This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in tRNA and related compounds. (wikipedia.org)
TRNA3
Tyrosine-tRNA ligase (EC 6.1.1.1), also known as tyrosyl-tRNA synthetase is an enzyme that is encoded by the gene YARS. (wikipedia.org)
Tyrosine-tRNA ligase catalyzes the chemical reaction ATP + L-tyrosine + tRNA(Tyr) ⇌ {\displaystyle \rightleftharpoons } AMP + diphosphate + L-tyrosyl-tRNA(Tyr) The three substrates of this enzyme are ATP, L-tyrosine, and a tyrosine-specific transfer RNA [tRNA(Tyr) or tRNATyr], whereas its three products are AMP, diphosphate, and L-tyrosyl-tRNA(Tyr). (wikipedia.org)
It is, as defined in biology, a class of enzyme that binds or joins two macromolecules by forming new bonds such as C-O, C-N, and C-S. Ligase enzyme catalyzes the ligase reaction, e.g. (changingyourbusiness.com)
Ligases are classified into six subclasses: (1) EC 6.1 (ligases that form carbon-oxygen bonds), (2) EC 6.2 (ligases that form carbon-sulfur bonds), (3) EC 6.3 (ligases that form carbon-nitrogen bonds), (4) EC 6.4 (ligases that form carbon-carbon bonds), (5) EC 6.5 (ligases that form phosphoric ester bonds), and ( 6) EC 6.6 (ligases that form nitrogen-metal bonds). (changingyourbusiness.com)
Synthetases1
Synthetases are a subclass of ligases that use the hydrolysis of ATP to drive this formation. (cliffsnotes.com)
Glutamate-cystei1
The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
Reactive oxygen2
Special cellular machinery should be activated to fight against increased reactive oxygen species (ROS) level to protect from oxidative injury. (springer.com)
This excess energy is transferred to oxygen via the photosynthetic machineries, causing the formation of toxic photosynthetic byproducts called ROS (reactive oxygen species). (ox.ac.uk)
Ubiquitin4
Alcat1 is a labile protein that is lysosomally degraded by the ubiquitin E3 ligase Skp-Cullin-F-box containing the Fbxo28 subunit (SCFFbxo28) that targets Alcat1 for monoubiquitylation at residue K183. (wustl.edu)
Alcat1 degradation was partially abrogated in LPS-treated cells that had been silenced for HDAC2 or treated with MLN4924, an inhibitor of Cullin-RING E3 ubiquitin ligases. (wustl.edu)
Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton [ 5 ], serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. (springer.com)
Our recent work demonstrated that the TOC machine is selectively targeted for a type of modification called ubiquitination, by a protein named SP1 (a RING-type ubiquitin E3 ligase) that is also located in the chloroplast outer envelope membrane. (ox.ac.uk)
Activity1
Toxin Mutants Are Defective in Biofilm Ligase and Sphingomyelinase Activity, and Causation of Infective Endocarditis and Sepsis. (ucdenver.edu)
Enzymes can be classified and named according to their reactions: (1) oxidoreductases, (2) transferases, (3) lyases, (4) isomerases, and (6) ligases. (changingyourbusiness.com)
Basically, ligases are a group of enzymes that enable the binding of two molecules. (changingyourbusiness.com)
Oligomerization is a frequently encountered physical characteristic of biological molecules that occurs for a wide number of transcription factors, ion channels, oxygen-carrying macromolecules such as hemocyanin and enzymes. (baumaschinen-knell.de)
Hydrolysis1
A ligase that makes the connection of two macromolecules and uses molecular energy obtained by the hydrolysis of nucleoside triphosphates (such as ATP, GTP, CTP, TTP, and UTP), for example, the hydrolysis of -adenosine triphosphate (ATP) is adenosine. (changingyourbusiness.com)
Enzyme5
What Is The Role Of Dna Ligase In Dna Replication - An enzyme is a catalyst or chemical produced by cells to speed up a biochemical reaction. (changingyourbusiness.com)
Ligase is a type of enzyme that brings about the binding or joining of two molecules. (changingyourbusiness.com)
Biology/Biochemistry: Ligase is an enzyme that catalyzes the binding of two molecules. (changingyourbusiness.com)
Based on the molecular bond catalyzed by the ligase enzyme, ligase can be classified into six subclasses (see Table 2). (changingyourbusiness.com)
Tricarboxylic acid2
Finally, to further improve the L-leucine yield, a toggle switch for dynamically controlling sucAB expression was applied to accurately regulate the tricarboxylic acid cycle and the carbon flux toward L-leucine biosynthesis. (bvsalud.org)
In silico simulation of a genome-scale metabolic model ( i ZX637) further verified that pyruvate carboxylase ( pyc ) via the reductive tricarboxylic acid cycle strengthened carbon flux for PMA synthesis. (biomedcentral.com)
Fatty1
Cancer cell energy metabolism is mainly dominated by three pathways of central carbon metabolism, including aerobic glycolysis, glutaminolysis, and fatty acid synthesis. (frontiersin.org)
Monoxide1
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
Catalyzes1
because, for example, amino acid-RNA ligase catalyzes, C-O bond formation between amino acid and RNA transfer. (changingyourbusiness.com)
Staphylococcus1
2020). Crystallographic analysis of Staphylococcus aureus LcpA, the primary wall teichoic acid ligase . (lightsource.ca)
Molecular2
Exposure to LPS selectively decreased levels of carbon 20 (C 20 )-containing cardiolipin molecular species, whereas the content of C 18 or C 16 species was not significantly altered, consistent with decreased levels of Alcat1. (wustl.edu)
Exposure to LPS selectively decreased levels of carbon 20 (C20)-containing cardiolipin molecular species, whereas the content of C18 or C16 species was not significantly altered, consistent with decreased levels of Alcat1. (wustl.edu)
Because of the decreased ambient oxygen concentration at high altitudes, people living in those locales can develop compensatory erythrocytosis as a physiologic response to tissue hypoxia. (medscape.com)
Genes2
Genes required for degradation of and growth on the carbon source pectin were down-regulated, whereas transcripts involved in redox processes were up-regulated. (frontiersin.org)
First, the flux-control genes in the L-homoserine degradation pathway were omitted to redistribute carbon flux. (bvsalud.org)
Lipoic Acid Ligase-Promoted Bioorthogonal Protein Modification and Immobilization. (ucdenver.edu)
Reaction1
ligases carry out the converse reaction, removing the elements of water from two functional groups to form a single bond. (cliffsnotes.com)
Catalyst1
2020). Active and Stable Pt-Ni Alloy Octahedra Catalyst for Oxygen Reduction via Near-Surface Atomical Engineering . (lightsource.ca)
Hemoglobin1
Hemoglobin abnormalities associated with high oxygen affinity and congenital defects can lead to oxidized or methemoglobin. (medscape.com)
Flux1
To drive more carbon flux into L-homoserine production, the phosphoenolpyruvate-pyruvate-oxaloacetate loop was redrawn. (bvsalud.org)
Family1
Patients with familial hemoglobinopathies that result in increased oxygen affinity usually have a family history of similar problems in several family members, although significant numbers of patients with congenital polycythemia have no family history of similar disorders. (medscape.com)
People2
This graph shows the total number of publications written about "Ligases" by people in this website by year, and whether "Ligases" was a major or minor topic of these publications. (ucdenver.edu)
Below are the most recent publications written about "Ligases" by people in Profiles. (ucdenver.edu)
Form1
18 The oxygen we inhale is the final electron acceptor in the electron transport chain and allows aerobic respiration to proceed, which is the most efficient pathway for harvesting energy in the form of ATP from food molecules. (dokumen.pub)
Bond1
An example is DNA ligase which joins two pieces of DNA by forming a phosphodiester bond. (changingyourbusiness.com)
Source1
2020). Shale as a Source of Organic Carbon in Floodplain Sediments of a Mountainous Watershed . (lightsource.ca)
Levels1
Cardiovascular diseases associated with a right-to-left shunt (arteriovenous malformations) can result in venous blood mixing in the arterial system and delivering low oxygen levels to tissues. (medscape.com)