• following surgery, chemotherapy (neoadjuvant or adjuvant) and radiotherapy (if applicable) (see section 5.1) - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)
  • A clinical trial testing the combination of Gemcitabine and Carboplatin saw overall positive results among the 50 patients tested. (maacenter.org)
  • Some patients with advanced non-small-cell lung cancer (NSCLC) have slightly higher survival rates when treated with the chemotherapy drug cisplatin than another platinum-based drug, carboplatin, according to a study in the June 6 Journal of the National Cancer Institute . (eurekalert.org)
  • Carboplatin is a chemotherapy drug that has been on the market since the 1980s, and has been popular for treating a variety of cancers, including lung and ovarian cancer. (maacenter.org)
  • This partially randomized phase III trial studies how well active surveillance, bleomycin, carboplatin, etoposide, or cisplatin work in treating pediatric and adult patients with germ cell tumors. (columbia.edu)
  • To compare the event-free survival of a carboplatin versus (vs.) cisplatin-based regimen in the treatment of pediatric, adolescent and young adult patients with standard risk germ cell tumors. (yalemedicine.org)
  • I. To compare the incidence of ototoxicity and nephrotoxicity in children, adolescents and young adults with standard risk germ cell tumors treated with carboplatin-based chemotherapy as compared to cisplatin-based chemotherapy. (yalemedicine.org)
  • To compare self-reported peripheral neuropathy and other patient-reported outcomes between children, adolescents and young adults with standard risk germ cell tumors treated with carboplatin-based chemotherapy as compared to cisplatin based chemotherapy. (yalemedicine.org)
  • The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of tiragolumab in combination with atezolizumab plus pemetrexed and carboplatin/cisplatin (Arm A) compared with placebo in combination with pembrolizumab plus pemetrexed and carboplatin/cisplatin (Arm B) in participants with previously untreated, locally advanced unresectable or metastatic non-squamous non-small cell lung cancer (NSCLC). (survivornet.com)
  • A combination of alimta and cisplatin has remained the standard of care for years. (maacenter.org)
  • Most often, Alimta is used in combination with cisplatin as a first-line therapy after a clinical trial showed pemetrexed plus Cisplatin extended the patients' survival to about 12 months, compared to 9 months when treated with cisplatin on its own. (maacenter.org)
  • In a clinical trial held from 2008 to 2014, 223 patients received a combination of Avastin, Alimta and Cisplatin. (maacenter.org)
  • This "triplet" therapy showed promising results, with patients' experiencing a median survival of 19 months versus 16 months with the combination of just Alimta and Cisplatin. (maacenter.org)
  • The chemo I will be starting with is Carboplatin, Alimta & Avastin. (cancer.org)
  • I had a very similar combination of Cisplatin/Alimta/Avastin. (cancer.org)
  • They include certain antibiotics like gentamicin, cancer treatment drugs like cisplatin and carboplatin, and pain relievers that contain salicylate like aspirin, quinine, loop diuretics. (cdc.gov)
  • In an accompanying editorial, Christopher Azzoli, M.D., and colleagues at the Memorial Sloan-Kettering Cancer Center in New York discuss the renewed rivalry between cisplatin and carboplatin, particularly in the face of new developments in adjuvant chemotherapy for NSCLC patients. (eurekalert.org)
  • Andrea Ardizzoni, M.D., of University Hospital in Parma, Italy, and colleagues conducted a review of nine randomized trials comparing the survival of 2,968 NSCLC patients who received either cisplatin- or carboplatin-based chemotherapy. (eurekalert.org)
  • Patients who received cisplatin lived slightly longer than those treated with carboplatin, with a median survival of 9.1 months compared with 8.4 months. (eurekalert.org)
  • Another clinical trial conducted between 2008 and 2014, found a median survival of 16 months for 225 patients treated with a combination of pemetrexed + Cisplatin. (maacenter.org)
  • Drugs used in chemotherapy, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (columbia.edu)
  • Some anticancer drugs, primarily cisplatin, can cause substantial hearing loss in the high- to ultra-high-frequency range-6,000 to 12,000 Hertz (Hz). (alexslemonade.org)
  • Chemotherapy drugs, including cisplatin and carboplatin, have been in short supply for months. (avma.org)
  • Cisplatin- Versus Carboplatin-Based Chemotherapy in First-Line Treatment of Advanced Non - Small-Cell Lung Cancer: An Individual Patient Data Meta-analysis. (eurekalert.org)
  • Cisplatin Versus Carboplatin for Patients With Metastatic Non - Small-Cell Lung Cancer - An Old Rivalry Renewed. (eurekalert.org)
  • Given the palliative nature of chemotherapy treatment in advanced NSCLC and the unquestionable practical advantage of carboplatin in terms of ease of administration, it could be argued that the small benefit achieved with cisplatin relative to carboplatin does not justify its preferential use in clinical practice. (eurekalert.org)
  • Before the discovery of cisplatin and its successful use as an anticancer agent in the 70s, metal complexes were rarely considered useful for medical applications. (hindawi.com)
  • Main advantages over cisplatin include less nephrotoxicity and ototoxicity not requiring extensive prehydration, less likely to induce nausea and vomiting, but more likely to induce myelotoxicity. (medscape.com)
  • Concurrent cisplatin-based chemotherapy should be considered in conjunction with radiation therapy. (medscape.com)
  • Cisplatin is a platinum-containing compound that exerts an antineoplastic effect by covalently binding to DNA, with preferential binding to N-7 position of guanine and adenosine. (medscape.com)
  • Equally inadvisable would be the overzealous use of cisplatin in patients with metastatic NSCLC for whom the drug may be poorly tolerated, such as those with significant baseline renal impairment, hearing loss, peripheral neuropathy, or other serious medical comorbidities," the authors write. (eurekalert.org)
  • Ethan's treatment for medulloblastoma, which included cisplatin, caused high-end hearing loss, which means that in rooms with a lot of people he can't hear at all. (alexslemonade.org)
  • Because of the change in her hearing, the cisplatin was removed from the remaining two cycles of chemotherapy called for in her protocol. (alexslemonade.org)
  • Most clinicians in North America prefer carboplatin to cisplatin because it has fewer side effects and is easier to administer. (eurekalert.org)
  • Cisplatin is a little bit stronger but tends to have more intense side effects. (cancer.org)
  • The authors conclude that cisplatin chemotherapy should remain the standard of care for these patients. (eurekalert.org)
  • Carboplatin and cisplatin shortages are delaying remedy, forcing medical doctors and sufferers to make powerful decisions, based on Carvajal. (newyorkct.com)
  • Carboplatin is also associated with hearing loss but to a much lesser degree. (alexslemonade.org)