The NCI solicits applications for cooperative agreements supporting innovative research in the discovery and development of diagnostic cancer biomarkers based specifically on complex carbohydrate structures. (nih.gov)
Malignant6
The aim of this study was to evaluate the diagnostic performance of several tumor markers in common use for detecting malignant pleural disease. (nih.gov)
Biodegradable implants of carmustine are already used in the treatment of malignant brain tumors. (researchandmarkets.com)
To investigate this association, we conducted a retrospective study of premalignant and malignant tumors diagnosed in Turkey. (escholarship.org)
Blood information was obtained for 98 individuals with premalignant and malignant skin tumors, and the distribution of ABO and Rh blood type for cases was compared with that of 419 healthy blood donors from the same geographic area. (escholarship.org)
In some tumors, alteration of ABO/Lewis-related antigens is associated with malignant transformation [5-19]. (escholarship.org)
Markers12
The diagnostic value of tumor markers in pleural fluid is subject to debate. (nih.gov)
Blinded comparison of four tumor markers in pleural fluid with a confirmatory diagnosis of malignancy by pleural cytology or thoracoscopic biopsy. (nih.gov)
Active cellular therapies aim to destroy cancer cells by recognition of distinct markers known as antigens. (wikipedia.org)
1. [The present and the future of tumor markers]. (nih.gov)
3. [Clinical usefulness of tumor markers associated with pancreatic cancer]. (nih.gov)
4. Combination assay of urinary beta-core fragment of human chorionic gonadotropin with serum tumor markers in gynecologic cancers. (nih.gov)
17. [Studies on clinical usefulness of new tumor markers of ovarian cancer, CA54/61 and CA602--III. (nih.gov)
We investigated the distribution of CTCs in peripheral and portal blood of CRC patients, and analyzed the relationship between serum tumor CEA/CA19-9 markers and CTCs blood levels. (oncotarget.com)
To stimulate innovative translational research in the field of complex carbohydrates with the overall goal to uncover and develop new classes of molecular markers for early detection of cancer, the National Cancer Institute (NCI) intends to establish a scientific consortium referred to as the "Alliance of Glycobiologists for Detection of Cancer and Cancer Risk. (nih.gov)
Antigens like CA 19-9 that give information about cancer are called tumour markers. (anticancerproject.co.in)
Circulating tumor cells (CTCs) are used for metastasis surveillance in cancer patients, but low detection rates limit their use in colorectal cancer (CRC). (oncotarget.com)
Antibodies3
Normal antibodies bind to external pathogens, but the modified immunotherapy antibodies bind to the tumor antigens marking and identifying the cancer cells for the immune system to inhibit or kill. (wikipedia.org)
Monoclonal antibodies can be used for the delivery of anticancer payloads such as radionucleotides, toxins and chemotherapeutic agents to the tumors. (researchandmarkets.com)
She is particularly interested in the immunological foundation of anti-carbohydrate antibodies, their effects on cancer and heart diseases, and the development of innovative diagnostics and treatments for these diseases. (glycanage.com)
Epitopes1
The advantages of this new technology are manifold: higher affinity, improved specificity, and recognition of antigens and epitopes that are nonimmunogenic to rodents. (mddionline.com)
Immunotherapy3
Cancer immunotherapy exploits the fact that cancer cells often have tumor antigens, molecules on their surface that can bind to antibody proteins or T-cell receptors, triggering an immune system response. (wikipedia.org)
Active immunotherapy specifically targets tumor cells via the immune system. (wikipedia.org)
In contrast, passive immunotherapy does not directly target tumor cells, but enhances the ability of the immune system to attack cancer cells. (wikipedia.org)
Serum4
7. [Diagnosis and follow-up of ovarian cancer by a combination assay of serum sialyl SSEA-1 antigen and CA125 levels]. (nih.gov)
11. [Clinical value of a new serum tumor marker CA602 in ovarian cancers]. (nih.gov)
16. [Clinical evaluation of serum CA-50 and CA 19-9 in gynecological tumors]. (nih.gov)
20. [Clinical significance of serum sialyl Tn antigen in patients with gynecological cancer. (nih.gov)
Anticancer3
Encapsulating anticancer drugs in liposomes enables targeted drug delivery to tumor tissues and prevents damage to the normal surrounding tissues. (researchandmarkets.com)
Because most conventional anticancer agents cannot distinguish between normal and tumor cells, they produce side effects, such as nausea, hair loss, neutropenia, peripheral neuropathies, renal failure, encephalopathy, and cardiac toxicity [ 3 - 8 ]. (oncotarget.com)
Because a targeted drug delivery system can selectively guide therapeutics into tumor cells, the effective accumulation of anticancer agents occurs in the tumor, but not in normal tissue. (oncotarget.com)
MeSH1
Antigens, CD15" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
Cells17
T-cell transfer therapy: a treatment that takes T-cells from the tumor and selects or changes them in the lab to better attack cancer cells, then reintroduces them into the patient. (wikipedia.org)
Treatment vaccines: also known as therapeutic cancer vaccines, help the immune system learn to recognize and react to mutant proteins specific to the tumor and destroy cancer cells containing them. (wikipedia.org)
In cell-mediated therapies like CAR-T cell therapy, immune cells are extracted from the patient, genetically engineered to recognize tumor-specific antigens, and returned to the patient. (wikipedia.org)
Circulating tumor cells (CTCs) contribute to metastases by being released into the blood from primary tumors [ 9 ]. (oncotarget.com)
In specific embodiments, the disclosure concerns adoptive cell therapy cancer treatment in which tumor-1 infiltrating lymphocytes and/or engineered T cells are modified to increase their efficacy as a cancer treatment. (justia.com)
In specific cases, the cells are engineered for knock out of one or more genes, such as Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1), Bone Marrow Stromal Cell Antigen 2 (BST2), and/or programmed cell death protein 1 (PD-1). (justia.com)
The methods and compositions increase efficacy of the cells for the therapy in at least some cases by allowing them to overcome immunosuppression at the tumor microenvironment. (justia.com)
Particular embodiments of the disclosure concern modulation of particular immune cell surface proteins to enhance adoptive cell therapy, and in specific cases the immune cells are lymphoid cells, including at least T cells, tumor infiltrating lymphocytes, or B cells, for example. (justia.com)
The modulation of expression of the genes in the cells may be for the explicit purpose of improving efficacy of the cells for therapy, including improving efficacy in the tumor microenvironment. (justia.com)
In particular embodiments, the present disclosure involves the knockout (or knockdown, in certain cases) of genes in particular lymphoid cells, such as tumor-infiltrating lymphocytes (TILs) or engineered T cells, for example, to improve the function of the cells within the tumor microenvironment. (justia.com)
Embodiments of the disclosure allow for improved T cell resistance to immunosuppression compared to T cells with un-altered expression of SIT1, BST2, and PD-1, including to overcome immunosuppression in the tumor microenvironment. (justia.com)
Here, we generated antigenic peptides into non-linear trimers by solid phase peptide synthesis, thereby enhancing antigen presentation by dendritic cells to CD8+ T cells in vitro and in vivo. (eur.nl)
CD8+ T cells from mice vaccinated with trimers showed an KLRG1+ effector phenotype and were able to recognize and kill antigen-expressing tumor cells ex vivo. (eur.nl)
Hence, we provide pre-clinical support for the induction of effector CD8+ T cells through the adaptable AMAX platform as easy implementable peptidic vaccination strategy against any antigen of choice, including neoantigens for anti-tumor immunity. (eur.nl)
Blood group antigens, which are the major alloantigens in humans, are present on the surface of red blood cells and various epithelial cells. (escholarship.org)
As the majority of human cancers are derived from epithelial cells, changes in blood group antigens are an important aspect of human tumor [ 1 , 2 , 3 , 4 ]. (escholarship.org)
As a result, it is often impossible for chemotherapy to eradicate all tumor cells within the body, leading to tumor recurrence and poor prognosis. (oncotarget.com)
Genes1
In particular embodiments, the genes that are knocked out or knocked down are Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1), Bone Marrow Stromal Cell Antigen 2 (BST2), and Programmed cell death protein 1 (PD-1). (justia.com)
This disclosure provides adoptive cell therapy embodiments that allow therapeutic efficacy in individuals with cancer, including solid tumors. (justia.com)
demonstrated that HER2 antibody-guided liposomes loaded with doxorubicin markedly improved the therapeutic index with animal tumor models, both by increasing antitumor efficacy and by reducing systemic toxicity [ 10 ]. (oncotarget.com)
Diagnostic1
5. [Diagnostic value of serological tumor marker tests in patients with ovarian cancer]. (nih.gov)
Clinical5
51.9% of [Coley's] patients with inoperable soft-tissue sarcomas showed complete tumour regression and survived for more than 5 years, and 21.2% of the patients had no clinical evidence of tumour at least 20 years after this treatment. (wikipedia.org)
8. [Basic and clinical evaluation of an immunoradiometric competitive inhibition assay for sialyl TN antigen: (2). (nih.gov)
14. Clinical evaluations of the tumor marker sialyl SSEA-1 antigen for clinical gynecological disease. (nih.gov)
Importantly, immunization with a mix of neoantigen AMAX could reduce tumor growth in a pre-clinical syngeneic mouse model. (eur.nl)
Documentation of clinical findings included: (a)Gender (b)Age (c)Clinic types of the skin cancer including SCC, BCC and ISCC and (d) tumor location. (escholarship.org)
Synthetic1
AMAX outperformed synthetic long peptides in terms of both CD8+ and CD4+ T cell responses and allowed functionalization with DC-SIGN-binding carbohydrates for in vivo dendritic cell targeting strategies, boosting T cell responses even further. (eur.nl)
Urinary2
15. [Assessment of urinary beta-core fragment of hCG as a tumor marker of cervical cancer]. (nih.gov)
19. Urinary gonadotropin fragment, a new tumor marker. (nih.gov)
Bind1
And that's why we get auto xeno antigens that can be recognised by xeno-autoantibodies that bind to these non-human sugars. (glycanage.com)
Cancers1
Therefore, we hypothesized that analysis of blood group and related antigens on skin cancers would provide useful information on the risk factors. (escholarship.org)
Antibody1
Moreover, we show that agonistic CD40 antibody combined with MF59 (AddaVax) emulsion synergistically improves the antigen-specific T cell response of the AMAX in vivo. (eur.nl)
Blood2
This test looks for the antigen called cancer antigen 19-9 (CA 19-9) in your blood. (anticancerproject.co.in)
This platform, termed Antigen MAtriX (AMAX) improved yield, purity and solubility of trimers over conventional solid phase synthesis strategies. (eur.nl)
However, certain cellular therapies have limited success because of immunosuppression in the tumor microenvironment. (justia.com)
Cell1
Also, tumor-associated antigens and neo-antigens could be incorporated in AMAX for tumor-specific CD8+ T cell responses. (eur.nl)
Patients1
This study aimed to determine the underlying pathophysiologic mechanism of elevated carbohydrate antigen 19-9 (CA19-9) in pulmonary sequestration (PS) patients. (biomedcentral.com)
Specific1
In addition, CD15 antigen is a stage-specific embryonic antigen. (childrensmercy.org)
Targeted drug del1
These may be injected into the arterial circulation and guided to the tumor by a magnetic field for targeted drug delivery. (researchandmarkets.com)
Major1
This graph shows the total number of publications written about "Antigens, CD15" by people in this website by year, and whether "Antigens, CD15" was a major or minor topic of these publications. (childrensmercy.org)
Research2
April 19, 2011 - See Notice NOT-CA-11-012 Request for Information (RFI) Related to a Planned Funding Opportunity for Support of Basic and Translational Research in the Area of Tumor Glycomics. (nih.gov)
This Funding Opportunity Announcement (FOA) solicits applications for research awards designed to support a number of Tumor Glycome Laboratories that will comprise the principal components of this new consortium. (nih.gov)