• Activity of the systems involved in generation and utilization of superoxide radicals was studied in microsomes, mitochondria and nuclei of liver tissue from intact mice, mice with developed Ehrlich ascites carcinoma and of the animals treated with antitumoral drug ruboxyl. (msk.ru)
  • There aren't any studies about the in vivo effect of duloxetine on the effect of duloxetine on the tumor progression and on the immune response. (biomedcentral.com)
  • The tumor was cultured in vivo, which became known as the Ehrlich cell. (wikipedia.org)
  • The Ehrlich cell became popular because it could be expanded by in vivo passage. (wikipedia.org)
  • 11 , 12 ] Mistletoe extracts have been shown to enforce natural killer cell -mediated tumor cell lysis, reduce the migratory and invasive potential of tumor cells, and stimulate immune system cells both in vitro and in vivo . (cancer.gov)
  • In this work, the scorpion fish Scorpaena plumieri crude venom (SPB) and a gelatinolytic protease purified from this venom (SPGP) were evaluated for their applicability for in vivo tumor detection. (worldwidescience.org)
  • Antimicrobial activity and cytotoxic action against tumour cells in vitro, as well as anti‑tumour effects, acute toxicity and anti‑inflammatory activities in vivo, were evaluated. (spandidos-publications.com)
  • Its anti‑tumour action in vivo on mice with the ascitic form of Ehrlich carcinoma was promising, particularly with joint application of MT and the antitumour drug doxorubicin. (spandidos-publications.com)
  • Tolerated Doses in Zebrafish of Cytochalasins and Jasplakinolide for Comparison with Tolerated Doses in Mice in the Evaluation of Pre-clinical Activity of Microfilament-directed Agents in Tumor Model Systems in Vivo In Vivo (Athens, Greece). (jove.com)
  • Our study presents magnetodynamic nanotherapy using DNA aptamer-functionalized 50 nm gold-coated magnetic nanoparticles exposed to a low frequency alternating magnetic field for selective elimination of tumor cells in vivo . (thno.org)
  • Transplantable leukemia and solid tumor models were developed from spontaneous or induced tumors subsequently adapted to serial in vivo passage in the same animal strain [ 6 ] . (sciepub.com)
  • The research study was conducted to determine the antitumor effect of the flower of Alangium salvifolium (crude extract and diethylether fractions) against Ehrlich Ascites Carcinoma (EAC) in mice at the doses of 10 mg kg -1 body weight intraperitoneally. (scialert.net)
  • Twenty-four hours of last dose and 18 h of fasting, the mice were sacrificed and antitumor effect was assessed by evaluating tumor volume, viable and nonviable tumor cell count, tumor weight and hematological parameters of EAC bearing host. (scialert.net)
  • The desoxyribonucleic acid injury was attenuated in neoplasm tissue of tumor-bearing mice when treatment with immune suppressant drug and hyperbolic considerably in tumor tissue of tumor-bearing mice treated with sulforaphane before and after carcinogenesis and together with methotrexate treatment after carcinogenesis. (scirp.org)
  • Gurevich S.M., Vartanian L.S., Nagler L.G., Disorders in metabolism of superoxide radicals in tumor-bearing mice during development of Ehrlich ascites carcinoma and their normalization under the effect of ruboxyl, Voprosy meditsinskoi khimii, 1993, vol: 39(6), 16-20. (msk.ru)
  • The first part of the study (tumor imaging) was to investigate the biodistribution of NBPQD in the organs of EAC-bearing mice using iodine-125 isotope stressing on its distribution in the main organs (stomach, liver, spleen, kidney) in addition to blood and ascetic fluid. (scirp.org)
  • Antitumor effects of dietary black and brown rice brans in tumor-bearing mice: Relationship to composition. (greenmedinfo.com)
  • The cytotoxic activities appear to be as effective as cyclophosphamide in solid tumor-bearing mice. (mskcc.org)
  • The treatment of Ehrlich ascites carcinoma-bearing mice with complexes 1 and 2 increased the number of Annexin V positive cells and cleaved caspase-3 levels and induced changes in the cell morphology and in the cell cycle phases by induction of sub-G1 and G0/G1 cell cycle arrest. (bireme.br)
  • In the present study, we evaluated the ability of Gr-1 + myeloid cells, derived from the bone marrow or spleen of tumor-bearing mice, to inhibit CD3/CD28-mediated T cell activation. (jimmunol.org)
  • The proliferative response of T cells was dramatically decreased when naive T cells were activated by anti-CD3 and anti-CD28 Abs in the presence of a myeloid-enriched cell fraction derived from spleen or bone marrow of tumor-bearing mice vs the bone marrow of naive mice. (jimmunol.org)
  • Tumor growth is accompanied by an increase in the number of immature myeloid cells having strong natural suppressive activity, in BM as well as peripheral lymphoid organs in cancer patients ( 6 , 7 ) or tumor-bearing mice ( 8 , 9 , 10 ). (jimmunol.org)
  • It has been demonstrated previously that cells expressing Gr-1 or Mac-1 myeloid lineage cell markers are involved in T cell hyporesponsiveness in tumor-bearing mice. (jimmunol.org)
  • Ascitic fluid was drawn out from tumor bearing mice at log phase (day 7-8 of tumor bearing) of tumor cells. (ispub.com)
  • 0.001) increases of survival times 30±0.96 and 25±0.40 days for crude extract and diethylether fraction of the A. salvifolium (10 mg kg -1 ) treated tumor bearing mice, respectively were confirmed with respect to the control group (20±0.13 days). (scialert.net)
  • The extract/fraction also decreased the body weight of the EAC tumor bearing mice. (scialert.net)
  • 0.001) increases of survival times 33±1.81 days for crude extract of the (50 mg kg -1 ) treated tumor bearing mice were confirmed with respect to the control group (20±0.12 days). (scialert.net)
  • The tumor progression was evaluated by body weight, abdominal circumference, ascites volume and tumor cell count. (biomedcentral.com)
  • Next, we will review and critically discuss how dys-regulation of cell volume or given ion transporters can lead to loss of epithelial architecture, altered cell survival, tumor progression, and drug resistance. (frontiersin.org)
  • They serve as tools for the elucidation of the molecular basis of neoplastic transformation, the processes involved in tumor progression and metastasis, and the determinants of therapeutic success or failure [ 1 ] . (sciepub.com)
  • Group IV, V treated with SFN before and when Paul Ehrlich cells implantation group VI (Methotrexate and sulforaphane-treated group). (scirp.org)
  • The intracellular accumulation of poly-γ-glutamyl derivatives of methotrexate was evaluated in the presence of vincristine or probenecid (agents which raise the intracellular level of free methotrexate) in Ehrlich ascites tumor cells. (elsevier.com)
  • These studies (a) indicate that vincristine and probenecid may be potentially useful for selectively increasing methotrexate polyglutamates in tumor cells and (b) introduce another basis for synergism observed between alkaloids and methotrexate. (elsevier.com)
  • Fry, DW, Yalowich, JC & Goldman, ID 1982, ' Augmentation of the intracellular levels of polyglutamyl derivatives of methotrexate by vincristine and probenecid in Ehrlich ascites tumor cells ', Cancer Research , vol. 42, no. 7, pp. 2532-2536. (elsevier.com)
  • The cell specific DNA aptamer AS-14 binds to the fibronectin protein in Ehrlich carcinoma hence helps deliver the gold-coated magnetic nanoparticles to the mouse tumor. (thno.org)
  • This study was aimed to ameliorate neoplasm cell model Solid Ehrlich malignant neoplastic disease with sulforaphane extracted from cabbage alone and together with immune suppressant drug (MTX) by study the activity of simple protein deacetylase accelerator (HDAC). (scirp.org)
  • The mouse Ehrlich ascites tumor cell line (EAT) and a human small-cell carcinoma line (GLC4) were incubated for 4 hr at 37 degrees C, with the cross-linking agent cis-diamino-dichloro platinum (cDDP). (nih.gov)
  • Administration of ruboxyl into healthy animals led to distinct increase in this ratio in mitochondria, while the drug normalized patterns of the O-(-)-SOD system in all the cell compartments studied in tumor-bearing animals. (msk.ru)
  • An Economical, Quantitative, and Robust Protocol for High-Throughput T Cell Receptor Sequencing from Tumor or Blood. (bioportfolio.com)
  • The T cell receptor repertoire provides a window to the cellular adaptive immune response within a tumor, and has the potential to identify specific and personalized biomarkers for tracking host respo. (bioportfolio.com)
  • Ehrlich-Lettre ascites carcinoma (EAC) is also known as Ehrlich cell. (wikipedia.org)
  • E. W. Haeffner, C. J. K. Hoffmann, M. Stoehr and H. Scherf, Cholesterol induced growth stimulation, cell aggregation and membrane properties of ascites tumor cells in culture, Cancer Res. (springer.com)
  • Ehrlich inner body - a round oxyphil body found in the red blood cell in case of hemocytolysis due to a specific blood poison. (thefreedictionary.com)
  • Lysis of autologous tumor cells by peripheral blood lymphocytes treated with interleukin 2 in patients with renal cell carcinoma. (biomedsearch.com)
  • Peripheral blood lymphocytes derived from patients with renal cell carcinoma were stimulated with interleukin 2 and tested in a 4-hour 51chromium-release cytotoxicity assay against autologous cultured tumor and myeloid K562 cells. (biomedsearch.com)
  • Since no significant correlation between the degree of cytotoxicity and the pathological findings of tumor stage, grade, cell type or lymphocyte infiltration in the tumor was found, it was impossible to predict from the pathological findings which tumor could be lysed by peripheral blood lymphocytes treated with interleukin 2. (biomedsearch.com)
  • Our results demonstrate that adoptive immunotherapy with peripheral blood lymphocytes activated by interleukin 2 in patients with renal cell carcinoma could be appropriate as a therapeutic procedure. (biomedsearch.com)
  • Renal cell carcinoma (RCC) is a tumor whose past is filled with failed treatments and unpreventable patient death. (springer.com)
  • In this chapter, we discuss one of the newest discoveries in RCC tumor immunology: T-cell coinhibition. (springer.com)
  • This chapter will first introduce key concepts of T-cell function and tumor immunology that are necessary for a good understanding of how coinhibition works. (springer.com)
  • HE-02 reduced Ehrlich tumor cell viability and peritumoral microvessels density. (mdpi.com)
  • This effect may not be limited to prostate cells in that potent anti-tumor effect of fenugreek are also seen in a panel of pancreatic and breast cancer cell lines. (b92.net)
  • Our findings suggest that one mechanism by which an increased number of immune suppressive Gr-1 + cells can induce T cell unresponsiveness or immune tolerance in tumor hosts could be through peroxynitrite production upon primary T cell activation. (jimmunol.org)
  • These studies indicate that progressive tumor growth is associated with the down-regulation of T cell responses. (jimmunol.org)
  • The freshly drawn fluid was diluted with ice-cold normal saline (0.9 %) and tumor cell number was adjusted to 2x10 6 cells/ml for inoculation. (ispub.com)
  • All groups were treated with EAC ascetic carcinoma cell lines (0.2 ml of 2x10 6 cells/mice) intraperitoneally except normal group. (ispub.com)
  • Furthermore, MT exhibited 5‑10 times higher cytotoxic activities against tumour cell lines HCT‑116, МСF‑7 and K‑562 than TR, but was less toxic than TR (LD50 of MT was 375 mg/kg, while LD50 for TR was 75 mg/kg). (spandidos-publications.com)
  • Structure-activity studies on gossypol in tumor cell lines," Anticancer Drugs, 11:209-216 (2000). (patentgenius.com)
  • This metastatic suppression was accompanied by a 91% reduction of viable circulating tumor cells ( P = 0.041), suggesting that S -allylmercaptocysteine prevents dissemination by decreasing tumor cell intravasation. (aacrjournals.org)
  • The differential diagnosis for cysts in the neck includes congenital neck masses, metastatic squamous cell carcinoma , acquired laryngoceles, and cystic schwannomas. (medscape.com)
  • Applying an alternating magnetic field of 50 Hz at the tumor site causes the nanoparticles to oscillate and pull the fibronectin proteins and integrins to the surface of the cell membrane. (thno.org)
  • Moderate coffee intake was associated with smaller invasive primary tumors and lower proportions of ER positive tumors compared with patients with low consumption. (greenmedinfo.com)
  • The cells of Ehrlich ascites (EACs) tumor were obtained from National Cancer Institute (Cairo, Egypt). (hindawi.com)
  • D. E. Brennemann, L. McGee and A. A. Spector, Cholesterol metabolism in the Ehrlich ascites tumor, Cancer Res. (springer.com)
  • In parallel experiments, an identical low-molecular-weight fraction that impairs the type II interferon induction in mice was isolated from the ascitic fluids of rats bearing AH-100B ascites tumor and from a human hepatoma case with advanced cancer metastatic to the peritoneal cavity. (aacrjournals.org)
  • 29 Even so, women who develop breast cancer while using HRT at the time of diagnosis have a similar prognosis in terms of type, size, or grade of tumor as that of nonusers. (glowm.com)
  • Cancer immunoediting: from immunosurveillance to tumor escape. (springermedizin.de)
  • There is epidemiologic evidence that high garlic consumption decreases the incidence of prostate cancer, and compounds isolated from garlic have been shown to have cancer-preventive and tumor-suppressive effects. (aacrjournals.org)
  • We used a newly established fluorescent orthotopic androgen-independent prostate cancer mouse model to assess the ability of S -allylmercaptocysteine to inhibit tumor growth and dissemination. (aacrjournals.org)
  • Despite the widespread presence of clinically insignificant tumors in elderly men, prostate cancer commonly has an aggressive phenotype that requires prompt intervention ( 2 ). (aacrjournals.org)
  • various strategies have been suggested to selectively target tumor cancer cells. (thno.org)
  • Murine models of cancer include transplantable models, spontaneous and autochthonous models, human tumor xenografts, orthotopic models, models of metastasis and transgenic tumor models. (sciepub.com)
  • Ehrlich carcinoma is one of the commonest transplantable tumors that appeared firstly as a spontaneous breast cancer in a female mouse, and then Ehrlich and Apolant in 1905 used it as an experimental tumor by transplanting tumor tissues subcutaneously from mouse to mouse. (sciepub.com)
  • Then, this tumor was converted to a tumor model which is suitable for qualitative and quantitative cancer researches. (sciepub.com)
  • The preparation of the anti-tumor substance is far superior in the anti-tumor activity to that of water-soluble fraction and has less inflammation-, feverand paincausing properties than any ones of prior art. (google.com)
  • While the preparations obtained by these methods are superior in their anti-tumor activity, they are not desirable in viewpoint of the form of preparation. (google.com)
  • All of the anti-tumor preparations prepared according 3,786,141 Patented Jan. 15, 1974 to the above processes come from water-soluble fractions of the cells of the Streptococci, and their anti-tumor activity is not sufficient as compared with that of PCB-45 which is a preparation of streptococcal cells. (google.com)
  • Conclusion: Novel strategies focused towards targeting drug substances specifically to brain tumor site would increase the therapeutic efficiency and reduce the toxicity of chemotherapeutics. (eurekaselect.com)
  • To achieve better therapeutic effect by immune modulating therapy, it is important to study the mechanisms of tumor-induced immune suppression. (jimmunol.org)
  • Despite the increasing knowledge about the molecular basis of tumor development, few advances have been reached in clinical therapy and diagnoses, which shows the importance of new drugs development for therapeutic and diagnosis purpose. (worldwidescience.org)
  • Therapeutic application of tryptanthrin-containing topical preparations in Chinese folk medicine ( 4 ) confirmed its potent anti-inflammatory action as well as anti-tumour and antimicrobial activities, particularly against mycobacteria and pathogenic protozoa, including malaria plasmodia ( 5 - 8 ). (spandidos-publications.com)
  • The high oncotic pressure in tumors is consistent with the elevated interstitial fluid pressure, and it contributes to the suboptimal delivery of large therapeutic agents to neoplastic cells. (aacrjournals.org)
  • Genome Medicine (2018) 10:42 Page 2 of 11 are diagnosed at an early stage , while the 5-year that the circulating tumor DNA (ctDNA) methylation of survival rate decreases to approximately 10% for another ten CpGs could also discriminate HCC patients advanced HCC patients . (deepdyve.com)
  • Therefore, these complexes could be used to reduce tumor growth and increase mean survival time with less toxicity than cisplatin. (bireme.br)
  • Unfortunately, androgen-independent tumor recurrence is almost ubiquitous, for which only palliative treatment is available, and even the newest docetaxel-based regimes confer only a 2.4-month survival advantage ( 3 ). (aacrjournals.org)
  • Also, the effect of 2-mercaptopyrimidine-5-carboxylic acid and S-analogy of pyrimidinic bases on oral epidermoid human carcinoma (KB) have been reported [ 10 , 11 ]. (hindawi.com)
  • To study the effect of ACD on the healing rate of full-thickness cutaneous wound in rats after cisplatin (CP) administration, and on a complicated wound process in Guerin's carcinoma-bearing rats after a CP course followed by tumor resection. (exp-oncology.com.ua)
  • The Iowa Women's Health Study found a longer duration of HRT was associated with increased risk of invasive carcinoma with a favorable histology, with a relative risk (RR) of 1.81 for HRT use of less than five years duration versus a RR of 2.65 for use longer than five years. (glowm.com)
  • Finally, we propose a model to explain why certain renal tumors are eliminated by the immune system and others are not. (springer.com)
  • Immune surveillance against a solid tumor fails because of immunological ignorance. (springer.com)
  • Tumor cells can escape from the attack by the immune system through various mechanisms, including immune evasion, immune suppression, or both. (jimmunol.org)
  • In addition, the tumors grow in an immune-competent host, making these models appropriate for the study of immune modulation and vaccine approaches [ 4 ] . (sciepub.com)
  • It was observed that TF/EGCG encapsulated PLGA nanoparticles (NPs) offered an up to ~7-fold dose advantage when compared with bulk TF/EGCG in terms of exerting its antiproliferative effects and also enhanced the anticancer potential of cisplatin (CDDP) in A549 (lung carcinoma), HeLa (cervical carcinoma), and THP-1 (acute monocytic leukemia) cells. (dovepress.com)
  • In our opinion, further evaluation on the biological effects of MT and its synthetic analogues could lead to safer and more effective anti‑tumour and anti‑tuberculosis agents than TR itself. (spandidos-publications.com)
  • Experimental tumors have nice importance for the needs of modeling, and one among the most typical is that the bacteriologist pathology tumor, that springs from a spontaneous murine exocrine gland carcinoma . (scirp.org)
  • Expression level of tumor/metastasis suppressive miRNAs in the WNT signaling associated medulloblastomas is likely to determine their response to treatment, and thus, these miRNAs would be important biomarkers for risk stratification within the WNT signaling associated medulloblastomas. (cancerjournal.net)