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  • metastatic
  • Phase I trial to study the effectiveness of combination chemotherapy in treating patients who have metastatic or unresectable solid tumors. (bioportfolio.com)
  • Determine the maximum tolerated dose, recommended phase II dose, and associated toxic effects of the triple combination of continuous infusion fluorouracil, weekly gemcitabine, and oxaliplatin in patients with metastatic or unresectable solid tumors. (bioportfolio.com)
  • This phase I trial is studying the side effects and best dose of eribulin mesylate and gemcitabine hydrochloride in treating patients with metastatic or unresectable solid tumors. (bioportfolio.com)
  • vivo
  • There aren't any studies about the in vivo effect of duloxetine on the effect of duloxetine on the tumor progression and on the immune response. (biomedcentral.com)
  • In this work, the scorpion fish Scorpaena plumieri crude venom (SPB) and a gelatinolytic protease purified from this venom (SPGP) were evaluated for their applicability for in vivo tumor detection. (worldwidescience.org)
  • anti-tumor
  • Structure B) are DNA binder and possess excellent anti-tumor activities [3, (exp-oncology.com.ua)
  • 424-95 10 Claims ABSTRACT OF THE DISCLOSURE A water-insoluble anti-tumor active substance is prepared from the living cells of hemolytic streptococci by lysing the cells of hemolytic streptococci with a lytic enzyme and collecting a water-insoluble fraction which corresponds to a protoplast membrane fraction of the cells. (google.com)
  • The preparation of the anti-tumor substance is far superior in the anti-tumor activity to that of water-soluble fraction and has less inflammation-, feverand paincausing properties than any ones of prior art. (google.com)
  • The present invention relates to anti-tumor substances, and more particularly, it relates to water-insoluble antitumor substances prepared from the lysed cells of hemolytic streptococci and the production thereof. (google.com)
  • The anti-tumor preparation prepared by the use of cephalosporin C is hereinafter referred to as CEB-45, and that prepared by the use of cycloserine as CYB-45. (google.com)
  • While the preparations obtained by these methods are superior in their anti-tumor activity, they are not desirable in viewpoint of the form of preparation. (google.com)
  • On the other hand, there have been reported many processes for the production of preparation comprising anti-tumor substances as a water-soluble fraction from the cells of hemolytic streptococci. (google.com)
  • All of the anti-tumor preparations prepared according 3,786,141 Patented Jan. 15, 1974 to the above processes come from water-soluble fractions of the cells of the Streptococci, and their anti-tumor activity is not sufficient as compared with that of PCB-45 which is a preparation of streptococcal cells. (google.com)
  • Further, these preparations contain also many components other than anti-tumor substances, which may cause an inflammation fever or pain. (google.com)
  • An object of this invention is to provide a new type of Water-insoluble anti-tumor preparation. (google.com)
  • lymphocytes
  • The drug increased the SOD that fights free radicals and led the migration of lymphocytes, suggesting that duloxetine could be used in tumor-bearing individuals. (biomedcentral.com)
  • anticancer activity
  • Our results indicate that the oil has a promising anticancer activity and causes loss in tumor cell viability by activating the apoptotic process as identified by electron microscopy. (nih.gov)
  • Antibodies
  • en] We investigated the ultrastructural distribution of histones within Ehrlich tumor cell nucleoli by means of three cytochemical methods and by a Lowicryl post-embedding immunogold labeling procedure involving anti-histone (H2B, H3, H4) antisera as well as antibodies to synthetic peptides of histones. (uliege.be)
  • cell
  • The tumor progression was evaluated by body weight, abdominal circumference, ascites volume and tumor cell count. (biomedcentral.com)
  • Administration of ruboxyl into healthy animals led to distinct increase in this ratio in mitochondria, while the drug normalized patterns of the O-(-)-SOD system in all the cell compartments studied in tumor-bearing animals. (msk.ru)
  • An Economical, Quantitative, and Robust Protocol for High-Throughput T Cell Receptor Sequencing from Tumor or Blood. (bioportfolio.com)
  • The T cell receptor repertoire provides a window to the cellular adaptive immune response within a tumor, and has the potential to identify specific and personalized biomarkers for tracking host respo. (bioportfolio.com)
  • Clinical activity of eribulin in advanced desmoplastic small round-cell tumor. (bioportfolio.com)
  • Desmoplastic small round-cell tumor is a rare but highly aggressive tumor occurring mainly in adolescents and young adults. (bioportfolio.com)
  • Ultrastructural distribution of histones within Ehrlich tumor cell nucleoli: a cytochemical and immunocytochemical study. (uliege.be)
  • Reference : Ultrastructural distribution of histones within Ehrlich tumor cell nucleoli: a cytoch. (uliege.be)
  • In addition, the morphological changes in tumor cells were studied to ascertain the mechanism of cell death. (nih.gov)
  • Chloroethylnitrosoureas are a group of anticancer agents with a high demonstrated activity against a variety of hematological malignancies and solid tumors, especially Hodgkin's disease, small cell carcinoma of the lung and glioma, however, clinical use rather limited due to their delayed and cumulative hematological toxicity . (exp-oncology.com.ua)
  • liver
  • During tumoral development, the pattern studied was altered in all the subcellular organelles used, thus demonstrating an impairment of free radical oxidation status in liver tissue of tumor-bearing animals. (msk.ru)
  • Naphthal-NU and 5-Nitro-naphthal-NU were effective to normalize the tumor induced structural abnormalities of liver and kidney. (exp-oncology.com.ua)
  • vessels
  • We previously reported that eribulin mesylate (eribulin), a tubulin-binding drug (TBD), could remodel tumor vasculature (i.e., increased tumor vessels and perfusion) in human breast cancer xenograft m. (bioportfolio.com)
  • solid
  • Phase I trial to study the effectiveness of combretastatin A4 phosphate in treating patients who have advanced solid tumors that have not responded to previous therapy. (bioportfolio.com)
  • OBJECTIVES: I. Determine the maximum tolerated dose of combretastatin A4 phosphate when administered at single doses every 21 days in patients with advanced solid tumors. (bioportfolio.com)
  • Tumor-Infiltrating Podoplanin+ Fibroblasts Predict Worse Outcome in Solid Tumors. (bioportfolio.com)
  • This is an open-label, multicenter, single arm QT Interval prolongation study of eribulin mesylate (E7389) in patients with advanced solid tumors. (bioportfolio.com)
  • behavior
  • MicroRNA expression is known to be deregulated in various cancers and has been found to be useful in predicting tumor behavior. (cancerjournal.net)
  • activity
  • A number of miRNAs like miR-193a, miR-224/miR-452 cluster, miR-182/miR-183/miR-96 cluster, and miR-148a having potential tumor/metastasis suppressive activity were found to be overexpressed in the WNT signaling associated medulloblastomas. (cancerjournal.net)
  • determine
  • Expression level of tumor/metastasis suppressive miRNAs in the WNT signaling associated medulloblastomas is likely to determine their response to treatment, and thus, these miRNAs would be important biomarkers for risk stratification within the WNT signaling associated medulloblastomas. (cancerjournal.net)
  • drugs
  • The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (curehunter.com)
  • Despite the increasing knowledge about the molecular basis of tumor development, few advances have been reached in clinical therapy and diagnoses, which shows the importance of new drugs development for therapeutic and diagnosis purpose. (worldwidescience.org)
  • membrane
  • Energetics of Ehrlich ascites mitochondria: membrane potential of isolated mitochondria and mitochondria within digitonin-permeabilized cells. (naver.com)
  • E. W. Haeffner, K. Kolbe, D. Schroeter and N. Paweletz, Plasma membrane heterogeneity in ascites tumor cells. (springer.com)
  • Isolation of a light and a heavy membrane fraction of the glycogen-free Ehrlich-Lettr substrain, Biochim. (springer.com)
  • E. W. Haeffner, A. Holl and D. Schroeter, Preparation of two plasma membrane fractions from ascites tumor cells by gel chromatography on Sephacryl S-1000, J. Chromatogr. (springer.com)