• Chloroacetic acid was first prepared (in impure form) by the French chemist FĂ©lix LeBlanc (1813-1886) in 1843 by chlorinating acetic acid in the presence of sunlight, and in 1857 (in pure form) by the German chemist Reinhold Hoffmann (1831-1919) by refluxing glacial acetic acid in the presence of chlorine and sunlight, and then by the French chemist Charles Adolphe Wurtz by hydrolysis of chloroacetyl chloride (ClCH2COCl), also in 1857. (wikipedia.org)
  • Then, the optimal pretreatment method was determined by comparing the recovery rates of the 40 drugs obtained with different extraction solvents (methanol, acetonitrile, acetonitrile containing 0.1% ammonia, acetonitrile with 1% acetic acid), different extraction methods (ultrasonic extraction, shaking extraction), and purification with primary secondary amine (PSA) and C18. (bvsalud.org)
  • This group of compounds includes amino acids and fatty acids. (lookformedical.com)
  • Related compounds are dichloroacetic acid and trichloroacetic acid. (wikipedia.org)
  • The compounds of the formula (I) can optionally exist as geometric and/or optical isomers or isomer mixtures of different composition, depending on type of the substituents R.sup.1 and R.sup.2. (justia.com)
  • This carboxylic acid is a useful building block in organic synthesis. (wikipedia.org)
  • Illustrative of its usefulness in organic chemistry is the O-alkylation of salicylaldehyde with chloroacetic acid, followed by decarboxylation of the resulting ether, producing benzofuran. (wikipedia.org)
  • Chloroacetic acid is also used in the production of phenoxy herbicides by etherification with chlorophenols. (wikipedia.org)
  • Mechanism and kinetics of tyrosinase inhibition by glycolic acid: a study using conventional spectroscopy methods and hydrogen/deuterium exchange coupling with mass spectrometry. (harvard.edu)
  • It is conjugated to GLYCINE in the liver and excreted as hippuric acid. (lookformedical.com)
  • It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (lookformedical.com)
  • 2-Methyl-4-chlorophenoxyacetic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
  • Chloroacetic acid, industrially known as monochloroacetic acid (MCA), is the organochlorine compound with the formula ClCH2CO2H. (wikipedia.org)
  • Twenty alpha-amino acids are the subunits which are polymerized to form proteins. (lookformedical.com)
  • Like other chloroacetic acids and related halocarbons, chloroacetic acid is a hazardous alkylating agent. (wikipedia.org)
  • This graph shows the total number of publications written about "2-Methyl-4-chlorophenoxyacetic Acid" by people in UAMS Profiles by year, and whether "2-Methyl-4-chlorophenoxyacetic Acid" was a major or minor topic of these publications. (uams.edu)