Called carcinoid syndromeAssociated with carcinoid syndromeSecreted by carcinoid tumorsDiagnosed with carcinoid tumorsMalignant Carcinoid SyndromeTreat carcinoid syndromeCause carcinoid syndromeAppendixTumourRectumPeople living with carcinoid sEndoscopic resection for rectal carcinoidImprovement of carcinoid syndrome symptomsMetastaticPrimary carcinoidDiarrheaBronchialCases of carcinoid tumorsSymptoms of carcinoid tumorsDiagnosis of carcinoid tumorsTreatment of carcinoid syndromeLaboratory diagnosis of carcinoidMidgutTumor of the commonDevelop carcinoid syndromeMetastasisAmounts of the hormone serotoninAppendicealTricuspid valveSurgicalPancreaticChemotherapySomatostatinSupra-carcinoidsRectal carcinoidsPulmonary carcinoidIntestinal carcinoidType of neuroendocrine tumorPancreasAsymptomaticValvular heart dGastrointestinal tractLungsAtypicalTypicallyPathologyCrisisEndocrinePatients with neuroendocrine tumorsNeuroendocrine Tumor Research FoundationSecrete excessiveCarcinomaDirectly into the systemic circulationDigestive tractEnterochromaffin cells
Called carcinoid syndrome1
- This constellation of symptoms is called carcinoid syndrome or (if acute) carcinoid crisis. (wikipedia.org)
Associated with carcinoid syndrome2
- Carcinoid tumors of the midgut (jejunum, ileum, appendix, and cecum) are associated with carcinoid syndrome. (wikipedia.org)
- The drug is used in combination with a somatostatin analog to control diarrhea associated with carcinoid syndrome. (netrf.org)
Secreted by carcinoid tumors1
- If a patient is thought to have carcinoid syndrome, blood and urine tests must be performed to determine levels of bioactive substances secreted by carcinoid tumors. (medscape.com)
Diagnosed with carcinoid tumors2
- According to the National Organization for Rare Disorders (NORD), 2017, each year, only 27 individuals per million population are estimated to be diagnosed with carcinoid tumors in the U.S., amongst whom, only 10% individuals develop carcinoid syndrome. (openpr.com)
- Researchers have estimated that more than 12,000 people are diagnosed with carcinoid tumors every year in the United States. (aacr.org)
Malignant Carcinoid Syndrome5
- Malignant Carcinoid Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- This graph shows the total number of publications written about "Malignant Carcinoid Syndrome" by people in Harvard Catalyst Profiles by year, and whether "Malignant Carcinoid Syndrome" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Malignant Carcinoid Syndrome" by people in Profiles. (harvard.edu)
- Malignant carcinoid syndrome occurs in fewer than 10% of patients with a carcinoid tumor. (medscape.com)
- Carcinoids do not produce the malignant carcinoid syndrome until they are no longer confined to the small bowel or mesentery, perhaps because the liver breaks down the secretory products of tumors restricted to those locations. (medscape.com)
Treat carcinoid syndrome8
- Development of first-of-its-kind therapeutic approach to treat carcinoid syndrome diarrhea creates highly lucrative growth opportunities for market players. (openpr.com)
- Oral medications that act upon specific cell signaling pathways (such as mTOR, VEGF, VEGF-A) may be used in combination with other approaches to treat carcinoid syndrome. (netrf.org)
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Cause carcinoid syndrome4
- Over the years it became clear that carcinoid tumors can be quite aggressive, can metastasize, and can cause carcinoid syndrome . (medifocus.com)
- An intestinal carcinoid does not usually cause carcinoid syndrome unless hepatic metastases have occurred because metabolic products released by the tumor are rapidly destroyed by blood and liver enzymes in the portal circulation (eg, serotonin by hepatic monoamine oxidase). (msdmanuals.com)
- A somatostatin analog is a medication that mimics the function of somatostatin and can reduce the production and release of substances by tumors that cause carcinoid syndrome. (netrf.org)
- If the tumor has spread to the liver and the liver enzymes cannot destroy the extra hormones made by the tumor, high amounts of these hormones may remain in the body and cause carcinoid syndrome. (navigatingcare.com)
Appendix10
- Carcinoid tumors are the most common malignant tumor of the appendix, but they are most commonly associated with the small intestine, and they can also be found in the rectum and stomach. (wikipedia.org)
- carcinoid tumors are the most common malignancy of the appendix. (wikipedia.org)
- [ 125 ] In patients with carcinoid tumors located in the appendix, age, primary tumor size, histologic features, lymph node involvement, and distant metastasis are significant factors in predicting survival. (medscape.com)
- Scott A, Upadhyay V. Carcinoid tumours of the appendix in children in Auckland, New Zealand: 1965-2008. (medscape.com)
- Vandevelde A, Gera P. Carcinoid tumours of the appendix in children having appendicectomies at Princess Margaret Hospital since 1995. (medscape.com)
- Carcinoid tumors can also occur in the appendix. (holyname.org)
- Typically, 90% of carcinoid tumors originate from the distal ileum or appendix (the embryologic midgut. (medscape.com)
- Carcinoid syndrome is a group of symptoms associated with carcinoid tumors - tumors of the small intestine, colon, appendix, and bronchial tubes in the lungs. (health32.com)
- Carcinoids typically occur in the tip of the appendix and are among the commonest tumours of the small intestine. (en-academic.com)
- carcinoid - A slow growing type of tumor usually found in the gastrointestinal system (most often in the appendix), and sometimes in the lungs or other sites. (en-academic.com)
Tumour9
- Because of serotonin's growth-promoting effect on cardiac myocytes, a serotonin-secreting carcinoid tumour may cause a tricuspid valve disease syndrome, due to the proliferation of myocytes onto the valve. (wikipedia.org)
- Fourteen-year-old girl with endobronchial carcinoid tumour presenting with asthma and lobar emphysema. (medscape.com)
- Arming compared this tumour to carcinoid, but classified it with basal cell carcinoma. (whonamedit.com)
- Aside from the symptomatic treatment of carcinoid syndrome due to neuroendocrine tumours and acromegaly, BIM 23A760 may reduce the tumour size, Ipsen said. (pharmaceutical-technology.com)
- Glandular duodenal carcinoid--a somatostatin rich tumour with neuroendocrine associations. (bmj.com)
- The clinical and pathological features of four cases of duodenal carcinoid tumour are presented. (bmj.com)
- If a gastrointestinal tumour has spread to the liver, excess amounts of these substances are released into the systemic circulation and the carcinoid syndrome results - flushing, headache, diarrhoea, bronchial constriction causing asthma-like attacks, and in some cases damage to the right side of the heart associated with fibrosis of the tricuspid valve. (en-academic.com)
- 3 Caption = Picture of a carcinoid tumour that encroaches into lumen of the small bowel (centre of image). (en-academic.com)
- ParetoTI theory identified four tumour archetypes within the tetrahedron, corresponding to the three previously reported molecular groups, and the fourth enriched for the aggressive supra-carcinoids. (who.int)
Rectum2
- Hindgut Carcinoid Tumors - These tumors originate in the large intestines, specifically in the transverse colon, descending colon, and rectum. (medifocus.com)
- They may also occur in the rectum and other parts of the digestive tract and in the bronchial tree ( bronchial carcinoid adenoma ). (en-academic.com)
People living with carcinoid s1
- The PAN Foundation today opened a new patient assistance program for people living with carcinoid syndrome. (curetoday.com)
Endoscopic resection for rectal carcinoid2
- Local surgical excision versus endoscopic resection for rectal carcinoid: A meta-analysis. (jcancer.org)
- Sui Q, Lin J, Peng J, Zhao Y, Deng Y, Pan Z. Local surgical excision versus endoscopic resection for rectal carcinoid: A meta-analysis. (jcancer.org)
Improvement of carcinoid syndrome symptoms2
- Cost reduction from resolution/improvement of carcinoid syndrome symptoms following treatment with above-standard dose of octreotide LAR. (harvard.edu)
- If liver metastases can be surgically removed, it often leads to the improvement of carcinoid syndrome symptoms. (netrf.org)
Metastatic7
- They are known to grow in the liver, but this finding is usually a manifestation of metastatic disease from a primary carcinoid occurring elsewhere in the body. (wikipedia.org)
- We report the gratifying response of functioning metastatic neuroendocrine tumor with carcinoid heart disease (uncontrolled by long-acting octreotide) to treatment with 177 Lu-DOTATATE. (snmjournals.org)
- A 30-y-old man who had been diagnosed with a grade II jejunal neuroendocrine tumor metastatic to the liver and abdomen was found clinically and on 2-dimensional (2D) echocardiography to have the complication of carcinoid heart disease. (snmjournals.org)
- The syndrome results from vasoactive substances (including serotonin , bradykinin, histamine, prostaglandins, polypeptide hormones) secreted by the tumor, which is typically a metastatic intestinal carcinoid. (msdmanuals.com)
- Metastatic carcinoid tumors show very high levels of serum serotonin, usually exceeding 1000 ng/mL. (clinlabnavigator.com)
- Chromogranin A is almost always elevated in patients with symptomatic or metastatic carcinoid tumors. (clinlabnavigator.com)
- Although pulmonary carcinoids show relatively good prognosis in comparison to carcinomas, metastatic disease and relapse do occur. (who.int)
Primary carcinoid2
- We herein present what we believe is only the 47th reported case of a primary carcinoid tumor occurring in the extrahepatic bile ducts. (springer.com)
- Scintigraphy with indium-111 diethylenetriamine pentaacetic acid (DTPA) octreotide (In-111 DTPA Octr), or OctreoScan, localizes the primary carcinoid and eventual recurrences, as well as other neuroendocrine tumors, with high sensitivity and specificity. (medscape.com)
Diarrhea9
- Increasing prevalence of the disease is in turn, increasing demand for carcinoid syndrome diarrhea treatment devices. (openpr.com)
- This in turn is expected to fuel growth of the carcinoid syndrome diarrhea treatment market. (openpr.com)
- In February 2017, Lexicon Pharmaceutical Inc., announced that the U.S. Food and Drug Administration (FDA) approved Xermelo (Telotristat etiprate) as the first and only orally administered therapy for the treatment of carcinoid syndrome diarrhea in combination with somatostatin analog therapy (SSA) for adults. (openpr.com)
- Xermelo mainly targets the overproduction of serotonin hormone inside mNET cells and reduces the frequency of carcinoid syndrome diarrhea. (openpr.com)
- However, low awareness and certain side effects associated with this therapy are expected to hinder growth of the carcinoid syndrome diarrhea treatment market. (openpr.com)
- Some carcinoid tumors produce symptoms that are not specific to this disease, such as facial flushing, diarrhea, abdominal pain, rash, and intestinal bleeding. (aacr.org)
- Some people may not notice symptoms of carcinoid tumors, while others could experience abdominal pain, diarrhea, nausea and vomiting, flushing skin, rectal pain, or rectal bleeding. (mountsinai.org)
- Serotonin , the primary hormone produced by carcinoid tumors, acts on smooth muscle to cause diarrhea, colic, and malabsorption. (msdmanuals.com)
- Serotonin production by disseminated carcinoid tumors can sometimes be so substantial that body tryptophan stores become depleted and clinical tryptophan deficiency, resembling pellagra (triad of diarrhea, dementia, and dermatitis), develops. (clinlabnavigator.com)
Bronchial2
- Intraoperative bronchoscopy for bronchial carcinoid parenchymal-sparing resection: a pediatric case report. (medscape.com)
- Bronchial carcinoids can give rise to the syndrome without metastasizing. (en-academic.com)
Cases of carcinoid tumors1
- Approximately 8,000 new cases of carcinoid tumors are diagnosed each year in the United States and the incidence seems to be rising. (holyname.org)
Symptoms of carcinoid tumors1
- Signs and symptoms of carcinoid tumors vary greatly and depend on the tumor location and size as well as on the presence of metastases. (medscape.com)
Diagnosis of carcinoid tumors3
- Bochemical diagnosis of carcinoid tumors is based on the measurement of the serotonin metabolite 5-HIAA in urine. (medscape.com)
- Due to their vague and intermittent symptoms, diagnosis of carcinoid tumors may be delayed, especially in children, in whom the tumor is rare and the diagnosis is unexpected. (medscape.com)
- Laboratory diagnosis of carcinoid tumors depends on the identification of the characteristic biomarkers of the disease. (medscape.com)
Treatment of carcinoid syndrome2
- Furthermore, in 2017, Ipsen Biopharmaceutical, announced the U.S. Food and Drug Administration (FDA) approval for a supplemental indication of Somatuline Depot (lanreotide) Injection 120 mg for the treatment of carcinoid syndrome, to reduce the frequency of short-acting somatostatin analogue rescue therapy. (openpr.com)
- Changes in Weight Associated With Telotristat Ethyl in the Treatment of Carcinoid Syndrome. (harvard.edu)
Laboratory diagnosis of carcinoid1
- The laboratory diagnosis of carcinoid syndrome relies on measurement of serum serotonin, urinary 5-hydroxyindoleacetic acid and serum chromogranin A. In most cases, if none of these 3 analytes is elevated, carcinoids can be excluded as a cause of symptoms suggestive of carcinoid syndrome. (clinlabnavigator.com)
Midgut1
- Urinary 5-HIAA is elevated in almost all carcinoid-syndrome patients with midgut tumors, in about 30% of individuals with foregut carcinoids, but almost never in hindgut tumors. (clinlabnavigator.com)
Tumor of the common1
- Carcinoid tumor of the common bile duct in children: a case report. (medscape.com)
Develop carcinoid syndrome1
- It is estimated that less than 6% of carcinoid patients will develop carcinoid syndrome, and of these, 50% will have cardiac involvement. (wikipedia.org)
Metastasis4
- Metastasis of carcinoid can lead to carcinoid syndrome. (wikipedia.org)
- The most serious complications of carcinoid tumors are carcinoid syndrome /crisis and metastasis, which is often observed in patients who have foregut tumors and high levels of 5-HIAA. (medscape.com)
- Overall, localized carcinoid tumor which is completely resected has an excellent prognosis, the outcome for patients with metastasis, however, remains poor. (medscape.com)
- Carcinoid tumors have high potential for metastasis. (medscape.com)
Amounts of the hormone serotonin3
- Carcinoid tumors secrete excessive amounts of the hormone serotonin. (health32.com)
- Carcinoid syndrome - A syndrome due to carcinoid tumor which secretes large amounts of the hormone serotonin. (en-academic.com)
- Carcinoid tumor - A tumor which secretes large amounts of the hormone serotonin. (en-academic.com)
Appendiceal4
- They behave in a more aggressive manner than do classical appendiceal carcinoids. (wikipedia.org)
- Kim SS, Kays DW, Larson SD, Islam S. Appendiceal carcinoids in children--management and outcomes. (medscape.com)
- Neuroendocrine tumors (carcinoid and neuroendocrine carcinoma) presenting at extra-appendiceal sites in childhood and adolescence. (medscape.com)
- [ 4 ] ) Carcinoid tumors represent 90% of appendiceal tumors. (medscape.com)
Tricuspid valve1
- Carcinoid heart disease: successful tricuspid valve replacement. (bmj.com)
Surgical9
- Carcinoid syndrome may occur due to infection or other related diseases, and medical or surgical treatments such as anesthesia, chemotherapy, embolization, and tumor debulking. (openpr.com)
- The PLCC has a multi-disciplinary team of experienced and skilled medical oncologists , surgical oncologists , radiologists, nurses and support staff to treat carcinoid tumors. (holyname.org)
- At present, the only cure for a carcinoid tumor or any other neuroendocrine tumor is the surgical removal of the tumor. (mountsinai.org)
- Studies of local surgical excision compared with endoscopic resection for rectal carcinoids less than 20mm without adverse features were included. (jcancer.org)
- For rectal carcinoids sized 20mm or smaller without adverse features, endoscopic resection might be an efficient treatment, which achieved a comparable oncological safety as local surgical excision. (jcancer.org)
- The use of adjuvant chemotherapy following the surgical resection of pulmonary typical or atypical carcinoids has been highly debated. (jnccn.org)
- Surgical treatments aim to remove or reduce the volume of NETs, causing carcinoid syndrome. (netrf.org)
- If feasible, the treatment of choice for carcinoid tumors is surgical excision. (medscape.com)
- Between February 2009 and July 2013, 402 patients with clinical stage I non-small cell lung cancer (NSCLC) underwent "non-grasping en bloc MLND" conducted by one surgical team. (medscape.com)
Pancreatic3
- The highest percentage of nonlocalized lesions were noted for pancreatic (76.1%), colonic (71.2%), and small intestinal carcinoids (70.7%) and this corresponded to their poor 5-year survival rates (34.1%, 41.6%, and 55.4%, respectively). (nih.gov)
- The organization's mission is to fund research to discover cures and more effective treatments for carcinoid, pancreatic, and related neuroendocrine cancers. (aacr.org)
- elevated human chorionic gonadotropin and pancreatic polypeptide levels are occasionally present with carcinoids. (msdmanuals.com)
Chemotherapy7
- To overcome the carcinoid crisis, treatment options may considered such as surgery, chemotherapy, targeted radionuclide therapy, radiofrequency ablation, and chemoembolization on the basis of patient-by-patient. (openpr.com)
- Chemotherapy is typically not very effective in treating carcinoid tumors. (holyname.org)
- A total of 80 studies were identified through PubMed search of "chemotherapy" AND "pulmonary" AND "carcinoid. (jnccn.org)
- Of those 12, only 4 clearly reported any survival statistics on typical and/or atypical carcinoids treated with a chemotherapy regimen. (jnccn.org)
- Although the NCCN guidelines state the use of chemotherapy in the intermediate grade (atypical) carcinoid (Category IIB) stage the literature demonstrates no clear survival advantage conferred when doing so. (jnccn.org)
- There are a variety of carcinoid syndrome treatments, including somatostatin analogs and other medications, liver-directed therapies, surgery, and chemotherapy. (netrf.org)
- In contrast, cytoreductive chemotherapy does not prolong survival or improve quality of life of patients suffering from well-differentiated (G1) carcinoids. (carcinoids.de)
Somatostatin5
- Impact of carcinoid syndrome symptoms and long-term use of somatostatin analogs on quality of life in patients with carcinoid syndrome: A survey study. (harvard.edu)
- The somatostatin analogs (SSAs) octreotide and lanreotide are used to control carcinoid symptoms and tumor progression in advanced inoperable disease. (medscape.com)
- Carcinoid heart disease manifests in many patients with carcinoid syndrome ( 2 ), but the prevalence dropped to approximately 20% after the introduction of newer therapies such as somatostatin analogs and 177 Lu-DOTATATE, along with everolimus, sunitinib, and the combination of capecitabine and temozolomide ( 3 ). (snmjournals.org)
- The function of somatostatin is to inhibit (reduce or limit) the release of gastrointestinal and endocrine hormones in the body, some of which are substances (e.g., serotonin) that contribute to carcinoid syndrome. (netrf.org)
- Octreotide) to control symptoms of carcinoid syndrome that are difficult to or cannot be controlled with a somatostatin analog alone. (netrf.org)
Supra-carcinoids1
- Additionally, we identified six tumours, termed supra-carcinoids, that displayed genuine carcinoid-like morphology, but had clinical and molecular characteristics of LNECs. (who.int)
Rectal carcinoids1
- To date, there is not enough evidence concerning the optimal treatment strategy for early rectal carcinoids, we conducted a meta-analysis in order to determine the feasible local treatment for these selected patients. (jcancer.org)
Pulmonary carcinoid1
- Pediatric pulmonary carcinoid: a case report and review of the literature. (medscape.com)
Intestinal carcinoid1
- A section (on the right) of an intestinal carcinoid mass arising from the mucosa (150 X). Image courtesy of Professor Pantaleo Bufo, University of Foggia, Italy. (medscape.com)
Type of neuroendocrine tumor3
- A carcinoid (also carcinoid tumor) is a slow-growing type of neuroendocrine tumor originating in the cells of the neuroendocrine system. (wikipedia.org)
- Carcinoid syndrome is a rare condition that occurs when a type of neuroendocrine tumor called carcinoid tumors produce excessive amounts of hormones. (centerwatch.com)
- Carcinoid tumors are a type of neuroendocrine tumor that typically originates in the digestive tract. (mountsinai.org)
Pancreas1
- Overview of Carcinoid Tumors Carcinoid tumors develop from neuroendocrine cells in the gastrointestinal tract (90%), pancreas, pulmonary bronchi, and rarely the genitourinary tract. (msdmanuals.com)
Asymptomatic3
- While most carcinoids are asymptomatic through the natural life and are discovered only upon surgery for unrelated reasons (so-called coincidental carcinoids), all carcinoids are considered to have malignant potential. (wikipedia.org)
- For instance, in 2009, a study by Journal of Clinical Oncology, showed 4 to 5 out of every 100,000 people are diagnosed with a neuroendocrine tumor and over 100,000 people suffering from neuroendocrine tumor in the U.S., also most individual suffering from carcinoid are asymptomatic until the tumor is fully developed. (openpr.com)
- It is probable that more people may actually have carcinoid tumors but because carcinoids are often asymptomatic, an individual may never know that a carcinoid has developed. (medifocus.com)
Valvular heart d1
- Treatment focuses on control of the underlying carcinoid syndrome, targeting subsequent valvular heart disease and managing consequent heart failure. (karger.com)
Gastrointestinal tract4
- Over two-thirds of carcinoid tumors are found in the gastrointestinal tract. (wikipedia.org)
- Carcinoid tumors are slow-growing tumors that can develop in various parts of the body, including the gastrointestinal tract and the lungs. (centerwatch.com)
- The carcinoid tumors are usually located in the gastrointestinal tract and metastasize to the liver. (harvard.edu)
- About 66% of all carcinoid tumors develop in the gastrointestinal tract. (medifocus.com)
Lungs4
- Carcinoid tumors are also found in the lungs. (wikipedia.org)
- Carcinoid tumors are slow growing cancers that typically start in the digestive tract or the lungs, but can develop throughout the body. (holyname.org)
- Carcinoid tumors are rare, slow-growing cancers that usually start in the lining of the digestive tract and lungs, but can also occur in other areas, including the testes and ovaries. (aacr.org)
- The next most common site for the development of carcinoid tumors is in the lungs. (medifocus.com)
Atypical4
- Soga J, Yakuwa Y, Osaka M. Evaluation of 342 cases of mediastinal/thymic carcinoids collected from literature: a comparative study between typical carcinoids and atypical varieties. (medscape.com)
- Neuroendocrine Tumors of the Bronchopulmonary System (Typical and Atypical Carcinoid Tumors): Current Strategies in Diagnosis and Treatment. (karger.com)
- There is need for prospective studies to further evaluate the utilization of adjuvant therapy in atypical carcinoid. (jnccn.org)
- Carcinoids are further divided into atypical and typical, based on mitotic count and presence of necrosis. (who.int)
Typically2
- The age at diagnosis varies somewhat among specific tumor locations but typically, most people diagnosed with a carcinoid tumor are in their 50s. (medifocus.com)
- Carcinoid syndrome is the pattern of symptoms that typically are exhibited by people with carcinoid tumors. (health32.com)
Pathology1
- To address this aim we have designed the lungNENomics study, an international cohort of over 250 cases of pulmonary carcinoids, with clinical data and central pathology review, as well as whole-genome sequencing, RNA sequencing, DNA methylation array, and digital spatial profiling data. (who.int)
Crisis1
- Carcinoid crisis - when all of the above symptoms occur at the same time. (medifocus.com)
Endocrine6
- They do not produce sufficient hormonal substances to cause carcinoid or other endocrine syndromes. (wikipedia.org)
- Risk factors for carcinoid cancers include having a family history of multiple endocrine neoplasia type 1 (MEN1) syndrome or neurofibromatosis type 1 (NF1) syndrome, and having certain conditions that affect the stomach's ability to make stomach acid, such as atrophic gastritis, pernicious anemia, or Zollinger-Ellison syndrome. (aacr.org)
- Carcinoid tumors and related syndromes may be a part of multiple endocrine neoplasia . (medscape.com)
- The importance of these unusual features is discussed, and it is suggested that these glandular carcinoids are a specific subgroup of endocrine cell tumours which appear to have potentially important clinical and pathological associations. (bmj.com)
- Endocrinologically active tumors of the diffuse peripheral endocrine or paracrine system (neuroendocrine tumors) produce various amines and polypeptides with corresponding symptoms and signs, including carcinoid syndrome. (msdmanuals.com)
- In 1980, the World Health Organization (WHO) applied the term carcinoid to all tumors of the diffuse endocrine system (synonymous with amine precursor uptake and decarboxylation [APUD] and neuroendocrine cell system). (medscape.com)
Patients with neuroendocrine tumors1
- Retrospective review of serotonergic medication tolerability in patients with neuroendocrine tumors with biochemically proven carcinoid syndrome. (harvard.edu)
Neuroendocrine Tumor Research Foundation1
- The Neuroendocrine Tumor Research Foundation (NETRF) - formerly the Caring for Carcinoid Foundation - has been a partner of the American Association for Cancer Research (AACR) since 2011. (aacr.org)
Secrete excessive1
- About 10% of carcinoids secrete excessive levels of a range of hormones, most notably serotonin (5-hydroxytryptamine), causing: Flushing (serotonin itself does not cause flushing). (wikipedia.org)
Carcinoma2
- The term 'crypt cell carcinoma' has been used for them, and though perhaps more accurate than considering them carcinoids, has not been a successful competitor. (wikipedia.org)
- Carcinoid tumors were initially identified in 1888 and were thought to clinically and histologically (cellular appearance under a microscope) resemble carcinoma cells (highly malignant cancer cells) but behave in a more benign fashion than true cancer cells. (medifocus.com)
Directly into the systemic circulation1
- Rare intestinal carcinoids with only intra-abdominal spread can drain directly into the systemic circulation or the lymphatics and cause symptoms. (msdmanuals.com)
Digestive tract1
- It is often done to detect certain tumors in the digestive tract ( carcinoid tumors ) and to track a person's condition. (medlineplus.gov)
Enterochromaffin cells3
- Carcinoid tumors are apudomas that arise from the enterochromaffin cells throughout the gut. (wikipedia.org)
- Carcinoid syndrome is caused by carcinoid tumors, which are small slowly growing tumors of enterochromaffin cells. (clinlabnavigator.com)
- In 1914, Gosset and Masson demonstrated that carcinoid tumors might arise from enterochromaffin cells (Kulchitsky cell) within glands of Lieberkühn using silver impregnation techniques. (medscape.com)