Intestinal carcinoid tumors are gastrointestinal neuroendocrine tumors (GI-NETs). (medscape.com)
They are conventionally considered to originate from the serotonin-secreting enterochromaffin cells (ECs) of the intestine (also known as Kulchistky cells), but technically, intestinal carcinoid tumors include any collection of well-differentiated neuroendocrine cells within the digestive tract that are capable of secreting bioactive hormones and/or amines. (medscape.com)
Of neoplasms in the appendix, carcinoid tumors remain the most common. (medscape.com)
The most common symptom associated with carcinoid tumors is vague abdominal pain, with diagnosis occurring either incidentally or late in the course of disease, when the lesion may manifest as a complication of mechanical effects or as a result of significant hormone production. (medscape.com)
[ 2 ] is classically associated with carcinoid tumors. (medscape.com)
Collectively, the recognition that carcinoid tumors have functional potential occurred within a 50-year timeframe. (medscape.com)
In 1907, by which time carcinoid tumors were already histologically described and had been classified as carcinoma, Oberndorfer used the term "carcinoid" (carcinoma-like) as a modifier in order to distinguish their indolent behavior from other common gastrointestinal neoplasms. (medscape.com)
Shortly thereafter, in 1954, Thorson and colleagues were the first to report an association between carcinoid tumors and the carcinoid syndrome symptoms (ie, flushing, diarrhea, bronchoconstriction, and cardiac disease). (medscape.com)
[ 15 ] Finally, when elevated levels of 5-hydroxyindoleacetic acid (5-HIAA), the major metabolite of 5-HT, were discovered in the urine of patients with the carcinoid syndrome, investigators realized that the carcinoid syndrome may be a humorally-mediated disorder caused by production and secretion of ectopic serotonin by carcinoid tumors. (medscape.com)
Approximately 10% of neuroendocrine tumors of the gastrointestinal (GI) tract (except carcinoids) are VIPomas. (medscape.com)
As tumor localization techniques have improved over the years, the incidence profile of carcinoid tumor location within the digestive tract has changed. (medscape.com)
Between 1952 and 1953, serotonin [5-hydroxytryptamine (5-HT)] was identified as the secretory product of enterochromaffin cells (ECs) and isolated from a carcinoid tumor of the small bowel. (medscape.com)
carcinoid - A slow growing type of tumor usually found in the gastrointestinal system (most often in the appendix), and sometimes in the lungs or other sites. (en-academic.com)
Carcinoid syndrome - A syndrome due to carcinoid tumor which secretes large amounts of the hormone serotonin. (en-academic.com)
Carcinoid tumor - A tumor which secretes large amounts of the hormone serotonin. (en-academic.com)
Carcinoid tumor is also called an argentaffinoma. (en-academic.com)
Tumour3
In pathology, an apudoma is an endocrine tumour that arises from an APUD cell from structures such as the ampulla of Vater. (wikipedia.org)
If a gastrointestinal tumour has spread to the liver, excess amounts of these substances are released into the systemic circulation and the carcinoid syndrome results - flushing, headache, diarrhoea, bronchial constriction causing asthma-like attacks, and in some cases damage to the right side of the heart associated with fibrosis of the tricuspid valve. (en-academic.com)
3 Caption = Picture of a carcinoid tumour that encroaches into lumen of the small bowel (centre of image). (en-academic.com)
Serotonin2
[ 16 ] The term carcinoid was also used interchangeably with APUDoma, so named by Pearse in the 1960s, who developed the concept of the amine precursor uptake and decarboxylation (APUD) system after observing the ability of the secretory granules to take up and decarboxylate amino acid precursors of biogenic amines, such as serotonin and catecholamines. (medscape.com)
Carcinoids sometimes produce 5-hydroxytryptamine (serotonin), prostaglandins, and other physiologically active substances, which are inactivated in the liver. (en-academic.com)
Intestine1
Carcinoids typically occur in the tip of the appendix and are among the commonest tumours of the small intestine. (en-academic.com)
Small bowel1
Carcinoids are also the most common neoplasm of the small bowel, accounting for approximately 48% of all small bowel neoplasms. (medscape.com)
Argentaffin1
Carcinoids have also been referred to synonymously with other descriptors, such as argentaffinoma, which was used to describe the similarity between carcinoid granules and ECs in their affinity for staining with chrome salts and ability to reduce silver salts in an argentaffin reaction. (medscape.com)
Digestive tract1
They may also occur in the rectum and other parts of the digestive tract and in the bronchial tree ( bronchial carcinoid adenoma ). (en-academic.com)
Syndrome1
Bronchial carcinoids can give rise to the syndrome without metastasizing. (en-academic.com)
Cells1
Neural crest cells are precursors of APUDoma and neurogenic cells. (medscape.com)
Term1
Because the label "apudoma" is very general, it is preferred to use a more specific term when possible. (wikipedia.org)