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  • metastatic
  • Avelumab for metastatic Merkel cell carcinoma after chemotherapy. (ecancer.org)
  • I'm really happy to show you this slide because this is the disclaimer because about ten days ago we were pleasantly surprised that the FDA has, in fact, approved avelumab, or the trade name of Bavencio, for the treatment of metastatic Merkel cell carcinoma. (ecancer.org)
  • So if you don't know about Merkel cell carcinoma it's a fairly rare but very aggressive form of skin cancer and has been associated with very poor survival, particularly in patients with metastatic disease. (ecancer.org)
  • patients
  • Dr Kaufman presents results at AACR 2017 of a trial administering avelumab to patients with advanced Merkel cell carcinoma who had not responded to chemotherapy. (ecancer.org)
  • either
  • In our lab, and later confirmed, actually, by the Johns Hopkins group that many Merkel cell carcinomas were associated with the expression of PD-L1 either on the tumour cell or other cells within the tumour microenvironment. (ecancer.org)
  • SCLC
  • LCC is differentiated from small-cell lung carcinoma (SCLC) primarily by the larger size of the anaplastic cells, a higher cytoplasmic-to-nuclear size ratio, and a lack of "salt-and-pepper" chromatin. (wikipedia.org)
  • Prostate
  • Umasankar Mathuram Thiyagarajan, A. Ponnuswamy, A. Bagul, and A. Gupta, "An Unusual Case of Resistant Hypokalaemia in a Patient with Large Bowel Obstruction Secondary to Neuroendocrine Carcinoma of the Prostate," Case Reports in Surgery , vol. 2017, Article ID 2394365, 4 pages, 2017. (hindawi.com)
  • large
  • Clinical features of ovarian large-cell neuroendocrine carcinoma: four case reports and review of the literature," Experimental and Therapeutic Medicine , vol. 2, no. 6, pp. 1083-1090, 2011. (hindawi.com)
  • According to the Nurses' Health Study, the risk of large cell lung carcinoma increases with a previous history of tobacco smoking, with a previous smoking duration of 30 to 40 years giving a relative risk of approximately 2.3 compared to never-smokers, and a duration of more than 40 years giving a relative risk of approximately 3.6. (wikipedia.org)
  • medullary thyroid c
  • Medullary thyroid carcinoma is a neoplasm of the thyroid gland arising from parafollicular c-cells producing calcitonin, and pituitary adenoma is a benign hyperplasia of the cells of the pituitary gland. (biomedcentral.com)
  • His past medical history was significant for non-functional pituitary macroadenoma and medullary thyroid carcinoma and he had received a total thyroidectomy and a transsphenoidal surgery several years ago. (biomedcentral.com)
  • To the best of our knowledge, it is the first case reported in the literature of a patient who has been affected by recurrent non-functional pituitary adenoma and medullary thyroid carcinoma, concomitantly. (biomedcentral.com)
  • lymphoma
  • Our study confirms that PAX5 and TdT expression can be expressed in a high percentage of Merkel cell carcinomas and so when positive are not diagnostic of lymphoblastic leukemia/lymphoma. (blogspot.com)