• Despite the presumed importance of this enzyme, mice lacking Ogg1 have been generated and found to have a normal lifespan, and Ogg1 knockout mice have a higher probability to develop cancer, whereas Mth1 gene disruption concomitantly suppresses lung cancer development in Ogg1-/- mice. (wikipedia.org)
  • Lewis lung carcinoma (LLC) and B 16 melanoma], to metastasize, apparently as a consequence of increased expression of a cell adhesion glycoprotein ( 8 ). (pnas.org)
  • Increased MMP-2 activity has also been linked with a poor prognosis in multiple forms of cancer including colorectal, melanoma, breast, lung, ovarian, and prostate. (wikipedia.org)
  • In her work with chick embryos, Margaret Lewis studied connective tissue formation within the tissues as well as outside of an environment where factors involved in coagulation are present. (wikipedia.org)
  • Invasive ductal carcinomas of the breast often have a scirrhous, stellate appearance caused by desmoplastic formations. (wikipedia.org)
  • The transfection efficiency was evaluated in Lewis lung carcinoma (LLC) cell lines cultured in vitro and in orthotopic cancer grafts in syngeneic mice. (aacrjournals.org)
  • Margaret Adaline Reed Lewis (1881-1970) was an American cell biologist and embryologist who made contributions to cancer research and cell culture techniques, and was likely the first person to successfully grow mammalian tissue in vitro. (wikipedia.org)
  • Conclusion In the research of animals with Lewis lung carcinoma was shown, that mechano- magnetochemically synthesized nanocomplex on the basis of nanoparticles from iron (II,III) oxide and doxorubicin had a greater antitumor effect than conventional doxorubicin. (techconnectworld.com)
  • The payload is the chemotherapy drug doxorubicin which is connected with a hydrazone linker to cysteine residues of the Lewis-Y specific (chimeric) monoclonal antibody BR96. (wikipedia.org)
  • Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates. (wikipedia.org)
  • This simple nonviral formulation approach showed negligible cytotoxicity in four different human cell lines (cervix, breast, kidney, and lung cell lines) and one mouse cell line (a lung cancer cell line). (aacrjournals.org)
  • Biologic barriers and toxicity continue to confound lung cancer treatment, even though the lungs may be accessed via inhalation or intravenous administration. (aacrjournals.org)
  • also known as cBR96-Dox) is an antibody-drug conjugate or (ADC) directed to the Lewis-Y antigen designed for the treatment of cancer. (wikipedia.org)
  • Metastasis is the main cause of death in patients with lung cancer. (medsci.org)
  • Since the Lewises main interest was microscopic cell structures, their objective was to create optically clear media, which led to the creation of the Locke-Lewis solution. (wikipedia.org)