Carbonic anhydrase xii antibody. Medical search. Frequent questions

Girentuximab (trade name Rencarex) is a chimeric IgG1 monoclonal antibody to carbonic anhydrase IX (CAIX). (wikipedia.org)
This radiolabeled monoclonal antibody from Telix Pharmaceuticals targets carbonic anhydrase IX (CAIX), an enzyme that regulates cell proliferation and is highly expressed in many tumor types. (medscape.com)
This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Canine CAIX / CA9. (advancedbiochemicals.com)
Herein we used a single bicistronic lentiviral vector to develop a new combination immunotherapy that consists of human anti-carbonic anhydrase IX (CAIX)-targeted chimeric antigen receptor (CAR) T cells engineered to secrete human anti-programmed death ligand 1 (PD-L1) antibodies at the tumor site. (oncotarget.com)
factor receptor (MET) and carbonic anhydrase 9 (CAIX) 'detected' 45.5% of tumors especially basal/triple negative and HER2-driven ductal cancers. (opioid-receptors.com)
OPALESCENCE Phase II feasibility study of TLX250-CDx in patients with triple-negative breast cancer - early results suggest potential to detect carbonic anhydrase IX (CAIX) expression, theranostic potential in this difficult to treat disease. (aap.com.au)
The primary objective of OPALESCENCE ( NCT04758780 ) is to evaluate how carbonic anhydrase IX (CAIX) targeting imaging with positron emission tomography (PET) can be utilised for the diagnosis and staging of triple-negative breast cancer (TNBC) and to develop a deeper understanding of CAIX as a potential therapeutic target in this patient population with a significant unmet medical need. (aap.com.au)
The objective of PERTINENCE ( NCT04897763 ), an open-label, proof of concept study, is to evaluate safety profile, biodistribution and tumour targeting properties of TLX250-CDx given directly into the bladder in patients with NMIBC and to establish carbonic anhydrase IX (CAIX) as a potential therapeutic target in this condition. (aap.com.au)

The following product was used in this experiment: Cofilin Polyclonal Antibody from Thermo Fisher Scientific, catalog # 10960-1-AP. (thermofisher.com)
Using a polyclonal antibody (anti-p210) raised against the C-terminal part of p210, it was shown that the protein was highly enriched in the basal apparatuses. (lookformedical.com)

Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. (advancedbiochemicals.com)
R. Opavský, S. Pastoreková, V. Zelník, A. Gibadulinová, E. J. Stanbridge, J. Závada, R. Kettmann, J. Pastorek: Human MN/Ca9 gene, a novel member of the carbonic anhydrase family: Structure and exon to protein domain relationships. (learned.cz)

Monoclonal antibodies targeting endosialin have entered clinical trials, including soft tissue sarcomas. (hindawi.com)

The spike (S) protein found on the surface of the causative agent, the SARS-CoV-2 virus, has been the prime target for current vaccine research since antibodies directed against the S protein were found to neutralize the virus. (mdpi.com)
Why are there so many carbonic anhydrase structures in the Protein Data Bank? (stackexchange.com)
I've been looking through PDB - the Protein Data Bank - and I noticed that the protein with the most structures is human carbonic anhydrase II ( UniProt: P00918 ), with over a thousand X-ray structures. (stackexchange.com)
More particularly, the present invention relates to a regulator for the activity of inositol-1,4,5-triphosphate (IP 3 ) receptor (IP 3 R) comprising carbonic anhydrase-related protein (CARP), a control agent for intracellular calcium release comprising carbonic anhydrase-related protein (CARP), and a method of control therewith. (justia.com)
We report here that the previously described carbonic anhydrase from Aedes aegypti is similar to mammalian CA IV in that it is a GPI-linked peripheral membrane protein. (silverchair.com)
A monoclonal antibody raised against purified flagellar basal apparatuses from the green flagellate Spermatozopsis similis reacted with a protein of 210 kDa (p210) in western blots. (lookformedical.com)

I had a look at the hits on PDB, and a huge number are of inhibitors of CA. I searched for 'Carbonic Hydrase Inhibitors' and found a short piece on this topic on NCBI Bookshelf that starts: 'Carbonic anhydrase inhibitors are a medication used to manage and treat glaucoma, idiopathic intracranial hypertension, altitude sickness, congestive heart failure, and epilepsy, among other diseases. (stackexchange.com)
Mutations from the EGFR have already been seen in about 10% of lung adenocarcinomas and sufferers whose tumors include these mutations present increased awareness to EGFR tyrosine kinase inhibitors gefitinib (Iressa) or erlotinib (Tarceva) (11 12 In research using both mice and individual non-small-cell lung adenocarcinoma cell lines Gao et al. (biopaqc.com)

We have previously described the first cloning and partial characterization of carbonic anhydrase from larval Aedes aegypti mosquitoes. (silverchair.com)

Oriented Surface Immobilization of Antibodies at the Conserved Nucleotide Binding Site for Enhanced Antigen Detection. (quantabiodesign.com)
IL-12 is a heterodimeric inflammatory cytokine produced by activated antigen-presenting cells (APCs), neutrophils, and macrophages. (biomedcentral.com)

Since NIRF antibodies will not be very easily internalized intracellular molecular focuses on relevant for optical detection of breast cancer have so far been p53 and MDM2 proteins-interaction-inhibitor racemic ignored. (opioid-receptors.com)
Intracellular carbonic anhydrases (CA) in aquatic photosynthetic organisms are involved in the CO2-concentrating mechanism (CCM), which helps to overcome CO2 limitation in the environment. (lookformedical.com)

Abcam: antibodies, proteins, kits. (abcam.com)
[ 1 , 2 ] Paraneoplastic retinopathies (PR) are characterized by retinal antibodies in the setting of an underlying malignancy, whereas autoimmune retinopathies (AR) are characterized by autoantibodies directed against retinal proteins without a known malignancy. (medscape.com)
Samples are mixed with a cocktail of biotinylated detection antibodies (Step 1) and then incubated with the array membrane which is spotted in duplicate with capture antibodies to specific target proteins (Step 2) . (rndsystems.com)
Furthermore IL-6 is proven to additional promote malignancy in breasts cancer tumor stem cells by upregulating the hypoxia response proteins carbonic anhydrase IX (CA-IX) that your writers propose allows these cells to survive in hypoxic circumstances. (biopaqc.com)

The investigation of treatment regimens featuring antibody-drug conjugates or radiotherapeutics are part of the ongoing wave of research in renal cell carcinoma. (onclive.com)
Evaluation of Nonpeptidic Ligand Conjugates for SPECT Imaging of Hypoxic and Carbonic Anhydrase IX-Expressing Cancers. (quantabiodesign.com)

Scientific research has shown that a hostile tumor microenvironment can be significantly regulated by IL-12 through multiple mechanisms, including reactivation of anergic tumor-infiltrated lymphocytes (TILs), inhibition of Treg-mediated suppression of effector T cells, recruitment of NK cells to the tumor site, and inhibition of IL-10 and transforming growth factor-β (TGF-β) secretion by tumor-associated macrophages (TAM). (biomedcentral.com)
Therefore, they modified CD19-targeted CAR T cells to constitutively secrete IL-12, and the results showed that this treatment was able to safely eradicate established disease in the absence of prior conditioning and to acquire intrinsic resistance to Treg-mediated inhibition. (biomedcentral.com)

Because development of such antibody-based probes is definitely labor-intensive and expensive we set out to display for expression of a selected set of candidate targets on cells microarrays comprising 483 instances of human invasive breast cancer in search of the minimum antibody panel that would be suitable for detection of most breast cancers by molecular imaging. (opioid-receptors.com)

A membrane-based antibody array for the parallel determination of the relative levels of selected mouse cytokines and chemokines. (rndsystems.com)
Why Use an Antibody Array to Detect Multiple Cytokines? (rndsystems.com)
The use of a multiplex antibody array to detect multiple cytokines in a single sample can be cost-effective and also save time and sample. (rndsystems.com)
The Mouse Cytokine Array, Panel A utilizes capture antibodies spotted onto a nitrocellulose membrane to allow high-throughput multi-analyte profiling of 40 cytokines, chemokines, and more in a single sample. (rndsystems.com)

DS-6000a is a CDH6-targeted ADC that consists of a humanized anti-CDH6 IgG1 monoclonal antibody attached to a topoisomerase I inhibitor payload. (onclive.com)

As such, a patent application relating to a monoclonal antibody against IP 3 R (See prior art document 1), a patent application relating to a method of competition for IP 3 (See prior art document 2) and a patent application relating to polypeptides that bind to IP 3 R with high affinity (see prior art document 3) have been filed. (justia.com)

Horseradish peroxidase conjugated Mouse anti Histidine tag antibody clone AD1.1.0 ( MCA1396P ) used for the detection of recombinant scTCR varients by western blotting. (bio-rad-antibodies.com)
Recombinant Mouse Carbonic Anhydrase 12 is produced by our Mammalian expression system and the target gene encoding Ala25-Ser301 is expressed with a 6His tag at the C-terminus. (bonopusbio.com)

Among the biologic therapies, the greatest experience in primary Sjögren syndrome is with rituximab, an anti-CD20 (which is expressed on B-cell precursors) monoclonal antibody. (medscape.com)
The carbonic anhydrase inhibitor dichlorphenamide is indicated for long-term treatment of primary hyperkalemic periodic paralysis, primary hypokalemic periodic paralysis, and related variants. (medscape.com)

Fourth no protective measures are required since no ionizing radiation is definitely emitted [16] and fifth NIRF probes can be conjugated to highly specific targeted molecules such as antibodies antibody fragments peptides or protease activatable substrates to increase the specificity of the transmission in the tumor as examined by Pleijhuis et al. (opioid-receptors.com)
Therefore, as in mammals which similarly possess numerous carbonic anhydrase genes, insects require a large family of these genes to handle the complex metabolic pathways influenced by carbonic anhydrases and their substrates. (silverchair.com)

In an attempt to evaluate the immune response of renal cell carcinoma (RCC) patients, tumor lesions and / or blood samples from 12 RCC patients underwent deep T cell receptor (TCR) sequencing. (oncotarget.com)

Various lysates were subjected to SDS PAGE followed by western blot with 16961-1-AP (CA2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. (ptglab.com)
Western Blot: ITPR2 Antibody [NB100-2466] - 2 sec exposure using NB100-2466 on 80 ug total cell lysates listed above. (novusbio.com)

These authors demonstrated monoclonal antibody FB5 reactivity in a significant proportion of tumor blood vessels, including those of sarcoma, while ostensibly being absent from normal tissues. (hindawi.com)

Mouse splenocytes treated with 100 ng/mL LPS for 20 hours were mixed with a cocktail of biotinylated detection antibodies, and then incubated with the Mouse Cytokine Array. (rndsystems.com)

An antibody prepared against a peptide sequence specific to the Aedes aegypti GPI-linked carbonic anhydrase labels plasma membranes of a number of cell types including neuronal cells and muscles. (silverchair.com)

[ 3 ] The onset of visual symptoms and detection of antibodies may precede the diagnosis of malignancy by months to years, the longest reported interval being 11 years. (medscape.com)
This study thereby serves as a starting point for further development of a set of antibody-based optical tracers with a high breast cancer detection rate. (opioid-receptors.com)
Ultrasonography and magnetic resonance imaging (MRI) have been shown to contribute to early detection of breast cancer as offers positron emission tomography (PET) imaging but these three imaging products also have their limitations [12]. (opioid-receptors.com)

Additionally we take advantage of the recently published genome of the mosquito Anopheles gambiae to assess the complexity of the carbonic anhydrase gene family in these insects. (silverchair.com)
Bioinformatic analyses using the Ensembl automatic analysis pipeline show that there are at least 14 carbonic anhydrase genes in the Anopheles gambiae genome, including a homologue to the GPI-linked gene product described herein. (silverchair.com)

These armed second-generation CAR T cells empowered to secrete human anti-PD-L1 antibodies in the ccRCC milieu to combat T cell exhaustion is an innovation in this field that should provide renewed potential for CAR T cell immunotherapy of solid tumors where limited efficacy is currently seen. (oncotarget.com)
Interestingly, they found that the co-expression of IL-12 may contribute to TIA-1 expression in tumors after MUC1 CAR T cell treatment. (biomedcentral.com)

For screening purposes a panel of probes i.e. antibodies or antibody fragments will likely be necessary. (opioid-receptors.com)

This antibody has been used for staining of 44 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type. (atlasantibodies.com)
The results are part of an ongoing effort to map the human proteome using antibodies. (atlasantibodies.com)
Human anti Human CD5 (HuCAL dHLX antibody with HIS tag) staining human peripheral blood lymphocytes, visualized with Mouse anti-HIS tag: FITC antibody ( MCA1396F ). (bio-rad-antibodies.com)
Immunohistochemistry-Paraffin: ITPR2 Antibody [NB100-2466] - (3.75ug/ml) staining of paraffin embedded Human Kidney. (novusbio.com)
28-30 kDa band in human heart lysates after 0.1 ug/ml antibody staining. (novusbio.com)

Acute experimental exposures of humans to lower concentrations of zinc oxide (14 mg/m3 for 8 hours or 45 mg zinc/m3 for 20 minutes) and occupational exposures to low concentrations of zinc (8-12 mg zinc/m3 for 1-3 hours and 0.034 mg zinc/m3 for 6-8 hours) did not produce symptoms of metal fume fever. (cdc.gov)
As HCO 3 − can diffuse through the proteinaceous carboxysome shell but CO 2 cannot 5 , carbonic anhydrase generates high concentrations of CO 2 for carbon fixation by Rubisco 6 . (nature.com)

This is mediated, at least in part, through direct cell-cell interaction as well as through secreted molecules, including extracellular matrix components (ECM) [ 11 , 12 ]. (hindawi.com)

J. Závada, Z. Závadová, M. Zaťovičová, L. Hyršl, I. Kawaciuk: Soluble form of carbonic anhydrase IX (CA IX) in the serum and urine of renal carcinoma patients. (learned.cz)

Endosialin expression positively correlated with PDGFR- β and heparin sulphate proteoglycan 2 and negatively correlated with carbonic anhydrase IX. (hindawi.com)
In this report we further examine the nature of the previously described carbonic anhydrase and test the hypothesis that its pattern of expression is consistent with a role in gut alkalization. (silverchair.com)
In situ hybridization analyses identify multiple locations of carbonic anhydrase expression in the larval mosquito. (silverchair.com)

Whilst a small patient population at this stage, early data from the OPALESCENCE study is encouraging as an indicator for future therapy applications of TLX250 and demonstrating the value of a "theranostic" approach" with this radiolabelled antibody. (aap.com.au)

[ 4 ] In some cases, patients with an underlying malignancy have been found to have high titers of antiretinal antibodies but no evidence of visual loss. (medscape.com)
In patients with antienolase retinal antibodies, symptoms are often less acute and progression is slower. (medscape.com)
Long-term anticoagulation may be needed in patients with vascular thrombosis related to antiphospholipid antibody syndrome. (medscape.com)
Indeed, a central core of 16 different TCRs were shared by 3 patients, whereas other 6 patients shared between 4 and 6 TCR sequences, with two sub-groups sharing 12 to 17 different clonotypes. (oncotarget.com)
While the 5-year survival rate for localized RCC is above 70%, it drops to 12% when the disease has spread to distant organs, which is the case in more than half of the patients at presentation [ 2 ]. (oncotarget.com)

It triggers antibody-dependent cell-mediated cytotoxicity (ADCC). (wikipedia.org)

Flexible antibodies with nonprotein hinges. (quantabiodesign.com)

The PBAC recommended a restriction wording of "elevated intra-ocular pressure in a patient with open angle glaucoma/ocular hypertension not adequately controlled with monotherapy" be applied to all restricted benefit listings of combination eye drops containing an alpha-agonist with timolol, a carbonic anhydrase inhibitor with timolol or a prostaglandin/prostamide analogue with timolol. (pbs.gov.au)

Its development was suspended as a "naked" or unconjugated antibody during phase III trials due to efficacy. (wikipedia.org)
antibodies suppressed spheroid development. (biopaqc.com)

CAR affects both rods and cones, whereas MAR is typically characterized by antibodies directed toward bipolar cells that interfere with rod function. (medscape.com)

The local antibody delivery led to marked immune checkpoint blockade. (oncotarget.com)

Diseases1

Chemicals and Drugs16

Phenomena and Processes1

CAIX8

Polyclonal Antibody2

Member of the carbonic anhydrase2

Monoclonal antibodies1

Protein6

Inhibitors2

Characterization1

Antigen2

Intracellular2

Proteins4

Conjugates2

Inhibition2

Cancers1

Cytokines4

IgG11

Affinity1

Recombinant2

Primary2

Substrates2

Receptor1

Western blot2

Reactivity1

Cytokine1

Membranes1

Detection3

Gene2

Tumors2

Probes1

Human5

Concentrations2

Molecules1

Serum1

Expression3

Therapy1

Patients5

Cell1

Flexible1

Drops1

Development2

Typically1

Immune1