Loading...
  • Cardiac
  • Cardiac manifestations, also known as carcinoid heart disease (CaHD), are caused by endocardial deposition of pearly fibrotic plaques (notable for absence of elastic fibers) that generally extend to the right-sided valves, leading to multiple patterns of severe valve dysfunction. (onlinejacc.org)
  • liver
  • In an exploratory laparotomy, a 15 cm-size hepatic tumor was located in the right lobe with multiple satellite lesions in both lobes of the liver. (nagasaki-u.ac.jp)
  • patients
  • To evaluate the usefulness of methyl guanine methyltransferase (MGMT) status (by immunohistochemistry [IHC] and promoter methylation) for predicting response in pancreatic neuroendocrine tumor patients treated with either temozolomide or temozolomide and capecitabine. (clinicaltrials.gov)
  • cases
  • Carcinoid tumors are rare (2.5 to 5.0 cases per 100,000 of the population per year), slow-growing neuroendocrine malignancies with significant potential to produce hepatic metastases and release excessive amounts of vasoactive amines into the systemic circulation (1) . (onlinejacc.org)
  • benign
  • Carcinoids follow a more benign clinical course than most other malignancies. (medscape.com)
  • Carcinoid tumors are noncancerous ( benign ) or cancerous ( malignant ) growths that produce excessive amounts of hormonelike substances. (psyweb.com)
  • Carcinoid tumors, a subgroup of neuroendocrine tumors, are biologically different from other types of cancer and can be either malignant or benign. (fortherecordmag.com)
  • The fourth and fifth digits identify the specific location of the carcinoid tumor and whether it is malignant or benign. (fortherecordmag.com)
  • In 1907, Siegfried Obendorfer (1876-1944), a German pathologist at the University of Munich, coined the term karzinoide , or "carcinoma-like", to describe the unique feature of behaving like a benign tumor despite resembling a carcinoma microscopically [ 4 ]. (pubmedcentralcanada.ca)
  • This disease often runs in families and is characterized by many neurofibromas (benign tumors that form in nerves under the skin and in other parts of the body). (cancer.org)
  • The World Health Organization (WHO) classification scheme places neuroendocrine tumors into three main categories, which emphasize the tumor grade rather than the anatomical origin: well-differentiated neuroendocrine tumours, further subdivided into tumors with benign and those with uncertain behavior well-differentiated (low grade) neuroendocrine carcinomas with low-grade malignant behavior poorly differentiated (high grade) neuroendocrine carcinomas, which are the large cell neuroendocrine and small cell carcinomas. (wikipedia.org)
  • pancreas
  • However, it may be used for neuroendocrine tumors starting in the pancreas or aggressive fast-growing neuroendocrine tumors. (mdanderson.org)
  • Depending on the size of the tumor and whether it is growing into nearby tissues, other options include surgery to remove the tumor (local excision), removing all or part of the duodenum with nearby lymph nodes, and removing the duodenum and part of the pancreas (a pancreatoduodenectomy). (cancer.org)
  • These tumors can also start in the lungs (see Lung Carcinoid Tumor for more information) and the pancreas, and a small number develop in other organs. (cancer.org)
  • People with this syndrome have a very high risk of getting tumors of 3 glands: the pituitary, parathyroid, and pancreas. (cancer.org)
  • They most commonly occur in the intestine, where they are often called carcinoid tumors, but they are also found in the pancreas, lung and the rest of the body. (wikipedia.org)
  • incidence
  • Even though the frequency of the primary tumor is high, the incidence of metastasis is quite low (one metastasis per 300,000 cases). (medscape.com)
  • Incidence of Gastric Carcinoid is increased in Achlorhydria,Hashimoto's thyroiditis,Pernicious anemia. (wikipedia.org)
  • appearance of the tumor
  • Immunohistochemistry will help to show the biphasic appearance of the tumor, highlighting the basal or the luminal cells: Luminal cells: positive with CK7 and CD117 Basal cells: positive with p63, S100 protein and CK5/6 It is important to exclude a tumor which is directly extending into the ear canal from the parotid salivary gland, especially when dealing with an adenoid cystic or mucoepidermoid carcinoma. (wikipedia.org)
  • US demonstrates a complex appearance with multiple cystic and solid areas, findings that reflect the gross pathologic appearance of the tumor. (wikipedia.org)
  • necrosis
  • It is uncommon to see tumor necrosis, but when it is present, it is diagnostic of cancer. (wikipedia.org)
  • Mucocutaneous dysfunctions of paraneoplastic syndromes can be seen in cases of itching (hypereosinophilia), immune system depression (latent varicella-zoster virus in sensory ganglia), pancreatic tumors (leading to adipose nodular necrosis of subcutaneous tissues, flushes (prostaglandin secretions), and even dermic melanosis (cannot be eliminated via urine and results in grey to black-blueish skin tones). (wikipedia.org)
  • anti-tumor
  • In this paradigm, tumor cells express tissue-restricted antigens (e.g., neuronal proteins), triggering an anti-tumor immune response which may be partially or, rarely, completely effective in suppressing tumor growth and symptoms. (wikipedia.org)
  • neoplasm
  • Due to its 5-HT2A receptor antagonism, phenoxybenzamine is useful in the treatment of carcinoid tumor, a neoplasm that secretes large amounts of serotonin and causes diarrhea, bronchoconstriction, and flushing. (wikipedia.org)
  • This is a very rare neoplasm accounting for approximately 0.0003% of all tumors and about 2.5% of all external ear neoplasms. (wikipedia.org)
  • Squamous
  • The tumor may expand into the overlying squamous surface epithelium, but it usually does not arise from the surface epithelium. (wikipedia.org)
  • surgery
  • If the cancer cannot be treated with surgery other techniques such as freezing the tumour or treating it with high temperatures may be used. (wikipedia.org)
  • cells
  • This study will also look at specific substances called biomarkers in your blood, and in the tumor tissue which are involved in the growth of tumor cells, and determine if the levels of these biomarkers are related to your response to treatment or development of side effects. (clinicaltrials.gov)
  • When the tumour cells start to move in a different direction - vertically up into the epidermis and into the papillary dermis - the behaviour of the cells changes dramatically. (thetanningguru.com)
  • Neuroendocrine tumors are abnormal growths that begin in specialized cells called neuroendocrine cells. (mayoclinic.org)
  • In contrast, these phenomena are mediated by humoral factors (such as hormones or cytokines) secreted by tumor cells or by an immune response against the tumor. (wikipedia.org)
  • surgical
  • The treatment includes surgical removal of the tumor. (thetanningguru.com)
  • its irreversible antagonism and the resultant depression in the maximum of the agonist dose-response curve are desirable in a situation where surgical manipulation of the tumour may release a large bolus of pressor amine into the circulation. (wikipedia.org)
  • however
  • In some cases this involves removing the whole kidney however most tumors are amenable to partial removal to eradicate the tumor and preserve the remaining normal portion of the kidney. (wikipedia.org)
  • site
  • This tumor only affects the outer 1/3 to 1/2 of the external auditory canal as a primary site. (wikipedia.org)