OrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation Science
Protein Array AnalysisPolysaccharidesCarbohydratesGlycomicsMicroarray AnalysisOligonucleotide Array Sequence AnalysisCarbohydrate SequenceMacluraComputational BiologyCarbohydrate MetabolismLectinsMagnetsCarbohydrate ConformationDietary CarbohydratesProteomicsPlant LectinsGene Expression ProfilingScavenger Receptors, Class CProtein BindingOligosaccharidesSoftwareMolecular Sequence DataN-Acetylneuraminic AcidProteomeMannoseImmobilized Proteins
FunctionalAntibodyMassGenomicMethodsMicroarraysDetectionScientistsSurvivalMoleculesPlatformNaturalStudyMakesServicesLargeCancerCustom microarrays on glass slidesGlycoproteinsNatural glycansMass spectrometryGlycomicsRecombinantStructuralAntibodiesInteractionsRecognitionStructuresMolecularPotentialProductionDataExpressionDevelopment
Functional2
  • The National Center for Functional Glycomics has developed GlycoPattern, a web-based bioinformatics resource to assist in analysis of glycan array data. (wikipedia.org)
  • The National Center for Functional Glycomics offers the following services: Printing custom microarrays on glass slides Analysis of qualitative and quantitative changes in glycans associated with diseases and disorders by Glycan Reductive Isotope Labeling and mass spectrometry. (wikipedia.org)
Antibody2
  • An antibody is used to precipitate a protein along with bound proteins. (genomicglossaries.com)
  • An antibody ( Ab ), also known as an immunoglobulin ( Ig ), [1] is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses . (wikipedia.org)
Mass1
  • Based on immunological and mass spectrometric analysis, SALSA was estimated to constitute up to 4-10% of the total protein amount in meconium, making it one of the most abundant proteins. (researchgate.net)
Genomic1
  • CD BioGlyco can provide genomic information analysis services related to the cancer pentose phosphate pathway, laying the foundation for the development of cancer treatment strategies targeting the pentose phosphate pathway. (bioglyco.com)
Methods1
  • We can predict the function of PPP related genes based on the bioinformatics methods provided by the MOPCGM platform and analyze the functions of PPP related genes through gene editing technology. (bioglyco.com)
Microarrays1
  • Stu Borman, Chemical and Engineering News, Dec. 16, 2002 lists as highlights of 2002 http://pubs.acs.org/cen/coverstory/8050/8050chemhighlights5.html with references to the literature on polysaccharide and glycoconjugate microarrays, monosaccharide chips, natural and synthetic oligosaccharide arrays, and synthetic oligosaccharides in microtiter plate format. (genomicglossaries.com)
Detection1
  • CD BioGlyco can provide bioinformatics analysis services such as detection services for pentose phosphate pathway related gene mutations, differential gene expression analysis, and signal pathway enrichment analysis. (bioglyco.com)
Scientists1
  • University scientists have described the first chip- based chemical strategy for rapidly screening carbohydrates for biologically useful activity. (genomicglossaries.com)
Survival1
  • Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analyses. (immunetolerance.org)
Molecules2
  • A synthetic, specially- designed oligonucleotide with the ability to recognize and bind a protein ligand molecule or molecules with high affinity and specificity. (genomicglossaries.com)
  • The basic format of the yeast-two hybrid system involves the creation of two hybrid molecules, one in which the " bait ' protein is fused with a transcription factor, and one in which the " prey " protein is fused with a related transcription factor . (genomicglossaries.com)
Platform2
  • Based on our MOPCGM platform, the combined analysis of genome and metabolome can more effectively reveal the molecular mechanism of the reprogramming process of glucose metabolism. (bioglyco.com)
  • Based on our MOPCGM platform, the combined analysis of genome and protein makes the study of gene function more in-depth. (bioglyco.com)
Natural1
  • The oxidative release of natural glycans technique was developed at the center. (wikipedia.org)
Study2
  • 2023). Omics-Oriented Research illustrated with the LEAP Study and the OASIS Bioinformatics Tool. . (immunetolerance.org)
  • A Fatty Diet Induces a Jejunal Ketogenesis Which Inhibits Local SGLT1-Based Glucose Transport via an Acetylation Mechanism-Results from a Randomized Cross-Over Study between Iso-Caloric High-Fat versus High-Carbohydrate Diets in Healthy Volunteers. (gu.se)
Makes1
Services1
  • We can provide high-throughput sequencing services for PPP related genes, and provide customers with customized analysis services based on the sequencing results. (bioglyco.com)
Large1
  • the creation of a large number of compounds (usually proteins or peptides) through technologies such as phage display . (genomicglossaries.com)
Cancer1
  • We can provide analysis of single nucleotide polypeptides of PPP related enzyme encoding genes to help customers explore the relationship between single-nucleotide polymorphisms of PPP related enzyme encoding genes and cancer prognosis and recurrence, and promote the clinical application of research results. (bioglyco.com)
Custom microarrays on glass slides2
  • The National Center for Functional Glycomics offers the following services: Printing custom microarrays on glass slides Analysis of qualitative and quantitative changes in glycans associated with diseases and disorders by Glycan Reductive Isotope Labeling and mass spectrometry. (wikipedia.org)
  • Printing custom Microarrays on glass slides using natural occurring glycans, commercially available glycans, or proteins and glycoproteins. (bidmc.org)
Glycoproteins1
  • These changes may be studied at the level of glycoproteins, glycolipids, glycosaminoglycans, and/or their binding proteins. (nih.gov)
Natural glycans1
  • The oxidative release of natural glycans technique was developed at the center. (wikipedia.org)
Mass spectrometry2
  • Structural analysis of glycans by mass spectrometry and chromatographic techniques. (bidmc.org)
  • Analysis of qualitative and quantitative changes in glycans associated with diseases and disorders by Glycan Reductive Isotope Labeling (GRIL) and mass spectrometry. (bidmc.org)
Glycomics3
  • The center's projects are: Analysis of potential glycan-binding proteins on various glycan arrays (CFG glycan array, Microbial glycan array, NCFG-derived arrays)[clarification needed] Structural analysis of glycans Production of naturally occurring glycans by isolation The center researches shotgun glycomics techniques in which glycans harvested and purified from various materials such as breast milk and pig lungs. (wikipedia.org)
  • This process involves household bleach treatment of tissues to release glycans for glycomics. (wikipedia.org)
  • The National Center for Functional Glycomics has developed GlycoPattern, a web-based bioinformatics resource to assist in analysis of glycan array data. (wikipedia.org)
Recombinant1
  • Production of recombinant carbohydrate binding proteins by fermentation or cell culture. (bidmc.org)
Structural4
  • The GlycoPattern website offers tools and algorithms to discover structural motifs, heatmap visualizations for multiple experiment comparisons, clustering of Glycan Binding Proteins. (wikipedia.org)
  • He is trained in the fields of protein engineering, molecular biology and structural biology at University of Toronto and Stanford University and Queen's University. (chi-peptalk.com)
  • His research focuses on the applications of NMR in the higher-order structural characterization of antibodies and fusion proteins. (chi-peptalk.com)
  • He has over 30 peer-reviewed publications in the area of protein formulation, biophysical characterization and structural biology. (chi-peptalk.com)
Antibodies1
  • Such proteins, including lectins and glycan-binding antibodies, are particularly valuable if accurate information is available about the glycans that a protein binds. (nih.gov)
Interactions3
  • Because protein-glycan interactions are so complex, simplistic modes of analyzing the data and describing glycan-binding specificities have proven inadequate in many cases. (nih.gov)
  • This review surveys the methods for handling high-content data on protein-glycan interactions. (nih.gov)
  • We also give an outlook on the promising experimental technologies for generating new insights into protein-glycan interactions, as well as a perspective on the limitations that currently face the field. (nih.gov)
Recognition1
  • They are specifically focused on glycan analysis and molecular mechanisms of glycan recognition by proteins important in human biology and disease. (wikipedia.org)
Structures2
  • Proteins that bind carbohydrate structures can serve as tools to quantify or localize specific glycans in biological specimens. (nih.gov)
  • The NCI solicits applications for cooperative agreements supporting innovative research in the discovery and development of diagnostic cancer biomarkers based specifically on complex carbohydrate structures. (nih.gov)
Molecular1
  • To stimulate innovative translational research in the field of complex carbohydrates with the overall goal to uncover and develop new classes of molecular markers for early detection of cancer, the National Cancer Institute (NCI) intends to establish a scientific consortium referred to as the "Alliance of Glycobiologists for Detection of Cancer and Cancer Risk. (nih.gov)
Potential1
  • Through this FOA, the NCI solicits new and competing renewal applications for research projects to elucidate how changes in cellular carbohydrates may promote cancer initiation and progression and use this information to identify glycan-based abnormalities that have the potential to serve as biomarkers for early cancer detection or risk assessment. (nih.gov)
Production2
  • Rich Altman has 30 years of experience in protein expression and production. (chi-peptalk.com)
  • Production of naturally occurring glycans by isolation from natural products or by enzymatic modification of existing glycans. (bidmc.org)
Data1
  • A challenge, however, has been the analysis of the data. (nih.gov)
Expression1
  • Genome-wide analyses showed that CD147 expression was significantly negatively correlated with immune-related genes. (oncotarget.com)
Development1
  • Subsequently, he worked as a postdoctoral researcher in the group of Prof. T.P.J. Knowles at the Department of Chemistry at the University of Cambridge, U.K. His research interests include the development, characterization and formulation of therapeutic proteins. (chi-peptalk.com)