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Polycyclic Hydrocarbons, AromaticBay-Region, Polycyclic Aromatic HydrocarbonPhenanthrenesChrysenesCreosotePolycyclic CompoundsGlutathione TransferaseEpoxy CompoundsBenzopyrenes7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxidePyrenesBenzo(a)pyreneHydrocarbonsDNA AdductsMetabolic Detoxication, Phase IIStereoisomerismGlutathioneHydrocarbons, AromaticEpoxide HydrolasesBenz(a)AnthracenesCarcinogensReceptors, Aryl HydrocarbonSoil PollutantsCoal TarDihydroxydihydrobenzopyrenesCytochrome P-450 CYP1A1DinitrochlorobenzeneCokeBiodegradation, EnvironmentalMutagensEnvironmental MonitoringCarcinogens, EnvironmentalAcenaphthenesAir PollutantsBiotransformationMethylcholanthreneWater Pollutants, ChemicalPetroleumAir Pollutants, OccupationalEnvironmental PollutantsGlutathione S-Transferase piTetrachlorodibenzodioxinOccupational ExposureMutagenicity TestsCoalFluorenesPetroleum PollutionVehicle EmissionsMetabolic Detoxication, DrugIsoenzymesEstuariesGlutathione PeroxidaseGeologic SedimentsGas Chromatography-Mass SpectrometryChromatography, High Pressure LiquidAnthracenesMolecular Sequence DataAryl Hydrocarbon HydroxylasesSubstrate SpecificityHydrocarbons, HalogenatedEnvironmental ExposureParticulate MatterKineticsMetallurgyFuel OilsGlutathione ReductaseCookingNaphthalenesBenzoflavones9,10-Dimethyl-1,2-benzanthraceneLiverCytochrome P-450 Enzyme SystemDioxinsMolecular StructureCatalysisEnzyme InductionMicrosomes, LiverSphingomonasInhalation ExposureSoil MicrobiologyXenobioticsGulf of MexicoAmino Acids, AromaticDeoxyguanosinebeta-NaphthoflavoneIncinerationHydrocarbons, ChlorinatedAryl Hydrocarbon Receptor Nuclear TranslocatorStructure-Activity RelationshipNaphtholsDNADioxygenasesSteelDominican RepublicAir Pollution, IndoorGlutathione DisulfideAmino Acid SequencePolychlorinated BiphenylsOxidation-ReductionSmoking
AdductsMutationsMiceHumanCells
Adducts5
  • 2. Differential removal of DNA adducts derived from anti-diol epoxides of dibenzo[a,l]pyrene and benzo[a]pyrene in human cells. (nih.gov)
  • 3. H2AX phosphorylation in A549 cells induced by the bulky and stable DNA adducts of benzo[a]pyrene and dibenzo[a,l]pyrene diol epoxides. (nih.gov)
  • 8. Formation and differential repair of covalent DNA adducts generated by treatment of human cells with (+/-)-anti-dibenzo[a,l]pyrene-11,12-diol-13,14-epoxide. (nih.gov)
  • 17. Arsenite enhances the benzo[a]pyrene diol epoxide (BPDE)-induced mutagenesis with no marked effect on repair of BPDE-DNA adducts in human lung cells. (nih.gov)
  • 1995. Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas. (cdc.gov)
Mutations2
  • 4. Both replication bypass fidelity and repair efficiency influence the yield of mutations per target dose in intact mammalian cells induced by benzo[a]pyrene-diol-epoxide and dibenzo[a,l]pyrene-diol-epoxide. (nih.gov)
  • 10. DNA repair and replication influence the number of mutations per adduct of polycyclic aromatic hydrocarbons in mammalian cells. (nih.gov)
Mice1
Human5
  • 6. Glutathione conjugation and DNA adduct formation of dibenzo[a,l]pyrene and benzo[a]pyrene diol epoxides in V79 cells stably expressing different human glutathione transferases. (nih.gov)
  • 7. Catalytic activities of human alpha class glutathione transferases toward carcinogenic dibenzo[a,l]pyrene diol epoxides. (nih.gov)
  • 9. Enhanced sensitivity to anti-benzo(a)pyrene-diol-epoxide DNA damage correlates with decreased global genomic repair attributable to abrogated p53 function in human cells. (nih.gov)
  • 12. Nickel (II) enhances benzo[a]pyrene diol epoxide-induced mutagenesis through inhibition of nucleotide excision repair in human cells: a possible mechanism for nickel (II)-induced carcinogenesis. (nih.gov)
  • Determination of exposure to polycyclic aromatic hydrocarbons by analysis of human urine. (cdc.gov)
Cells1
  • 14. PYK2 mediates anti-apoptotic AKT signaling in response to benzo[a]pyrene diol epoxide in mammary epithelial cells. (nih.gov)