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  • PDAC
  • We then investigated the expression profile of these apoptosis-associated genes in microdissected tissue from 14 normal pancreatic ducts and 19 samples of PDAC using a virtual subarray from a whole genome analysis. (aacrjournals.org)
  • Modelling of different genetic events in mice suggests both ductal and acinar cells can give rise to PDAC. (rare-cancer.org)
  • DESIGN: We examined the contribution of cellular origin to PDAC development by inducing PDAC-associated mutations, KrasG12D expression and Trp53 loss, specifically in ductal cells (Sox9CreER;KrasLSL-G12D;Trp53flox/flox ('Duct:KPcKO ')) or acinar cells (Ptf1aCreER;KrasLSL-G12D;Trp53flox/flox ('Acinar:KPcKO ')) in mice. (rare-cancer.org)
  • Cells
  • Large cell carcinoma Composed of large, monotonous rounded or overtly polygonal-shaped cells with abundant cytoplasm. (wikipedia.org)
  • Small cell carcinoma Cells are usually round and are less than approximately 3 times the diameter of a resting lymphocyte and little evident cytoplasm. (wikipedia.org)
  • The study found that 228 miRNAs were expressed differently relative to normal pancreatic cells. (wikipedia.org)
  • body
  • The pancreatic duct is generally regarded as abnormally enlarged if being over 3 mm in the head and 2 mm in the body or tail. (wikipedia.org)