ProteinsAnimal lectinsReceptorsSuperfamilyInteractionsReceptorProteinBelongs to the C-type lectinLigandsAbstractMacrophageCRDsSelected carbohydrate antigensHigh-mannoseComplex Carbohydrate Research CenterIntracellularAntigensEnzymesEndogenousBindsStructuresImmunityGlycanDENDRITIC CELLSMoleculesGlycoproteinsAntibodiesGlycosylationPathwayTissuesGeneAntigen preseAffinityBacterialPhagocytosisMammalianGlycansGalactoseCalcium-dependentStructuralGalectinsMoietiesFamilySugar recognitionInhibitoryTrehaloseSpecific recognitionInteraction
Proteins24
- Carbohydrates differ from proteins in two important features. (iucr.org)
- Lectins are a diverse group of proteins, both in terms of structure and activity. (embl.de)
- When examined from the viewpoint of the bound sugar, the structural information accumulated so far on lectins and other proteins that are specific to galactose and glucose (or mannose), provides suggestive evidence for distinct ligand-dependent distribution of hydrogen-bond partners in the combining site. (embl.de)
- Mechanisms involve competitive inhibition of carbohydrate binding within sets of defined proteins, in contrast to broadly indiscriminate, irreversible glycation of proteins. (nih.gov)
- At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
- The cellulose nanocrystals were subsequently applied in interaction studies with carbohydrate-binding proteins and in bacterial imaging. (docksci.com)
- Dr. Brumer's research interests include the discovery, functional and structural characterization, and biotechnological applications of carbohydrate-active enzymes and carbohydrate-binding proteins. (glyco26.org)
- Fundamental Process 2: GLYCAN ARRAY PROFILING OF CARBOHYDRATE-BINDING PROPERTIES Many different glycan-binding proteins (GBPs) could be researched using glycan microarrays. (spierarchitecturalarts.com)
- C-type lectin CD209/DC-SIGN and CD209L/L-SIGN proteins are distinct cell adhesion and pathogen recognition receptors that mediate cellular interactions and recognize a wide range of pathogens including, viruses such as SARS, SARS-CoV-2, bacteria, fungi and parasites. (preprints.org)
- Pathogens exploit CD209L family proteins to promote infection and evade the immune recognition system. (preprints.org)
- The carbohydrate-recognition domain (CRD) and the neck/repeat region represent the key features of CD209L family proteins that are also central to facilitating cellular ligand interactions and pathogen recognition. (preprints.org)
- Considering the role of CD209L and related proteins in diverse pathogen recognition, this review article discusses the recent advances in the cellular and biochemical characterization of CD209 and CD209L and their roles in viral uptake, which has important implications in understanding the host-pathogen interaction, the viral pathobiology and driving vaccine development of SARS-CoV-2. (preprints.org)
- Recent studies have shown that carbohydrates and lectins (carbohydrate-binding proteins) play an essential role in mediating such interactions. (tamu.edu)
- Carbohydrates, due to their chemical nature, can potentially form structures that are more variable than proteins and nucleic acids. (tamu.edu)
- On the basis of knockdown experiments at the larval stage the identification of PPLs in the shell matrix and CaCO3 crystallization analysis we conclude that two novel jacalin-related lectins participate in the biomineralization of nacre as matrix proteins. (cancer-ecosystem.com)
- Lectins which are carbohydrate recognition proteins have been found in viruses bacteria fungi plants and animals. (cancer-ecosystem.com)
- Surfactant proteins, SP-A and SP-D, are collagen-containing C-type (calcium dependent) lectins called collectins, which contribute significantly to surfactant homeostasis and pulmonary immunity. (ox.ac.uk)
- We have previously shown that hemocyanins are internalized by APCs through receptor-mediated endocytosis with proteins that contain C-type lectin domains, such as mannose receptor (MR). However, the contribution of other innate immune receptors to the proinflammatory signaling pathway triggered by hemocyanins is unknown. (exeter.ac.uk)
- These bisected N -glycans and their non-bisected counterparts were used to construct a distinctive glycan microarray to study their recognition by a wide variety of glycan-binding proteins (GBPs), including plant lectins, animal lectins, and influenza A virus hemagglutinins. (rsc.org)
- Changes in glycan structures and the interactions of these structures with endogenous carbohydrate- binding proteins, known as lectins, are now considered to be potential biomarkers on cancer cells for monitoring tu- mor progression. (fdocuments.net)
- It belongs to a family of proteins called collectins, which consists of collagenous region and a carbohydrate recognition domain (Taylor et al. (springeropen.com)
- Proteins that share the common characteristic of binding to carbohydrates. (bvsalud.org)
- Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. (bvsalud.org)
- PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). (bvsalud.org)
Animal lectins2
- The emergence of functional studies on animal lectins during the 1990s has provided the appropriate framework to better understand their roles in cell death. (nature.com)
- It belongs to the C-type lectin domain family and contains an extracellular C-type carbohydrate recognition domain (CRD) that shares similarities with mannose-, glucose-, or glucosamine-bound C-type animal lectins. (cusabio.com)
Receptors16
- We compared the lectin activity of Dectin-2 with that of two other C-type lectin receptors (mannose receptor and SIGNR1) known to bind fungal mannans. (elsevierpure.com)
- The differences in the specificity of these three mannose-specific lectins indicate that mannose recognition is mediated by distinct receptors, with unique specificity, that are expressed by discrete subpopulations of cells, and this further highlights the complex nature of carbohydrate recognition by immune cells. (elsevierpure.com)
- Studies were also presented on novel molecules involved in the recognition of carbohydrate antigens such as specific intercellular adhesion molecule (ICAM)-grabbing nonintegrins, which are C-type lectins that show substantial expression in many tissues, and toll-like receptors, which function as pattern recognition receptors for conserved pathogen structures and serve as key links between innate and adaptive immunity. (cdc.gov)
- Accumulating evidence shows that the fates of glycoproteins in cells are determined through interactions of their carbohydrate moieties with a variety of intracellular lectins operating as molecular chaperones, cargo receptors, and ubiquitin ligases. (go.jp)
- Druggability of mammalian C-type lectin receptors. (mpg.de)
- In addition, the functionalized CNCs were applied to imaging of E. coli strains by targeting lectin receptors at the bacterial surface. (docksci.com)
- His work on identifying a common carbohydrate recognition led to the definition of C-type lectins as one of the major groups of glycan-binding receptors. (glyco26.org)
- In addition, they seek to determine how such recognition leads to the targeting of biological functions, such as innate immunity to pathogens, clearance of serum glycoproteins, cell adhesion, and cell signaling, and how genetic variation in sugar-binding receptors causes changes in their molecular properties and hence contributes to human disease. (glyco26.org)
- Plasmacytoid dendritic cells (pDCs) are a specialized subclass of dendritic cells (DCs) that primarily secrete interferon type I (IFN-I). These cells play a crucial role in antiviral immunity by activating adaptive immune responses through the secretion of abundant IFN-I. pDCs achieve this activation by recognizing pathogen-associated molecules through Toll-like receptors 7 and 9 ( TLR7 and TLR9 ), triggering the production of interferon alpha ( IFN-α ). (cusabio.com)
- We investigate how binding of carbohydrates, altered due to tissue inflammation or wound healing processes, control modulation of immune cells through recognition/signaling of glycan binding receptors, such as C-type lectins and Siglecs. (immunologyamsterdam.org)
- We investigate glycan binding receptors such as C-type lectins and Siglecs on innate myeloid, macrophages and DC for targeting purposes to guide glycosylated antigens binding and uptake that influence antigen presentation, T cell differentiation and immune cell signaling. (immunologyamsterdam.org)
- The immune system utilizes sensors on immune cells named pattern recognition receptors to recognize invading pathogens and foreign substances. (exeter.ac.uk)
- In the Brown Group, we are interested in a superfamily of receptors called C-type lectin receptors (CLRs). (exeter.ac.uk)
- In this review, we summarized the current knowledge of hemocyte-mediated phagocytosis, in particular focusing on the related receptors for recognition and internalization of pathogens as well as the downstream signal pathways and intracellular regulators involved in the process of hemocyte phagocytosis. (frontiersin.org)
- The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
- Various cell types can process and present these antigens to T cells, or antigens may be soluble and bound to B-cell receptors. (medscape.com)
Superfamily3
- LSECtin (liver and lymph node sinusoidal endothelial cell C-type lectin), also known as C-type lectin superfamily 4, member G (CLEC4G), is a member of subgroup II of the C-type (Ca 2+ -dependent) lectin superfamily (1). (rndsystems.com)
- Ly-49A is a single-pass type-II transmembrane that is encoded by Klra1 (Killer cell lectin-like receptor, subfamily A member 1) which belongs to the C-type lectin superfamily. (bdbiosciences.com)
- It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. (elabscience.com)
Interactions12
- The Dectin-2 CRD exhibited only weak interactions to some of these capsular polysaccharides, indicative of different structural or affinity requirements for binding, when compared with the other two lectins. (elsevierpure.com)
- Knowledge of the three-dimensional structures of the carbo-hydrate molecules is indispensable for a full understanding of the molecular processes in which carbohydrates are involved, such as protein glycosylation or protein-carbohydrate interactions. (iucr.org)
- Lectin-carbohydrate interactions: different folds, common recognition principles. (embl.de)
- Within the immune system, host-pathogen and regulatory host-host interactions operate through binding of oligosaccharides by C-type lectin. (nih.gov)
- Recent advances in developments of high-mannose type oligosaccharide libraries and structural biology of the carbohydrate-lectin interactions have revealed insights into sugar recognition by those intracellular lectins and the underlying mechanisms of quality control of glycoproteins. (go.jp)
- Two decades later, pioneering studies suggested that lectin-like molecules constitutively expressed on the surface of macrophages can selectively recognize changes on glycans decorating the surface of apoptotic thymocytes, 4 , 5 although these studies likewise did not provide substantial insight into the mechanisms by which lectin-glycan interactions regulate cell death. (nature.com)
- We discuss here the contribution of glycan-lectin interactions to the initiation, execution and resolution of apoptosis and their emerging roles in other cell death programs including autophagy. (nature.com)
- The C−CNCs were conjugated with specific carbohydrate ligands, as well as a fluorophore emitting in the yellow-green range, and the binding of the resulting multifunctional C−CNCs was evaluated through the interactions with their corresponding cognate lectins. (docksci.com)
- Homology modelling showed that four of these residues are located on a surface region on the CRD that is separate from the Ca2+-binding residues involved in carbohydrate interactions. (brighton.ac.uk)
- Structural Characterization of N-Linked Glycans in the Receptor Binding Domain of the SARS-CoV-2 Spike Protein and their Interactions with Human Lectins. (ucibio.pt)
- This β -sandwich fold is conserved in all galectins and includes a gly- cine, which stabilizes the galectin-carbohydrate interactions [4]. (fdocuments.net)
- Evidence suggesting that the interactions between lectins and their ligands have a major role in the different steps of cancer progression has accumulated at a rapid pace and has gained the attention of several on- cologists. (fdocuments.net)
Receptor12
- We examined the carbohydrate-binding potential of the C-type lectin-like receptor Dectin-2 (Clecf4n). (elsevierpure.com)
- The carbohydrate-recognition domain (CRD) of Dectin-2 exhibited cation-dependent mannose/fucose-like lectin activity, with an IC50 for mannose of approximately 20 mM compared to an IC50 of 1.5 mM for the macrophage mannose receptor when assayed by similar methodology. (elsevierpure.com)
- Description: This MR6F3 antibody recognizes mouse CD206 also known as Macrophage Mannose Receptor (MMR) or Mannose Receptor C, Type 1 (MRC1). (fishersci.com)
- CD206 is a 175-kDa, type 1 integral membrane glycoprotein receptor that is present in macrophages, some dendritic cells, as well as liver and lymphoid endothelial cells. (fishersci.com)
- Its extracellular region consists of two N-linked glycosylation sites (aa 73 and 159), a coil‑coil neck domain (aa 96‑136), a C‑type lectin-like domain (CTLD) of the type found in human DC‑SIGN and DC‑SIGN receptor (aa 165‑289), and a C-terminal Ca 2+ -dependent carbohydrate‑recognition domain (C-type CRD) (1). (rndsystems.com)
- High affinity sugar ligands of C-type lectin receptor langerin. (mpg.de)
- Bacterial polysaccharide specificity of the pattern recognition receptor langerin is highly species-dependent. (mpg.de)
- Computational and experimental prediction of human C-type lectin receptor druggability. (mpg.de)
- CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. (elabscience.com)
- We explore how glycan- glycan binding receptor control the immune signature and regulate tumor growth or pathogen recognition and inflammation. (immunologyamsterdam.org)
- The trimeric CRDs can recognize carbohydrate or charge patterns on microbes, allergens and dying cells, while the collagen region can interact with receptor molecules present on a variety of immune cells in order to initiate clearance mechanisms. (ox.ac.uk)
- Now, the identification of the monocyte-inducible C-type lectin (Mincle) as an essential receptor for TDM provides new insight into the formation of the characteristic granulomas in tuberculosis and an avenue for rational adjuvant design. (silverchair.com)
Protein12
- The Protein Data Bank (PDB) is a valuable resource for three-dimensional structural information on glycoproteins and protein-carbohydrate complexes. (iucr.org)
- Glycosylation is classified by the way the carbohydrate chain is linked to the protein. (iucr.org)
- Mechanisms for sugar recognition have evolved independently in diverse protein structural frameworks, but share some key features. (embl.de)
- Mannose-binding lectin, soluble DC-SIGN and DC-SIGNR, and surfactant protein D, were tested for carbohydrate binding in the presence of glucose concentrations typical of diabetes, via surface plasmon resonance and affinity chromatography. (nih.gov)
- C-type lectin (CTL) is a protein that binds to saccharides and plays an important role in parasite adhesion, host cell invasion and immune evasion. (bvsalud.org)
- Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple α-helical coiled-coil. (lu.se)
- Thus, we hypothesized that the endogenous mannose-binding lectin (MBL)/ficolin-associated protein-1 (MAP-1) that inhibits complement activation in vitro also could be an in vivo regulator by attenuating myocardial schema/reperfusion injury and thrombogenesis when used at pharmacological doses in wild-type mice. (regionh.dk)
- Thus, we hypothesized that the endogenous mannose-binding lectin (MBL)/ficolin-associated protein-1 (MAP-1) that inhibits complement activation in vitro also could be an in vivo regulator by attenuating myocardial schema/reperfusion injury and thrombogenesis when used at pharmacological doses in wild-type mice.METHODS AND RESULTS: In 2 mouse models, MAP-1 preserves cardiac function, decreases infarct size, decreases C3 deposition, inhibits MBL deposition, and prevents thrombogenesis. (regionh.dk)
- One soluble factor modulating the interplay between immune cells and microbes is galectin-3 (gal-3), a carbohydrate-binding protein that regulates a wide variety of neutrophil functions. (lu.se)
- Mannose binding lectin (MBL) is a liver derived protein which plays an important role in innate immunity. (springeropen.com)
- Mannose binding lectin (MBL) is a liver derived acute phase protein. (springeropen.com)
- Novel variant pathway in the synthesis of protein- and lipid-1inked, complex-type oligosaccharides. (or.jp)
Belongs to the C-type lectin1
- CD206 belongs to the C-type lectin family. (fishersci.com)
Ligands2
- Fragment-based design of novel lectin ligands. (mpg.de)
- The cellulose nanocrystals were prepared by TEMPO-mediated oxidation and acidic hydrolysis, followed by functionalization with a quinolone fluorophore and carbohydrate ligands. (docksci.com)
Abstract1
- ABSTRACT: Multifunctional cellulose nanocrystals have been synthesized and applied as a new type of glyconanomaterial in lectin binding and bacterial imaging. (docksci.com)
Macrophage4
- We have previously demonstrated that the C-type lectin macrophage galactose-type lectin (MGL), expressed by human antigen presenting cells, can distinguish healthy tissue from CRC through its specific recognition of Tn antigen. (oncotarget.com)
- Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen. (ucibio.pt)
- 2019. The Plasticity of the Carbohydrate Recognition Domain Dictates the Exquisite Mechanism of Binding of Human Macrophage Galactose‐Type Lectin. (ucibio.pt)
- macrophage , type of white blood cell that helps eliminate foreign substances by engulfing foreign materials and initiating an immune response . (planschwitzer-naturstein.de)
CRDs2
- Extracellular regions of CD206 include an N-terminal cysteine-rich (CR) domain that binds sulfated glycoproteins, a fibronectin II (FNII) domain that binds collagens, and eight carbohydrate recognition domains (CRDs) that bind sugars like mannose and fucose with high affinity. (fishersci.com)
- The 15 members of the family are normally classified according to their struc- ture and number of carbohydrate recognition domains (CRDs). (fdocuments.net)
Selected carbohydrate antigens1
- The goals of this workshop were to examine the mechanisms involved in generating an appropriate immune response to selected carbohydrate antigens, highlight recent and novel advances, and discuss how this information could be used in the development of effective vaccines. (cdc.gov)
High-mannose1
Complex Carbohydrate Research Center1
- Dr. Debra Mohnen is a Distinguished Research Professor at the Complex Carbohydrate Research Center and Department of Biochemistry and Molecular Biology, University of Georgia. (glyco26.org)
Intracellular3
- This article outlines the current knowledge on the molecular basis of sugar recognition by the intracellular lectins that control folding, transport, and degradation of glycoproteins in cells. (go.jp)
- Intracellular lectins and glycan-modifying enzymes mediate autophagy and control host immunity and inflammation. (nature.com)
- G3 is implicated in the intracellular processing of aggrecan and contains a C-type lectin carbohydrate recognition domain (CRD), frequent occurrences of a C-terminal short complement repeat (SCR) domain, and occasionally an N-terminal epidermal growth factor domain. (brighton.ac.uk)
Antigens3
- The meeting was organized into 7 sessions on such topics as genetic and cellular mechanisms of carbohydrate immunity, carbohydrate antigens for vaccines, and new tools for studying carbohydrates. (cdc.gov)
- Understanding the mechanistic aspects of the genetic control and the cellular pathways of the immune response to bacterial carbohydrate antigens should provide insights into ways to enhance the immune response and thus facilitate vaccine development. (cdc.gov)
- MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. (elabscience.com)
Enzymes2
- Since then, progress has been made in the search of prokaryotic glycosyltransferases, increasing the types of enzymes that can be employed in synthesis and modification of sugar chains. (go.jp)
- The number of gene models and genes that code for carbohydrate-active enzymes in the E. abortivum transcriptome was reduced compared to other closely related species, perhaps as a result of the specialized nature of this interaction. (unl.edu)
Endogenous2
- Endogenous lectins and glycans are critical signals in the resolution of cell death. (nature.com)
- CONCLUSIONS: Our results suggest that the natural, endogenous inhibitor MAP-1 effectively inhibits lectin pathway activation in vivo. (regionh.dk)
Binds3
- Crystallography and mutation studies have shown that mannose binds to the conserved Ca2+ at the major binding site of the C-type CRD ( Figure 1 ) [7-9] . (cusabio.com)
- It contains a carbohydrate recognition domain that binds mannose, glucose, or N-acetylglucosamine. (cusabio.com)
- It binds to carbohydrates on the surface of mannose-rich pathogens and mediates clearing by phagocytosis or complement activation (Nepomuceno et al. (springeropen.com)
Structures7
- This article gives an overview of the information that can be obtained from individual PDB entries and from statistical analyses of sets of three-dimensional structures, of typical problems that arise during the analysis of carbohydrate three-dimensional structures and of the validation tools that are currently available to scientists to evaluate the quality of these structures. (iucr.org)
- A number of C-type lectins recognise oligosaccharides rich in mannose and fucose - sugars with similar structures to glucose. (nih.gov)
- Elevated cell-surface expression of truncated carbohydrate structures such as Tn antigen (GalNAcα-Ser/Thr) is frequently observed during tumor progression. (oncotarget.com)
- Lectins can exist in either soluble or cell-associated form, and although overall structures vary, invariably possess carbohydrate-recognition domains (CRD) with various specificities. (tamu.edu)
- In particular three types of calcium carbonate structures (calcite aragonite and vaterite) are major materials used in marine biominerals [7]. (cancer-ecosystem.com)
- PPL1 has two tandem carbohydrate recognition domain (CRD) structures in its sequence which has sequence homology with rhamnose-binding lectins (RBLs) from various fish eggs and a galactose-binding lectin (SUEL) from sea urchin eggs [24]. (cancer-ecosystem.com)
- Their basic structures include a triple-helical collagen region and a C-terminal homotrimeric lectin or carbohydrate recognition domain (CRD). (ox.ac.uk)
Immunity3
- How do C-type lectins tailor adaptive immunity following phagocytosis of apoptotic cells? (nature.com)
- Additional study the experiment Tibiofemoral joint along with simulators, supplies, production method, and also request can also be described with your knowledge.The C-type lectin (PtCLec2) via Portunus trituberculatus had been identified for depiction of the function inside protection as well as innate immunity. (ag-881inhibitor.com)
- The two recognized types of immunity are innate and adaptive. (medscape.com)
Glycan4
- Understanding the function of lectin-glycan recognition systems in cell death will facilitate the implementation of novel therapeutic strategies aimed at controlling unbalanced cell proliferation and survival in several pathologic conditions. (nature.com)
- Over the years, she has developed and optimized glycomic workflows based on off-line HPLC-MALDI-TOF MS, suitable for discovering a wide range of glycan epitopes, including unusual fucosylated, glucuronylated, sulphated, and zwitterionic modifications of N-glycans, with roles in self/non-self-recognition. (glyco26.org)
- N -glycan recognition of specific GBPs, and is tolerated by many others. (rsc.org)
- The microarray data provide new information regarding the fine details of N -glycan recognition by GBPs, and in turn improve their applications. (rsc.org)
DENDRITIC CELLS1
- CLEC4C, also known as BDCA-2 or CD303, is a type II transmembrane glycoprotein expressed on plasmacytoid dendritic cells (pDCs). (cusabio.com)
Molecules2
- The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
- The immune system consists of various types of cells and molecules that specifically interact with each other to initiate the host defense mechanism. (tamu.edu)
Glycoproteins2
- They have used a combination of biochemical, biophysical, and molecular biological approaches to understand how carbohydrate-recognition domains provide selective recognition of glycoproteins and cell surfaces. (glyco26.org)
- Our data showed the involvement of TLR4 in the hemocyanin-mediated proinflammatory response in APCs, which could cooperate with MR in innate immune recognition of these glycoproteins. (exeter.ac.uk)
Antibodies3
- Previous studies showed that recombinant T. spiralis C-type lectin (rTsCTL) promotes larval invasion of intestinal epithelium cells (IEC), whereas anti-rTsCTL antibodies inhibits larval invasion. (bvsalud.org)
- Epitope recognition of antibodies against a Yersinia pestis lipopolysaccharide trisaccharide component. (mpg.de)
- Some of the most frequently researched samples consist of lectins, monoclonal antibodies, and serum antibodies. (spierarchitecturalarts.com)
Glycosylation2
- Although one typically thinks of carbohydrates as associated with cell growth and viability, glycosylation also has an integral role in many processes leading to cell death. (nature.com)
- We are currently working on 1) The role of glycans and glycosylation in cancer, 2) Identification of glycobiomarkers for cancer diagnosis, monitoring, and prognostic prediction, and 3) Application of lectins for detection of glycobiomarkers. (glyco26.org)
Pathway5
- Complement activation via the lectin pathway was inhibited in high glucose and also in high trehalose - a nonreducing sugar with glucoside stereochemistry. (nih.gov)
- Lectin pathway initiation complexes are composed of multimolecular carbohydrate recognition subcomponents and 3 lectin pathway-specific serine proteases. (regionh.dk)
- We have recently shown that the lectin pathway-specific carbohydrate recognition subcomponent mannose-binding lectin plays an essential role in the pathophysiology of thrombosis and ischemia/reperfusion injury. (regionh.dk)
- MAP-1 at pharmacological doses represents a novel therapeutic approach for human diseases involving the lectin pathway and its associated MASPs. (regionh.dk)
- Moreover, DCs from mice deficient for MyD88-adapter-like (Mal), a downstream adapter molecule of TLR4, were partially activated by FLH, suggesting a role of the TLR pathway in hemocyanin recognition to activate APCs. (exeter.ac.uk)
Tissues1
- Both lectins and carbohydrates are widely distributed in the mammalian tissues as well as in microorganisms. (tamu.edu)
Gene2
- Entrez Gene: CLEC3B C-type lectin domain family 3, member B". Human CLEC3B genome location and CLEC3B gene details page in the UCSC Genome Browser. (wikipedia.org)
- Mannose binding lectin gene 2 ( MBL2 ) polymorphisms are reported to be associated with various diseases. (springeropen.com)
Antigen prese1
- Mollusk hemocyanins have biomedical uses as carriers/adjuvants and nonspecific immunostimulants with beneficial clinical outcomes by triggering the production of proinflammatory cytokines in antigen-presenting cells (APCs) and driving immune responses toward type 1 T helper (Th1) polarization. (exeter.ac.uk)
Affinity1
- In 1994, a joint effort by several investigators in the field led to a new nomenclature in which the term "galectins" was used to define lectins with an affinity for - galactosides and with sequence similarity in the carbohydrate-binding site [3]. (fdocuments.net)
Bacterial1
- Synthesis of multifunctional cellulose nanocrystals for lectin recognition and bacterial imaging. (docksci.com)
Phagocytosis2
- The interaction between lectins and carbohydrates have been shown to be involved in such activities as opsonization of microorganisms, phagocytosis, cell adhesion and migration, cell activation and differentiation, and apoptosis. (tamu.edu)
- Phagocytes are a type of white blood cell that use phagocytosis to engulf bacteria, foreign particles, and dying cells to protect the body . (planschwitzer-naturstein.de)
Mammalian1
- Allosteric inhibition of a mammalian lectin. (mpg.de)
Glycans1
- Although lectins were already known because of their ability to agglutinate red blood cells, 3 the involvement of lectins and glycans in PCD had not been elucidated. (nature.com)
Galactose1
- PtCLec2 has a one carbohydrate-recognition website (CRD) using a maintained QPD motif, that has been predicted to own galactose nature. (ag-881inhibitor.com)
Calcium-dependent1
- Many of these domains function as calcium-dependent carbohydrate binding modules. (embl.de)
Structural4
- The stereochemical principles underlying the recognition process have been the subject of extensive biochemical and structural studies. (embl.de)
- Structural basis of lectin-carbohydrate recognition. (embl.de)
- The structural basis for selective sugar recognition by members of all of these groups has been investigated by x-ray crystallography. (embl.de)
- Structural Insights into the Molecular Recognition Mechanism of the Cancer and Pathogenic Epitope, LacdiNAc by Immune-Related Lectins. (ucibio.pt)
Galectins1
- Introduction Galectins, formerly known as S-type lectins, rep- resent a family of evolutionarily conserved ani- mal lectins that are widely distributed from lower invertebrates to higher vertebrates. (fdocuments.net)
Moieties1
- Unfortunately, many carbohydrate moieties in the PDB contain inconsistencies or errors. (iucr.org)
Family1
- These observations spotlight the unique functions diversity and molecular evolution of this lectin family involved in the mollusk shell formation. (cancer-ecosystem.com)
Sugar recognition2
- Lectins are responsible for cell surface sugar recognition in bacteria, animals, and plants. (embl.de)
- The aim is to develop a broad understanding of the biological roles of sugar recognition. (glyco26.org)
Inhibitory1
- Using the gal-3 inhibitor GB0139 (TD139) and gal-3C we found that the gal-3-induced inhibitory effect on ROS production was dependent on the carbohydrate recognition domain of the lectin. (lu.se)
Trehalose1
- Furthermore it was found that trehalose which is usually specific recognizing carbohydrates for PPL2A and is abundant in the secreted fluid of mantle functions as a regulatory factor for biomineralization via PPL2A. (cancer-ecosystem.com)
Specific recognition1
- Lectins can be found in many organisms and are involved in a multitude of cellular processes that depend on specific recognition of complex carbohydrates. (embl.de)
Interaction1
- Lectin-carbohydrate interaction in the immune system. (tamu.edu)