Treatment of lithiated homoallylic phosphonates wiht dimethyl carbamyl chloride gave 2-amidophosphonate derivatives. (heterocycles.jp)
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Beginning with carbamyl phosphate1
Compounds comprising the urea cycle are numbered sequentially, beginning with carbamyl phosphate (1). (medscape.com)
Urea2
A urea cycle enzyme deficiency targeted workup revealed CPS (carbamyl phosphate synthetase) deficiency which responded well to supportive therapy and was discharged home. (jaccr.com)
Valproate-induced hyperammonemia is probably the result of depletion of mitochondrial acetyl CoA and decreased production of N-acetylglutamate, the obligatory activator of the first enzyme of the urea cycle, carbamyl phosphate synthetase I. Anticonvulsant-mediated microsomal enzyme induction may also contribute. (qxmd.com)
Phosphate synthase1
Carbamyl phosphate synthase deficiency: diagnosed during pregnancy in a 41-year-old. (medscape.com)
Deficiency3
Patients with OTC deficiency have increased excretion of orotic acid because carbamyl phosphate spills into the cytoplasm, where it enters the pathway of pyrimidine synthesis. (nih.gov)
Carbamyl-phosphate-synthetase deficiency with neonatal onset of symptoms. (medscape.com)
Though they are rare the most commonly described enzyme deficiencies are ornithine transcarbamylase and carbamyl phosphate synthetase deficiency. (jaccr.com)
Mitochondrial1
A signal sequence domain essential for processing, but not import, of mitochondrial pre-ornithine carbamyl transferase. (mcmaster.ca)
Ornithine transcarbamylase1
Following condensation with ornithine, carbamyl phosphate is converted to citrulline in the ornithine transcarbamylase ( OTC ) reaction. (nih.gov)
Enzyme2
at this step, N-acetylglutamate exerts its regulatory control on the mediating enzyme, carbamyl phosphate synthetase (CPS). (medscape.com)
As an alternative,-20°C,-90°C freezers and dry ice (-80°C) can give more flexibility for storing and transporting material, provided initial freezing has been carried out at-196°C. ATCase specific activity was stable over a large range of total protein concentrations (2-55 mg ml"') for most mesozooplankton samples, and the enzyme activity was linear between 0.8 and 80 nmol carbamyl aspartate min~' mg~' of total protein. (ird.fr)
Neonatal1
Neonatal hyperammonaemia with complete absence of livercarbamyl phosphate synthetase activity. (bmj.com)
Expression1
Summar ML, Hall L, Christman B. Environmentally determined genetic expression: clinical correlates with molecular variants of carbamyl phosphate synthetase I. Mol Genet Metab . (medscape.com)
Synthetase9
Human carbamyl phosphate synthetase I (CPSI) is an essential hepatic enzyme that initiates the urea cycle. (nih.gov)
Valproic acid given to patients with urea cycle disorders may exacerbate their condition and antagonize the efficacy of AMMONUL through inhibition of the synthesis of N- acetylglutamate, a co-factor for carbamyl phosphate synthetase. (nih.gov)
The first stage in the synthesis of urea in animals may be considered to be the formation of carbamyl phosphate the reaction being catalyzed by carbamyl phosphate synthetase. (preservearticles.com)
The enzyme carbamyl phosphate synthetase catalyzes a two-step reaction leading to the formation of this high-energy compound. (preservearticles.com)
also at this step, N-acetylglutamate exerts its regulatory control on the mediating enzyme, carbamyl phosphate synthetase (CPS). (medscape.com)
Relation of Macrophage Migration Inhibitory Factor to Pulmonary Hemodynamics and Vascular Structure and Carbamyl-Phosphate Synthetase I Genetic Variations in Pediatric Patients with Congenital Cardiac Shunts. (cdc.gov)
The normal function of N -acetylglutamate (NAG), the reaction product, is to act as an activator of carbamyl phosphate synthetase (CPS), which is also a mitochondrial enzyme. (medscape.com)
this results in failure to activate the enzyme responsible for the reaction NH 4 + + CO 2 + ATP → H 2 N-CO-PO 3 2- + ADP, which is the entry step into the urea cycle (see Carbamyl Phosphate Synthetase Deficiency ). (medscape.com)
Group is transferred1
The carbamyl group is transferred to esteratic site (Ser). (anesthesiaexam.com)
Carbamates2
Carbamyl sulfonate (CS) compounds are a novel class of carbamates derived from amino acid methyl esters. (nih.gov)
Carbamates -like neostigmine and physostigmine have carbamyl group. (howmed.net)
AMMONIA1
Meister, A. (1973) Enzymatic conversion of O-carbamyl-L-serine to pyruvate and ammonia Biochem Biophys Res Commun 55 780-7. (unipr.it)
Urea cycle1
Compounds that comprise the urea cycle are numbered sequentially, beginning with carbamyl phosphate. (medscape.com)
Synthesis1
Carbamyl phosphate supplies one of the nitrogen atoms for urea synthesis. (preservearticles.com)
Liver1
Lack of alkylation of 17α-carbamyl significantly reduces liver toxicity of the drug. (buysteroidtablets.com)
Class1
Carbamoyl phosphate, also known as carbamoyl-p or phosphate, carbamyl, belongs to the class of organic compounds known as organic phosphoric acids and derivatives. (hmdb.ca)