AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceHealth CareGeographicals
Pseudomonas aeruginosaPseudomonas InfectionsCarbapenemsbeta-LactamasesIntegronsMicrobial Sensitivity TestsAnti-Bacterial AgentsDrug Resistance, Multiple, Bacterialbeta-Lactam ResistanceBacterial ProteinsAcinetobacter baumanniiElectrophoresis, Gel, Pulsed-FieldPseudomonasAcinetobacter InfectionsImipenemDNA, BacterialMolecular Sequence DataDrug Resistance, BacterialThienamycinsAcinetobacterGenes, BacterialDrug Resistance, MicrobialKlebsiella pneumoniaeEnterobacteriaceaePorinsKlebsiella Infectionsbeta-LactamsGram-Negative BacteriaCross InfectionSequence Analysis, DNABacterial Outer Membrane ProteinsPseudomonas putidaPlasmidsEnterobacteriaceae InfectionsCystic FibrosisPolymerase Chain ReactionPseudomonas fluorescensGram-Negative Bacterial InfectionsPseudomonas PhagesGene Expression Regulation, BacterialPyocyanineDisk Diffusion Antimicrobial TestsBiofilmsAlginatesDNA Transposable ElementsEscherichia coliDNA FingerprintingMultilocus Sequence TypingADP Ribose TransferasesMolecular EpidemiologyCeftazidimeMutationBacteremiaBacterial Typing TechniquesLactamsTobramycinVirulence FactorsBacteriaAnti-Infective AgentsHospitalsGram-Positive BacteriaDrug ResistanceBase SequenceCulture MediaQuorum SensingVirulenceAmino Acid SequenceCephalosporinsCarbenicillinMolecular TypingGenotypeDrug Resistance, MultipleCiprofloxacinPyocinsGentamicinsStaphylococcus aureusExotoxinsAmikacinGlucuronic AcidDisease OutbreaksHospitals, UniversityAminoglycosidesDipeptidasesPiperacillinColony Count, MicrobialColistinIntensive Care Units4-ButyrolactoneBacterial ToxinsCilastatinPenicillin ResistancePhenotypePhylogenyPseudomonas syringaeBacterial InfectionsConjugation, GeneticCluster AnalysisPenicillinsFluoroquinolonesSerotyping
AcinetobacterSusceptibilityKlebsiellaAntibioticsEnterobacteriaceaeInfectionsStrains IsolatedAminoglycosidesEnterobacteralesGenesPathogensCRPAAddition to demonstrating carbapeStaphylococcusPrevalence of carbapenem-resistantAbstractESBLBaumanniiAmikacinMicrobiologyImipenemMechanisms of Carbapenem ResistancePhenotypicEnterococcusGentamicinWhole genomeEzriCare Artificial TearsMultidrugCefepimePatientsCarbapenemasesPneumoniaeBacteremiaGenomicProteusMeropenemBacteriaPathogenVitroBacterial isolatesMolecularResistant isolatesSpecimenPandrug-resistantMortality rateColistin-resistantIntrinsically resistantNosocomialEmergenceCarbapenemase producersGram
Acinetobacter15
Susceptibility23
  • the subset of isolates that underwent antimicrobial susceptibility testing for cefiderocol were susceptible to this agent. (cdc.gov)
  • Can all susceptibility test methods accurately detect carbapenem resistance? (cdc.gov)
  • Can the susceptibility test results of one carbapenem be used to predict results for the other? (cdc.gov)
  • All the isolates were tested for their antimicrobial susceptibility patterns, using the standard guidelines issued by the clinical and laboratory standards institute (CLSI). (brieflands.com)
  • Aim: It was aimed to compare the antimicrobial susceptibility of carbapenem resistant (CRPA) andsusceptible P. aeruginosa (CSPA) strains and to determine the presence of carbapenemasegenes in CRPA strains. (ijmlr.com)
  • The antibiotic susceptibility of 125 P. aeruginosa isolated from 215 clinical samples (blood, urine, wound swab samples, sputum, and cerebrospinal fluid) was determined using the disk diffusion method on the Muller-Hinton agar medium. (edu.iq)
  • Antimicrobial susceptibility results of the Gram-negative isolates were recorded. (researchid.co)
  • Results A total of 1,043 isolated Gram-negative bacteria were analyzed for carbapenem susceptibility. (researchid.co)
  • Among individual countries, Enterobacterales and P. aeruginosa collected in Venezuela showed the greatest reductions in ceftazidime-avibactam susceptibility over time. (scielo.br)
  • Submit the CRE/CRPA isolate, antibiotic susceptibility report, test requisition , and chain of custody to the DC PHL during your next scheduled twice-weekly PHL pickup. (dc.gov)
  • A total of 110 clinical isolates of A. baumannii , collected in a recent 2-year period, were tested for carbapenem antibiotic susceptibility, followed by a molecular analysis of carbapenemase genes. (frontiersin.org)
  • Cultures, identification of isolates and antibiotic susceptibility tests were made by standard microbiologic methods. (jceionline.org)
  • Studies were conducted using phenotypic (susceptibility testing to carbapenems ± efflux pump inhibitors (EPIs)) and molecular (determining expression levels of efflux operon with regulatory-gene and whole genome sequencing (WGS)) methods. (bvsalud.org)
  • To determine the prevalence of UTIs, aetiological agents and antimicrobial susceptibility profile of the isolates among pregnant women attending antenatal clinics in some selected hospitals in Enugu. (ispub.com)
  • Antimicrobial susceptibility profile showed that the majority of the isolates were sensitive to Imipenem and Nitrofurantoin while most were significantly resistant to, augmentin, ampicillin, cotrimoxazole, gentamicin, cefuroxime, cefotaxime, and ceftazidime. (ispub.com)
  • Apramycin susceptibility of multidrug-resistant Gram-negative blood culture isolates in five countries in South-East Asia. (ox.ac.uk)
  • Here, we collected a panel of 470 MDR GNB isolates from health care facilities in Cambodia, Laos, Singapore, Thailand, and Vietnam for a multi-centre assessment of their antimicrobial susceptibility to apramycin in comparison to other aminoglycosides and colistin by broth microdilution assays. (ox.ac.uk)
  • Susceptibility to gentamicin and tobramycin (MIC ≤ 4 µg/mL) was significantly lower at 122 (26.0%) and 101 (21.5%) susceptible isolates, respectively. (ox.ac.uk)
  • Identification and antimicrobial susceptibility testing data from the clinical microbiology laboratories from samples sent in for routine diagnostics were used. (ox.ac.uk)
  • Clinical and Laboratory Standards Institute 2018 guidelines were used for antimicrobial susceptibility testing interpretation. (ox.ac.uk)
  • The primary hypothesis is that these interventions will lead to improved clinical outcomes amongst patients with hospital-acquired bloodstream infection, hospital-acquired pneumonia or ventilator-associated pneumonia due to carbapenem non-susceptible Pseudomonas aeruginosa or Enterobacterales, compared to standard antibiotic susceptibility testing. (pfizerclinicaltrials.com)
  • Biotyping and antimicrobial susceptibility profile was done for isolated strains. (who.int)
  • Outbreaks have hospital in which the ICUs comprise Antibiotic susceptibility testing was been increasingly reported and most an internal medicine unit (10 beds), a determined using modified Kirby- of those outbreaks are caused by multi- coronary care unit (7 beds), a hepatol- Bauer method following the Clinical drug resistant (MDR) strains of this ogy unit (7 beds), a burns unit (10 beds) Laboratory Standards Institute guide- organism. (who.int)
Klebsiella7
Antibiotics25
  • Carbapenem-resistant Enterobacteriaceae (CRE) or carbapenemase-producing Enterobacteriaceae (CPE) are Gram-negative bacteria that are resistant to the carbapenem class of antibiotics, considered the drugs of last resort for such infections. (wikipedia.org)
  • revealed that exposure to antibiotics, especially fluoroquinolones and previous hospitalization dramatically increased the risk of acquisition carbapenem-resistant bacteria. (wikipedia.org)
  • Yellow pigment-producing strains presented significant resistance to antibiotics groups, including β-lactam (91.5%), aminoglycosides (70.5%), and carbapenems (51.9%) compared to green and non-pigmented strains. (biomedcentral.com)
  • Similarly, between 1999 and 2003, Pseudomonas aeruginosa resistance to fluoroquinolone antibiotics increased from 23% to 29.5% in NNIS ICUs (74). (cdc.gov)
  • Our objective was to describe the clinical outcomes and molecular characteristics and in vitro synergy of antibiotics against CRAB isolates. (bvsalud.org)
  • Clinical success was defined as resolution of signs/symptoms of infection without need for additional antibiotics. (bvsalud.org)
  • BACKGROUND: Greece is among the countries characterized by high rates of antimicrobial resistance and high consumption of antibiotics, including carbapenems. (bvsalud.org)
  • Tetracyclines are a vital class of antibiotics, but increasing resistance threatens their efficacy. (wustl.edu)
  • Increasingly, resistance to late-generation tetracyclines, including antibiotics of last-resort, through enzymatic inactivation is being detected in environmental and clinical samples. (wustl.edu)
  • This coupled with the fact that antibiotics are available on the counter without the need for a prescription has resulted in antibiotic abuse that has driven the levels of antibiotic resistance to above average. (biomedcentral.com)
  • A small percentage of isolates (20.0%) showed resistance to antibiotics. (who.int)
  • Its scarcity in the medical literature and resistance to numerous broad-spectrum antibiotics such as carbapenems, cephalosporins, and beta-lactam/lactamase inhibitors pose a diagnostic and therapeutic challenge. (hindawi.com)
  • Carbapenemases are a versatile group of Ã�-lactamases that are characterised by their resistance to virtually all Ã�-lactam antibiotics including cephalosporins and carbapenems, complicating therapy and limiting treatment options. (omicsonline.org)
  • However, there are already clinical isolates of Gram-negative bacteria that are resistant to all available antibiotics, including polymyxins. (illinois.edu)
  • Our findings indicate that rational application of antibiotics is indispensable for minimizing widespread of drug resistance. (frontiersin.org)
  • Various types of β-lactam antibiotics, for example carbapenems, contain β-lactam rings in their structures and can be inactivated by β-lactamase enzymes. (frontiersin.org)
  • In Enterobacterales , the prime antimicrobial resistance mechanism against β-lactam antibiotics is mainly the production of β-lactamases, particularly extended-spectrum β-lactamases (ESBLs). (frontiersin.org)
  • In recent years, increasing resistance rates to antibiotics such as carbapenems and extended-spectrum cephalosporins have been reported, as well as multi-drug resistant and possible extremely drug-resistant rates of approximately 21% and 15%, respectively. (who.int)
  • The concordance between phenotypic and genotypic resistance was 93.27% overall for 6 antibiotics in 3 classes, but varied widely between aminoglycosides. (who.int)
  • Increasing antibiotic resistance to commonly used antibiotics is a challenge to the health-care system. (ispub.com)
  • The results from an in-vitro study, which investigated the activity of murepavadin and standard of care antibiotics* against a collection of 495 Pseudomonas aeruginosa (PA) recent clinical isolates, including 179 strains resistant to colistin, demonstrated that murepavadin was more potent than the comparator anti-Pseudomonas antibiotics tested and showed potent activity against colistin-resistant clinical isolates of PA. (swissbiotech.org)
  • Overall, 30% of CREs carry a carbapenemase - an enzyme that can make them resistant to carbapenem antibiotics. (medscape.com)
  • Aminoglycoside antibiotics such as gentamicin or amikacin are essential medicines in the treatment of BSIs, but their clinical efficacy is increasingly compromised by antimicrobial resistance. (ox.ac.uk)
  • Some of the most clinically relevant resistance genes, such those encoding carbapenemases (ß-lactamase enzymes able to degrade carbapenem antibiotics), are carried on conjugative plasmids that spread across high-risk bacterial clones 5 , 6 . (nature.com)
  • All isolates showed resistance to more than 3 classes of antibiotics. (who.int)
Enterobacteriaceae7
  • a recent study of bloodstream infections showed that patients with a Pseudomonas bloodstream infection had a higher mortality rate than patients with infections caused by members of Enterobacteriaceae or other non-lactose fermenting gram-negative bacilli ( 3 ). (cdc.gov)
  • Carbapenem resistance among Enterobacteriaceae has also increased. (ceufast.com)
  • The aim of this study was to characterise the molecular mechanism of resistance in the clinical isolates of Enterobacteriaceae causing bacteremia and showing resistance to β-lactams, including carbapenems. (omicsonline.org)
  • Carbapenemase producing Enterobacteriaceae (CPE) causing bacteremia is of great clinical concern. (omicsonline.org)
  • DC PHL is working with Epidemiologists at DC Health and the CDC to enhance detection of carbapenem-resistant Enterobacteriaceae (CRE) and carbapenem-resistant Pseudomonas aeruginosa (CRPA) in the District, track trends in resistance patterns, inform guidelines to interrupt the transmission of these pathogens within different healthcare facility settings, and prevent future threats. (dc.gov)
  • Our aim was to evaluate the epidemiological relationship between carbapenem-resistant (CR) Enterobacteriaceae isolates from patients in COVID-19 wards and to investigate the main mechanisms of carbapenem resistance in these isolates during the period April 2020-July 2021. (bvsalud.org)
  • Clinical Trial for Blood Stream Infections, Ventilator Associated Pneumonia, Healthcare Associated Infection, Carbapenem-Resistant Enterobacteriaceae Infection and Hospital-acquired Pneumonia. (pfizerclinicaltrials.com)
Infections25
  • Pseudomonas aeruginosa is an opportunistic pathogen that causes an estimated 51,000 healthcare-associated infections (HAI) in the United States annually and was the third most common gram-negative cause of selected HAI reported to the National Healthcare Safety Network (NHSN) during 2011-2014 ( 1 , 2 ). (cdc.gov)
  • For these reasons, carbapenems have become important antimicrobial drugs for clinical management of serious P. aeruginosa infections. (cdc.gov)
  • Imipenem and meropenem are carbapenem antimicrobial agents used to treat a variety of serious infections when an organism is resistant to the primary agent of choice. (cdc.gov)
  • Carbapenems also are used to treat nosocomial and mixed bacterial infections. (cdc.gov)
  • Citing a multistate cluster of carbapenem‐resistant Pseudomonas aeruginosa associated with eye infections, the Centers for Disease Control and Prevention (CDC) has recommended immediate discontinuation of the use of EzriCare Artificial Tears. (aao.org)
  • According to a statement issued by the CDC on January 20, 2023, the agency is investigating a cluster of 56 isolates from 50 patients in 11 states that link these infections to the use of EzriCare Artificial Tears. (aao.org)
  • Contact your health department's healthcare‐associated infections contact for help submitting isolates of Carbapenem‐resistant P. aeruginosa ocular specimens. (aao.org)
  • It is the most common pathogen isolated from patients who have been hospitalized longer than 1 week, and it is a frequent cause of nosocomial infections. (medscape.com)
  • Seven patients had recurrent infections, during which further antimicrobial resistance to SUL or PMB was not evident. (bvsalud.org)
  • CONCLUSIONS: Use of three-drug regimens for severe CRAB infections among COVID-19 resulted in high rates of clinical response and low mortality relative to previous studies. (bvsalud.org)
  • Borgatta B, Lagunes L, Imbiscuso AT, Larrosa MN, Lujan M,Rello J. Infections in intensive care unit adult patients harboring multidrug-resistant Pseudomonas aeruginosa: implications for prevention and therapy. (ijmlr.com)
  • The isolates were associated with multiple different infection types, including eye infections, and colonization. (umn.edu)
  • Antimicrobial resistance is by far a very pressing research question, especially in low resource settings as it affects our ability to treat infections that otherwise would be curable. (biomedcentral.com)
  • Epidemiologists who staff the DC Department of Health (DC Health) Healthcare-Associated Infections (HAI) Program work closely with microbiologists at the DC Department of Forensic Science (DFS) Public Health Lab (PHL) to respond to alerts of new and unusual MDROs that are detected from isolates submitted by clinical labs serving District healthcare facilities. (dc.gov)
  • Infections secondary to these pathogens are widely common but multidrug resistance (MDR) in Enterobacterales has become a significant challenge with increased morbidity, mortality, and cost of management. (frontiersin.org)
  • Pseudomonas aeruginosa is an opportunistic pathogen often causing nosocomial infections that are resilient to treatment due to an extensive repertoire of intrinsic and acquired resistance mechanisms. (who.int)
  • Antibiotic selection in the treatment of acute invasive infections by Pseudomonas aeruginosa: Guidelines by the Spanish Society of Chemotherapy. (cmac-journal.ru)
  • Prospective multicenter study of the impact of carbapenem resistance on mortality in Pseudomonas aeruginosa bloodstream infections. (cmac-journal.ru)
  • The aminoglycoside apramycin has demonstrated preclinical efficacy against aminoglycoside- and multidrug-resistant (MDR) Gram-negative bacilli (GNB) and is currently in clinical development for the treatment of critical systemic infections. (ox.ac.uk)
  • Assessing the prevalence and antibiotic resistance patterns of Neisseria gonorrhoeae in sexually transmitted infections. (dissertation-help.uk)
  • 8,793 (21%) were from ICUs and 7,439 (18%) isolates were from invasive infections. (ox.ac.uk)
  • The goal of this clinical trial is to propose a seamless intervention linking rapid bacterial isolate identification and antibiotic resistance gene detection and targeted antibiotic prescription to minimise time between infection onset and appropriate treatment in patients with Pseudomonas aeruginosa or carbapenemase producing Enterobacterales infections. (pfizerclinicaltrials.com)
  • Antimicrobial Resistance (AMR) is rampant among bacteria that cause healthcare- and community-acquired infections, driving up costs and increasing the difficulty of therapeutic management. (europa.eu)
  • Trials optimizing timing of antibiotic administration with regard to known antimicrobial pharmacokinetic/pharmacodynamic properties (e.g., prolonging infusion times of β-lactams to reduce bacterial resistance) should also assist in improving outcomes in penetrating traumatic infections, which are increasingly antibiotic resistant. (medscape.com)
  • A multidisciplinary guideline development group covering clinical infectious diseases, clinical microbiology, clinical pharmacology, infection control, and guideline methodology experts jointly developed the present clinical practice guidelines based on best available scientific evidence to address the clinical issues regarding laboratory testing, antimicrobial therapy, and prevention of CRGNB infections. (bvsalud.org)
Strains Isolated3
  • Mohammadzadeh A, Mardaneh J, Ahmadi R, Adabi J. Evaluation of the Virulence Features and Antibiotic Resistance Patterns of Pathogenic Pseudomonas aeruginosa Strains Isolated from Hospitalized Patients in Gonabad, Iran. (brieflands.com)
  • Together with other studies conducted in our hospital, this study showed that carbapenemases were not common in P. Aeruginosa strains isolated in our hospital. (ijmlr.com)
  • This study investigates the contribution of efflux mechanism to carbapenem resistance in 61 acquired blaCHDL-genes-carrying A. baumannii clinical strains isolated in Warsaw, Poland. (bvsalud.org)
Aminoglycosides3
Enterobacterales8
  • The focus of this report is to examine changes in antimicrobial resistance epidemiology among clinical isolates of Enterobacterales and Pseudomonas aeruginosa collected in six Latin American countries as part of the Antimicrobial Testing Leadership and Surveillance (ATLAS) program from 2015 to 2020, with a focus on the in vitro activity of ceftazidime-avibactam against Multidrug-Resistant (MDR) isolates. (scielo.br)
  • Results In total, 23.3% of Enterobacterales and 25.1% of P. aeruginosa isolates were MDR. (scielo.br)
  • For Enterobacterales, 99.3% of all isolates and 97.1% of MDR isolates from 2015‒2017 were ceftazidime-avibactam-susceptible compared to 97.2% and 89.3% of isolates, respectively, from 2018‒2020. (scielo.br)
  • The escalating global prevalence of MDR in Enterobacterales has led to limited treatment options, raising an urgent need for novel antimicrobial therapy(s) and detailed studies exploring underlying resistance mechanisms. (frontiersin.org)
  • ESBL-producing Enterobacterales from the GCC region show high levels of resistance to ampicillin, aztreonam, third-/fourth-generation cephalosporins, fluoroquinolones, and trimethoprim-sulfamethoxazole. (frontiersin.org)
  • Enterobacterales isolates that are concomitant ESBL producers and are carbapenem resistant have been increasingly reported and demonstrate alarmingly increased antibiotic resistance patterns compared with ESBL Enterobacterales . (frontiersin.org)
  • A new study from the Centers for Disease Control and Prevention (CDC) found that a surprising proportion of cases of carbapenem-resistant Enterobacterales (CRE) are found in isolates from patients in the community (CA-CRE). (medscape.com)
  • AMR proportions were higher in 2016-2017 for most pathogen-antimicrobial combinations of interest including imipenem-resistant A. baumannii, P. aeruginosa and Enterobacterales.ConclusionsThe data show alarmingly high and increasing resistant proportions among important organisms in Viet Nam. (ox.ac.uk)
Genes14
  • Genes encoding carbapenemases were identified in 3 (2.3%) of 129 isolates tested. (cdc.gov)
  • The aim of the present study was to examine the antibiotic resistance patterns and presence of nan1 and int1 virulence genes (encoding neuraminidase and class 1 integrons, respectively) in clinical P. aeruginosa isolates and to analyze the measured values with regard to hospital wards, specimens, and antibiotic resistance of the strains. (brieflands.com)
  • The carbapenemase genes were detected using PCR technology, and the most prevalent genes were MBL genes, which were carried by 17/33 (51%) of the isolates. (edu.iq)
  • However, results revealed that bla IMP -type genes were the most common MBL gene combination among the isolates. (edu.iq)
  • The CDC says P aeruginosa strains harboring both VIM and GES genes have not previously been observed in the United States. (umn.edu)
  • One of my early Master's students, Marwa Naguib, reported the prevalence of fusidic acid resistance among isolates from Alexandria, Egypt that were also methicillin resistant and we found a role for plasmid mediated fusB and fusC genes in mediating resistance in these isolates . (biomedcentral.com)
  • Isolates of E.coli (n=42) and K. pneumoniae (n=134) from blood culture collected during 2013-2015 were screened for carbapenemase production by using carba NP test and the presence of carbapenem resistant genes (KPC, IMP, VIM, NDM and OXA- 48 like). (omicsonline.org)
  • bla CTX-M (subtype group 1) followed by/co-dominated by bla TEM and bla SHV , whereas the most common carbapenem-resistant genes are bla OXA-48 and bla NDM-1 . (frontiersin.org)
  • This was further supported by long-read sequencing of one representative XDR isolate, which revealed the presence of an integron carrying multiple resistance genes, including bla VIM-2 , with differences in gene composition and synteny to other P. aeruginosa class 1 integrons described before. (who.int)
  • Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
  • This report presents the status of AMR in Africa by analysing the main types of resistance and the underlying genes where possible. (who.int)
  • The two CR isolates of E. coli possessed blaKPC and blaOXA-48 genes. (bvsalud.org)
  • Health departments working with the Centers for Disease Control and Prevention (CDC) Antibiotic Resistance Lab Network (ARLN) found more than 220 instances of germs with "unusual" antibiotic resistance genes in the United States last year, according to a Vital Signs report released Tuesday. (medscape.com)
  • The bottom line is that resistance genes with the capacity to turn regular germs into nightmare bacteria have been introduced into many states, but with an aggressive response we have been able to stomp them out promptly and stop their spread between people, between facilities and between other germs," CDC Principal Deputy Director Anne Schuchat, MD, reported during a media briefing. (medscape.com)
Pathogens5
  • The frequency of clinical infection caused by these pathogens is low in LTCFs (77, 78). (cdc.gov)
  • Sukhum KV, Diorio-Toth L, Dantas G. 2019 Genomic and Metagenomic Approaches for Predictive Surveillance of Emerging Pathogens and Antibiotic Resistance. (wustl.edu)
  • The work package focusing on molecular studies generated new evidence about the changes effected by antibiotic therapy on commensal organisms or opportunistic pathogens in the oropharyngeal, nasal and gastro-intestinal flora and study AMR mechanisms and the dissemination of successful clones of fluoroquinolone-resistant, carbapenem-resistant or extended-spectrum beta-lactamase harboring Gram-negative bacteria, MRSA and fluoroquinolone-resistant viridans streptococci. (europa.eu)
  • Risk factors for infection with multidrug-resistant pathogens include antibiotic therapy within the preceding 90 days, a high incidence of antibiotic resistance in the community or facility, chronic hemodialysis, and immunosuppression. (aafp.org)
  • The Vital Signs report also details changes in the annual proportion of selected pathogens that were nonsusceptible to extended-spectrum cephalosporins (extended-spectrum β-lactamase [ESBL] phenotype) or resistant to carbapenems (CRE), using infection data from the National Healthcare Safety Network from 2006 to 2015. (medscape.com)
CRPA6
  • During July-October 2015 in the United States, we piloted laboratory-based surveillance for carbapenem-resistant P. aeruginosa (CRPA) at sentinel facilities in Georgia, New Mexico, Oregon, and Tennessee, and population-based surveillance in Monroe County, NY. (cdc.gov)
  • Although this proportion has remained stable since 2009 ( 1 , 5 ), some reports have suggested recent increases in the prevalence of carbapenem-resistant P. aeruginosa (CRPA) among certain subpopulations, including children ( 6 ). (cdc.gov)
  • The multidrug resistance (MDR) rate was 14,6% and higher in the CRPA group. (ijmlr.com)
  • In a Jan 20 statement , the CDC said it identified 56 isolates of Verona integron-mediated metallo beta-lactamase and Guiana extended-spectrum beta-lactamase--producing carbapenem-resistant P aeruginosa (VIM-GES-CRPA) from 50 case patients in 11 states from May 17, 2022, to Jan 19. (umn.edu)
  • The CDC is asking clinical labs that identify any CRPA from an ocular specimen or VIM-CRPA from any specimen to submit the isolates to the Antimicrobial Resistance Laboratory Network for further analysis. (umn.edu)
  • If DC ARLN is unable to fully characterize a CRE/CRPA isolate, or if an unusual resistance mechanism is detected, the isolate will be forwarded to the Mid-Atlantic Regional laboratory for further analysis. (dc.gov)
Addition to demonstrating carbape1
  • In addition to demonstrating carbapenem resistance, isolates in this cluster have demonstrated resistance to ceftazidime and cefepime. (aao.org)
Staphylococcus2
Prevalence of carbapenem-resistant1
  • Objective This study aims to identify the prevalence of carbapenem-resistant gram-negative bacterial isolates. (researchid.co)
Abstract4
  • Abstract Background With the absence of new antimicrobial drugs being developed to replace those facing resistance, bacterial resistance continues to grow. (researchid.co)
  • ABSTRACT Pseudomonas aeruginosa is an important agent of opportunistic infection in aquatic environments. (who.int)
  • Abstract Background Two-Drug Regimens (2DR) have proven effective in clinical trials but real-world data, especially in resource-limited settings, is limited. (scielo.br)
  • Abstract Introduction The incidence of antimicrobial resistance is increasing in many parts of the world. (scielo.br)
ESBL3
  • In another study of patients with pyelonephritis presenting to EDs across the U.S., approximately 6% of the 453 E. coli isolates produced ESBL, although rates varied by region and complicating features. (ceufast.com)
  • In one study of E. coli clinical isolates from extraintestinal sites, predominantly urine, collected at Veterans Affairs (VA) laboratories across the U.S., the ST131 clone accounted for the majority of fluoroquinolone-resistant and ESBL isolates and was calculated to account for 28% of all VA E. coli isolates nationwide. (ceufast.com)
  • Among Gram-negatives 59% (4,085/6,953) and 40% (1,186/2,958) of E. coli and K. pneumoniae produced ESBL and 29% (376/1,298) and 11% (961/8,830) were resistant to carbapenems, respectively. (ox.ac.uk)
Baumannii6
  • Also, a 3-month survey of 15 Brooklyn hospitals in 1999 found that 53% of A. baumannii strains exhibited resistance to carbapenems and 24% of P. aeruginosa strains were resistant to imipenem (10). (cdc.gov)
  • A. baumannii is developing into multidrug resistant (MDR), extensively drug resistant (XDR), and pandrug resistant (PDR) bacteria, and its adaptation to the environment with drug resistance has previously been reported ( Durante-Mangoni and Zarrilli, 2011 ). (frontiersin.org)
  • reported the dissemination of MDR OXA-23-producing A. baumannii clones throughout multiple cities in China, but little is known about the molecular mechanisms of resistance to carbapenems in western China. (frontiersin.org)
  • Our study for the first time reports the involvement of the insertion of the ΔAbaR25-type resistance island fragment with ISAba1 element upstream the efflux operon in the carbapenem resistance of A. baumannii. (bvsalud.org)
  • This study determined the prevalence of MDR A. baumannii isolates from intensive care units in a large tertiary-care hospital in Ismailia, Egypt, and the occurrence of different beta-lactamases in these isolates. (who.int)
  • 10 strains (2.9%) of A. baumannii were isolated. (who.int)
Amikacin1
Microbiology11
  • Selection of the most effective anti-Pseudomonal drug (including in vitro test and report) is a decision best made by each clinical microbiology laboratory in consultation with the infectious diseases practitioners and pharmacologists, as well as therapeutic and hospital infection control committees. (brieflands.com)
  • Journal of clinical microbiology. (edu.iq)
  • Clinical Microbiology and Infection. (edu.iq)
  • As a pharmacist with a special interest in Microbiology, I found antimicrobial resistance, particularly in developing countries, a challenge I wanted to tackle. (biomedcentral.com)
  • Journal of Clinical Microbiology , 42 (11), 5094-5101. (uea.ac.uk)
  • Polyphor AG (SIX: POLN) presented new data on its lead clinical antibacterial candidate, murepavadin, currently in Phase III, and its preclinical medium-spectrum anti Gram-negative antibiotic POL7306 at the European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) in Amsterdam, Netherlands. (swissbiotech.org)
  • FacebookXEmailWhatsAppRedditPinterestLinkedInAre you a student on the lookout for captivating research topics in the realm of Clinical Microbiology for your upcoming undergraduate, master's, or doctoral thesis or dissertation? (dissertation-help.uk)
  • The field of Clinical Microbiology offers a vast landscape ripe for investigation and scholarly inquiry. (dissertation-help.uk)
  • Clinical Microbiology, often referred to as Medical Microbiology, or Applied microbiology in healthcare, is the study of microorganisms such as bacteria, viruses, fungi, and parasites that are of clinical significance. (dissertation-help.uk)
  • Assessing comprehensive risk management strategies in clinical microbiology: a holistic approach to infection control and prevention. (dissertation-help.uk)
  • Patients randomised to the control arm, will have samples analysed by clinical microbiology laboratories using standard of care diagnostics. (pfizerclinicaltrials.com)
Imipenem8
  • Why is imipenem and meropenem resistance important? (cdc.gov)
  • How much resistance to imipenem or meropenem occurs in clinical isolates? (cdc.gov)
  • Stenotrophomonas maltophilia isolates are intrinsically resistant to imipenem. (cdc.gov)
  • However, studies have shown false resistance to imipenem in commercially prepared test panels due to degradation of the drug or to a manufacturing problem where concentrations of imipenem were too low (1,2,4,5). (cdc.gov)
  • The imipenem-meropenem-EDTA disk synergy test showed that only 17 isolates (51.5%) were positive. (edu.iq)
  • resistant to imipenem, please only submit if the isolate is also resistant to another carbapenem antibiotic. (dc.gov)
  • The prevalence of imipenem resistance among Pseudomonas aeruginosa isolates at a 195-bed tertiary care medical center in Cali, Colombia, rose from 2% in 1996 to 28% in 1997 and to over 40% in 2003. (uea.ac.uk)
  • Only 4 of 13 resistant isolates (2 clinical isolates and 2 environmental isolates) assigned to other PFGE types carried blaVIM alleles, whereas the others were less multiresistant and mostly had lower levels of imipenem resistance (MICs, =32 µg/ml) which was not significantly reduced by EDTA. (uea.ac.uk)
Mechanisms of Carbapenem Resistance1
  • Abram, Maja (2015) Mechanisms of carbapenem resistance in multi drug resistant clinical isolates of Pseudomonas aeruginosa from a Croatian hospital . (irb.hr)
Phenotypic5
  • Phenotypic and molecular detecting of carbapenem resistant Pseudomonas aeruginosa in Najaf Hospitals (Doctoral dissertation, PhD Thesis. (edu.iq)
  • Found to be a carbapenemase-producer via Carba-NP test, Modified Carbapenem Inactivation Method (mCIM), MBL-screen, PCR, or other phenotypic or genotypic carbapenemase test. (dc.gov)
  • Phenotypic detection of carbapenemase production will be carried out using the Modified Carbapenem Inactivation Method (mCIM). (dc.gov)
  • Many isolates showed high-level multiresistance, and phenotypic characterization suggested the spread of a predominant strain with minor variants. (uea.ac.uk)
  • The concordance between phenotypic and genotypic resistance was also determined. (who.int)
Enterococcus1
  • VRE accounted for almost 25% of enterococcus isolates in NNIS ICUs in 1999 (94), and 28.5% in 2003 (93). (cdc.gov)
Gentamicin1
  • Intermediate resistance rates are observed against nitrofurantoin, piperacillin/tazobactam, and gentamicin, with increasing resistance observed against tigecycline. (frontiersin.org)
Whole genome4
  • Isolates in this outbreak are sequence type (ST) 1203, harbor bla VIM-80 and bla GES-9 (a combination not previously observed in the United States) and are closely related based on analysis of whole genome sequencing (WGS) data. (cdc.gov)
  • Whole-Genome Sequencing Reveals Multiple Subpopulations of Dominant and Persistent Lineage I Isolates of Listeria monocytogenes in Two Meat Processing Facilities during 2011-2015. (cdc.gov)
  • Whole-genome sequencing data indicate that all isolates are closely related. (umn.edu)
  • But in this study, published in the American Journal of Infection Control , of the 12 isolates that underwent whole-genome sequencing, 42% of the CA-CRE isolates carried the carbapenemase gene. (medscape.com)
EzriCare Artificial Tears1
  • In a statement today , EzriCare said, "As of today, we are not aware of any testing that definitively links the Pseudomonas aeruginosa outbreak to EzriCare Artificial Tears. (umn.edu)
Multidrug8
  • 13% of isolates causing HAI are multidrug resistant (MDR) ( 2 ). (cdc.gov)
  • As the primary goal of this study, we wanted to determine how pigment color production differed between clinical strains of P. aeruginosa , and whether or not that variation was associated with multidrug resistance or the ability to form biofilms. (biomedcentral.com)
  • Despite the fact that previous studies have demonstrated a direct correlation between multidrug resistance behaviors and biofilm production, no such statistically significant association between pigment and biofilm formation was found in our investigation. (biomedcentral.com)
  • Yellow pigment-producing P. aeruginosa strains posed a significant problem due to the lack of alternative agents against such transformed strains, which may be associated with the development of multidrug resistance. (biomedcentral.com)
  • The Centers for Disease Control and Prevention (CDC) Antibiotic Resistance Laboratory Network (ARLN) is a national initiative that enables state public health labs and state health departments to collaborate with local healthcare facilities and clinical labs to detect, respond to, and contain emerging threats of multidrug resistant organisms (MDROs). (dc.gov)
  • Results generated from this project are highlighting the importance of initiating active ongoing surveillance on multidrug resistance organisms in the GCC states. (edu.au)
  • Influence of Multidrug Resistance and Appropriate Empirical Therapy on the 30-Day Mortality Rate of Pseudomonas aeruginosa Bacteremia. (cmac-journal.ru)
  • In-vitro Antibacterial Activity of a Fosfomycin-Trimethoprim-Sulfamethoxazole Combination Against a Bacterial Collection of Multidrug-Resistant Clinical Isolates. (asm.org)
Cefepime2
  • In addition to carbapenem resistance, isolates in the cluster are resistant to ceftazidime and cefepime, and a subset of isolates is also resistant to ceftazidime-avibactam and ceftolozane-tazobactam. (umn.edu)
  • The superiority of cefepime-taniborbactam was sustained for the composite microbiologic and clinical response at the Late-Follow-Up (Day 28-35) visit. (businesswire.com)
Patients10
  • Pseudomonas aeruginosa has become an important cause of gram-negative infection, especially in patients with compromised host defense mechanisms. (medscape.com)
  • Clinical resolution was achieved in 50% of patients and 30-day mortality was 22% (4/18). (bvsalud.org)
  • The study involved screening electronic medical records to identify patients with clinical cultures showing the growth of Gram-negative bacteria. (researchid.co)
  • Pseudomonas is more common in patients with health care exposures or instrumentation. (ceufast.com)
  • The patient population in the CREDIBLE-CR study represents a real clinical scenario with the highest unmet need and provides descriptive evidence that cefiderocol may be a treatment option for physicians treating such critically ill patients," commented Professor Matteo Bassetti, Lead Author and Head of the Infectious Diseases Clinic, San Martino Hospital, Genoa, Italy. (dutchnews.nl)
  • Sixty-six resistant isolates collected between February 1999 and July 2003 from hospitalized patients (n = 54) and environmental samples (n = 12) were subjected to a fuller analysis. (uea.ac.uk)
  • Burden of Antimicrobial Resistance in Hospitalized Patients with Cancer: A Multicenter Analysis. (asm.org)
  • An excellent example is the recent demonstration of substantially higher ampicillin/sulbactam resistance in a center where abdominal trauma patients repeatedly received ampicillin/sulbactam. (medscape.com)
  • The CDC's containment strategy calls for rapid detection of unusual resistance in patients, assessing infection control in the facility if unusual resistance is found, screening of exposed contacts to identify asymptomatic colonization, coordinating the response with other facilities, and continuing these interventions until transmission is controlled. (medscape.com)
  • The screenings showed that about 1 in 10 tests were also positive - meaning the unusual resistance had spread to other patients and could have continued spreading if left undetected. (medscape.com)
Carbapenemases1
  • The modified Hodge test was used to identify carbapenem-resistant isolates, which detects the probability of isolates being able to produce carbapenemases enzyme and out of the isolates, 11 (33.3%) were Hodge positive. (edu.iq)
Pneumoniae2
  • In 2003, 20.6% of all K. pneumoniae isolates from NNIS ICUs were resistant to these drugs (93). (cdc.gov)
  • Epidemiological typing identified 18 ERIC profiles among K. pneumoniae, some presented as clusters of identical and/or closely related isolates. (bvsalud.org)
Bacteremia4
  • Buehrle DJ, Shields RK, Clarke LG, Potoski BA, Clancy CJ and Nguyen MH.Carbapenem-resistant bacteremia: Risk factors for mortality and microbiologic treatment failure. (ijmlr.com)
  • Clinical Significance and Predictors of Community-Onset Pseudomonas aeruginosa Bacteremia. (cmac-journal.ru)
  • Pseudomonas aeruginosa Bacteremia: Risk Factors for Mortality and Influence of Delayed Receipt of Effective Antimicrobial Therapy on Clinical Outcome. (cmac-journal.ru)
  • 5. Siegman-Igra Y., Ravona R., Primerman H., Giladi M. Pseudomonas aeruginosa bacteremia: an analysis of 123 episodes, with particular emphasis on the effect of antibiotic therapy. (cmac-journal.ru)
Genomic1
  • Diorio-Toth L, Irum S, Potter RF, Wallace MA, Arslan M, Munir T, Andleeb S, Burnham CD, Dantas G. 2022 Genomic Surveillance of Clinical Pseudomonas aeruginosa Isolates Reveals an Additive Effect of Carbapenemase Production on Carbapenem Resistance. (wustl.edu)
Proteus1
  • Some species, such as Proteus mirabilis , P. vulgaris , and Morganella morganiii , often have MICs (1-4 µg/ml) just below the carbapenem intermediate breakpoint of 8 mg/ml. (cdc.gov)
Meropenem2
  • Meropenem is a relatively new drug and more studies need to be published before susceptibilities of one carbapenem can be used to predict the other. (cdc.gov)
  • Dynamic Interplay of MexAB-OprM, PDC-5 and OprD in Pseudomonas aeruginosa Facilitates Emergence of Meropenem Resistant Phenotype in Rabbit Pneumonia Model. (asm.org)
Bacteria5
  • People most likely to acquire carbapenem-resistant bacteria are those already receiving medical attention. (wikipedia.org)
  • Despite previous studies conducted in various countries, there is a lack of comprehensive local reporting on the occurrence of carbapenem resistance among gram-negative bacteria. (researchid.co)
  • 8.2%) and 2/8 from hydrotherapy tosurvivalinwhirlpools,hottubsand Total heterotrophic bacteria were pools(25%)werepositivefor P. aerugi- indoorpoolsbecauseofthewarmwater countedonplatecountagarusing1mL nosa (total45/271,16.6%).Thehighest temperatures.Thesewatersareespe- infusiontechniqueafterincubationat isolationrateof P. aeruginosa (25.0%) cial ypronetocontaminationduring 37ºCfor48h.Fortotalcoliforms,the wasfromhydrotherapypools.However, nosignificantdifferenceswerefound periodsofhighusewhenitisdifficultto 100mLmembranefiltrationtechnique wasused,withm-Endomediumat3ºC betweendifferentamenitycategoriesin maintainadequatedisinfectionlevels. (who.int)
  • Many studies report an increase in antimicrobial resistance of Gram - negative bacteria during the COVID-19 pandemic. (bvsalud.org)
  • Investigating the molecular mechanisms of antibiotic resistance in Gram-negative bacteria. (dissertation-help.uk)
Pathogen1
  • Pseudomonas aeruginosa is an adaptable bacterial pathogen that infects a variety of organs, including the respiratory tract, vascular system, urinary tract, and central nervous system, causing significant morbidity and mortality. (biomedcentral.com)
Vitro1
Bacterial isolates2
  • In my PhD years (2007-2010), I focused on the factors affecting biofilm formation among Gram positive and Gram negative bacterial isolates from Egypt. (biomedcentral.com)
  • Bacterial isolates were identified based on their colonial morphology, Gram staining and biochemical reactions. (ispub.com)
Molecular2
  • The SATURN project had as aim to study the impact of antibiotic exposure on AMR with a multidisciplinary approach that bridges molecular, epidemiological, clinical and pharmacological research. (europa.eu)
  • 6. Molecular characterization of isolated CRE from repetitive colonisation surveys to inform IPC. (who.int)
Resistant isolates1
  • The bla IMP gene (578 bp) was the most frequently detected MBL gene, being present in 15 (45.5%) of the carbapenem-resistant isolates. (edu.iq)
Specimen1
  • Isolates have been identified from multiple specimen sites, including clinical cultures of cornea. (aao.org)
Pandrug-resistant2
  • In fact, we are now faced with growing clones of pandrug-resistant P. aeruginosa in hospital settings. (brieflands.com)
  • CRGNB isolates are usually extensively drug-resistant or pandrug-resistant, resulting in limited antimicrobial treatment options and high mortality. (bvsalud.org)
Mortality rate1
  • This study found that carbapenem-resistant acquisition has a significantly higher mortality rate and poorer clinical response compared to that of the ertapenem-resistance acquisition. (wikipedia.org)
Colistin-resistant1
  • Results demonstrated that POL7306 shows a potent activity against a large collection of Gram-negative organisms collected worldwide that include colistin-resistant, extensively drug-resistant, and extended spectrum beta-lactamase- and carbapenemase-producing isolated for which there are currently limited treatment options. (swissbiotech.org)
Intrinsically resistant1
  • Pseudomonas aeruginosa is intrinsically resistant to many antimicrobial drugs, making carbapenems crucial in clinical management. (cdc.gov)
Nosocomial1
  • Development of a Rabbit Model of Nosocomial Pneumonia to Combat Emergence of Resistance. (asm.org)
Emergence1
  • The emergence of further antibiotic resistance was not detected phenotypically or through WGS analysis. (bvsalud.org)
Carbapenemase producers1
  • Among the isolates, 6 isolates were carbapenemase producers, 2 were AmpC beta-lactamase producers and no isolates were metallo-beta- lactamase producers. (who.int)
Gram6
  • AL-Muhannak FH, Al-Mohana A. Spread of Some Extended-spectrum Beta-lactamases: In Clinical Isolates of Gram-negative Bacilli in Najaf. (edu.iq)
  • Pneumonia is the most common NI and carbapenem resistance in Gram-negative bacilli was remarkably high in our ICU. (jceionline.org)
  • Hosam is a member of the Infection and Immunity Theme, where he is studying antimicrobial resistant Gram-negative bacilli isolated from the countries of the Gulf Cooperation Council (GCC). (edu.au)
  • This project is giving snapshots of the different resistance mechanisms associated with antibiotic resistant Gram-negative bacilli and helping to identify the predominate genotype spread in the GCC hospitals. (edu.au)
  • The dissemination of carbapenem-resistant Gram-negative bacilli (CRGNB) is a global public health issue. (bvsalud.org)
  • Antibiotic resistance Staphylococci are gram-positive aerobic organisms. (msdmanuals.com)