Glutathione and thiol compounds (cysteine, thioglycolic acid or thiocresol) or ascorbic acid have a protective effect on browning and disappearance of caffeic acid. (wikipedia.org)
Within the field of steroids the use of coupling agents have also found use, especially in the preparation of carbothioic acids and esters of the androstane series (e.g. (allindianpatents.com)
Mandelic Acids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
This graph shows the total number of publications written about "Mandelic Acids" by people in this website by year, and whether "Mandelic Acids" was a major or minor topic of these publications. (jefferson.edu)
Below are the most recent publications written about "Mandelic Acids" by people in Profiles. (jefferson.edu)
Salts2
Method for preparing a steroidal carbothioic acid by reacting steroidal carboxylic acids or salts with carbodiimides alone or in conjunction with a coupling enhancer followed by reaction with a nucleophilic sulfur containing agent. (allindianpatents.com)
WO 2006/135881 describes quaternized ammonium salts prepared by condensation of a hydrocarbyl-substituted acylating agent and of an oxygen- or nitrogen-containing compound with a tertiary amino group, and subsequent quaternization by means of hydrocarbyl epoxide in the presence of stoichiometric amounts of an acid, especially acetic acid. (trea.com)
Ester6
Caffeic acid, which is unrelated to caffeine, is biosynthesized by hydroxylation of coumaroyl ester of quinic acid (esterified through a side chain alcohol). (wikipedia.org)
This hydroxylation produces the caffeic acid ester of shikimic acid, which converts to chlorogenic acid. (wikipedia.org)
Caffeic acid and its derivative caffeic acid phenethyl ester (CAPE) are produced in many kinds of plants. (wikipedia.org)
The introduction of sulfur proceeds via nucleophilic attack of S -thiocysteine to the Michael acceptor of tropone-2-carboxylic acid coenzyme A ester and oxidative elimination of cysteine. (beilstein-journals.org)
The intermediate (such as an ester of formula (III)) is very suitable for use in a method for the conversion of a steroidal carboxylic acid to a steroidal carbothioic acid or a carbothioate. (allindianpatents.com)
In organic chemistry, Carboxylate , an organic compound , is a salt, ester or anion of a carboxylic acid . (wellnessadvantage.com)
Aromatic1
Carboxylic acids can be saturated, unsaturated, or aromatic. (bvsalud.org)
Acetic acid1
A 3-O-methyl ETHER of (3,4-dihydroxyphenyl)acetic acid. (nih.gov)
Niflumic Acid3
Niflumic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
This graph shows the total number of publications written about "Niflumic Acid" by people in this website by year, and whether "Niflumic Acid" was a major or minor topic of these publications. (childrensmercy.org)
Below are the most recent publications written about "Niflumic Acid" by people in Profiles. (childrensmercy.org)
Derivatives6
Analogs or derivatives of mandelic acid (alpha-hydroxybenzeneacetic acid). (jefferson.edu)
The present invention relates to a novel process for the conversion of steroidal carboxylic acids to carbothioate derivatives such as fluticasone propionate via novel intermediates. (allindianpatents.com)
The problem to be solved by the present invention is to provide a new method for the preparation of steroidal carbothioic acid and derivatives thereof such as fluticasone propionate, especially a method in which a number of the relevant method steps may be performed as a continuous one-pot synthesis. (allindianpatents.com)
In organic chemistry, Carboxylic Acid is an organic compound and the principle member of the carboxylic acids and derivatives class in the organic acids superclass with as a carbonyl compound has the general formula of a carboxylic acid as a R-COOH, where R is some monovalent functional group. (wellnessadvantage.com)
The aim of these studies has been to develop a much-needed general synthetic route to amino acids (and other amine derivatives) possessing a quaternary chiral centre alpha -to the nitrogen atom and in particular, alpha , alpha -disubstituted alpha -amino acids. (exeter.ac.uk)
The central theme of this methodology is the formation of alpha -aminoalkyl radicals from existing amino acid and alpha -amino alcohol derivatives by 1,5-hydrogen atom transfer and the subsequent trapping of these radicals with appropriate radicalphiles, thus generating quaternary centres with high efficiency and excellent stereocontrol. (exeter.ac.uk)
Synthesis3
Coupling agents and enhancers have primarily been used in peptide chemistry where the need to activate carboxylic acids in order to facilitate peptide couplings has been recognized for decades (Handbook of Reagents for Organic Synthesis, Activating Agents and Protecting Groups, ed. (allindianpatents.com)
Recent studies have focused on asymmetric synthesis of structurally complex amino acids, using what has proved to be a very versatile radical-based methodology and also the use of structurally unusual heterocycles for masking the reactivity of synthetically valuable functional groups. (exeter.ac.uk)
The use of radical-based methodology in the synthesis of highly substituted amines and amino acids. (exeter.ac.uk)
Ascorbic acid1
M. jaboticaba reportedly contains peonidin 3-glucoside and its aglycone (5), and the related camu-camu berry ( M. dubia ), an edible fruit known for its high levels of ascorbic acid, contains Compound 3 and delphinidin 3-glucoside (Compound 4) as its main pigments (6). (justia.com)
Structurally1
Tropodithietic acid (TDA) is a structurally unique sulfur-containing antibiotic from the Roseobacter clade bacterium Phaeobacter inhibens DSM 17395 and a few other related species. (beilstein-journals.org)
Compound3
Caffeic acid is an organic compound that is classified as a hydroxycinnamic acid. (wikipedia.org)
It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. (drugbank.com)
The Carboxylate Ion, is a negatively charged organic compound with its conjugate base of a Carboxylic Acid . (wellnessadvantage.com)
Ferulic3
It is the precursor to ferulic acid, coniferyl alcohol, and sinapyl alcohol, all of which are significant building blocks in lignin. (wikipedia.org)
The transformation to ferulic acid is catalyzed by the enzyme caffeate O-methyltransferase. (wikipedia.org)
Caffeate O-methyltransferase is an enzyme responsible for the transformation of caffeic acid into ferulic acid. (wikipedia.org)
Caffeic18
Caffeic acid can be found in the bark of Eucalyptus globulus the barley grain Hordeum vulgare and the herb Dipsacus asperoides. (wikipedia.org)
Free caffeic acid can be found in a variety of beverages, including brewed coffee at 0.13 mg per 100 ml and red wine at 2 mg per 100 ml. (wikipedia.org)
Caffeic acid occurs at moderate levels in sunflower seeds (8 mg per 100 g), apple sauce, apricots and prunes (at about 1 mg per 100 g). (wikipedia.org)
Caffeic acid and related o-diphenols are rapidly oxidized by o-diphenol oxidases in tissue extracts. (wikipedia.org)
Caffeate 3,4-dioxygenase is an enzyme that uses caffeic acid and oxygen to produce 3-(2-carboxyethenyl)-cis,cis-muconate. (wikipedia.org)
Caffeic acid has a variety of potential pharmacological effects in in vitro studies and in animal models, and the inhibitory effect of caffeic acid on cancer cell proliferation by an oxidative mechanism in the human HT-1080 fibrosarcoma cell line has recently been established. (wikipedia.org)
Caffeic acid is an antioxidant in vitro and also in vivo. (wikipedia.org)
Caffeic acid also shows immunomodulatory and anti-inflammatory activity. (wikipedia.org)
Caffeic acid outperformed the other antioxidants, reducing aflatoxin production by more than 95 percent. (wikipedia.org)
The studies are the first to show that oxidative stress that would otherwise trigger or enhance Aspergillus flavus aflatoxin production can be stymied by caffeic acid. (wikipedia.org)
Studies of the carcinogenicity of caffeic acid have mixed results. (wikipedia.org)
Oral administration of high doses of caffeic acid in rats has caused stomach papillomas. (wikipedia.org)
In the same study, high doses of combined antioxidants, including caffeic acid, showed a significant decrease in growth of colon tumors in those same rats. (wikipedia.org)
More recent data show that bacteria in the rats' guts may alter the formation of metabolites of caffeic acid. (wikipedia.org)
Other than caffeic acid being a thiamine antagonist (antithiamine factor), there have been no known ill effects of caffeic acid in humans. (wikipedia.org)
Also, caffeic acid treatment attenuated lipopolysaccharide (LPS)-induced sickness behaviour in experimental animals by decreasing both peripheral and central cytokine levels along with oxidative stress inflicted by LPS. (wikipedia.org)
Caffeic acid is susceptible to autoxidation. (wikipedia.org)
Chemical oxidation of caffeic acid in acidic conditions using sodium periodate leads to the formation of dimers with a furan structure (isomers of 2,5-(3′,4′-dihydroxyphenyl)tetrahydrofuran 3,4-dicarboxylic acid). (wikipedia.org)
Oxidative1
Copper-catalyzed oxidative C(sp 3 )-H/C (sp 2 )-H cross-coupling en route to carbocyclic rings. (ustc.edu.cn)
Thereof1
The present invention provides a method which comprises A) reacting a steroidal carboxylic acid or a salt thereof with a coupling agent alone or in conjunction with a coupling enhancer, and B) reacting the product of step A) with a nucleophilic agent comprising a sulfur atom. (allindianpatents.com)
Isomers1
3-O-caffeoylshikimic acid (dactylifric acid) and its isomers, are enzymic browning substrates found in dates (Phoenix dactylifera fruits). (wikipedia.org)
Group1
Dicarboxylic acids in which one of the carboxyl groups (-COOH) has been replaced by an aldehyde group (-CHO). (wakehealth.edu)
Total1
This graph shows the total number of publications written about "Abscisic Acid" by people in this website by year, and whether "Abscisic Acid" was a major or minor topic of these publications. (ouhsc.edu)
Activity1
We have synthesised several structural analogues of TDA and used them in bioactivity tests against Staphylococcus aureus and Vibrio anguillarum for a structure-activity relationship (SAR) study, revealing that the sulfur-free analogue of TDA, tropone-2-carboxylic acid, has an antibiotic activity that is even stronger than the bioactivity of the natural product. (beilstein-journals.org)
Study1
Particularly interesting is the mechanism of sulfur introduction that we have recently investigated in a study combining gene knockouts and feeding experiments with 34 S-labelled amino acids [8] . (beilstein-journals.org)