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  • epithelium
  • This early use of electrospun fibrous lattices for cell culture and tissue engineering showed that various cell types including Human Foreskin Fibroblasts (HFF), transformed Human Carcinoma (HEp-2), and Mink Lung Epithelium (MLE) would adhere to and proliferate upon the fibers. (wikipedia.org)
  • renal cell car
  • A report in Nature Medicine describes the creation of a new autochthonous mouse model of clear cell renal cell carcinoma (ccRCC) based on deletion of Vhl, Trp53, and Rb1. (rare-cancer.org)
  • The symptoms may be similar to those classically associated with renal cell carcinoma, and may include polycythemia, abdominal pain, hematuria and a palpable mass. (wikipedia.org)
  • found that intense and diffuse immunoreactivity for alpha-methylacyl-CoA racemase (AMACR) is useful in differentiating renal cell carcinoma from MA but a panel including AMACR, CK7 and CD57 is better in this differential diagnosis. (wikipedia.org)
  • proliferation
  • In urologic pathology, atypical small acinar proliferation, abbreviated ASAP, is a collection of small prostatic glands, on prostate biopsy, whose significance is uncertain and cannot be determined to be benign or malignant. (wikipedia.org)
  • As the natural extracellular matrix (ECM) is important in the survival, proliferation, differentiation and migration of the cells, different hydrogel matrices mimicking natural ECM structure are considered as potential approaches towards in vivo -like cell culturing. (wikipedia.org)
  • Thus, perlecan core protein and HS chains could modulate matrix assembly, cell proliferation, lipoprotein binding and cell adhesion. (wikipedia.org)
  • Perlecan is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. (wikipedia.org)
  • RTK-dependent p130Cas/BCAR1 tyrosine phosphorylation and the subsequent binding with specific downstream signaling molecule modulate cell processes such as actin cytoskeleton remodeling, cell adhesion, proliferation, migration, invasion and survival. (wikipedia.org)
  • They are integral regulators of essential cell signaling pathways affecting cell growth, proliferation, differentiation, and migration. (wikipedia.org)
  • epithelial cells
  • Results Non-neoplastic acinar cells were stained diffusely, but epithelial cells of the pancreatic duct and the islets of Langerhans were not stained. (bmj.com)
  • Carcinoma is a type of cancer that develops from epithelial cells. (wikipedia.org)
  • CUP), but that possess certain specific molecular, cellular, and histological characteristics typical of epithelial cells. (wikipedia.org)
  • It has been proposed that a cytologic smear primarily composed of acini rich in chronic inflammatory cells (lymphocytes, plasma cells), with rare ductal epithelial cells lacking atypia, favors the diagnosis of AIP. (wikipedia.org)
  • Two morphologic types have been described: the open type, extending slender apical processes to the ductal or acinar lumen, and the closed type cells, which lack lumenal protrusions but display dendrite-like processes that extend between adjacent epithelial cells. (wikipedia.org)
  • synaptophysin
  • In case 2, a low percentage of neoplastic cells expressed glucagon and synaptophysin. (nottingham.ac.uk)
  • Immunohistochemically, prostatic small cell carcinoma are positive for thyroid transcription factor 1 (TTF-1), CD56, chromogranin A, synaptophysin, neuron-specific enolase, calcitonin and bombesin/gastrin-releasing peptide, while lacking, or rarely and weakly expressing, androgen receptor and prostate-specific antigen. (wikipedia.org)
  • lung
  • Early studies suggested that patients with SCLC fared better when treated with chemotherapy and/or radiation than when treated surgically, while non-small cell lung carcinoma (NSCLC) patients generally did better after surgery, and usually did not respond well to chemoradiation. (wikipedia.org)
  • In the last two decades, however, the development of molecularly targeted agents have led to an increased emphasis on more precise typing and subtyping of lung carcinomas. (wikipedia.org)
  • BAC is a type of non-small-cell lung cancer (NSCLC). (wikipedia.org)
  • Like other forms of lung carcinoma, BAC possesses unique clinical and pathological features, prognosis, and responses to different treatments. (wikipedia.org)
  • metaplasia
  • Metaplasia is the replacement of one differentiated somatic cell type with another differentiated somatic cell type in the same tissue. (rare-cancer.org)
  • Universally, metaplasia is a precursor to low-grade dysplasia, which can culminate in high-grade dysplasia and carcinoma. (rare-cancer.org)
  • pancreatic cells
  • The death of pancreatic cells occurs via two main mechanisms: necrosis, which is less organized and more damaging, or apoptosis, which is more controlled. (wikipedia.org)
  • As part of the initial injury there is an extensive inflammatory response due to pancreatic cells synthesizing and secreting inflammatory mediators: primarily TNF-alpha and IL-1. (wikipedia.org)
  • Typically
  • They are thus not typically carcinomas. (wikipedia.org)
  • at the initial stages, typically, there is a cuff of lymphoplasma cells surrounding the ducts but also more diffuse infiltration in the lobular parenchyma. (wikipedia.org)
  • It was noted that as opposed to the flattened morphology typically seen in 2D culture, cells grown on the electrospun fibers exhibited a more histotypic rounded 3-dimensional morphology generally observed in vivo. (wikipedia.org)
  • differentiation
  • Nonmucinous BAC is thought to derive from a transformed cell in the distal airways and terminal respiratory units, and often shows features of club cell or Type II pneumocyte differentiation. (wikipedia.org)
  • tissue
  • Specifically, a carcinoma is a cancer that begins in a tissue that lines the inner or outer surfaces of the body, and that arises from cells originating in the endodermal, mesodermal and ectodermal germ layer during embryogenesis. (wikipedia.org)
  • This work focused on the importance of the extracellular matrix and the ability of cultures in artificial 3D matrices to produce physiologically relevant multicellular structures, such as acinar structures in healthy and cancerous breast tissue models. (wikipedia.org)
  • In living tissue, cells exist in 3D microenvironments with intricate cell-cell and cell-matrix interactions and complex transport dynamics for nutrients and cells. (wikipedia.org)
  • These matrices help the cells to be able to move within their spheroid similar to the way cells would move in living tissue. (wikipedia.org)
  • nucleoli
  • The cytologic features included small to moderate-sized loose groups with numerous single cells, prominent acinar formation, little anisonucleosis and prominent nucleoli. (ovid.com)
  • Cells are small with dark staining nuclei and inconspicuous nucleoli. (wikipedia.org)
  • liver
  • Once acinar cell cancer is established, patients should undergo an abdominal CT scan to verify the extent of disease, as well as a complete blood count and serum chemistries (including liver function tests and serum lipase). (knowcancer.com)
  • Chronic
  • The molecular mechanisms through which established risk factors, such as chronic pancreatitis, acinar cell damage, and/or defective autophagy increase the likelihood of PDAC development are poorly understood. (rare-cancer.org)
  • Autoimmune pancreatitis (AIP) is an increasingly recognized type of chronic pancreatitis that can be difficult to distinguish from pancreatic carcinoma but which responds to treatment with corticosteroids, particularly prednisone. (wikipedia.org)
  • predominant
  • The two types of acute pancreatitis are mild and severe, which are defined based on whether the predominant response to cell injury is inflammation (mild) or necrosis (severe). (wikipedia.org)
  • small
  • Medical Research Council comparative trial of surgery and radiotherapy for primary treatment of small-celled or oat-celled carcinoma of bronchus. (wikipedia.org)
  • Small cell carcinoma Cells are usually round and are less than approximately 3 times the diameter of a resting lymphocyte and little evident cytoplasm. (wikipedia.org)
  • Occasionally, small cell malignancies may themselves have significant components of slightly polygonal and/or spindle-shaped cells. (wikipedia.org)
  • These three-dimensional cultures are usually grown in bioreactors, small capsules in which the cells can grow into spheroids, or 3D cell colonies. (wikipedia.org)
  • typically
  • They are thus not typically carcinomas. (wikipedia.org)
  • at the initial stages, typically, there is a cuff of lymphoplasma cells surrounding the ducts but also more diffuse infiltration in the lobular parenchyma. (wikipedia.org)
  • It was noted that as opposed to the flattened morphology typically seen in 2D culture, cells grown on the electrospun fibers exhibited a more histotypic rounded 3-dimensional morphology generally observed in vivo. (wikipedia.org)