Cytokeratin 19TumourCarcino-embryonic antigenMetastaticMetastasisValue of tumor markersCarbohydrateBiomarkersCell adhesionPreoperativeAssayFragmentPrognosisGlycoproteinColon cancerTissueAlpha-fetoproteinUric acidAlbuminAntibodyNeoplasmSensitivityCytologyPrognosticEstradiolCyfraProteinUrineBiopsySubstancesLiverRecurrencePatientsRadiographicConcentrationBiomarkerProteinsLevelsAssaysBenignDiagnosisThyroidSpecificityColorectal carcinomaRelapseMalignanciesMonoclonalCA125Cancer marker
Cytokeratin 197
- To explore the application value of tumor markers carcinoembryonic antigen and cytokeratin 19 fragment in the progression and prognosis of middle-advanced non-small cell lung cancer. (ijpsonline.com)
- Both carcinoembryonic antigen and cytokeratin 19 can be used in the diagnosis of squamous cell carcinoma and adenocarcinoma. (ijpsonline.com)
- When cytokeratin 19 was positive and carcinoembryonic antigen was negative, the proportion of squamous cell carcinoma was significantly higher than that of adenocarcinoma. (ijpsonline.com)
- Serum carcinoembryonic antigen and cytokeratin 19 were abnormally highly expressed in non-Small cell lung cancer patients, which are useful for clinical diagnosing, treatment planning, efficacy monitoring, and prognosis evaluation. (ijpsonline.com)
- Specimens were analyzed with a four-marker protein panel (4MP) consisting of the precursor form of surfactant protein B, cancer antigen 125, carcinoembryonic antigen, and cytokeratin-19 fragment. (ascopost.com)
- Levels of cytokeratin 19 fragments (CYFRA 21-1) and carcinoembryonic antigen (CEA) from serum and cytological fluid were measured. (elsevierpure.com)
- serum autoantibodies was in comparison to that of the tumor markers carcinoembryonic antigen (CEA), squamous cell carcinoma antigen (SCC-Ag) and cytokeratin 19 fragment antigen 21-1(CYFRA21-1). (pkc-inhibitor.com)
Tumour7
- Preoperative serum carcinoembryonic antigen (CEA) tumour marker is recommended to guide subsequent follow-up. (bccancer.bc.ca)
- Serum levels of tumour markers for carcinoembryonic antigen (CEA) and prostate specific antigen (PSA) were assessed using sandwich ELISA. (oncotarget.com)
- Tumour marker levels were consistent within all rhAFP/ACA treatment groups where levels of CEA and PSA were initially elevated upon commencement of treatment, and consecutively reduced corresponding to a decrease in tumour bulk volume. (oncotarget.com)
- ABSTRACT The value of serum tumour markers in the prognosis of patients with breast cancer is controversial. (who.int)
- This prospective study in Yazd, Islamic Republic of Iran, assessed the value of the tumour markers carcinoembryonic antigen (CEA) and cancer antigen (CA) 15-3 in 159 patients with primary breast cancer. (who.int)
- sis in primary breast cancer patients, toms of metastasis or recurrence and Tumour markers assays with elevated levels reflecting adverse with no other malignant disorders. (who.int)
- What is a high Tumour marker? (pfeiffertheface.com)
Carcino-embryonic antigen1
- All tumor markers, including serum carcino-embryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) were within normal limits. (koreamed.org)
Metastatic3
- Cancer antigen (CA) 27.29 most frequently is used to follow response to therapy in patients with metastatic breast cancer. (aafp.org)
- Circulating tumor cells (CTCs) have been accepted as a prognostic marker in patients with metastatic colorectal cancer (mCRC, UICC stage IV). (biomedcentral.com)
- A panel of four immunohistochemical markers (CK7, CK20, TTF-1, and p63) allows accurate diagnosis of primary and metastatic lung carcinoma on biopsy specimens. (novodiax.com)
Metastasis4
- Whether in the early diagnosis of tumor, in the monitoring of metastasis and recurrence or in the evaluation of efficacy and prognosis, tumor markers were very important clinical reference indicators[ 4 , 5 ]. (ijpsonline.com)
- Currently, detection of breast cancer metastasis relies on clinical manifestations of the spread to distant organs, biopsies of affected organs, radiological evaluations, imaging methods and serum tumor markers ( 3 , 4 ). (iiarjournals.org)
- The results of non-smoker females with primary CA15-3) suspicion of symptomatic serum CEA assay can reflect progno- breast cancer, without signs or symp- metastasis. (who.int)
- Synergistic interaction between galectin-3 and carcinoembryonic antigen promotes colorectal cancer metastasis. (novodiax.com)
Value of tumor markers1
- The aim of the study was to assess diagnosis value of tumor markers for differential diagnosis between mesothelioma and other pleural tumors. (nih.gov)
Carbohydrate3
- To investigate the prognostic value of postoperative serum carcinoembryonic antigen(CEA) combined with carbohydrate antigen 19-9(CA19-9), human chondroglycoprotein(YKL-40), C-reactive protein(CRP) and interleukin 6(IL-6) in patients with colorectal cancer(CRC) after radical resection. (xdyx.org.cn)
- 14] LEE T, TENG T Z J, SHELAT V G. Carbohydrate antigen 19-9-tumor marker:past, present, and future[J].World J Gastrointest Surg, 2020, 12(12):468-490. (xdyx.org.cn)
- Serum carbohydrate antigen 19-9 and CEA are tumor markers that can help diagnose CCA. (rarediseaseadvisor.com)
Biomarkers1
- Compared with the clinical monitoring techniques of Computed tomography (CT), Positron emission tomography computed tomography (PET-CT), and specific biomarkers, the detection of serum tumor markers was more simple, rapid and less invasive and has important clinical application value[ 6 - 9 ]. (ijpsonline.com)
Cell adhesion2
- Carcinoembryonic antigen (CEA) describes a set of highly-related glycoproteins involved in cell adhesion. (wikipedia.org)
- Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8. (cusabio.cn)
Preoperative3
- Because pathologic diagnosis of ovarian cancer is difficult without laparotomy, tumor markers such as CA-125, in addition to diagnostic imaging, are useful in preoperative evaluation for ovarian cancer. (medscape.com)
- Association of preoperative and postoperative serum carcinoembryonic antigen and colon cancer outcome[J].JAMA Oncol, 2018, 4(3):309-315. (xdyx.org.cn)
- High preoperative serum CA 19-9 levels can predict poor oncologic outcomes in colorectal cancer patients on propensity score analysis[J].Ann Surg Treat Res, 2019, 96(3):107-115. (xdyx.org.cn)
Assay1
- Carcinoembryonic antigen (CEA) assay. (cancer.gov)
Fragment1
- Many studies showed that the carcinoem-bryonic antigen (CEA) and human cytokeratin fragment antigen 21-1 (CYFRA21-1) has a high value in predicting tumor recurrence and judging the prognosis of patients[ 2 , 3 ]. (ijpsonline.com)
Prognosis4
- The various tumor markers differ in their usefulness for screening, diagnosis, prognosis, assessing therapeutic response, and detecting recurrence. (medscape.com)
- Each tumor marker has a variable profile of usefulness for screening, determining diagnosis and prognosis, assessing response to therapy, and monitoring for cancer recurrence. (aafp.org)
- Inflammatory markers and microRNAs:the backstage actors influencing prognosis in colorectal cancer patients[J].Int J Mol Sci, 2018, 19(7):1867-1880. (xdyx.org.cn)
- High pretreatment serum CA19-9 level predicts a poor prognosis for patients with stage III colon cancer after curative resection and adjuvant chemotherapy[J].J Cancer, 2019, 10(16):3810-3818. (xdyx.org.cn)
Glycoprotein2
- Carcinoembryonic antigen (CEA) is glycoprotein associated with various functions of endothelial cells, including adhesion, proliferation, and migration. (degruyter.com)
- Cancer antigen (CA) 27.29 is a monoclonal antibody to a glycoprotein (MUC1) that is present on the apical surface of normal epithelial cells. (aafp.org)
Colon cancer1
- Among these proteins is carcinoembryonic antigen, the most important serum marker clinically used in colon cancer patients to track disease progression or remission," said Dr Rudloff. (hudson.org.au)
Tissue5
- Carcinoembryonic antigen (CEA), hyaluronic acid, tissue polypeptide antigen and cyfra 21 to 1 were measured in serum and pleural fluid. (nih.gov)
- The tissue which is found in embryonic tissue is called carcinoembryonic antigen (CEA). (labpedia.net)
- CEA is a tumor-associated, oncofetal antigen seen in embryonic and fetal tissue. (labpedia.net)
- Another suggestion is to have intensive postoperative follow-up which includes consultations every 4-6 months, physical examination and evaluation of serum carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA) and breast cancer-associated antigen 115 D8/DF3 (CA15.3), at each visit. (iiarjournals.org)
- Serum and tissue markers in colorectal cancer: State of art. (novodiax.com)
Alpha-fetoprotein2
- Beta-hCG and alpha-fetoprotein have proved to be useful markers for ovarian germ cell tumors. (medscape.com)
- Alpha-fetoprotein (AFP), a marker for hepatocellular carcinoma, sometimes is used to screen highly selected populations and to assess hepatic masses in patients at particular risk for developing hepatic malignancy. (aafp.org)
Uric acid1
- Other common ones include C-reactive protein, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, lactate dehydrogenase, thyroid stimulating hormone (TSH), uric acid and serum uric acid levels. (newsnux.com)
Albumin2
- Patients with advanced pancreatic cancer and weight loss have laboratory evidence of malnutrition (eg, low serum albumin or cholesterol level). (medscape.com)
- The nanoclusters were synthesized with bovine serum albumin (BSA) and ovalbumin (OVA), respectively. (bvsalud.org)
Antibody1
- Monoclonal Antibody Analysis of Keratin Expression in Epidermal Diseases: A 48- and 56-kdalton Keratin as Molecular Markers for Hyperproliferative Keratinocytes. (novodiax.com)
Neoplasm1
- Is ca 72 a good marker for gastrointestinal neoplasm? (pfeiffertheface.com)
Sensitivity8
- The usefulness of a tumor marker is in its sensitivity and specificity, as well as its influence on patient management decisions. (medscape.com)
- No tumor markers with high sensitivity and high specificity for endometrial cancer are known at present, although CA-125 is often used in clinical practice. (medscape.com)
- Although CEA testing is a cost-effective and widely available diagnostic tumor marker, its lack of sensitivity and specificity precludes any pathognomonic diagnosis. (degruyter.com)
- With the exception of prostate-specific antigen (PSA), tumor markers do not have sufficient sensitivity or specificity for use in screening. (aafp.org)
- The sensitivity and area under the curve (AUC) of NAB alone were compared with those of NAB combined with serum or cytological tumor markers. (elsevierpure.com)
- In general, serum tumor markers are characterized by low sensitivity and low specificity. (doctorlib.info)
- The sensitivity, pecificity and positive predictive value(PPV) of postoperative serum CEA in predicting the recurrence were 21.3%, 90.3% and 80.3% respectively. (xdyx.org.cn)
- A blood test for cancer screening has been the 'holy grail' ever since the carcinoembryonic antigen blood test in the 1960s was claimed to have nearly 100% sensitivity and specificity - but turned out not to - for colorectal cancer," wrote David F. Ransohoff, MD, a gastroenterologist at the University of North Carolina (UNC), in a 2021 article . (medscape.com)
Cytology1
- The following are some of the most common tests: Complete blood count (CBC), serum tumor markers, carcinoembryonic antigen (CEA), prostate-specific antigen (PSA), urine cytology, and stool DNA tests. (newsnux.com)
Prognostic3
- Conclusions Recognition of serum CDC25B-Abs can be more advanced than detection from the tumor markers CEA, CYFRA21-1 and SCC-Ag for analysis of ESCC, and CDC25B-Abs certainly are a potential prognostic serological marker for advanced ESCC. (pkc-inhibitor.com)
- Serum CEA combined with CA19-9, YKL-40, CRP and IL-6 after radical resection can be used as prognostic indicators for colorectal cancer recurrence and survival. (xdyx.org.cn)
- Postoperative serum CA19-9, YKL-40, CRP and IL-6 in combination with CEA as prognostic markers for recurrence and survival in colorectal cancer[J].Acta Oncol, 2020, 59(12):1416-1423. (xdyx.org.cn)
Estradiol1
- The serum levels of estradiol (E2) and follicle stimulating hormone (FSH) were determined by ELISA. (bvsalud.org)
Cyfra1
- The cutoff values of 3.3 ng/mL for CYFRA 21-1 and 5.0 ng/mL for CEA (threshold A) or thresholds by adding 2 standard deviations to the mean levels of markers found in patients without malignancy (threshold B) were used to identify malignancy. (elsevierpure.com)
Protein3
- According Light et al's criteria for pleural fluid, an exudate is considered if one of the following parameters are met: the total protein fluid-to-serum ratio is higher than 0.5, the LDH fluid-to-serum ratio is more than 0.6, or the LDH fluid level exceeds two thirds of upper limit of normal serum level. (medscape.com)
- CEA is a protein that is a type of " tumor marker . (medlineplus.gov)
- A CA 125 test measures the amount of the protein CA 125 (cancer antigen 125) in the blood. (pfeiffertheface.com)
Urine1
- Tumor markers are soluble glycoproteins that are found in the blood, urine, or tissues of patients with certain types of cancer. (medscape.com)
Biopsy1
- Background: The purpose of this study was to assess whether analyses of tumor markers in cytological fluid can improve the performance of computed tomography (CT)-guided needle aspiration biopsy (NAB) for the diagnosis of ground-glass opacity (GGO) pulmonary lesions. (elsevierpure.com)
Substances2
- Tumor markers are substances that can be detected in the peripheral blood and are derived from neoplastic populations, but lack functional hormonal or other physiologic activity. (doctorlib.info)
- Tumor markers are substances that are often made by cancer cells or by normal cells in response to cancer. (medlineplus.gov)
Liver3
- Imaging studies in- was one of the first serum-based tu- The study sample was women with cluding chest X-rays, liver ultrasonog- mour markers to be characterized, primary breast cancer attending a pri- raphy and bone scans were performed and its utility has been assessed in vate clinic in Yazd, Islamic Republic if there was clinical or laboratory a variety of malignancies including of Iran. (who.int)
- Western blot was used to detect the changes of epithelial mesenchymal transition (EMT) markers in liver cancer cells after down-regulation of SNRPB expression. (bvsalud.org)
- Western blot showed that the expression level of epithelial phenotype marker E-cadherin was decreased after down-regulation of SNRPB, while the expression levels of mesenchymal phenotype markers N-cadherin and vimentin was increased, suggesting that down-regulation of SNRPB inhibited EMT in liver cancer cells. (bvsalud.org)
Recurrence1
- In monitoring patients for disease recurrence, tumor marker levels should be determined only when there is a potential for meaningful treatment. (aafp.org)
Patients12
- Tumor markers are not elevated in all cancer patients, particularly patients with early-stage cancer. (medscape.com)
- The present case illustrates potential clinical challenges in using serum tumor markers, namely CEA, to monitor cancer patients. (degruyter.com)
- Relevance of Traditional CEA and CA15-3 and Bone Turnover Markers in Predicting Bone Relapse in Breast Cancer Patients. (her2support.org)
- This tumor marker is used to find the extent of disease in patients, particularly gastrointestinal cancers. (labpedia.net)
- 6 ) emphasized that the inclusion of serum tumor markers is an important factor in the postoperative monitoring of breast cancer patients ( 7 , 8 ). (iiarjournals.org)
- Because family physicians are assuming a greater role in caring for patients with cancer, an understanding of tumor markers is becoming increasingly important. (aafp.org)
- Nevertheless, tumor markers can play a crucial role in detecting disease and assessing response to therapy in selected groups of patients. (aafp.org)
- Several studies have We excluded patients who had other In the present study CEA and CA15-3 shown that changes in the CEA serum disorders that could affect the serum levels were measured from patients' level might be linked to progression level of CEA or CA15-3, whether on- serum sample. (who.int)
- A total of 2226 deter- or regression status in breast cancer cological (lung, colorectal, pancreas minations of serum CEA and CA15-3 patients [5-8]. (who.int)
- Nursing based on oxygen administration decreased the value of renal function indexes, serum inflammatory factors, and tumor markers in renal cell carcinoma patients. (biomedcentral.com)
- Receiver operating characteristic (ROC) curve analysis showed that combination of serum miRNA-18a and miRNA-21 overexpression could efficiently distinguish patients of ESCC from healthy controls. (gastrores.org)
- The researchers also reported that patients with a carcinoembryonic antigen (CEA) concentration of 5 ng/mL or less before treatment had longer progression-free and overall survival times than those with a CEA concentration higher than 5 ng/mL. (rarediseaseadvisor.com)
Radiographic1
- Normalization of tumor marker values may indicate cure despite radiographic evidence of persistent disease. (medscape.com)
Concentration2
- Results: In some of the outlier controls, higher than expected AA concentration was linked to increased serum carcinoembryonic antigen. (figshare.com)
- The concentration of CDC25B autoantibodies in serum was correlated with tumor stage ( em P /em 0 significantly.001). (pkc-inhibitor.com)
Biomarker2
- Carcinoembryonic antigen is the preferred biomarker for in vivo colorectal cancer targeting. (novodiax.com)
- The 2022 ACG guidelines suggest that use of a swallowable, nonendoscopic capsule sponge device combined with a biomarker obtained from the device (trefoil factor 3 [TFF3] or methylated DNA markers [MDMs]) is an acceptable alternative to endoscopy for screening for Barrett esophagus. (medscape.com)
Proteins1
- Lately, a proteomics-based strategy identified many autoantibodies in sera of individuals with ESCC, such as for example anti-heat shock proteins 70 [10] and anti-peroxiredoxin VI [11]. (pkc-inhibitor.com)
Levels15
- However, the serum levels are raised in some types of cancer, which means that it can be used as a tumor marker in clinical tests. (wikipedia.org)
- Serum levels can also be elevated in heavy smokers. (wikipedia.org)
- Serum from individuals with colorectal carcinoma often has higher levels of CEA than healthy individuals (above approximately 2.5 µg/L). CEA measurement is mainly used as a tumor marker to monitor colorectal carcinoma treatment, to identify recurrences after surgical resection, for staging or to localize cancer spread through measurement of biological fluids. (wikipedia.org)
- The levels of serum tumor markers were detected by electrochemiluminescence immunoassay. (ijpsonline.com)
- Particular emphasis is given to when these tests should be ordered and to common factors that influence the interpretation of tumor marker levels. (aafp.org)
- Conversely, tumor marker levels may rise after effective treatment (possibly related to cell lysis), but the increase may not portend treatment failure. (aafp.org)
- However, a consistent increase in tumor marker levels, coupled with lack of clinical improvement, may indicate treatment failure. (aafp.org)
- In laboratory findings, we found elevated serum levels of bilirubin (3.38 mg/dl), alkaline phosphatase (229 U/L), gamma-glutamyl transpeptidase (843 U/L), alanine aminotransferase (389 U/L), and aspartate aminotransferase (602 U/L). There were no leukocytosis, and viral hepatitis markers were normal. (koreamed.org)
- The inclusion criteria were (abnormal serum levels of CEA or breast cancer [1-3]. (who.int)
- The levels of serum CEA, CA19-9, YKL-40, CRP and IL-6 were measured before adjuvant chemotherapy. (xdyx.org.cn)
- Conditions besides cancer can raise tumor marker levels. (pfeiffertheface.com)
- High tumor marker levels can be a sign of cancer. (pfeiffertheface.com)
- Many circumstances, such as other health issues or disease, can contribute to raised tumor marker levels. (pfeiffertheface.com)
- For example, noncancerous conditions can sometimes cause the levels of certain tumor markers to increase. (pfeiffertheface.com)
- In fact, an elevation of serum levels of Ca 72.4 should always be taken seriously. (pfeiffertheface.com)
Assays1
- In addition, beta-hCG serves as an ideal tumor marker for monitoring gestational trophoblastic disease and has set the standard with which other assays must be compared. (medscape.com)
Benign1
- The most important advantage of the CA 72‑4 marker over others is its particularly high diagnostic specificity for benign illnesses. (pfeiffertheface.com)
Diagnosis6
- A CEA level above 3 ng/mL in pleural fluid eliminated the diagnosis of mesothelioma, whereas the other markers were not sufficiently discriminant. (nih.gov)
- The study involved analysis of 1,299 sera collected preceding lung cancer diagnosis and 8,709 noncase sera from the PLCO Cancer Screening Trial. (ascopost.com)
- Use of the 4MP alone was associated with a receiver operating characteristic area under the curve of 0.79 (95% confidence interval [CI] = 0.77-0.82) for case sera collected within 1 year preceding diagnosis and 0.72 (95% CI = 0.69-0.75) among case sera collected within 1 to 6 years preceding diagnosis (all case sera). (ascopost.com)
- The combined 4MP plus PLCOm2012 model yielded an area under the curve of 0.85 (95% CI = 0.82-0.88) for case sera collected within 1 year preceding diagnosis. (ascopost.com)
- Immunologic Markers in the Differential Diagnosis of Small Round Cell Tumors from Lymphocytic Lymphoma and Leukemia. (novodiax.com)
- What are the current best immunohistochemical markers for the diagnosis of epithelioid mesothelioma? (novodiax.com)
Thyroid1
- Unexplained increase of serum carcinoembryonic antigen: don't forget the thyroid! (degruyter.com)
Specificity1
- In conclusion, the high specificity of this marker for gastrointestinal neoplasms may be very interesting in follow-up studies. (pfeiffertheface.com)
Colorectal carcinoma1
- This was found in the serum of a patient with colorectal carcinoma. (labpedia.net)
Relapse2
Malignancies2
- Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
- Monoclonal antibodies are used to detect serum antigens associated with specific malignancies. (aafp.org)
Monoclonal1
- Many new tumor markers have been discovered since the development of monoclonal antibodies, and most tumor markers are now detected with them. (medscape.com)
CA1251
- Evaluation of serum CEA, CA19-9, CA72-4, CA125 and ferritin as diagnostic markers and factors of clinical parameters for colorectal cancer[J].Sci Rep, 2018, 8(1):2732-2740. (xdyx.org.cn)
Cancer marker1
- What are good cancer marker numbers? (pfeiffertheface.com)