Carcinogenicity and mutagenicity of PAHs/nitrosamines as potential contaminants of MWFs. (cdc.gov)
The aim of the Monographs has been, from their inception, to evaluate evidence of carcinogenicity at any stage in the carcinogenesis process, independently of the underlying mechanisms. (who.int)
N-nitrosamines are carcinogenic substances often found in rubber products. (e-jehs.org)
ethylene Monographs , a review was undertak icals and other agents that may oxide (in 1994), based on strong ev en during 2008-2009 of relevant in pre sent carcinogenic hazards to idence of genotoxicity and limited formation on all the agents classified humans. (who.int)
As nitrates change gastric cancer prevalence nitrosamines, the carcinogenic potential of these types of food increases. (wishstudio.ro)
Bladder6
The effects of three sweeteners, sodium saccharin, aspartame and stevioside, on urinary bladdercarcinogenesis in rats initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) were evaluated. (nih.gov)
The data also suggest that aspartame and stevioside do not promote bladder carcinogenesis. (nih.gov)
Chemopreventive Prospective involving Myrtenal in opposition to Nitrosamine-Initiated, Radiation-Promoted Rat Bladder Carcinogenesis. (gp120-inhibitors.com)
Potential chemoprotective effects of green propolis, L-lysine and celecoxib on bone marrow cells and peripheral blood lymphocytes of Wistar rats subjected to bladder chemical carcinogenesis. (propolisscience.org)
To evaluate the genotoxicity of propolis and L-lysine, as well as their effects on the possible cellular damage in erythroblasts (bone marrow) and leukocytes (peripheral blood) caused by the carcinogen BBN (n - butyl - n {4 - hydroxybutyl} nitrosamine) in rats subjected to bladder carcinogenesis and treated with green propolis and L-lysine. (propolisscience.org)
Tobacco1
Tobacco-specific nitrosamines in urine are measured by an isotope-dilution high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (ID HPLC-ESI MS/MS). For "total" TSNA assays, the urine sample is fortified with internal standards, and then hydrolyzed using β-glucuronidase in incubations for at least 24 hours. (cdc.gov)
Morphine, as the most prevalent and important alkaloid in opium, has also been associated with carcinogenesis via increasing the methylation of DNA through the reduction of N-nitrosamines and N-nitrosodimethylamine through liver clearance [15-23]. (waocp.com)
IARC1
100 of the IARC Monographs at different sites in separate ani en the scientific value of Volume confirm that the induction of mal models. (who.int)
Chemical2
Chemical analysis was conducted by HPLC-MS/MS according to the method EN 71-12. (e-jehs.org)
However, nitrosamine formation may occur under certain work conditions or in the presence of nitrate-reducing microorganisms. (cdc.gov)
Foods2
The scientific review stated that extensive experimental data suggests that humans are susceptible to carcinogenesis by N-nitroso compounds and that the presence of these compounds in some foods may be regarded as a risk factor for certain human cancers, such as cancer of the esophagus, stomach and nasopharynx. (lorphicweb.com)
The U.S. Food and Drug Administration (FDA) maintains that everyone is exposed to some level of nitrosamines since they are common in water and foods, including cured and grilled meats, dairy products and vegetables. (lorphicweb.com)
For integrated risk management of N-nitrosamines, further studies and discussion regarding exposure and risk assessment are required. (e-jehs.org)
The FDA states that nitrosamine impurities in drugs can increase the risk of cancer if people are exposed to high levels over a long period of time. (lorphicweb.com)
a person taking a drug that contains nitrosamines at-or-below the acceptable daily intake limits every day for 70 years is not expected to have an increased risk of cancer. (lorphicweb.com)
The health benefits of stopping smoking outweigh the cancer risk from the nitrosamine impurity in varenicline. (lorphicweb.com)
Important1
Nicotine: Multiple chemicals are present but nicotine is the most important because of carcinogenesis and addiction reinforcing features via the reward system. (jacobchills.com)
Environmental2
1,2) In addition, the Occupational Safety and Health Administration and the U.S. Environmental Protection Agency have promulgated standards to prevent nitrosamine formation in new MWFs. (cdc.gov)
E-cigarettes can contain many of the same toxic chemicals that are found in traditional cigarettes, including nicotine, formaldehyde, and nitrosamines. (jacobchills.com)
Pfizer, Inc. announced on Mar. 21, 2022 that it was recalling three drugs used to treat high blood pressure due to an excessive amount of nitrosamines found in the tablets. (lorphicweb.com)
Model2
We have previously shown that dietary polyethylene-glycol (PEG)suppresses the occurrence of azoxymethane-induced cancers in an accelerated rat model of coloncarcinogenesis. (aacrjournals.org)
For instance, studies of PAH have been in vogue through the Seventies and Eighties, followed by nitrosamines within the Nineteen Nineties. (willarybacka.pl)
Finally, although some studies have been done on the morphine-induced carcinogenesis, most of the mechanistic studies have used pyrolyzed opium, isolation of opium derivatives and elucidation of their association with cancer have been remained for further research. (waocp.com)
Determine2
ㆍ Total of 68 balloons purchased from Korean market were analysed to determine the migration of N-nitrosamines and N-nitrosatable substances. (e-jehs.org)
This study was conducted to determine the concentrations of N-nitrosamines in rubber balloons in the South Korean market and assess exposure among Korean children. (e-jehs.org)
Cell1
First, albumin can be a major protecting component can against carcinogenesis by nitrosamine and aflatoxin and may stabilize DNA replication and cell development, and buffer sex hormone homeostasis to avoid sex hormone-induced tumor [19]. (forgetmenotinitiative.org)
Study1
2018. Expression profile of microRNA-146a along HPV-induced multistep carcinogenesis: A study in HPV16 transgenic mice. (livedna.net)
Level2
Among the 68 rubber balloons, N-nitrosamines were detected in 18 (26.5%) with an average level of 60.77 μg/kg. (e-jehs.org)
Pfizer said it is recalling Accuretic (quinapril HCl/hydrochlorothiazide) tablets, which are distributed by Pfizer, as well as two authorized generics distributed by Greenstone (quinapril, hydrochlorothiazide and quinapril HCl/ hydrochlorothiazide) because nitrosamine is in the tablets at above the Acceptable Daily Intake (ADI) level. (lorphicweb.com)
Oral2
El licopeno ha sido utilizado con mayor frecuencia por adultos en dosis de 15 a 45 mg por vía oral al día durante un máximo de 6 meses. (medlineplus.gov)
We evaluated the N-nitrosamines contained in rubber balloons purchased in the domestic market and assessed oral exposure among South Korean children. (e-jehs.org)
Total1
Forty eight rubber balloon products in the domestic market were purchased and a total of 68 balloons were analyzed for N-nitrosamines and N-nitrosatable substances. (e-jehs.org)
Market1
If drugs on the market contain levels of nitrosamines above the ADI limits, the FDA recommends the manufacturer recall the drugs. (lorphicweb.com)
Products1
ㆍ N-nitrosamines and N-nitrosatable substances were detected in 44 products and 23 balloons exceeded the European limit. (e-jehs.org)