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  • carcinogens
  • The major impetus for developing the International Program for the Evaluation of Short-term Tests for Carcinogenicity (IPESTTC) was that our need for rapid identification and control of carcinogens is not satisfied by traditional rodent bioassays. (springer.com)
  • This need places tremendous pressure on the scientific community to develop test systems for identifying chemical carcinogens in the environment at a lower cost and on a shorter time scale. (springer.com)
  • tumor
  • and Armitage, 1955, Biometrics 11, 375-386) is routinely applied to carcinogenicity data as a test for linear trend in lifetime tumor incidence rates. (rti.org)
  • This technique is compared to that of Bailer and Portier (1988, Biometrics 44, 417-431), who introduced a survival-adjusted quantal response test for trend in lifetime tumor incidence rates. (rti.org)
  • Although the delta method approach is slightly more computationally intensive, small-sample simulations indicate that it has superior operating characteristics over the Poly-3 trend test of Bailer and Portier when background tumor incidence rates are low (under 3%) and survival patterns differ markedly across treatments. (rti.org)
  • tumor development following carcinogen exposure," which demonstrate equivalent performance with the standard two-year tests. (taconic.com)
  • The reliability and stability of the model provided Taconic, combined with the design improvements, comprehensive nature of the tumor database and published experience of BioReliance, make rasH2 a dominant and valuable force in carcinogenicity testing. (taconic.com)
  • dose
  • The delta method and weighted least squares techniques are applied here to approximate the variance of such ratio statistics and test for a linear dose-response relationship among treatments. (rti.org)
  • Even though the tests were poorly conducted they did demonstrate that aspartame was associated with a dramatic, dose-dependent, increase in a variety of brain tumors-mainly astrocytomas-the type commonly seen in humans. (redicecreations.com)
  • regulatory
  • A two-year rodent bio-assay to ascertain carcinogenicity has been a regulatory requirement for over 40 years. (taconic.com)
  • Regulatory bodies now recognize this potential and are on the move to incorporate this understanding into testing requirements. (taconic.com)
  • One of the first priorities set by ECVAM was the implementation of procedures which would enable it to become well-informed about the state-of-the-art of non-animal test development and validation and the potential for the possible incorporation of alternative tests into regulatory procedures. (jhsph.edu)
  • animal
  • Their test modifies the usual Cochran-Armitage computing formula by weighting the denominators of the response rates to reflect less-than-whole-animal contributions to risk. (rti.org)
  • GEN Exclusives has published an article by Amar Thyagarajan, PhD, Senior Product Manager at Taconic Biosciences, titled New Guidelines Involve the Testing Done on Animal Models . (taconic.com)
  • guidelines
  • Of even more concern is that the American College of Obstetrics and Gynecology has raised pap testing guidelines to age 21 leaving many adolescents without proper cervical screening tools post-vaccination. (menstruationresearch.org)
  • months
  • Only a very few lung adenomas but no other tumors were seen as spontaneous tumors during the months of carcnogenicity tests. (nii.ac.jp)
  • possible
  • These are critical tests with any new drug because it determines possible dangers to unborn children when their mothers are exposed to the product during pregnancy. (redicecreations.com)