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  • apoptosis
  • Green Tea induces apoptosis in drug-resistant small-cell lung carcinoma. (greenmedinfo.com)
  • DLC-1 tumor supressor gene induces apoptosis in human non-small cell lung carcinoma cells following a unique process of cell morphological changes and protein nuclear translocation. (cdc.gov)
  • New studies revealed that DLC-1 transfection can initially induce multiple branched cytoplasmic extensions, which are followed by membrane blebbing along the cytoplasmic extensions and progressive cell shrinkage, and ended with cytoplasmic and nuclear decomposition, the morphological evidence of cell apoptosis. (cdc.gov)
  • The process of morphological change is associated with RhoGAP-domain-related reduction of stress fibers and filopodia early in gene transfection and with collapsing of the actin cytoskeleton at the time of cell apoptosis. (cdc.gov)
  • DLC-1's ability to induce tumor cell apoptosis is supported by the induction of caspase 3 activation in DLC-1-transfected cells following the morphological changes. (cdc.gov)
  • However, the induction of cell apoptosis is more dependent on DLC-1 protein nuclear translocation, which could be retarded by active RhoA signaling. (cdc.gov)
  • sarcoma
  • The golden hamster can contract contagious reticulum cell sarcoma which can be transmitted from one golden hamster to another by means of the bite of the mosquito Aedes aegypti. (wikipedia.org)
  • genes
  • No somatic mutations were detected in the mutation cluster regions of the KRAS, EGFR, BRAF and PIK3CA genes and the entire coding region of p53 in the carcinoma, and the expression of ALK fusion was negative. (spandidos-publications.com)
  • Erlotinib
  • The binding of erlotinib to the ATP-binding sites of the EGFR receptors prevents EGFR from producing phosphotyrosine residues (due to competitive inhibition), thus rendering the receptor incapable of generating signal cascades to promote cell growth. (wikipedia.org)
  • mucus
  • Hemoptysis is the coughing up of blood or blood-stained mucus from the bronchi, larynx, trachea, or lungs. (wikipedia.org)
  • behavior
  • In view of this evidence for calcium-spike electrogenesis and previous evidence of secretory activity in these cells, this cell line (DMS 53) can provide a model for the study of excitation-secretion behavior in human neoplastic cells. (sciencemag.org)
  • lobe
  • Surgical option is usually the last resort, and can involve, removal of a lung lobe or removal of the entire lung. (wikipedia.org)
  • vitro
  • However, in vitro work with DCA on neuroblastomas (which have fewer recognised mitochondrial abnormalities) also showed some activity against very malignant, undifferentiated cells. (wikipedia.org)
  • syndrome
  • Hypertrophic osteoarthropathy (also known as hypertrophic pulmonary osteoarthropathy, Bamberger-Marie syndrome or Osteoarthropathia hypertrophicans) is a medical condition combining clubbing and periostitis of the small hand joints, especially the distal interphalangeal joints and the metacarpophalangeal joints. (wikipedia.org)
  • protein
  • Hint/PKCI-1, which is the only other characterized human histidine triad (HIT) nucleotide-binding protein in addition to tumor-suppressor gene FHIT, might be involved in lung carcinogenesis. (cdc.gov)
  • Basal Cell Carc
  • Transgenic mice over-expressing the transcription factor Gli2 under the K5 promoter in cutaneous keratinocytes develop multiple skin tumours on the ears, tail, trunk and dorsal aspect of the paw, resembling those of basal cell carcinoma (BCC). (wikipedia.org)
  • subtypes
  • CB2 receptors are structurally different (the sequence similarity between the two subtypes of receptors is 44%), found only on cells of the immune system, and seems to function similarly to its CB1 counterpart. (wikipedia.org)
  • disease
  • Pregnancy endometriosis polycystic disease carcinoma the infantile form is associated rotator tendon tears detection and treatment of musculoskeletal conditions. (pmpediatrics.org)
  • Disease is typically classified as low- or high-grade (with signet ring cells). (wikipedia.org)
  • 2007) argued that continued use of non-malignant terms, i.e., adenoma, for those frequent cases with low-grade features (such as DPAM), is misleading because pseudomyxoma peritonei is a disease state that results from invasion of the abdominal cavity by cells with uncontrolled growth. (wikipedia.org)
  • mechanistic
  • Mechanistic studies showed that the synergistic cell death was not due to an increase in viral replication but occurred through an enhancement of apoptotic cell death. (biomedcentral.com)
  • abdomen
  • This may be done by an open incision in the abdomen (laparotomy) or through a few smaller incisions with the help of cameras (laparoscopy). (wikipedia.org)
  • symptoms
  • Positive bone scans are routinely used and patients in each anchor with the distal clavicular osteolysis, although symptoms began after trauma to the smallest diameter is. (pmpediatrics.org)
  • Other late symptoms may include feeling tired due to low levels of red blood cells. (wikipedia.org)
  • apoptotic
  • During a normal embryologic processes, or during cell injury (such as ischemia-reperfusion injury during heart attacks and strokes) or during developments and processes in cancer, an apoptotic cell undergoes structural changes including cell shrinkage, plasma membrane blebbing, nuclear condensation, and fragmentation of the DNA and nucleus. (wikipedia.org)
  • Human
  • Pembrolizumab is an immunoglobulin G4, with a variable region against the human programmed cell death 1 receptor, a humanized mouse monoclonal [228-L-proline(H10-S>P)]γ4 heavy chain (134-218') disulfide and a humanized mouse monoclonal κ light chain dimer (226-226:229-229)-bisdisulfide. (wikipedia.org)
  • However, the N-terminal part of human Gli2 is much smaller than its mouse or frog homologs, suggesting that it may lack repressor function. (wikipedia.org)
  • Mutations of the GLI2 gene are associated with several phenotypes including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. In human keratinocytes Gli2 activation upregulates a number of genes involved in cell cycle progression including E2F1, CCND1, CDC2 and CDC45L. (wikipedia.org)
  • membrane
  • A signature of this type of receptor is the distinct pattern of how the receptor molecule spans the cell membrane seven times. (wikipedia.org)
  • The location of cannabinoid receptors exists on the cell membrane, and both outside (extracellularly) and inside (intracellularly) the cell membrane. (wikipedia.org)
  • Another function of Hsc70 is as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. (wikipedia.org)
  • In Gram-negative bacteria, such as Escherichia coli (E. coli), alkaline phosphatase is located in the periplasmic space, external to the inner cell membrane and within the peptidoglycan portion of the cell wall. (wikipedia.org)
  • methylation
  • Altered DNA methylation at various CpG sites was associated with exposure to mercury, lead or BPA, providing candidates to be investigated using a larger study sample, as the results may reflect an independently associated predictor (e.g. socioeconomic status, diet, genetic variants, altered blood cell composition). (pubmedcentralcanada.ca)
  • Genome-wide DNA methylation profiling of non-small cell lung carcinomas. (ox.ac.uk)
  • abnormal
  • This is also called carcinoma in situ, which simply means that there are abnormal cells that are centered in one place. (livingalongerlife.com)
  • It is due to the abnormal growth of cells that have the ability to invade or spread to other parts of the body. (wikipedia.org)
  • However, loss of Gli3 leads to abnormal patterning and loss of Gli2 affects the development of ventral cell types, most significantly in the floor plate. (wikipedia.org)
  • Leukemia
  • The physiological role of Dock10 is poorly characterised, however a study in lymphocytes has shown that Dock10 expression is upregulated in B-lymphocytes and Chronic Lymphocytic Leukemia (CLL) cells in response to the cytokine IL-4. (wikipedia.org)
  • Brain
  • Dock10 is expressed in peripheral blood leukocytes as well as in the brain, spleen, lung and thymus. (wikipedia.org)
  • cases
  • proposed separating pseudomyxoma peritonei cases into two diagnostic categories: adenoma (disseminated peritoneal adenomucinosis, DPAM) or carcinoma (peritoneal mucinous carcinomatosis, PMCA) with a third category reserved for cases with intermediate features. (wikipedia.org)
  • In this classification system, cases of DPAM were characterized by peritoneal lesions composed of abundant extracellular mucin containing scant simple to focally proliferative mucinous epithelium with little cytologic atypia or mitotic activity (in other words, most cells looked fairly normal and there was no evidence of mitosis which would indicate that cells were rapidly dividing), with or without an associated appendiceal mucinous adenoma. (wikipedia.org)
  • regulates
  • For example, Hsc70 regulates the nuclear accumulation of cyclin D1, which is a key player in G1 to S phase cell cycle transition. (wikipedia.org)
  • immune
  • You just need to match quite closely to fool the immune system into accepting the other person's stem cells. (health24.com)
  • It blocks a protective mechanism of cancer cells, and allows the immune system to destroy those cancer cells. (wikipedia.org)
  • Cannabis cofactor compounds have also been linked to lowering body temperature, modulating immune functioning, and cell protection. (wikipedia.org)
  • function
  • In children the heart and is nar - lung function tests are dictated by the body of sternum ribs body of. (pmpediatrics.org)
  • It is a member of the DOCK-D subfamily of the DOCK family of guanine nucleotide exchange factors, which function as activators of small G proteins. (wikipedia.org)
  • amounts
  • Figure 2) While metabolizing arachidonic acid primarily to PGG2, COX-2 also converts this fatty acid to small amounts of a racemic mixture of 15-Hydroxyicosatetraenoic acids (i.e., 15-HETEs) composed of ~22% 15(R)-HETE and ~78% 15(S)-HETE stereoisomers as well as a small amount of 11(R)-HETE. (wikipedia.org)
  • 3) small amounts of oxidation products are formed due to the oxygen trapping of an allylic radical intermediate at positions 13 and 15. (wikipedia.org)
  • Another psychoactive cannabinoid present in Cannabis sativa is tetrahydrocannabivarin (THCV), but it is only found in small amounts and is a cannabinoid antagonist. (wikipedia.org)
  • growth
  • however, it explains the next step in the process of the radial growth, when individual cells start to acquire invasive potential. (thetanningguru.com)