Urothelial carcinomaMetastasisTumorsSquamous Cell CarcHepatocellular carcinomaChemotherapyRenal Cell Carcinoma Treatment ProtMRCCMetastasesRecurrent or metastaticUnresectable or metastaticClear cell renalMerkelCutaneousMelanomaImmunotherapyDiseaseSurvivalClinicalOncologyNeuroendocrine CarcinomaSystemic therapiesTreatmentPrognosisHistologicallyTherapeutic approachLungCCRCCTherapyDiagnosisFindingsThyroidProstatePrimaryCancerMidlineOutcomes
Urothelial carcinoma20
- Centering discussion on a clinical scenario of metastatic urothelial carcinoma, panelists determine which first-line regimen they would utilize prior to maintenance therapy. (cancernetwork.com)
- Petros Grivas, MD, PhD, reviews emerging data from the 2021 ASCO GU Virtual Symposium on the role of immune checkpoint inhibitors for the treatment of advanced and metastatic urothelial carcinoma. (ajmc.com)
- Petros Grivas, MD, PhD, reviews data from recent subgroup analyses for the JAVELIN Bladder 100 study for advanced urothelial carcinoma from the 2021 ASCO GU Virtual Symposium. (ajmc.com)
- Petros Grivas, MD, PhD, discusses exciting findings and impactful data from the 2021 ASCO GU Virtual Symposium for the treatment of urothelial carcinoma. (ajmc.com)
- Petros Grivas, MD, PhD, shares his thoughts on the future of maintenance therapy in locally advanced or metastatic urothelial carcinoma. (ajmc.com)
- BACKGROUND: Patients with metastatic urothelial carcinoma have a dismal prognosis and few treatment options after first-line chemotherapy. (urotoday.com)
- We assessed nivolumab, a fully human IgG4 PD-1 immune checkpoint inhibitor antibody, for safety and activity in patients with metastatic or surgically unresectable urothelial carcinoma whose disease progressed or recurred despite previous treatment with at least one platinum-based chemotherapy regimen. (urotoday.com)
- INTERPRETATION: Nivolumab monotherapy provided meaningful clinical benefit, irrespective of PD-L1 expression, and was associated with an acceptable safety profile in previously treated patients with metastatic or surgically unresectable urothelial carcinoma. (urotoday.com)
- I've spent my career specializing in the care of patients with metastatic urothelial carcinoma and understand the need for new treatments for this disease," said Arlene O. Siefker-Radtke, M.D., professor of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, and lead study investigator. (jnj.com)
- BALVERSA is an important new therapy for this small subset of patients with urothelial carcinoma who, up until now, had limited treatment options. (jnj.com)
- CHICAGO, June 5, 2023 - The Janssen Pharmaceutical Companies of Johnson & Johnson today announced results from an interim analysis of Cohort 1 of the Phase 3 THOR study, evaluating treatment with BALVERSA ® (erdafitinib) versus chemotherapy in patients with metastatic or unresectable urothelial carcinoma (UC) and selected fibroblast growth factor receptor (FGFR) gene alterations who had received prior treatment with an anti-programmed death ligand 1 (PD-[L]1) agent. (janssen.com)
- These results represent the first data from a randomized, controlled trial evaluating BALVERSA ® for the treatment of patients with FGFR-altered urothelial carcinoma, who often experience poor disease outcomes," said Yohann Loriot*, M.D., Ph.D., Institut Gustave Roussy and University of Paris-Saclay, France, and principal study investigator. (janssen.com)
- The increasing research in cancer, rising occurrence of metastatic urothelial carcinoma and presence of a strong pipeline, are expected to be some major drivers for the market. (emergenresearch.com)
- Metastatic urothelial carcinoma is one of the leading cancer-related death across the globe. (emergenresearch.com)
- In Western Countries, Urothelial carcinoma accounts for nearly 90% of cases of bladder cancer. (emergenresearch.com)
- Looking at the statistics, the demand for Metastatic urothelial carcinoma is expected to escalate significantly in demand in the near future. (emergenresearch.com)
- Furthermore, the market of metastatic urothelial carcinoma is also going to get significantly affected due to continuous research. (emergenresearch.com)
- Rigorous research in the metastatic urothelial carcinoma industry has contributed to the high growth to the market of the industry. (emergenresearch.com)
- Integrated longitudinal circulating tumor DNA profiling predicts immunotherapy response of metastatic urothelial carcinoma in the POLARIS-03 trial. (bvsalud.org)
- Patients and Methods Atezolizumab data from clinical trials in non-small-cell lung cancer, metastatic urothelial carcinoma, renal cell carcinoma, and melanoma were evaluated. (medscape.com)
Metastasis8
- For example, prostate cancer is very common, but cutaneous metastasis from prostate carcinoma is relatively uncommon. (medscape.com)
- The term carcinoma of unknown primary site (CUPS) is used when dealing with a metastasis that occurs before primary tumor diagnosis. (medscape.com)
- A 42-year-old male presented with a rare intramedullary spinal cord metastasis from gastric carcinoma manifesting as rapidly worsening motor and sphincter disturbances. (unboundmedicine.com)
- Metastasis is a major cause of death in patients with hepatocellular carcinoma (HCC), although survival has improved due to advances in surgical techniques [ 1 ]. (oncotarget.com)
- Anatomopathological and immunohistochemical study revealed a preliminary diagnosis of breast carcinoma metastasis. (bvsalud.org)
- New anatomopathological and immunohistochemical exams confirmed the diagnosis of breast carcinoma metastasis. (bvsalud.org)
- About 25-30% of patients have metastatic disease at diagnosis, and fewer than 5% have a solitary metastasis. (medscape.com)
- The study also revealed increased risk of death due to renal cell carcinoma in patients who did not undergo surgical resection of metastasis. (medscape.com)
Tumors10
- Metastatic tumors are usually round, discrete tumor lobules in the dermis, with a Grenz zone, and are usually unassociated with the epidermis. (medscape.com)
- Surgical treatment may be considered for cases with even rapid-growing tumors such as gastric carcinoma with no evidence of multi-organ dissemination, especially when presenting with progressive neurological deterioration. (unboundmedicine.com)
- This phase II trial studies how well olaparib works in treating patients with bladder cancer and other genitourinary tumors with deoxyribonucleic acid (DNA)-repair defects that has spread to other places in the body (advanced or metastatic) and usually cannot be cured or controlled with treatment. (bcan.org)
- TRAP1 and/or its client proteins were quantified, by immunoblot analysis, in 60 surgical specimens of colorectal carcinomas at different stages and, by immunohistochemistry, in 9 colorectal adenomatous polyps, 11 in situ carcinomas and 55 metastatic colorectal tumors. (oncotarget.com)
- TRAP1 is upregulated at the transition between low- and high-grade adenomas, in in situ carcinomas and in about 60% of human colorectal carcinomas, being downregulated only in a small cohort of tumors. (oncotarget.com)
- Consistently, the prognostic relevance of TRAP1 was confirmed in a cohort of 55 metastatic colorectal tumors. (oncotarget.com)
- PD-1, PD-L1 and PD-L2 were differentially expressed between primary and metastatic tumors. (biomedcentral.com)
- Among them, the heterogeneity of the tumor may play an important role, especially the heterogeneity between the primary and metastatic tumors. (biomedcentral.com)
- In addition, immune peroxidase staining for immunoglobulin, chromosome studies, and immunophenotyping may help diagnose the various subtypes of malignant lymphomas, which may be difficult to recognize and differentiate from other tumors (even carcinomas) outside lymph nodes. (msdmanuals.com)
- Patients with these advanced unresectable or metastatic tumors that have progressed while on, or since finishing, the last treatment can join a phase 2 study assessing a three-drug combination of immunotherapy pembrolizumab (Keytruda), belzutifan (Welireg), an HIF-2a inhibitor, and kinase-inhibitor lenvatinib (Lenvima). (medscape.com)
Squamous Cell Carc2
- Evidence-based recommendations on nivolumab (Opdivo) with fluoropyrimidine- and platinum-based chemotherapy for untreated unresectable advanced, recurrent, or metastatic oesophageal squamous cell carcinoma in adults. (nice.org.uk)
- Additionally, squamous cell carcinoma is the most common bladder cancer in eastern Africa and the Middle East. (emergenresearch.com)
Hepatocellular carcinoma8
- On May 29, 2020 , atezolizumab in combination with bevacizumab was approved for treatment of patients with unresectable or metastatic hepatocellular carcinoma who have not received prior systemic therapy. (ascopost.com)
- In this study, 101 pairs of primary hepatocellular carcinoma (HCC) tissues and matched normal control tissues were analyzed for miR-200a expression and its clinicopathological value was determined. (oncotarget.com)
- Locally advanced or metastatic hepatocellular carcinoma (HCC). (medscape.com)
- Advanced hepatocellular carcinoma, pancreatic ductal adenocarcinoma (PDAC) and biliary tract cancer. (medscape.com)
- Hepatocellular carcinoma is cancer that starts in the liver. (medlineplus.gov)
- Hepatocellular carcinoma is the most common type of liver cancer. (medlineplus.gov)
- Hepatocellular carcinoma is not the same as metastatic liver cancer . (medlineplus.gov)
- NCCN clinical practice guidelines in oncology: hepatocellular carcinoma. (medlineplus.gov)
Chemotherapy4
- This is a Phase II, open-label, multi-center study to determine the efficacy and safety of MEDI4736 evaluated as single agent or in combination with tremelimumab in patients with metastatic pancreatic ductal adenocarcinoma (PDAC) whose disease has progressed on fluoropyrimidine containing or gemcitabine-containing first-line chemotherapy.This study will consist of Part A, lead-in, as well as a possible expansion Part B. (astrazenecaclinicaltrials.com)
- The drug was given as switch maintenance in 59 patients with metastatic colorectal cancer (mCRC) not progressing after 4.5 to 6 months of induction chemotherapy +/- bevacizumab, considered the most appropriate setting for an agent broadly activating the immune system. (bmj.com)
- as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)
- Biocon Biologics Ltd), BT-ON014 - in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease - in combination with an aromatase inhibitor for the treatment of postmenopausal patients with hormone-receptor positive MBC, not previously treated with trastuzumab. (who.int)
Renal Cell Carcinoma Treatment Prot1
- Go to Renal Cell Carcinoma Treatment Protocols , Clear Cell Renal Cell Carcinoma , and Sarcomatoid and Rhabdoid Renal Cell Carcinoma for complete information on these topics. (medscape.com)
MRCC6
- Metastatic renal cell carcinoma (mRCC) accounts for one-third of all newly diagnosed renal cell cancers. (mdpi.com)
- Objectives: Sarcomatoid metastatic renal cell carcinoma (mRCC) represents an aggressive subset of disease, and a definitive therapeutic strategy is lacking. (simulations-plus.com)
- The role of cytoreductive nephrectomy (CN) in treatment of locally advanced or metastatic renal cell carcinoma (mRCC) in the era of targeted therapies (TT) is still not clearly defined. (muni.cz)
- Tyrosine kinase inhibitors (TKIs) are currently approved for the treatment of metastatic renal cell carcinoma (mRCC). (biomedcentral.com)
- Histopathological examination of these immune check points in metastatic lesions of mRCC should be noticed, and its accurate diagnosis may be one of the effective ways to realize the individualized treatment. (biomedcentral.com)
- Among all RCC patients, nearly 20-30% of them were initially diagnosed as metastatic RCC (mRCC), and 20-40% of patients with localized disease will eventually develop metastatic disease after surgery [ 3 ]. (biomedcentral.com)
Metastases7
- Cutaneous metastases from carcinoma (see the image below) are relatively uncommon in clinical practice, but they are very important to recognize. (medscape.com)
- Primary cutaneous adnexal carcinomas may be difficult to distinguish from metastases in certain situations. (medscape.com)
- An 85-year-old woman presented with epigastric discomfort and was clinically diagnosed with locally advanced unresectable carcinoma of the gallbladder associated with liver metastases. (hindawi.com)
- Nasopharyngeal carcinoma (NPC) is notorious for the metastases, which are in close association with Epstein-Barr virus-encoded latent membrane protein 1 (LMP1). (scielo.br)
- Basal cell carcinoma may sometimes show metastatic spread to regional lymph nodes and, occasionally, in-transit metastases. (cancer.org.au)
- Merkel Cell Carcinoma (MCC) is an uncommon neuroendocrine cutaneous carcinoma which is characterized by high incidence of early loco-regional relapse and distant metastases (Poulsen 2004 ). (springeropen.com)
- [ 18 ] A study by Alt et al found that complete resection of multiple renal cell carcinoma metastases may be associated with long-term survival. (medscape.com)
Recurrent or metastatic2
- Lenvatinib is a multiple receptor tyrosine kinase inhibitor currently indicated for the treatment of patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer. (ascopost.com)
- People with recurrent or metastatic ovarian, fallopian, primary peritoneal or carcinoma are asked to participate in a research study being conducted by Monter Cancer Center. (brany.com)
Unresectable or metastatic1
- 2-4 In the trial, 501 patients with locally advanced unresectable or metastatic disease who had not received prior systemic therapy were randomly assigned 2:1 to receive atezolizumab at 1,200 mg followed by bevacizumab at 15 mg/kg on the same day every 3 weeks (n = 329) or sorafenib at 400 mg twice daily (n = 156), continuing treatment until disease progression or unacceptable toxicity. (ascopost.com)
Clear cell renal6
- Metastatic clear cell renal cell carcinoma is a disease without a comprehensive animal model for thorough preclinical investigation. (jove.com)
- Clear cell renal cell carcinoma or CCRCC, is the most common subtype of kidney cancer. (jove.com)
- among these, about 80% are clear cell renal carcinomas histologically ( 2 ). (iiarjournals.org)
- Pathological examination of the surgical specimens demonstrated pT3cN0Mx conventional (clear cell) renal carcinoma, Fuhrman Grade 3 with negative surgical margins. (biomedcentral.com)
- This study is being performed as a single-arm open-label study in order to rapidly provide information on the potential benefits of the combination of pembrolizumab and lenvatinib in participants with previously untreated advanced/metastatic non-clear cell renal cell carcinoma. (survivornet.com)
- Context While vascular endothelial growth factor-targeted therapy and mammalian target of rapamycin inhibition are effective strategies in treating clear cell renal cell carcinoma (ccRCC), the most effective therapeutic approach for patients with non-clear cell RCC (non-ccRCC) is unknown. (lu.se)
Merkel3
- Merkel cell carcinoma (MCC) is an uncommon neuroendocrine cutaneous carcinoma. (springeropen.com)
- A month later, this mass was surgically excised and the histology examination showed a poorly differentiated small cell carcinoma, with histopathologic features of a Merkel cell carcinoma. (springeropen.com)
- Metastatic Merkel cell carcinoma (MCC) is a disabling condition on the Compassionate Allowance List , which qualifies an individual for an expedited approval process. (callfred.com)
Cutaneous2
- See Cutaneous Clues to Diagnosing Metastatic Cancer , a Critical Images slideshow, to help identify various skin lesions that are cause for concern. (medscape.com)
- Primary cutaneous apocrine carcinomas can be particularly difficult to differentiate from adenocarcinomas of mammary origin because of the identical morphological and immunohistochemical features they may exhibit. (medscape.com)
Melanoma1
- Metastatic melanoma is a type of skin cancer that has spread across other parts of the body. (cancer.gov)
Immunotherapy4
- A personalized immunotherapy (AGS-003) nearly doubled expected progression-free survival and overall survival when added to standard sunitinib (Sutent) in patients with unfavorable-risk metastatic renal cell carcinoma, according to results from a single-arm phase II study. (urologytimes.com)
- The results support an ongoing phase III study of the approach in which patients with metastatic clear-cell RCC are being randomized to personalized immunotherapy plus sunitinib or sunitinib alone, with overall survival as the primary endpoint, said first author Asim Amin, MD, PhD. (urologytimes.com)
- At the Genitourinary Cancers Symposium in Orlando, FL, Dr. Amin described long-term survival in 21 patients with intermediate- or poor-risk metastatic RCC who were treated with autologous dendritic cell immunotherapy in combination with sunitinib. (urologytimes.com)
- The ongoing phase III ADAPT (The Autologous Dendritic Cell Immunotherapy Plus Standard Treatment of Advanced Renal Cell Carcinoma) study is using this approach to personalized immunotherapy, with the goal of randomizing 450 patients. (urologytimes.com)
Disease11
- Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
- Metastatic disease is associated with poor prognosis and short-term survival, even though urothelial cancer is considered a chemosensitive tumor. (emergenresearch.com)
- Up to 75% of RCCs are diagnosed in organ-confined stages (T1 and T2), whereas one fourth is already locally advanced or presenting as metastatic disease having a poor prognosis ( 1 ). (iiarjournals.org)
- In such cases direct treatment such as surgery or radiotherapy, if possible, would be appropriate after first evaluating if more widespread metastatic disease is present. (cancer.org.au)
- Mortality is attributable largely to metastatic disease and a dearth of effective therapeutic interventions. (biologists.com)
- Has locally advanced/metastatic disease (ie, Stage IV per the American Joint Committee on Cancer). (survivornet.com)
- Lenvatinib plus pembrolizumab might therefore be a future potential standard-of-care treatment for patients with metastatic clear cell RCC after disease progression with ICI therapy. (cancertherapyadvisor.com)
- Patients with this type of carcinoma should be treated with a cisplatin -based regimen because nearly 50% have long disease-free intervals. (msdmanuals.com)
- Treatment protocols for renal cell carcinoma are provided below, including treatment of localized and advanced disease and recommendations for patients with predominantly clear cell carcinoma and those with predominantly non-clear cell carcinoma. (medscape.com)
- Surgical resection remains the only known effective treatment for localized renal cell carcinoma, and it also is used for palliation in metastatic disease. (medscape.com)
- Targeted therapy and immunomodulatory agents are considered standard of care in patients with metastatic disease. (medscape.com)
Survival6
- Pure small cell carcinoma of the prostate (SCPCa) is a very rare condition usually with poor survival after diagnosis. (karger.com)
- Are you surprised that targeted therapeutics for metastatic renal cell carcinoma (RCC) have not improved survival? (renalandurologynews.com)
- Targeted therapeutic agents for treating metastatic RCC has not led to an improved survival. (renalandurologynews.com)
- A study published recently in Urologia Internationalis (online ahead of print) found that the advent of targeted therapeutic agents for treating metastatic renal cell carcinoma (RCC) -which began with the FDA approval of sorafenib in 2005-has not led to an improvement in survival rates. (renalandurologynews.com)
- All these treatment options are approximately comparable in terms of progression-free survival (PFS) and can be used under the premise of favorable to moderate prognosis according to the Memorial Sloan-Kettering Cancer Center (MKSCC)-criteria for first-line therapy of advanced or metastatic RCC. (iiarjournals.org)
- This applies as well in the adjuvant treatment of surgically resected renal cell carcinoma, for which no therapy has yet been found to offer survival benefit. (medscape.com)
Clinical2
- The management of metastatic BCC is largely based on clinical evidence and experience in the management of locally advanced BCCs. (cancer.org.au)
- The treatment of metastatic renal cell carcinoma is problematic, and, whenever possible, patients should be directed to approved and controlled clinical trials. (medscape.com)
Oncology1
- Combination lenvatinib and pembrolizumab demonstrated antitumor activity in patients with metastatic renal cell carcinoma (RCC) regardless of prior treatment, according to trial results published in The Lancet Oncology . (cancertherapyadvisor.com)
Neuroendocrine Carcinoma1
- The histopathology examination showed infiltration of the thyroid gland by a neuroendocrine carcinoma with characteristics compatible with MCC. (springeropen.com)
Systemic therapies1
- Objective To systematically review relevant literature comparing the oncological outcomes and adverse events of different systemic therapies for patients with metastatic non-ccRCC. (lu.se)
Treatment11
- There is no gold standard for the diagnosis and treatment of NUT carcinoma to date. (snmjournals.org)
- Sorafenib seems to be effective in the treatment of advanced MTC but not ATC, and could be a new treatment option for locally advanced or metastatic MTC and radioactive iodine-refractory DTC. (nih.gov)
- To explore tumor-mutational profiles in metastatic tumor biopsies, saliva "normal" DNA, changes in tumor or peripheral immune characteristics, or tumor associated somatic mutation load in blood DNA in response to treatment. (bcan.org)
- This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
- Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)
- Simple Summary: The treatment of metastatic renal cell carcinoma is traditionally initiated with the removal of the diseased kidney with the tumor in many patients. (muni.cz)
- Background/Aim: The combination of bevacizumab (BEV) plus interferon alpha-2a (IFN) constitutes an option for first-line treatment of metastatic renal cell carcinoma. (iiarjournals.org)
- In consequence, actual treatment guidelines ( 12 ) recommend a targeted first-line therapy with VEGFR-inhibitors, like sunitinib ( 9 ), pazopanib ( 10 ), or bevacizumab plus immune stimulative IFN, for patients with advanced or metastatic RCC with low to intermediate risk [per Motzer- or MSKCC-Score ( 13 ) /IDMC score International Metastatic Database Consortium (IMDC) adverse risk factors] ( 8 ). (iiarjournals.org)
- Glucose measurements are used in the diagnosis and treatment of pancreatic islet cell carcinoma and of carbohydrate metabolism disorders, including diabetes mellitus, neonatal hypoglycemia, and idiopathic hypoglycemia. (cdc.gov)
- Conclusions This systematic review and meta-analysis represent a robust summary of the evidence base for systemic treatment of metastatic non-ccRCC. (lu.se)
- Participants with a locally advanced or metastatic pathologically confirmed cancer who are candidates for treatment with atezolizumab, either alone or in combination with other FDA-approved drug(s) as part of guideline-endorsed regimens. (who.int)
Prognosis1
- Prognosis of basal cell carcinoma and Table 1. (cancer.org.au)
Histologically1
- Japanese patients with histologically confirmed ATC and locally advanced or metastatic MTC were enrolled from April to September 2014. (nih.gov)
Therapeutic approach1
- The therapeutic approach for renal cell carcinoma is guided by the probability of cure, which is related directly to the stage or degree of tumor dissemination. (medscape.com)
Lung1
- Carbon nanotube s enhance metastatic growth of lung carcinoma via up-regulation of myeloid-derived suppressor cells. (cdc.gov)
CCRCC1
- The purpose of this protocol is to introduce and compare the two animal models recently established for metastatic CCRCC. (jove.com)
Therapy3
- The U.S. Food and Drug Administration (FDA) granted lenvatinib (Lenvima) Breakthrough Therapy designation for investigational use in patients with advanced or metastatic renal cell carcinoma who were previously treated with a vascular endothelial growth factor (VEGF)-targeted therapy. (ascopost.com)
- Potential candidates for HPI therapy include patients with inoperable BCC, those in whom surgery is not appropriate, and those with metastatic BCC who have an adequate performance status. (cancer.org.au)
- Adult patients with this cancer who have received at least one prior systemic therapy - no more than two in the metastatic setting - are being recruited for a National Cancer Institute (NCI) phase 2 study testing two immune therapies with and without a MEK inhibitor, cobimetinib (Cotellic). (medscape.com)
Diagnosis4
- Sometimes adnexal carcinomas arise in the setting of a precursor benign adnexal neoplasm, making diagnosis straightforward. (medscape.com)
- Here, we describe the case of a mid-octogenarian who presented with severe pain and nonambulatory quadriparesis attributable to MESCC at the fifth cervical vertebra, which developed 10 months after the diagnosis of undifferentiated carcinoma of the gallbladder. (hindawi.com)
- The histopathological diagnosis was undifferentiated carcinoma. (hindawi.com)
- If you or a loved one has been diagnosed with metastatic MCC, then you are considered disabled for at least 24 months from the date of diagnosis. (callfred.com)
Findings2
- This educational exhibit will report the FDG PET/CT findings of metastatic NMC. (snmjournals.org)
- The rare case of metastatic infiltration of the thyroid gland by a MCC based on histological and immunohistochemical findings was described. (springeropen.com)
Thyroid1
Prostate2
- I. To evaluate the efficacy of olaparib in two cohorts of patients with metastatic/advanced non prostate genitourinary (GU) cancer pre-selected by DNA-repair defects as measured by overall response rate (ORR). (bcan.org)
- I. To determine the proportion of patients with DNA-repair pathway-mutated genes in metastatic non-prostate GU cancer (patient cohort referred for screening). (bcan.org)
Primary5
- Mahalingam et al have shown that positive staining with D2-40, p63, and CK15 also favors a primary adnexal carcinoma. (medscape.com)
- However, immune checkpoints may express differently between primary and metastatic tumor. (biomedcentral.com)
- Therefore, we aimed to compare the differential expressions of PD-1, PD-L1 and PD-L2 between the primary and metastatic sites of renal cell carcinoma (RCC). (biomedcentral.com)
- Although the patient had no medical history of breast cancer, due to this result, she was referred to a mastologist, who investigated her breast nodules for the possible primary focus of the carcinoma. (bvsalud.org)
- Given these results, the authors discuss the difficulty in diagnosing differentiation from a primary or metastatic neoplasm of the scalp, with the resources currently available, until the conclusion that it was a primary carcinoma of the sweat gland. (bvsalud.org)
Cancer6
- Alopecia neoplastica due to metastatic breast cancer. (medscape.com)
- Renal cell carcinoma is a form of kidney cancer that starts in the lining of the small tubes in the kidney. (cancer.gov)
- Metastatic epidural spinal cord compression (MESCC) is a common neurological complication of cancer and can have devastating consequences for patients [ 1 - 3 ]. (hindawi.com)
- The use of BALVERSA ® in this setting supports recommendations for FGFR testing in all patients with metastatic urothelial cancer. (janssen.com)
- Furthermore, the substantial ongoing research in the drug discovery process coupled with a multidisciplinary approach to treating patients with metastatic urothelial cancer is expected to fuel the market widely in the forecast period. (emergenresearch.com)
- Metastatic liver cancer starts in another organ (such as the breast or colon) and spreads to the liver. (medlineplus.gov)
Midline2
- NUT midline carcinoma (NMC) is a rare carcinoma that presents with rearrangement to the NUTM1 (aka NUT) gene affecting all ages, but predominantly teens and young adults. (snmjournals.org)
- Poorly differentiated carcinomas near or at midline regions of the mediastinum or retroperitoneum in young or middle-aged males should be considered germ cell neoplasms-even in the absence of a testicular mass. (msdmanuals.com)
Outcomes1
- The incidence of renal cell carcinoma (RCC) is high, and its outcomes remain poor. (biologists.com)