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  • amides
  • Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a carboxy terminated six carbon aliphatic structure. (ucdenver.edu)
  • alpha
  • alpha/beta-Hydrolase domain containing 12 ( ABHD12 ) is a serine hydrolase encoded by the ABHD12 gene that participates in the breakdown of the endocannabinoid neurotransmitter 2-arachidonylglycerol (2-AG) in the central nervous system . (thcscience.wiki)
  • domain
  • In vitro, enzymatic activity of ABHD12 can be eliminated by site mutation the residues Serine -246, Aspartate -333, or Histidine -372, which form a catalytic triad in the hydrolase domain. (thcscience.wiki)
  • Several unexpected evolutionary connections were identified, including the apparent origin of the beta-subunit of bacterial GlyRS from the HD superfamily of hydrolases, a domain shared by bacterial AspRS and the B subunit of archaeal glutamyl-tRNA amidotransferases, and another previously undetected domain that is conserved in a subset of ThrRS, guanosine polyphosphate hydrolases and synthetases, and a family of GTPases. (embl.de)