• A carboxypeptidase (EC number 3.4.16 - 3.4.18) is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide. (wikipedia.org)
  • In the case of pancreatic carboxypeptidase A, the inactive zymogen form - pro-carboxypeptidase A - is converted to its active form - carboxypeptidase A - by the enzyme trypsin. (wikipedia.org)
  • Angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a recently identified zinc metalloprotease with carboxypeptidase activity that was identified using our genomics platform. (acs.org)
  • The NH2-terminal amino acid sequence was determined and turned out to be identical to the NH2-terminal sequence of the membrane-bound carboxypeptidase M. By precipitation with antibodies MAX.1 and MAX.11, membrane preparations of macrophages and placental microvilli were almost completely depleted of enzyme activity, indicating that the two antibodies indeed recognize carboxypeptidase M. Immunoreactivity of both antibodies correlates with the reported tissue distribution of enzyme activity. (uni-regensburg.de)
  • Most peptide substrates were sequentially truncated from the carboxyl-terminus revealing that this enzyme is a bona fide carboxypeptidase. (usf.edu)
  • Function This molecular model depicts the enzyme Bovine Carboxypeptidase A (CPA). (harvard.edu)
  • A mutation of carboxypeptidase E (CPE), an enzyme active in the processing and sorting of prohormones, causes obesity in the fat/fat mouse. (nih.gov)
  • Description Carboxypeptidase M (CPM) is a membrane-bound zinc-dependent protease that cleaves C-terminal basic residues, such as arginine or lysine, from peptides/proteins. (razikurd.ir)
  • Carboxypeptidase M, also known as CPM, is a membrane-bound arginine/lysine carboxypeptidase which is a member of the carboxypeptidases family. (betalifesci.com)
  • Human pancreatic procarboxypeptidase A exists as three different active forms, two of which are designated carboxypeptidase A1 (CPA1) and carboxypeptidase A2 (CPA2). (neobiotechnologies.com)
  • This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with human recombinant protein of Carboxypeptidase A2 (CPA2). (angioproteomie.com)
  • This antibody was selected for its ability to detect human Carboxypeptidase A2 (CPA2). (angioproteomie.com)
  • It is a Zn(2+)-dependent D,L-carboxypeptidase that cleaves the bond between the γ-D-Glu and the mDAP of the non-cross-linked muramyltripeptide (muramyl-L-Ala-γ-D-Glu-mDAP) of the peptidoglycan to produce the muramyldipeptide (muramyl-L-Ala-γ-D-Glu) and mDAP. (rcsb.org)
  • Humans, animals, bacteria and plants contain several types of carboxypeptidases that have diverse functions ranging from catabolism to protein maturation. (wikipedia.org)
  • Analysis of Protein Array containing more than 19,000 full-length human proteins using Carboxypeptidase A1 / CPA1 Mouse Monoclonal Antibody (CPA1/2714). (neobiotechnologies.com)
  • ACE-2 is the SARS-CoV and SARS-CoV2 Spike protein receptor in vivo (4-6), functions catalytically as a carboxypeptidase to cleave several substrates including angiotensins I and II, and acts as a partner for B0AT1-family amino acid transporters (1, 2). (rndsystems.com)
  • Ghrelin regulates hypothalamic prolyl carboxypeptidase expression in m" by Jin Kwon Jeong, Jung Dae Kim et al. (gwu.edu)
  • Characterization of PdCP1, a serine carboxypeptidase from Pseudogymnoa" by Chapman Beekman, Zhenze Jiang et al. (usf.edu)
  • Glutamate carboxypeptidase II (GCPII, EC 3.4.17.21) is a membrane peptidase expressed in a number of tissues such as kidney, prostate and brain. (johnshopkins.edu)
  • In this paper we report expression of an extracellular portion of human glutamate carboxypeptidase II (amino acids 44-750) in Drosophila Schneider's cells and its purification to homogeneity. (johnshopkins.edu)
  • Glutamate carboxypeptidase II gene polymorphisms and neural tube defects in a high-risk Chinese population. (cdc.gov)
  • Pyrrolidone carboxypeptidases (Pcps) (E.C. 3.4.19.3) can cleave the peptide bond adjacent to pyro-glutamic acid (pGlu), an N-terminal modification observed in some proteins that provides protection against common proteases. (leehicam.com)
  • Dive into the research topics of 'The pro region is not required for the expression or intracellular routeing of carboxypeptidase E'. Together they form a unique fingerprint. (elsevierpure.com)
  • Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1. (iasp-pain.org)
  • Mast cells express ETRs and can thereby be degranulated by ET-1, and mast cell proteases chymase and carboxypeptidase A3 (CPA3) are known to either generate or degrade ET-1, respectively, suggesting a role for mast cell proteases in the regulation of ET-1-induced itch. (iasp-pain.org)
  • They also regulate biological processes, such as the biosynthesis of neuroendocrine peptides such as insulin requires a carboxypeptidase. (wikipedia.org)
  • Carboxypeptidases hydrolyze peptides at the first amide or polypeptide bond on the C-terminal end of the chain. (wikipedia.org)
  • Carboxypeptidases are usually classified into one of several families based on their active site mechanism. (wikipedia.org)
  • This mechanism ensures that the cells wherein pro-carboxypeptidase A is produced are not themselves digested. (wikipedia.org)
  • Expression of carboxypeptidase M on mRNA level and enzymatic activity markedly increase during in vitro differentiation of monocytes, according to the described increase in MAX.1 and MAX.11 antigen expression. (uni-regensburg.de)
  • Carboxypeptidases act by replacing the substrate water with a carbonyl (C=O) group. (wikipedia.org)
  • Another classification system for carboxypeptidases refers to their substrate preference. (wikipedia.org)
  • The D,L-carboxypeptidase domain recognizes the substrate by interacting primarily with the terminal mDAP moiety of the muramyltripeptide. (rcsb.org)
  • A ZINC-dependent carboxypeptidase primary found in the DIGESTIVE SYSTEM. (rush.edu)
  • Among the carboxypeptidases CPM is of particular importance because of its constitutive expression in an active form at the surface of specialized cells and tissues in the human body. (betalifesci.com)
  • Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (PubMed:8806703). (neobiotechnologies.com)
  • A carboxypeptidase that catalyzes the release of a C-terminal amino acid with a broad specificity. (bvsalud.org)
  • In addition, carboxypeptidase M expression could be detected in HL-60, U937, and THP-1 myeloid cell lines. (uni-regensburg.de)
  • Vitamin D3-induced monocytic differentiation resulted in an increased carboxypeptidase M expression in all three cell lines. (uni-regensburg.de)
  • Enzymes that use a metal in the active site are called "metallo-carboxypeptidases" (EC number 3.4.17). (wikipedia.org)
  • Other carboxypeptidases that use active site serine residues are called "serine carboxypeptidases" (EC number 3.4.16). (wikipedia.org)
  • Those that use an active site cysteine are called "cysteine carboxypeptidase" (or "thiol carboxypeptidases")(EC number 3.4.18). (wikipedia.org)
  • The table contains 1 products whose active ingredient are classified under the same pharmacologic class Carboxypeptidase [EPC]. (ndclist.com)
  • SDS-PAGE Analysis Purified Carboxypeptidase A1 / CPA1 Mouse Monoclonal Antibody (CPA1/2714). (neobiotechnologies.com)
  • The degradation of the GSH moieties requires the activity of the Cys-Gly carboxypeptidase GliJ, for which we describe the X-ray structure here. (cipsm.de)
  • Further studies are needed to elucidate the functional role of carboxypeptidase M during monocytic differentiation and activation. (uni-regensburg.de)
  • This graph shows the total number of publications written about "Carboxypeptidase B" by people in this website by year, and whether "Carboxypeptidase B" was a major or minor topic of these publications. (rush.edu)