Carcinoma cell line. Medical search. Frequent questions

BACKGROUND: For first-line therapy options for advanced renal cell carcinoma (RCC), clinical trials have demonstrated similar efficacy for pazopanib and sunitinib as well as differing side-effect profiles, which may affect patient persistence in self-administration of these oral medications. (rti.org)
Pembrolizumab plus axitinib versus sunitinib monotherapy as first-line treatment of advanced renal cell carcinoma (KEYNOTE-426): extended follow-up from a randomised, open-label, phase 3 trial. (urotoday.com)
The first interim analysis of the KEYNOTE-426 study showed superior efficacy of pembrolizumab plus axitinib over sunitinib monotherapy in treatment-naive, advanced renal cell carcinoma. (urotoday.com)
The exploratory analysis with extended follow-up reported here aims to assess long-term efficacy and safety of pembrolizumab plus axitinib versus sunitinib monotherapy in patients with advanced renal cell carcinoma. (urotoday.com)
In the ongoing, randomised, open-label, phase 3 KEYNOTE-426 study, adults (≥18 years old) with treatment-naive, advanced renal cell carcinoma with clear cell histology were enrolled in 129 sites (hospitals and cancer centres) across 16 countries. (urotoday.com)
Randomisation was done using an interactive voice response system or integrated web response system, and was stratified by International Metastatic Renal Cell Carcinoma Database Consortium risk status and geographical region. (urotoday.com)
These results continue to support the first-line treatment with pembrolizumab plus axitinib as the standard of care of advanced renal cell carcinoma. (urotoday.com)
In a phase II trial (KEYNOTE-B61) reported in The Lancet Oncology , Laurence Albiges, MD, PhD , of Gustave Roussy, Paris-Saclay University, Villejuif, France, and colleagues found that first-line pembrolizumab plus lenvatinib produced durable responses in patients with advanced non-clear cell renal cell carcinoma. (ascopost.com)
As stated by the investigators: "Immunotherapy-based combinations including pembrolizumab plus lenvatinib are the standard of care for patients with first-line clear-cell renal cell carcinoma, but these combinations are not well characterized in non-clear cell renal cell carcinoma. (ascopost.com)
Pembrolizumab plus lenvatinib produced an objective response in 49% of patients with advanced non-clear cell renal cell carcinoma. (ascopost.com)
The investigators concluded: "Pembrolizumab plus lenvatinib has durable antitumour activity in patients with previously untreated advanced non-clear cell renal cell carcinoma, with a safety profile consistent with that of previous studies. (ascopost.com)
Background/Aim: The combination of bevacizumab (BEV) plus interferon alpha-2a (IFN) constitutes an option for first-line treatment of metastatic renal cell carcinoma. (iiarjournals.org)
Renal cell carcinoma (RCC) has been predicted to occur in 9,900 men and 5,200 women in Germany for the year 2018, whereas in 2015, 3,306 deaths from renal carcinoma in men and 2,106 in women were documented by the German Robert Koch Institute ( 1 ). (iiarjournals.org)
among these, about 80% are clear cell renal carcinomas histologically ( 2 ). (iiarjournals.org)
Kaempferol has been shown to inhibit cell growth, induce apoptosis and cell cycle arrest in several tumors, but not in renal cell carcinoma (RCC). (nih.gov)
This study is being performed as a single-arm open-label study in order to rapidly provide information on the potential benefits of the combination of pembrolizumab and lenvatinib in participants with previously untreated advanced/metastatic non-clear cell renal cell carcinoma. (survivornet.com)
The therapeutic approach to renal cell carcinoma (RCC) is guided by the probability of cure, which is related directly to the stage or degree of tumor dissemination. (medscape.com)
Go to Renal Cell Carcinoma Treatment Protocols , Clear Cell Renal Cell Carcinoma , and Sarcomatoid and Rhabdoid Renal Cell Carcinoma for complete information on these topics. (medscape.com)
To view a multidisciplinary tumor board case discussion, see Memorial Sloan Kettering e-Tumor Boards: Metastatic Clear Cell Renal Cell Carcinoma . (medscape.com)
Surgical resection remains the only known effective treatment for localized renal cell carcinoma, and it also is used for palliation in metastatic disease. (medscape.com)
CAMBRIDGE, Mass.--( BUSINESS WIRE )--AVEO Oncology (NASDAQ:AVEO) today announced that the first patient has been dosed in the Company's pivotal TIVO-3 trial, a randomized, controlled, multi-center, open-label study to compare tivozanib to sorafenib in subjects with refractory advanced renal cell carcinoma (RCC). (businesswire.com)
Tivozanib has been investigated in several tumors types, including renal cell, colorectal and breast cancers. (businesswire.com)
The company is focused on developing and commercializing its lead candidate tivozanib, a potent, selective, long half-life inhibitor of vascular endothelial growth factor 1, 2 and 3 receptors, in North America as a treatment for renal cell carcinoma and other cancers. (businesswire.com)
We hypothesised that alternating inhibitors of the vascular endothelial growth factor receptor (VEGFR) and mammalian target of rapamycin pathways would delay the development of resistance in advanced renal cell carcinoma (aRCC). (edu.au)
Results of the phase I/II RAPPORT trial demonstrate the feasibility of stereotactic ablative body radiotherapy followed by pembrolizumab as a treatment modality for patients with oligometastatic clear cell renal cell carcinoma. (congressupdateoncology.be)
Stereotactic ablative body radiotherapy (SABR) is a treatment option for patients with oligometastatic clear cell renal cell carcinoma (ccRCC), however, patients often experience distant progression. (congressupdateoncology.be)
Renal cell carcinoma is one of the ten most commonly diagnosed cancers in the world. (oncovestnik.ru)
A randomized phase III study METEOR evaluated the efficacy of cabozantinib versus everolimus in patients with renal cell carcinoma that progressed after anti-VEGFR therapy with targeted drugs. (oncovestnik.ru)
A clinical case of a 32-year-old patient with metastatic renal cell carcinoma is presented. (oncovestnik.ru)
Renal cell carcinoma, sarcomatoid subtype, was morphologically established. (oncovestnik.ru)
The given clinical observation demonstrates a patient with one of the most unfavorable variants of renal cell carcinoma ― sarcomatoid subtype. (oncovestnik.ru)
Renal cell carcinoma is an immunogenic tumor, and spontaneous regressions have been documented. (medscape.com)
Surgical resection is recommended in selected patients with metastatic renal carcinoma. (medscape.com)
The study also revealed increased risk of death due to renal cell carcinoma in patients who did not undergo surgical resection of metastasis. (medscape.com)
[ 18 ] A study by Alt et al found that complete resection of multiple renal cell carcinoma metastases may be associated with long-term survival. (medscape.com)
The treatment of metastatic renal cell carcinoma is problematic, and, whenever possible, patients should be directed to approved and controlled clinical trials. (medscape.com)
This applies as well in the adjuvant treatment of surgically resected renal cell carcinoma, for which no therapy has yet been found to offer survival benefit. (medscape.com)

The Hep G2 cell line has been isolated from a liver biopsy of a male Caucasian aged 15 years, with a well differentiated hepatocellular carcinoma. (sigmaaldrich.com)
Sarcomatoid hepatocellular carcinoma (SHC) is a rare type of HCC with significantly poorer survival than ordinary HCC. (nycu.edu.tw)
In this study, we aimed at characterizing extracellular transcriptome gene networks of hepatocellular carcinoma patients compared to healthy controls. (frontiersin.org)
Our analysis revealed a number of genes previously associated with hepatocellular carcinoma and uncovered their association network in the blood. (frontiersin.org)
Our study thus demonstrates the feasibility of performing gene co-expression network analysis from cell-free RNA data and its utility in studying hepatocellular carcinoma. (frontiersin.org)
Four different human cell lines: HCT-15 (colorectal adenocarcinoma), PLC/PRF/5 (hepatocellular carcinoma), HeLa (adenocarcinoma) and Chang (likely derived from HeLa cells) cells, were exposed to 30 uM cadmium chloride for time intervals up to 24-hours and the expression level of eIF4E was determined by Western blot analysis using an antibody against human eIF4E. (cdc.gov)
ABSTRACT The study's objective was to evaluate the clinical significance of sCD40L in HCV- associated hepatocellular carcinoma (HCV-HCC) patients. (who.int)

However, there is limited information on the function of circRNA in oral squamous cell carcinoma (OSCC). (hindawi.com)
Oral squamous cell carcinoma (OSCC) is the third most common cancer in developing countries and ranks sixth among systemic cancers worldwide [ 1 , 2 ]. (hindawi.com)
The 13 homeobox genes were analyzed because previous studies done by our laboratory observed differences in expression of these homeobox genes when comparing atRA sensitive oral squamous carcinoma cells (SCC) to atRA resistant oral squamous cell carcinoma cells. (temple.edu)
Retinoid-induced suppression of squamous cell differentiation in human oral squamous cell carcinoma xenografts (line 1483) in athymic nude mice. (tamu.edu)

Adrenocortical carcinoma is remarkable for the many hormonal syndromes that can occur in patients with steroid hormone-producing ("functional") tumors, including Cushing's syndrome, Conn syndrome, virilization, and feminization. (wikipedia.org)
Expression of the h19 gene is markedly reduced in both nonfunctioning and functioning adrenal cortical carcinomas, especially in tumors producing cortisol and aldosterone. (wikipedia.org)
Almost all the rest of anal cancers are tumors that start in cells lining the area between the anus and rectum. (medlineplus.gov)
Hepatic carcinomas are among the most common malignant tumors in China, and cause serious threat to individuals' health ( 1 ). (spandidos-publications.com)
The fatality rate of Hepatic carcinoma ranks second among malignant tumors. (spandidos-publications.com)
This cell line may represent a useful model to investigate the significance of the K-ras gene product for the pathogenesis of human tumors. (johnshopkins.edu)
Mutation signatures, genes with SNA or CNA of CSEC216 and published ESCC cell lines were similar with the mutation spectrum of original ESCC tumors. (biomedcentral.com)
The current study also reported the genomic similarity of 28 ESCC cell lines and original ESCC tumors. (biomedcentral.com)
Apocrine ductal carcinoma in situ (ACDIS) is a very rare breast carcinoma which is regarded as a variant of the ductal carcinoma in situ breast tumors. (wikipedia.org)
ACDIS tumors have microscopic histopathology features that are similar to pure apocrine carcinoma of the breast tumors but differ from them in that they are completely localized, i.e. have not invaded nearby tissues or metastasized to distant tissues. (wikipedia.org)

Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent malignancies and a major cause of cancer related death worldwide, especially in China. (biomedcentral.com)
There are abundant esophageal squamous cell carcinoma (ESCC) cell lines around the world. (biomedcentral.com)
Esophageal cancer, also called esophagus cancer, begins in the cells that line the esophagus. (cancer.net)
This type of esophageal cancer starts in squamous cells that line the esophagus. (cancer.net)
These include small cell neuroendocrine cancers , lymphomas , and sarcoma and make up less than 1% of esophageal cancers. (cancer.net)

Mutation of the VHL tumor suppressor gene is observed in up to 80% in clear cell kidney cancers, leading to increased rates of VEGF secretion in RCC ( 11 ), thus being a promising candidate for VEGF-targeted therapy. (iiarjournals.org)
Cloacogenic carcinoma looks different than squamous cell cancers, but behaves similarly and is treated the same. (medlineplus.gov)
These same cells line the inside of the ureters and the urethra, and cancers can form in those places as well. (mayoclinic.org)
Some bladder cancers include more than one type of cell. (mayoclinic.org)
The overall pattern of copy number change was strikingly similar between cell lines and primary cancers with a few obvious exceptions such as loss of chromosome 6 and gain of chromosomes 15 and 12p in the former. (ox.ac.uk)
For example, loss of chromosome 8p was a common event in CIN+ cell lines and cancers but was often found to be gained in MSI+ cancers. (ox.ac.uk)

Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line. (jci.org)
A human ovarian small cell carcinoma line (BIN-67) expresses abundant calcitonin (CT) receptors (CTR) (143,000 per cell) that are coupled, to adenylate cyclase. (jci.org)
In this study, the new epithelial ovarian cancer cell line CAISMOV24 was described and compared with its original low-grade serous ovarian carcinoma. (biomedcentral.com)
The in vitro culture was established with cells isolated from ascites of a 60-year-old female patient with recurrent ovarian cancer. (biomedcentral.com)
The CAISMOV24 line was assessed for cell growth, production of soluble biomarkers, expression of surface molecules and screened for typical mutations found in serous ovarian carcinoma. (biomedcentral.com)
Our results corroborate with the idea that genomic alterations, depicted by CNVs, can be used for subtyping epithelial ovarian carcinomas. (biomedcentral.com)
Additionally, CAISMOV24 cell line was characterized as a low-grade serous ovarian carcinoma, which still resembles its primary malignant cells. (biomedcentral.com)
We have recently reported that ascitic cells from a human ovarian carcinoma have a 10- to 20-fold K-ras amplification and that the level of such amplification did not change over a 9-month period during which the patient received chemotherapy and underwent clinical progression. (johnshopkins.edu)
Here we describe an ovarian tumor cell line (HOC-8) which has been derived from that tumor and which also shows a similar level of K-ras amplification. (johnshopkins.edu)
All-trans retinoic acid (atRA) mediated growth inhibition results in the arrest of the cell cycle during the G1 phase in CAOV3 cells but not SKOV3 ovarian carcinoma cells. (temple.edu)
Nevertheless, these results show that p16 plays a role in atRA mediated growth inhibition in ovarian carcinoma cells and that modulation of p16 expression can determine the growth response to atRA. (temple.edu)
Of the 13 homeobox genes analyzed in the ovarian carcinoma cell model system, we found HOXA1 and HOXB4 to be upregulated by atRA in CAOV3 cells but not in SKOV3 cells. (temple.edu)
Establishment of a human ovarian clear cell carcinoma cell line (RMG-I) and its single cell cloning--with special reference to the stem cell of the tumor. (elsevierpure.com)
A cell line, designated RMG-I, has been established from ascites of a patient with ovarian clear cell carcinoma. (elsevierpure.com)
Thus, the RMG-I cell line was identified to be an ovarian clear cell carcinoma. (elsevierpure.com)

The spontaneous immortalization of primary malignant cells is frequently assigned to their genetic instability during in vitro culturing. (biomedcentral.com)
Additionally, comparative genomic hybridization was employed to compare genomic alterations between the CAISMOV24 cell line and its primary malignant cells. (biomedcentral.com)
The cell surface molecules EpCAM, PVR and CD73 are overexpressed on CAISMOV24 cells compared to the primary malignant cells. (biomedcentral.com)
Although the cell line had developed alongside the accumulation of genomic alterations (28 CNV in primary cells and 37 CNV in CAISMOV24), most of them were related to CNVs already present in primary malignant cells. (biomedcentral.com)
Its lethality is a consequence of the lack of symptoms or biomarkers enabling the early diagnosis of disease, and the propensity of malignant cells to seed the peritoneal cavity. (biomedcentral.com)
However, cell lines are known for their susceptibility to genetic and metabolic alterations, which can alter their characteristics in relation to the primary malignant cells. (biomedcentral.com)
Ideally, the more a cell line resembles the primary malignant cells, the more useful it will be for scientific research. (biomedcentral.com)
Male breast cancer is a disease in which malignant (cancer) cells form in the tissues of the breast. (cancer.gov)
Objective: Clear cell odontogenic carcinoma (CCOC) is a rare malignant odontogenic tumor (MOT) characterized by sheets and lobules of vacuolated and clear cells. (tokushima-u.ac.jp)
A human breast cancer cell line that was derived in 1973 from the MALIGNANT PLEURAL EFFUSION of a patient with stage III BREAST CARCINOMA and was characterized as being of breast cancer origin. (bvsalud.org)

CSEC216 was an uncontaminated cell line, exhibited epithelial cell features with polygonal morphology and adherent growth as monolayer. (biomedcentral.com)
These cell lines include a lung adenocarcinoma (A549), a non small cell lung carcinoma cell line (DLKP), normal bronchial epithelial cell line (NHBE), a breast adenocarcinoma (MCF-7) and human mammary epithelial cells (HMEC). (dcu.ie)

A549-Dual™ cells are adherent epithelial cells that have been derived from the human A549 lung carcinoma cell line by stable integration of two inducible reporter constructs. (invivogen.com)
The A549 cell line is a well-characterized cellular model for asthma, allergies and respiratory infections. (invivogen.com)
A549-Dual™ cells express a secreted embryonic alkaline phosphatase (SEAP) reporter gene under the control of the IFN-β minimal promoter fused to five NF-κB binding sites. (invivogen.com)
A549-Dual™ cells also express the Lucia luciferase gene, which encodes a secreted luciferase, under the control of an ISG54 minimal promoter in conjunction with five IFN-stimulated response elements. (invivogen.com)
As a result, A549-Dual™ cells allow to simultaneously study the NF-κB pathway , by assessing the activity of SEAP, and the interferon regulatory factor (IRF) pathway , by monitoring the activity of Lucia luciferase. (invivogen.com)
Stimulation of A549-Dual™ cells with the following PAMPs, Pam3CSK4 (TLR2 ligand, 300 ng/ml) Poly(I:C) (TLR3 ligand, 3 µg/ml ), FLA-ST Ultrapure (TLR5, 300 ng/ml), leads to the activation of NF-κB. (invivogen.com)
Stimulation of A549-Dual™ cells with RLR ligands, such as transfected poly(I:C) (100 ng/ml), 5'ppp-dsRNA (1 µg/ml) or poly(dA:dT) (100 ng/ml) triggers the IRF pathway. (invivogen.com)
The STING agonist 2'3'-cGAMP (30 µg/ml) leads to low-level IRF induction in A549-Dual™ cells. (invivogen.com)
For each lot, proper activation of the NF-κB pathway and IRF pathway is confirmed upon stimulation of A549-Dual™ cells by various pathogen associated molecular patterns (PAMPs) known to activate these pathways. (invivogen.com)
Stimulation of A549-Dual™ cells with the following PAMPs, Pam3CSK4 (TLR2) Poly(I:C) (TLR3), flagellin (TLR5), leads to the activation of NF-kB. (invivogen.com)

Invasive ductal carcinoma. (cdc.gov)
Ductal carcinoma in situ (DCIS) is a breast disease that may lead to invasive breast cancer. (cdc.gov)

If you have non-small-cell lung cancer (NSCLC), your disease began with changes to your genes. (webmd.com)
These changes, called "mutations," cause your lung cells to grow out of control. (webmd.com)
The cancer begins in squamous cells, the flat cells that line the inside of the lung airways. (webmd.com)
Here the proteomic alterations induced by IC8o 5-FU treatment of normal and cancer cells of epithelial origin of the lung and breast are investigated. (dcu.ie)
No significant differences were found in the survival from tumours largely refractive to therapy, e.g., carcinomas of the pancreas, lung and liver. (who.int)

This tumor expressed the fusion gene EWSR1-ATF1, which underlies the etiology of hyalinizing clear cell carcinoma (HCCC) and potentially that of CCOC. (tokushima-u.ac.jp)

Invasive lobular carcinoma (ILC) of the breast typically presents with clinical biomarkers consistent with a favorable response to endocrine therapies, and over 90 % of ILC cases express the estrogen receptor (ER). (nih.gov)
Lobular carcinoma in situ (abnormal cells found in one of the lobes or sections of the breast), which sometimes occurs in women, has not been seen in men. (cancer.gov)

Urothelial carcinoma. (mayoclinic.org)
Urothelial carcinoma, previously called transitional cell carcinoma, occurs in the cells that line the inside of the bladder. (mayoclinic.org)
Urothelial carcinoma is the most common type of bladder cancer in the United States. (mayoclinic.org)
I've spent my career specializing in the care of patients with metastatic urothelial carcinoma and understand the need for new treatments for this disease," said Arlene O. Siefker-Radtke, M.D., professor of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, and lead study investigator. (jnj.com)
BALVERSA is an important new therapy for this small subset of patients with urothelial carcinoma who, up until now, had limited treatment options. (jnj.com)

chemotherapy as second-line therapy for advanced oesophageal squamous cell carcinoma: a systematic review and economic evaluation. (bvsalud.org)
Recently, several novel programmed cell death protein 1 (PD-1) inhibitors have been approved for second-line treating advanced or metastatic oesophageal squamous cell carcinoma (OSCC), including camrelizumab, nivolumab , pembrolizumab, sintilimab and tislelizumab. (bvsalud.org)
The study investigated the use of a "pill-on-a-string" encapsulated sponge to collect cells from the lining of the oesophagus, in a region of East Africa with high rates of oesophageal squamous cell carcinoma. (who.int)
Now, for the first time, the Cytosponge device has been used in a Tanzanian community setting as part of the Oesophageal Squamous Cell Carcinoma African Prevention Research (ESCCAPE) project. (who.int)

In conclusion, acetone and methanol extracts from C. odontophyllum stem bark exhibited promising cytotoxic activity against human colorectal cancer cell line HCT 116 and paves way for further investigation in view of its mode of cancer cell death. (scirp.org)
All these treatment options are approximately comparable in terms of progression-free survival (PFS) and can be used under the premise of favorable to moderate prognosis according to the Memorial Sloan-Kettering Cancer Center (MKSCC)-criteria for first-line therapy of advanced or metastatic RCC. (iiarjournals.org)
Adrenocortical carcinoma (ACC) is an aggressive cancer originating in the cortex (steroid hormone-producing tissue) of the adrenal gland. (wikipedia.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Finally, we measured anchorage-independent cell growth, a characteristic cancer feature, by soft-agar colony formation assay. (oncotarget.com)
Here we show that methanolic extracts of Sapota fruit (MESF) induces cytotoxicity in a dose-dependent manner in cancer cell lines. (nature.com)
Annexin V-propidium iodide double-staining demonstrated that Sapota fruit extracts potentiate apoptosis rather than necrosis in cancer cells. (nature.com)
In a preliminary study it has been shown that phenolic antioxidants such as methyl 4- O -galloylchlorogenate and 4- O -galloylchlorogenic acid derived from Sapota fruits can induce cytotoxicity in colon cancer cells 23 . (nature.com)
Successive assays revealed that some compounds were endowed with a promising anti-proliferative effect against HCT116 cells, alone or stimulated by serotonin as a pro-inflammatory factor in order to mimick an inflamed model of cancer cell microenvironment. (amrita.edu)
Hepatoma cell lines (SUN449), hepatoblastoma cell line (HepG2, Huh‑6), liver cancer cell line (HepG2) and transformed human liver epithelial‑2 cells (THLE‑2) were used in the present study. (spandidos-publications.com)
For instance, Deng et al ( 8 ) compared 66 pairs of hepatic carcinoma tissues and normal tissues and found that CCAT1 expression was increased in liver cancer tissues, and that the degree of upregulation was associated with tumor size, vascular invasion and serum alpha-fetoprotein level. (spandidos-publications.com)
Patients in Europe with MSI-H/dMMR colorectal cancer have had only chemotherapy-containing regimens available to them in the first-line treatment setting and have historically faced poor outcomes," said Dr. Vicki Goodman, vice president, clinical research, Merck Research Laboratories. (merck.com)
Microsatellite instability (or MSI) is defined by the National Cancer Institute as a change that occurs in the DNA of certain cells, such as tumor cells, in which the number of repeats of microsatellites (short, repeated sequences of DNA) is different from the number of repeats that was in the DNA when it was inherited. (merck.com)
Colorectal cancer often begins with growths on the inner lining of the colon or rectum called polyps, which can change into cancer over time. (merck.com)
Bladder cancer is a common type of cancer that begins in the cells of the bladder. (mayoclinic.org)
Bladder cancer most often begins in the cells (urothelial cells) that line the inside of your bladder. (mayoclinic.org)
Bladder cancer begins when cells in the bladder develop changes (mutations) in their DNA. (mayoclinic.org)
The type of bladder cell where cancer begins determines the type of bladder cancer. (mayoclinic.org)
Squamous cell bladder cancer is rare in the United States. (mayoclinic.org)
These harmful chemicals may damage the lining of your bladder, which can increase your risk of cancer. (mayoclinic.org)
Chronic or repeated urinary infections or inflammations (cystitis), such as might happen with long-term use of a urinary catheter, may increase the risk of a squamous cell bladder cancer. (mayoclinic.org)
Here, we established a mouse liver cancer cell line and designated as Ymac-1. (nycu.edu.tw)
If cancer is found, tests are done to study the cancer cells. (cancer.gov)
Sustainable and uncontaminated cancer cell lines provide available resources for researchers to utilize. (biomedcentral.com)
Breast cancer is a disease in which cells in the breast grow out of control. (cdc.gov)
The kind of breast cancer depends on which cells in the breast turn into cancer. (cdc.gov)
The cancer cells begin in the ducts and then grow outside the ducts into other parts of the breast tissue. (cdc.gov)
Invasive cancer cells can also spread, or metastasize, to other parts of the body. (cdc.gov)
Cancer cells begin in the lobules and then spread from the lobules to the breast tissues that are close by. (cdc.gov)
The cancer cells are only in the lining of the ducts and have not spread to other tissues in the breast. (cdc.gov)
Cancer begins when healthy cells change and grow out of control, forming a mass called a tumor. (cancer.net)
Apocrine carcinoma is a very rare form of female breast cancer. (wikipedia.org)
Adherence was altered in one of the three cancer cell lines to the extracellular matrix proteins collagen type IV and fibronectin. (dcu.ie)
Liquid biopsy represents a promising alternative to invasive tissue biopsies in particular for cancer diagnosis as it enables the study of cell-free (cf) nucleic acids in the blood, which includes cfDNA and various cfRNAs (e.g., protein-coding, lncRNA, microRNA, etc. (frontiersin.org)
Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
Array comparative genomic hybridization analysis of colorectal cancer cell lines and primary carcinomas. (ox.ac.uk)
Array comparative genomic hybridization, with a genome-wide resolution of approximately 1 Mb, has been used to investigate copy number changes in 48 colorectal cancer (CRC) cell lines and 37 primary CRCs. (ox.ac.uk)
Squamous cell carcinoma, which means the cancer develops in the squamous cells that line the inside of the mouth or throat, is by far the most common type of oral cancer. (msdmanuals.com)
Melanoma Melanoma is a skin cancer that begins in the pigment-producing cells of the skin (melanocytes). (msdmanuals.com)
Human Papillomavirus (HPV) Infection Human papillomavirus (HPV) can be sexually transmitted and causes changes in cells, which can lead to genital warts or to precancer or cancer of the cervix, vagina, vulva, anus, or throat. (msdmanuals.com)

HeLa cells expressing Myc-GnT1IP-L (Myc-tagged GlcNAcT-1 inhibitory protein, long transcript, membrane-anchored) (red) and GlcNAcT-1-HA (green) were treated with cycloheximide and brefeldin A to cause retrograde transport of Golgi enzymes into the ER. (cellimagelibrary.org)
Transfected HeLa cells were fixed in 3% paraformaldehyde, blocked with 0.2% Triton X-100, 1% FBS, 0.5% BSA in PBS with Ca[2+] and Mg[2+], followed by incubation in primary antibodies (anti-Myc mouse mAb, 9E10 (Covance) and anti-HA mouse mAb, HA.11 (Covance)) and secondary antibodies (Alexa 568 and Alexa 488) and DAPI (blue) to stain nuclei. (cellimagelibrary.org)
Distribution of Nup133 (a component of the Nup107-160 nucleoporin complex, red) and CENP-B (kinetochores, green) in dividing Hela cells. (ucsd.edu)
Cultured HeLa cells were permeabilized, fixed with methanol at -20C for 10 min and processed for immunofluorescence microscopy and recorded using a Zeiss Axioskop microscope. (ucsd.edu)
The first continuous cell line Hela, was established in 1952 (7). (biomedcentral.com)
reported that many cell lines had been switched or cross-contaminated with Hela cells. (biomedcentral.com)

The cells will respond to stimulation with human growth hormone. (sigmaaldrich.com)
Hep G2 cell line human has been used to study the cytotoxicity of carbon monoxide-releasing molecules and organic solvents on HepG2 cells and to evaluate the antiproliferative activity of aqueous extracellular polysaccharides (AEPS) for HepG2 using the MTT colorimetric assay. (sigmaaldrich.com)
The dissociation constants (Kd) for the CTRs on these BIN-67 cells is approximately 0.42 nM for salmon CT and approximately 4.6 nM for human CT. (jci.org)
Transfection of this cDNA into COS cells resulted in expression of receptors with high affinity for salmon CT (Kd = approximately 0.44 nM) and for human CT (Kd = approximately 5.4 nM). (jci.org)
Moreover, the results clearly showed that kaempferol causes a strong inhibition of the activation of the EGFR/p38 signaling pathways, upregulation of p21 expression and downregulation of cyclin B1 expression in human RCC cells, together with activation of PARP cleavages, induction of apoptotic death and inhibition of cell growth. (nih.gov)
Cell Line Data Base: structure and recent improvements towards molecular authentication of human cell lines. (hsanmartino.it)
In a human prostate carcinoma cell line, small interfering RNA (siRNA)-mediated knockdown of USP9X reduced IGF-IR as well as IRS-2 protein levels and increased their ubiquitination. (oncotarget.com)
Synthesis and biological evaluation of new 3(2)-pyridazinone derivatives as non-toxic anti-proliferative compounds against human colon carcinoma HCT116 cells. (amrita.edu)
Hsa_circ_001242 expression levels were significantly downregulated in four OSCC cell lines (SCC-9, SCC-15, SCC25, and CAL-27) than in human normal oral keratinocyte (HOK) cell lines. (hindawi.com)
Human cell lines are now widely used in laboratories worldwide. (biomedcentral.com)
The present study analyzed the effect of adenovirus on bacterial adherence to human respiratory tract epithelial cells. (lu.se)
In the past biennium, working groups have concluded that there is sufficient evidence to classify infection with human immunodeficiency virus (HIV-1), human T-cell lymphotropic virus (HTLV-1), Epstein-Barr virus (EBV) and the Kaposi sarcoma-associated herpesvirus 8 as carcinogenic to humans (IARC 0RQRJUDSKV, Vol. 67 and 70). (who.int)
Anatomically accurate, 3-dimensional computational fluid dy- on major airflow patterns, air-phase diffusion, and absorption namics models of F344 rat, rhesus monkey, and human nasal at the air-lining interface. (cdc.gov)

MTT assay and colony formation assay were used to study cell growth, and flow cytometry was used to study apoptosis and cell cycles in different RCC cells treated with various doses of kaempferol. (nih.gov)
A significant inhibition on cell growth, induction of apoptosis and cell cycle arrest were observed in 786-O and 769-P cells after kaempferol treatment compared with the control group. (nih.gov)
Cell cycle analysis suggested activation of apoptosis, without arresting cell cycle progression. (nature.com)
Cell Counting Kit‑8 assay and flow cytometry were undertaken to measure proliferation and apoptosis. (spandidos-publications.com)
shlncRNA XIST attenuated cell proliferation, invasion and migration, while increasing the apoptosis of hepatic carcinoma cells. (spandidos-publications.com)
The miR‑320a mimic and PIK3CA inhibitor could recover the effect of oe‑lncRNA in terms of the proliferation, invasion, migration and apoptosis of hepatic carcinoma cells. (spandidos-publications.com)
Long non-coding (lnc)RNAs play important roles in the development, differentiation, proliferation and apoptosis of cells ( 6 , 7 ). (spandidos-publications.com)
Traditionally, cell death has been divided into apoptosis and necrosis. (nature.com)
It does not have the morphological characteristics of typical necrosis, such as swelling of the cytoplasm and organelles and rupture of the cell membrane, nor does it have the characteristics of traditional cell apoptosis, such as cell shrinkage, chromatin condensation, formation of apoptotic bodies and disintegration of the cytoskeleton. (nature.com)

Genes are pieces of DNA inside each of your cells. (webmd.com)
Turn on" the genes that help your cells grow, divide, or stay alive. (webmd.com)
Turn off" the genes that make sure cells divide or die at the right time. (webmd.com)
The result of all these changes to your genes: Some cells become cancerous and grow out of control. (webmd.com)
Additionally, we also examined the effect of atRA treatment on the expression of homeobox genes in the CAOV3 cells and SKOV3 cells model system. (temple.edu)
In these studies we examined the expression of 13 homeobox genes in CAOV3 cells and SKOV3 cells following ethanol or atRA treatment. (temple.edu)
The genes in cells carry the hereditary information that is received from a person's parents. (cancer.gov)
This correlation indicates that linked genes are likely part of a shared regulatory mechanism in the cell. (frontiersin.org)

Results from KEYNOTE-B61 support the use of pembrolizumab plus lenvatinib as a first-line treatment option for these patients. (ascopost.com)
In consequence, actual treatment guidelines ( 12 ) recommend a targeted first-line therapy with VEGFR-inhibitors, like sunitinib ( 9 ), pazopanib ( 10 ), or bevacizumab plus immune stimulative IFN, for patients with advanced or metastatic RCC with low to intermediate risk [per Motzer- or MSKCC-Score ( 13 ) /IDMC score International Metastatic Database Consortium (IMDC) adverse risk factors] ( 8 ). (iiarjournals.org)
Eligible patients may also have received checkpoint inhibitor therapy in earlier lines of treatment. (businesswire.com)
A total of 69 patients with hepatic carcinoma were included. (spandidos-publications.com)
With advancements in research on various surgical and drug treatments, the 5-year survival rate of hepatic carcinoma patients has increased ( 3 ). (spandidos-publications.com)
The approval of Zynyz offers healthcare providers another first-line treatment option against MCC that can result in durable responses in patients with metastatic disease. (medscape.com)
Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)

The US Food and Drug Administration (FDA) has approved retifanlimab-dlwr (Zynyz), an intravenous programmed death receptor-1 (PD-1) inhibitor, for the treatment of adults with metastatic or recurrent locally advanced Merkel cell carcinoma (MCC), the agency announced . (medscape.com)

lncRNA XIST was highly expressed in hepatic carcinoma tissues and cells. (spandidos-publications.com)
Hsa_circ_001242 expression levels in 40 paired OSCC tissues and four OSCC cell lines were selected using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). (hindawi.com)
We first confirmed that hsa_circ_001242, which is located at chr10: 17157441-17168917 (Figure 1 ), was significantly downregulated in OSCC cell lines and OSCC tissues. (hindawi.com)

The ILC cell lines MDA-MB-134-VI, SUM44PE, and BCK4 were used to assess WNT4 gene expression and regulation, as well as the role of WNT4 in estrogen-regulated proliferation. (nih.gov)
Further, WNT4 was required for endocrine response in ILC cells, as WNT4 knockdown blocked estrogen-induced proliferation. (nih.gov)
ILC-LTED cells remained dependent on WNT4 for proliferation, by either maintaining ER function and WNT4 regulation or uncoupling WNT4 from ER and upregulating WNT4 expression. (nih.gov)
In ILC and ILC-LTED cells, WNT4 led to suppression of CDKN1A/p21, which is critical for ILC cell proliferation. (nih.gov)
Insulin-like growth factors (IGFs) have been shown to induce proliferation of many types of cells. (oncotarget.com)
Site-specificity of and cell proliferation would allow DPX and cell proliferation formaldehyde-induced lesions in rats and monkeys implicates data to be interpolated from measurement sites to the rest of the regional tissue susceptibility and dose as factors potentially nasal passage. (cdc.gov)

Established CCOC-T cells grew extremely slowly, but the cells showed highly invasive activity. (tokushima-u.ac.jp)

To address this issue, head and neck squamous carcinoma cells (line 1483) were established as xenografts in nude mice. (tamu.edu)
Furthermore, in order to clarify whether these 3 kinds of cells originate from one stem cell or not, monoclonal cell population were transplanted into nude mice, and its histological investigation revealed that 3 types of cells existed in the transplanted tumor, proving that they originate from one stem cell. (elsevierpure.com)

KEYTRUDA is an anti-PD-1 therapy that works by increasing the ability of the body's immune system to help detect and fight tumor cells. (merck.com)
KEYTRUDA is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2, thereby activating T lymphocytes which may affect both tumor cells and healthy cells. (merck.com)
Retinoid treatment produced a marked suppression of the squamous cell differentiation of tumor cells manifest by decreased keratinization, loss of stratification, and accumulation of basal cells. (tamu.edu)

Conclusion: Overall, efficacy and safety data from BEV plus IFN administered in routine clinical practice in an observational NIS are in line with results from the controlled phase III trials. (iiarjournals.org)

lncRNA XIST accelerates hepatic carcinoma progression by targeting the miR‑320a/PIK3CA axis, which might provide the theoretical basis for the potential targeted therapy of hepatic carcinomas. (spandidos-publications.com)
Against the background of the first line of targeted therapy with sunitinib, the progression of the disease was registered after three months ― multiple metastases to the lungs, peritoneal carcinomatosis, ascites, hydrothorax. (oncovestnik.ru)

Using ILC cell lines, we previously demonstrated that ER regulates a distinct gene expression program in ILC cells, and we hypothesized that these ER-driven pathways modulate the endocrine response in ILC. (nih.gov)
In contrast, IGF-II gene expression has been shown to be high in adrenal cortical carcinomas. (wikipedia.org)
Moreover, the gene expression profile of CCOC-T cells was examined by microarray analysis. (tokushima-u.ac.jp)

Formaldehyde-induced nasal squamous cell carcinomas in rats normally lined by squamous epithelium. (cdc.gov)

Must have a histologically-confirmed diagnosis of non-clear cell RCC. (survivornet.com)
Results: Histologically, the primary tumor was comprised of cords and nests containing clear and squamoid cells separated by fibrous septa. (tokushima-u.ac.jp)

Also, a loss occurs of activity of the p57kip2 gene product in virilizing adenomas and adrenal cortical carcinomas. (wikipedia.org)
Extrapulmonary small-cell carcinoma (SCC) is a rare neoplasm that shares certain features with its pulmonary counterpart and occurs predominantly in the gastrointestinal tract (GIT). (mdpi.com)
Ferroptosis is a new type of programmed cell death, which occurs with iron dependence. (nature.com)
Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines. (lu.se)

Adenocarcinoma begins in cells that make up mucus-secreting glands in the bladder. (mayoclinic.org)
Second-line and subsequent therapy may involve single agents (eg, taxanes) or molecular therapy, such as ramucirumab to target vascular endothelial growth factor (VEGF) receptor or trastuzumab for metastatic adenocarcinoma that overexpresses HER2. (medscape.com)

Cite this: FDA Approves New Merkel Cell Carcinoma Drug Zynyz - Medscape - Mar 22, 2023. (medscape.com)

The cells secrete a variety of major plasma proteins e.g. albumin, α2-macroglobulin, α 1-antitrypsin, transferrin and plasminogen. (sigmaaldrich.com)
Both reporter proteins are readily measurable in the cell culture supernatant when using QUANTI-Blue™ Solution , a SEAP detection reagent, and QUANTI-Luc™ 4 Lucia/Gaussia , a Lucia and Gaussia luciferase detection reagent. (invivogen.com)
Proteins were identified in the total cell lysates that suggest that DLKP-M is mesenchymal-like in nature as originally described and that the interconversion process observed between the clones is regulated at least by key proteins involved in protein metabolism. (dcu.ie)
Adherence was not affected by pretreatment of the cells with virus particles or viral proteins. (lu.se)

In vitro, retinoids decrease expression of differentiation markers in head and neck squamous carcinoma cells. (tamu.edu)
These studies demonstrate that retinoids do not universally decrease tumor growth but profoundly suppress squamous cell differentiation in vivo in this xenograft model. (tamu.edu)

The abnormal cells form a tumor that can invade and destroy normal body tissue. (mayoclinic.org)
In time, the abnormal cells can break away and spread (metastasize) through the body. (mayoclinic.org)

It's more likely to happen if you have the squamous carcinoma type of NSCLC. (webmd.com)

Histological analyses indicated the formation of well-differentiated squamous carcinoma cells exhibiting pronounced stratification (basal and suprabasal cells) and keratinization (keratin pearls) with abundant stroma. (tamu.edu)
Cytokeratin 19 expression was restricted to the basal cell layers, and cytokeratin 4 expression was abundant in suprabasal cells. (tamu.edu)

Anatomy23

Organisms7

Diseases67

Chemicals and Drugs81

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes50

Disciplines and Occupations1

Information Science3

Renal37

Hepatocellular7

Oral squamous cell carc4

Tumors10

Esophageal5

Cancers6

Ovarian15

Malignant10

Epithelial cell2

A54910

Ductal2

Lung5

Clear cell carc1

Lobular carcinoma2

Urothelial Carcinoma5

Oesophageal squamous4

Cancer40

HeLa6

Human13

Apoptosis9

Genes8

Patients7

Locally advanced1

Tissues3

Proliferation6

Invasive1

Nude mice2

Tumor Cells3

Clinical1

Progression2

Gene expression3

Epithelium1

Histologically2

Occurs4

Adenocarcinoma2

20231

Proteins4

Differentiation2

Abnormal cells2

NSCLC1

Abundant2