress the cancer cells' metastasis potential? (scielo.br)
Thus, we conclude that As2O3 can reduce metastasis potential of NPC cells, involving inhibition of MMP-9 expression. (scielo.br)
Silencing PKM2 markedly inhibits proliferation and metastasis capacity in vivo and in vitro , and vice versa. (researchsquare.com)
For carcinoma, rapid proliferation, distant metastasis and immune escape rely heavily on energy metabolism. (researchsquare.com)
In studies on mouse mammary carcinoma, the IL-33/ST2 pathway promotes BC progression and metastasis through increased intratumoral accumulation of immunosuppressive cells and by diminishing innate anti-tumor immunity ( 11 ). (frontiersin.org)
reported that transgenic expression of IL-33 may activate CD8(+) T cells and NK cells, and inhibit tumor growth and metastasis in B16 melanoma and Lewis lung carcinoma metastatic models ( 12 ). (frontiersin.org)
Emerging roles ofthe tumor-associated stroma in promoting tumor metastasis.Cell Adh Migr. (edu.pl)

Finally, CAFs promote cancer progression and act in cancer cell drug resistance. (spandidos-publications.com)
LncRNA AGPG has been shown to play a role in esophageal cancer by binding to and stabilizing PFKB3, which increases glycolytic flux and cell cycle progression in esophageal cancer cells. (ijbs.com)
However, whether PKM2 can promote head and neck squamous cell carcinoma (HNSCC) progression and immunosuppression remains unknown. (researchsquare.com)
Our findings demonstrate that PKM2 promotes tumor progression and galectin-9-mediated immunosuppression via NF-κB signaling inhibition in HNSCC, which bridges metabolism and immunosuppression. (researchsquare.com)
However, how metabolism reprogramming promotes tumor progression and immune escape remains unclear. (researchsquare.com)
However, how PKM2 promotes tumor progression and its mechanism remain obscure. (researchsquare.com)
Purpose TGFβ signaling takes on a key part in tumor progression including malignant glioma. (researchatlanta.org)
It is unclear which core events drive the malignant progression of gliomas. (biomedcentral.com)
Transgelin can inhibit the malignant progression of ESCC by inhibiting the occurrence of EMT. (figshare.com)
Taken together, these results suggested that EphrinA2 could promote initiation or progression of HCC. (gabasignaling.com)
Our results suggest that the orchestrated response of macrophages and stromal elements to neoplastic cells enhances tumor progression through the release of soluble factors. (edu.pl)
We aimed to determine the antitumor effect of PL by treating OSCC cell lines with PL metabolites and evaluating its action during OSCC progression in vivo . (oulu.fi)
PL restrained OSCC progression in vivo by inhibiting tumor volume growth and decreasing the number of severe dysplasia lesions and squamous cell carcinomas. (oulu.fi)
In addition, 14 of the patients were the normal mammary gland and are also important in the development premenopausal (5 ER and 9 ER ) and 33 were postmenopausal (18 ER and progression of breast carcinoma. (lu.se)
The RET kinase inhibitor selpercatinib (Retevmo) more than doubled progression-free survival (PFS) compared with standard chemotherapy with or without pembrolizumab (Keytruda) in the first-line setting among patients with RET fusion advanced/metastatic non-small cell lung cancer (NSCLC). (medscape.com)
opment and progression including a The specimens were collected dur- Positive cells were counted in 10 possible viral etiology (5) . (who.int)

The effects of these target genes on ESCC malignant biological behavior were performed in vivo and in vitro . (hindawi.com)
CAFs maintain their phenotype for numerous passages during culture in vitro without exposure to cancer cells, while NFs cannot be infinitely proliferous like cancer cells ( 10 ). (spandidos-publications.com)
In vitro , propofol inhibited the growth and colony-formation of cervical carcinoma cells. (aging-us.com)
The migratory and invasive phenotypes of CRC cells were evaluated by in vitro transwell assays and in vivo metastatic models. (thno.org)
The effects of Pg and PDCD4 on CSCs, chemoresistance and malignancy of ESCC cells were evaluated by in vitro studies. (figshare.com)
LMP1-negative cell line HNE1 and LMP1-positive cell line HNE1-LMP1 were used as in vitro model. (scielo.br)
No significant difference was observed in in vitro proliferation between the control cells and www.selleckchem.com/products/VX-809.html check details 7404/EphrinA2 cells (Supporting Fig. 2A, 2B). (gabasignaling.com)
No significant difference was observed in in vitro proliferation between the control cells and Rucaparib nmr selleck chemical 7404/EphrinA2 cells (Supporting Fig. 2A, 2B). (gabasignaling.com)
In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)
Combined with in-vitro proliferation assays using CRISPR-Cas9/RNAi and patient survival analysis, MEK inhibitors PD19830 and BRD-K12244279, pilocarpine, and tremorine were discovered as potential new drug options for treating breast cancer. (cdc.gov)

A growing body of evidence has identified that epithelial-mesenchymal transition (EMT) plays pivotal parts in cancer cell metastatic dissemination via endowing them with a more migrate and invasive trait [ 4 ]. (aging-us.com)
Ackerman used the term verrucous carcinoma to denote the concept of a locally aggressive exophytic low-grade squamous cell carcinoma with little metastatic potential. (medscape.com)

The Wnt signaling pathway promotes the growth and division (proliferation) of cells and helps determine the specialized functions a cell will have (differentiation). (medlineplus.gov)
These genes increase the proliferation and differentiation of cells associated with the hair follicle matrix. (medlineplus.gov)
This research aims at characterizing molecules and signals involved in controlling the undifferentiated state and self-renewal capacity of stem cells, and to develop methods to direct the differentiation of stem cells into clinically relevant cell types. (ki.se)
Basic genetic and molecular biology methodologies are combined with complementary bioinformatic and genome-wide approaches, allowing investigation global molecular changes in cells in various differentiation processes. (ki.se)

SCARA5 expression is significantly downregulated in various tumor tissues including liver cancer (LC), rectal cancer, and glioblastoma [ 15 , 16 ] and might affect cell proliferation and invasion abilities by the focal adhesion kinase (FAK) signaling pathway and epithelial-mesenchymal transition (EMT) [ 5 , 17 - 20 ]. (hindawi.com)
Finally, we corroborated that CTNNB1 (or Axin1) ectopic expression or activation of Wnt/β-catenin pathway abrogated the effects of SNHG8 downregulation on the cellular process of ovarian carcinoma cells. (iospress.com)
To summarize, SNHG8 acted as an oncogene in ovarian carcinoma via targeting Wnt/β-catenin pathway, providing a new insight into understanding ovarian carcinoma at the molecular level. (iospress.com)
The beta-catenin protein is also involved in cell signaling as an essential part of the Wnt signaling pathway. (medlineplus.gov)
Certain proteins in this pathway attach (bind) to beta-catenin, which triggers a multistep process that allows the protein to move into the cell nucleus. (medlineplus.gov)
In adult tissues, this pathway plays a role in the maintenance and renewal of stem cells, which are cells that help repair tissue damage and can give rise to other types of cells. (medlineplus.gov)
Downregulation of Herg1 suppresses osteosarcoma proliferation and invasion by targeting Hippo signaling pathway]. (cancerindex.org)
Dr. Yasuhiro Miyake (Assistant Professor of Okayama University Hospital) with his colleagues have found the presence of anti-60S ribosomal protein L29 (RPL29) antibody in sera, and showed that the anti- recRPL29-peptides polyclonal antibody inhibited the proliferation of human pancreatic cancer Panc-1 cells via the down-regulation of Wnt/β-Catenin signaling pathway in a dose dependent manner. (okayama-u.ac.jp)
Further studies showed that UASR1 activated AKT and AKT-mediated mTOR signaling pathway to stimulate cell proliferation and growth. (jcancer.org)
Taken together, our data suggest that UASR1 plays an oncogenic role in breast cancer cells through activation of the AKT/mTOR signaling pathway, being a novel RNA oncogene. (jcancer.org)
It specifically negatively regulates the PI3K-AKT signaling pathway to induce cell cycle arrest. (medscape.com)
Inhibiting PARP-1 is lethal in a wide range of cancer cells that lack the homologous recombination repair (HR) pathway. (techscience.com)
IL-33 induces T cells to produce IL-4, IL-5, and IL-13, and potently induces pro-inflammatory cytokines and chemokines through a Th2-dependent pathway, and also promotes Th1-type responses ( 5 ). (frontiersin.org)

However, whether and whereby BrMC inhibits the stemness induced by co-culture of LCSCs and LX-2 cells remains to be investigated. (biomedcentral.com)

Consistently, the results from in vivo xenograft model indicated that propofol repressed cervical cancer cells growth and decreased the expression of MIR155HG in vivo . (aging-us.com)
Ex vivo drug screening refers to the out-of-body assessment of drug efficacy in patient derived vital tumor cells. (biomedcentral.com)
However, 7404/EphrinA2 cells generated larger xenografts in nude mice than control cells (Fig. 2B, left panel), indicating that EphrinA2 stimulated in vivo tumor growth. (gabasignaling.com)

To construct a prognostic signature composed of DNA repair genes to effectively predict the prognosis of patients with head and neck squamous cell carcinoma (HNSCC). (frontiersin.org)
The aim of the present study was to investigate the association between tumor protein 53 (TP53) gene deletion and protein expression and clinical features in esophageal squamous cell carcinoma (ESCC), and to evaluate the predictive value of these two characteristics in the prognosis of ESCC. (spandidos-publications.com)

Head and neck squamous cell carcinoma (HNSCC) is a type of tumor that originates from the squamous epithelium of the head and neck areas, including the mucous membranes of the lips, tongue, pharynx, larynx, and others ( 1 ). (frontiersin.org)

This article investigates the role of Transgelin (TAGLN) in the epithelial-mesenchymal transition (EMT) of esophageal squamous cell carcinomas (ESCC) and its possible mechanism of inhibiting the invasion of these cancers. (figshare.com)

We further explored the cancer-promoting mechanism of target genes in ESCC by sequencing of the genes' exons. (hindawi.com)
Therefore, it is important to explore candidate genes that could have significance to the clinical diagnosis, as well as the treatment of esophageal squamous cell carcinoma (ESCC) at the molecular level [ 4 ]. (hindawi.com)
Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
Given the strong link between the regulation of some of these genes and the growth and dissemination of gastrointestinal cancers, we believe their aberrant expression in UC may provide a mechanism for epithelial hyper-proliferation and, in the context of malignant transformation, for tumour growth. (bmj.com)
The multistep transformation of normal cells into malignant cells involves genetic and epigenetic alterations that promote the aberrant expression of critical oncogenes and tumor suppressor genes [ 1 , 2 ]. (ijbs.com)
In the post-genomic era, the cancer research is focused on the dysregulation of transcriptional dysregulation mediated by epigenetic modifications in the enhancer, SE, and gene promoter regions of key tumor suppressor and tumor-promoting genes [ 5 , 6 ]. (ijbs.com)
0.05) cell proliferation-associated genes was found in dysplastic lesions and TSCCs of PL-treated mice. (oulu.fi)
The total chromosomal content of a cell involves approximately 105 genes in a specialized macromolecule of deoxyribonucleic acid (DNA). (cdc.gov)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)

In cancer tissues, expression of IL-33 was higher than matched normal breast tissues from the same patients, and was also associated with a well-differentiated phenotype, HER2 overexpression, more lymph nodes involvement, and a family history of malignant carcinoma. (frontiersin.org)
In this study, we show that human glioblastoma cells secrete soluble factors that alter the phenotype and cytokine secretion profile of both macrophages and mesenchymal stem cells (MSCs). (edu.pl)

Thrombospondin type 1 domain-containing 7A ( THSD7A ) was reported to play a procancer role in esophageal squamous cell carcinoma (ESCC). (hindawi.com)
Studies have confirmed that the colonization of Porphyromonas gingivalis (Pg) could promote the malignant evolution of esophageal squamous cell carcinoma (ESCC). (figshare.com)
Since pathogenic microorganisms can promote malignant tumor proliferation by inhibiting programmed cell death factor 4 (PDCD4) and the decrease of PDCD4 activity can enhance the stemness of cancer cells, we here investigated the functional mechanism by which Pg promoted ESCC chemoresistance and malignancy through inhibiting PDCD4 and enriching cancer stem cells (CSCs). (figshare.com)
The results showed that Pg could inhibit PDCD4 expression and lead to CSCs enrichment in ESCC cells. (figshare.com)

It is widely recognized that the accumulation of various harmful genetic alterations in normal cells may induce malignant cancer cells ( 1 ). (spandidos-publications.com)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. (cancerindex.org)
PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)

Like pilomatricomas, pilomatrix carcinomas have somatic mutations in the CTNNB1 gene. (medlineplus.gov)
These mutations are somatic and occur only in kidney cells that give rise to the tumor. (medlineplus.gov)
Mutations in TP53 can lead to the loss of these functions, inducing uncontrolled cell growth and the promotion of tumor development ( 11 , 12 ). (spandidos-publications.com)
Genetic drivers are mutations or fusions that confer a survival advantage to "drive" malignant proliferation. (medscape.com)
Passenger mutations are additional mutations found in the cancers that do not contribute to cancer proliferation. (medscape.com)
The recognition of antigens by immune cells is a crucial step in tumor-specific killing, and neoantigens generated by mutations in cancer cells possess high immunogenicity and are selectively expressed in tumor cells, making them an attractive therapeutic target. (techscience.com)
Genomic instability creates a permissive state in which a potential cancer cell is allowed to acquire enough mutations to become a cancer cell. (proteinlounge.com)
Mutations in the epithelial cadherin (E-cadherin) gene have been shown to be associated with the occurrence of diffuse gastric carcinomas in affected families. (tum.de)

After overexpression of Transgelin, the invasion and proliferation abilities of Eca-109 and KYSE-150 cells were significantly decreased compared with those of the control group (P (figshare.com)

Our results indicated the presence of a 14-3-3ζ-YAP negative regulatory feedback loop, which has a crucial role in cell proliferation and survival and is a potential target for the clinical treatment of GC. (oncotarget.com)
c-Src potentiates proliferation, survival, and invasiveness in response to epidermal growth factor (EGF) in human mammary carcinoma cells. (aspetjournals.org)
HO-1 in Cancer Cell Survival" Encyclopedia , https://encyclopedia.pub/entry/14608 (accessed December 06, 2023). (encyclopedia.pub)

Since the advent of highly active antiretroviral therapy (HAART), the incidence of non-AIDS-defining cutaneous cancers-in particular, basal cell carcinoma-among HIV-infected persons has exceeded that of AIDS-defining cutaneous cancers such as KS. (medscape.com)
See also Verrucous Carcinoma , Proliferative Verrucous Leukoplakia , Cancers of the Oral Mucosa , and Smokeless Tobacco Lesions . (medscape.com)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
Almost all bladder cancers originate in the urothelium, which is a 3- to 7-cell mucosal layer within the muscular bladder. (medscape.com)

At a fundamental level, cancer is caused by an accumulation of genetic changes that result in unregulated cell growth and proliferation. (medscape.com)

qRT-PCR was used to detect the expression of miRNA-149 and FOXC1 in gastric cancer tissues and cells. (hindawi.com)
This protein is present in many types of cells and tissues, where it is primarily found at junctions that connect neighboring cells (adherens junctions). (medlineplus.gov)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Key areas of investigation are the identification and functional characterization of stem cell niches in developing tissues and adult organs. (ki.se)
In this study, we aim to determine the serum level and to detect the expression of IL-33 in human tissues in patients with breast carcinoma, using Luminex-based measurements and immunohistochemistry, to further explore the role of IL-33 in anti-tumor immunity in BC. (frontiersin.org)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
A further 20 blocks from The ISH results were given percentage vanced stages with a likely prevalence samples from normal breast tissues scores based on positive signals and of more aggressive tumour forms were labelled as a control group (i.e. number of cells that gave these signals. (who.int)
Cells Tissues Organs. (cancercentrum.se)

Their loss of function is a well described mechanism of malignant proliferation. (medscape.com)
Although several lines of evidence also suggest important interactions of ErbB and Src family kinase signaling in normal epithelial cells, little is known about the mechanism of this interaction. (aspetjournals.org)

Du X , Wang X , Zheng Y , Liu D , . Propofol suppresses the growth and invasion of cervical carcinoma cells by inhibiting MIR155HG. (aging-us.com)
Studies have revealed that 14-3-3ζ promotes cytoplasmic retention and suppresses the transcriptional activity of YAP by inducing its phosphorylation. (oncotarget.com)

Furthermore, reintroduction of MIR155HG into cervical cancer cells counteracted the inhibitory potency of propofol on the growth and aggressive phenotypes in cervical carcinoma cells. (aging-us.com)

Approximately 1%-2% of all NSCLC cases carry a RET fusion that stimulates oncogenic activity and promotes unchecked cellular proliferation. (medscape.com)

We also analyzed the tumor-infiltrating immune cells, immune-related gene expression, tumor mutation burden, and drug sensitivity of patients with HNSCC in the high- and low-risk groups. (frontiersin.org)
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
This gene encodes a nuclear protein which is involved in cell-cycle regulation. (nih.gov)
The key interests lie within the field of genome integrity and variation, cell division, regulation of gene expression, protein turnover and signal transduction. (ki.se)
Generate cell lines with stable, heritable gene silencing to develop a throrough understand of the target gene's function. (systembio.com)
A set of 26-gene mRNA expression profiles were used to identify invasive ductal carcinomas from histologically normal tissue and benign lesions and to select those with a higher potential for future cancer development (ADHC) in the breast associated with atypical ductal hyperplasia (ADH). (cdc.gov)

One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)

A mechanistic study indicated that HIF-2α might regulate the binding of twist1 to vascular endothelial cadherin (VE-cadherin) to promote VM formation in pancreatic cancer cells, and that the P1 (-421bp) and P4 (-2110bp) regions of the Twist1 binding sequences are positive regulatory elements for VE-cadherin. (oncotarget.com)
The targeted Transgelin siRNA and Transgelin-overexpressing plasmid can effectively regulate the expression of Transgelin mRNA and protein in Eca-109 and KYSE-150 cells. (figshare.com)

Almost all pilomatricomas are benign, but a very small percentage are cancerous (malignant). (medlineplus.gov)
This study in Iraq used in situ hybridization to detect the frequency and genotyping of HPV in tissue specimens from 129 patients diagnosed with malignant breast cancer, 24 with benign breast tumours and 20 healthy controls. (who.int)
Iraq have demonstrated that most patients with benign epithelial mam- 100 lens for counting the positive cells. (who.int)
This study sought to identify biomarkers for selecting patients with a high potential for developing invasive carcinoma in the breast with normal histology, benign lesions, or premalignant lesions. (cdc.gov)

These microbiota changes can already be seen with potentially malignant lesions of the oral cavity. (igenbiolabgroup.com)
Oral, laryngeal, pharyngeal, and esophageal lesions of this type are generally known as a verrucous carcinoma or an Ackerman tumor. (medscape.com)

The stemness of SMMC-7721 cells was evaluated by sphere formation assay and western blot analysis for expression levels of cancer stem cell markers (CD133 and CD44).The expression levels of cancer-associated fibroblast markers (FAP-α and α-SMA) were employed to evaluate pathologic activation of LX-2 cells. (biomedcentral.com)
Moreover, addition of IL-6 and/or HGF induced stemness of SMMC-7721 cells and activation of LX-2 cells, conversely, deletion of IL-6 and/or HGF suppressed those. (biomedcentral.com)
Furthermore, the inhibitory effects of BrMC and chrysin on stemness of SMMC-7721 cells and activation of LX-2 cells were attenuated by addition of IL-6 or HGF, and enhanced by deletion of IL-6 or HGF. (biomedcentral.com)
However, whether and whereby co-culture of LCSLCs and HSCs induces the stemness of HCC cells remains unclear. (biomedcentral.com)
however, restoration of CBY1 expression in tumor cells reduces BCSC and its enrichment, thus lnc408 plays an essential role in maintenance of BCSC stemness. (nature.com)
In MLL leukemia, LAMP5-AS1 facilitates the methyltransferase activity of DOT1L to drive leukemia cell stemness 18 . (nature.com)

The invasion of neoplastic cells into healthy brain tissue is a pathologic hallmark of Gliomas and contributes to the failure of current therapeutic modalities (surgery, radiation and chemotherapy). (proteinlounge.com)
Immunohistological studyof mononuclear cell infiltrate in malignant gliomas. (edu.pl)

Several studies have proven the carcinogenic role of SNHG8 in various malignancies, but the physiological functions of SNHG8 in ovarian carcinoma need more detailed explanations. (iospress.com)

Human gastric cancer cell lines AGS and MKN28 were cultured and transfected with miR-149 overexpression plasmid and its control or FOXC1 siRNA and its control. (hindawi.com)
Lactate production and the expression of galectin-9, a critical immunosuppression molecule, were detected after PKM2 knockdown and overexpression in HNSCC cells. (researchsquare.com)
In addition, we confirmed that the overexpression of HIF-2α increased Twist1 expression and promoted tumor growth and VM formation in pancreatic cancer xenografts in nude mice. (oncotarget.com)
The effects of Transgelin overexpression and knockdown on the proliferation of Eca-109 and KYSE-150 cells were examined by Transwell chamber, scratch assay, and CCK-8 cell activity assay. (figshare.com)

For example, propofol restrains pancreatic cancer cells growth and metastases via elevating miR-328 and depressing ADAM Metallopeptidase Domain 8 (ADAM8) [ 12 ]. (aging-us.com)
Nasopharyngeal carcinoma (NPC) is notorious for the metastases, which are in close association with Epstein-Barr virus-encoded latent membrane protein 1 (LMP1). (scielo.br)
Verrucous carcinoma of both the skin and the mucosa is an uncommon low-grade squamous cell carcinoma that is clinically evident as a slowly but relentlessly enlarging warty tumor, histologically characterized by local invasion with minimal dysplasia, if any, and biologically characterized by a low incidence of metastases. (medscape.com)

Growing evidence indicates that 14-3-3ζ and yes-associated protein (YAP) substantially promote tumorigenesis and tumor development. (oncotarget.com)
Colorectal cancer represents a relatively well-characterized tumorigenesis paradigm and colorectal carcinoma is one of the leading causes of cancer-related death. (proteinlounge.com)

however, whether HIF-2α promotes VM formation in pancreatic cancer remains unknown. (oncotarget.com)

HNSCC is highly malignant, and there are no specific prognostic-related biomarkers for clinical application. (frontiersin.org)
Although extensive knowledge has been obtained regarding biomarkers and the therapeutic targets that affect cancer cell properties, few studies have investigated the role of mutual regulation among these proteins in GC or their underlying mechanisms. (oncotarget.com)
Multi-omics biomarkers of response to the discovered drugs were identified using human breast cancer cell lines. (cdc.gov)

Knockdown of CAPRIN1 promoted the mRNA degradation of CTNNB1 and Axin1. (iospress.com)
More importantly, the EphrinA2 targeting siRNA can also knockdown the endogenous EphrinA2 in both 7402 and HepG2 cells, which expressed a relative high level of EphrinA2 (Fig. 2C), and the down-regulation of EphrinA2 strongly inhibited the tumor growth of 7402 cells in nude mice (Fig. 2D). (gabasignaling.com)

Ectopic expression of UASR1 promoted proliferation and clonogenic growth of breast cancer cells MCF7 and MDA-MB-231. (jcancer.org)

Deletion of IL-33/ST2 function enhances cytotoxicity of NK cells and increases levels of TNF-α, IFN-γ, and IL-17, and systemic pro-inflammatory cytokines, leading to attenuated tumor growth ( 8 ). (frontiersin.org)

In this study, we investigated the inhibitory effects of miR-149 on the biological functions of gastric cancer cells by targeting FOXC1. (hindawi.com)
The human gastric epithelial permanent cell line (GES-1), human gastric cancer cell lines (AGS, BGC-823, MKN45, and SGC-7901), and HEK293 cells were provided by the Biomedical Experiment Center of Xi'an Jiaotong University. (hindawi.com)
Herein, we tried to address the potential anti-cancer effects of propofol in cervical carcinoma. (aging-us.com)
Materials and Methods: The suppression effects of propofol on the proliferation and invasion of cervical cancer cells were analyzed by Cell Counting Kit-8 (CCK-8), colony formation and Transwell invasion assay. (aging-us.com)
Propofol treatment decreased the expression of MIR155HG in cervical cancer cells. (aging-us.com)
Conclusions: Altogether, these results indicated that propofol restrained the growth and invasion of cervical cancer cells partly via regulating MIR155HG expression. (aging-us.com)
For example, in liver cancer, circMDK upregulates ATG16L1 by inhibiting miR-346 and miR-874-3p, which promotes the occurrence and development of liver cancer [ 11 ]. (ijbs.com)
RPL29 is one of approximately 80 structural ribosomal proteins, and is highly expressed on the surface of a cancer cell. (okayama-u.ac.jp)
Gastric cancer (GC) has a high mortality rate and is one of the most fatal malignant tumours. (biomedcentral.com)
Tumor initiation, development, and relapse may be closely associated with cancer stem cells (CSCs). (nature.com)
CMB is comprised of more than 30 independent research groups organized in three themes: Cell Biology, Developmental and Stem Cell Biology and Infection and Cancer. (ki.se)
Through detailed characterization of fundamental molecular mechanisms of normal and perturbed cells, the theme strives to unravel information that increases the understanding of various diseases such as cancer and neurodegenerative, cardiovascular and inflammatory disorders. (ki.se)
The growing list of human syndromes associated with the immunophilin defect underscores the biological relevance of these proteins that are largely opportunistically exploited by cancer cells to support and enable the tumor's intrinsic properties. (techscience.com)
2023) Lnc-17Rik promotes the immunosuppressive function of Myeloid-Derived suppressive cells in esophageal cancer. (systembio.com)
Many human lung cancer cell lines express apolipoprotein E (ApoE), especially cells derived from malignant pleural effusions (MPE) in patients with lung adenocarcinoma. (ncku.edu.tw)
In the microenvironment TGFβ signaling affects several cell types such as immune cells (5) cancer-initiating cells (6 7 endothelial cells (8) and fibroblasts (9). (researchatlanta.org)
arations verified the presence of cancer cells in all samples. (lu.se)
L'étude menée en Iraq a utilisé la méthode d'hybridation in situ pour déterminer la fréquence du papillomavirus humain et pour son génotypage dans les échantillons de tissus prélevés auprès de 129 patientes ayant reçu un diagnostic de cancer du sein malin, de 24 patientes porteuses d'une tumeur du sein bénigne et de 20 femmes témoins en bonne santé. (who.int)
The treatment of non-muscle-invasive bladder cancer (Ta, T1, carcinoma in situ [CIS]) begins with transurethral resection of bladder tumor (TURBT). (medscape.com)

Breast carcinoma is the common- noma not otherwise specified, 17 cases sues (according to the specification of est malignancy among women in of lobular carcinoma, 5 cases of mixed the second differential kit which gave developed and developing countries ductal and lobular carcinoma and 7 the blue colour). (who.int)

The relative proportions of 22 types of infiltrating immune cells in each male GC sample were evaluated using CIBERSORT. (biomedcentral.com)
Besides, the results of tumour-infiltrating immune cell analysis indicated that the seven-IRGs signature could reflect the status of the tumour immune microenvironment. (biomedcentral.com)
Murine breast carcinoma models suggest disruption of ST2 signaling may enhance the anti-tumor immune response, suggesting IL-33 impedes anti-tumor immunity. (frontiersin.org)

Abstract Glioblastoma (GBM) is the most malignant form of glioma and is difficult to diagnose, leading to high mortality rates. (techscience.com)

Global burden of HPV-attributable squamous cell carcinoma of the anus in 2020, according to sex and HIV status: A worldwide analysis. (who.int)

We aim to study the coupling between LTCC and β adrenergic receptors in different cardiomyocyte microdomains, the distinct involvement of PKA and CAMKII (Ca2+/calmodulin-dependent protein kinase II) and explore how this functional complex is disrupted in heart failure.Methods:Global signaling between LTCCs and β adrenergic receptors was assessed with whole-cell current recordings and western blot analysis. (imperial.ac.uk)
This protein is active in cells that make up a part of the hair follicle known as the matrix. (medlineplus.gov)
As a result, the protein accumulates within cells. (medlineplus.gov)
This active beta-catenin protein promotes Wnt signaling longer than normal, which leads to the unchecked proliferation of kidney cells and tumor development. (medlineplus.gov)
The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. (cancerindex.org)
The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. (nih.gov)
Similarly, TP53 mutation does not always lead to the accumulation of p53 protein in cells. (spandidos-publications.com)
Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. (thermofisher.com)

We suggest that Wilms' tumor is more than nephroblastoma and propose a definition that Wilms tumor is a malignant embryonal neoplasm derived from pluripotential cells of nephrogenic blastema and of ureteric bud tip. (bvsalud.org)

Enhancement of head andneck squamous cell carcinoma proliferation, invasion, andmetastasis by tumor-associated fibroblasts in preclinicalmodels. (edu.pl)

Anatomy26

Organisms8

Diseases64

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Phenomena and Processes46

Disciplines and Occupations1

Information Science4

Health Care4

Tumors26

Apoptosis15

Hepatocellular6

Migration13

Metastasis11

Progression16

Vitro10

Metastatic2

Differentiation4

Pathway13

Inhibits1

Vivo3

Prognosis2

Neck squamous cell carc1

Squamous cell carcinomas1

Genes9

Phenotype2

ESCC4

Induce2

Functions as a tumor suppressor2

Mutations8

Invasion and proliferation1

Survival3

Cancers4

Growth and proliferation1

Tissues8

Mechanism2

Suppresses2

Phenotypes1

Cellular proliferation1

Gene6

Oncogenic1

Regulate2

Benign4

Lesions2

Stemness6

Gliomas2

Malignancies1

Overexpression4

Metastases3

Tumorigenesis2

Pancreatic cancer1

Biomarkers3

Knockdown2

Breast cancer1

Tumor growth1

Cancer19

Malignancy1

Immune3

Abstract1

20201

Protein8

Neoplasm1

Fibroblasts1