Nitric oxide and hydrogen sulfide are highly reactive with numerous molecular targets, whereas carbon monoxide is relatively stable and metabolically inert predominately limited to interacting with ferrous ion complexes within mammalian organisms. (wikipedia.org)
NO is biosynthesized endogenously from L-arginine by various nitric oxide synthase (NOS) enzymes. (wikipedia.org)
For the human body to generate NO through the nitrate-nitrite-nitric oxide pathway, the reduction of nitrate to nitrite occurs in the mouth by the oral microbiome. (wikipedia.org)
The most well-defined gasotransmitters currently are nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S), while other potent gasotransmitters include ammonia, methane, cyanide, hydrogen gas, and sulfur dioxide. (bvsalud.org)
I proposed the establishment of the 'gasotransmitter' concept and framework firstly in 2002 to characterize and clarify a class of endogenous gas molecules, including nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H 2 S), that function as signaling molecules to direct various molecular and cellular events. (rsc.org)
Gasotransmitter1
However, as a gasotransmitter, it is endogenously produced in the brain targets multiple molecules that affect neuronal viability in the mammalian brain [ 11 ]. (hindawi.com)
Ammonia1
Ammonia (NH 3 ) and hydrothion (hydrogen sulphide, H 2 S) have long been known for their poisoning effect to human central nervous system and may cause psychological disturbances and behavioral disorders. (hindawi.com)
Molecules1
SIGNIFICANCE: Gasotransmitters are small gas molecules that are endogenously generated and have well-defined physiological functions. (bvsalud.org)
Production1
As a biocide, acrolein is intentionally released into the environment as an herbicide and algicide to control the growth of aquatic plants in irrigation waters, drainage ditches, and processing waters, and as a microbiocide in the control of sulfide producing bacteria and the removal of hydrogen sulfide and iron sulfide from oil production and injection wells. (cdc.gov)
Brain1
These findings suggest that NO is involved in various brain functions and that H 2 S and CO can be endogenously produced in the honeybee brain. (elsevierpure.com)
Functions1
The scope of biological functions are different across phylogenetic kingdoms, however, exemplified by the important interactions of carbon monoxide with nickel or molybdenum carbon monoxide dehydrogenase enzymes. (wikipedia.org)