AChEOrganophosphates and carbamatesInhibitorsInsecticidesPesticidesToxicityPyrethroidsCarbarylInhibitorEnzymeInhibition of acetylcholinesteraseInhibit acetylcholinesteraseCholinergicPhysostigmineNerve agentsCompoundsAnticholinesterasePhenylButyrylcholinesterasePesticideSarinAcetylcholineResistanceCarbofuranPyrethroidDerivativesBiosensorExposuresBiosensorsStimulationToxicCholinesterase activityActivityFindingsMammalianDetectionBiochemicalDeterminationSensor BasedEnzymesDescription
AChE14
- The role of the clinical laboratory in evaluating persons to acetylcholinesterase (AChE) inhibiting pesticides was discussed. (cdc.gov)
- The limitations of biological monitoring were discussed, including problems in establishing baseline levels of enzyme activity, AChE activities not having decreased to steady state values before symptoms of organophosphate poisoning develop, and the inability of AChE monitoring to effectively detect exposure to some ChE inhibiting agents such as carbamates. (cdc.gov)
- We have previously designed and synthesized dimeric tacrine(10)-hupyridone (A10E), a novel tacrine derivative with acetylcholinesterase (AChE) inhibition and brain-derived neurotrophic factor (BDNF) activation activity, by linking tacrine and a fragment of huperzine A. However, it was largely unknown whether A10E could act on other AD targets and produce cognitive-enhancing ability in AD animal models. (inrae.fr)
- New insecticides are needed for control of disease-vectoring mosquitoes and this research evaluates the activity of new carbamate acetylcholinesterase (AChE) inhibitors. (inrae.fr)
- Among the pesticides, organophosphate and carbamate species are the most used, and their toxicity is mainly due to their inhibitory effect on acetylcholinesterase (AChE). (springer.com)
- The working principle of the AChE biosensor exploits the capability of carbamate and organophosphate pesticides to form a stable complex with the enzyme, which causes an impedimetric change. (springer.com)
- Moreover, the common amperometric evaluation of AChE inhibition degree was correlated to the impedimetric changes of the electrode surface, showing a good correlation ( R 2 = 0.99 for carbamates and R 2 = 0.98 for organophosphates) between the two methods. (springer.com)
- 2021. The Medical & Science Acronym /Abbreviation/Slang AChE means acetylcholinesterase enzyme. (novasystem-srl.com)
- ACHE: American College of Healthcare Executives: ACHE: Acetylcholinesterase: ACHE: AHS (American Headache Society) Committee for Headache Education: ACHE: Alabama Commission on Higher Education (Montgomery, AL) ACHE: Association for Continuing Higher Education: ACHE: Air Cargo Handling Equipment: ACHE A dull, generalized or localized pain, usually one of less than severe intensity. (novasystem-srl.com)
- Top ACHE abbreviation related to Medical: Acetylcholinesterase AChE (acetylcholinesterase): Abbreviation for acetylcholinesterase. (novasystem-srl.com)
- Acetylcholinesterase (AChE) activity levels can be used as an indicator for AChE inhibition due to pesticide poisoning in bird species. (scielo.br)
- The primary mechanism of action of organophosphate pesticides is inhibition of carboxyl ester hydrolases, particularly acetylcholinesterase (AChE). (medscape.com)
- Nerve agents inhibit the enzyme acetylcholinesterase (AChE), which hydrolyzes the neurotransmitter acetylcholine (ACh) once ACh has finished activating receptors in neurons, muscles, and glands. (msdmanuals.com)
- Organophosphorus compounds irreversibly bind to acetylcholinesterase (AChE), rendering this enzyme non-functional. (scielo.org.za)
Organophosphates and carbamates6
- A mutation at a single target site can result in mosquito resistance to DDT and pyrethroids or to organophosphates and carbamates. (cdc.gov)
- For example, in several populations of the major malaria vector in Africa, Anopheles gambiae s.l. mosquitoes, mutations in the DDT/pyrethroid target site, known as knockdown resistance ( kdr ) alleles, have been found in conjunction with resistance alleles of the acetylcholinesterase gene ( Ace-1 R ), the target site of organophosphates and carbamates ( 5 ). (cdc.gov)
- Chronic and subclinical effects of organophosphates and carbamates were considered. (cdc.gov)
- The classical active compounds used for these tools are pyrethroids, organochlorines, organophosphates and carbamates. (biomedcentral.com)
- The impedimetric biosensor showed a linearity between 5 and 170 ppb for carbamates and 2.5-170 ppb for organophosphate compounds, with a reproducibility (RSD%) interelectrode equal to 4.8 and 3.1% for organophosphates and carbamates, respectively. (springer.com)
- Organophosphate Poisoning and Carbamate Poisoning Organophosphates and carbamates are common insecticide ingredients that inhibit cholinesterase activity, causing acute muscarinic manifestations (eg, salivation, lacrimation, urination, diarrhea. (msdmanuals.com)
Inhibitors3
- Yuan-Ping Pang and Paul R. Carlier has developed three series of homo/hetero dimeric acetylcholinesterase inhibitors derived from tacrine and/or huperzine A. The representative dimers bis(3)-Cognitin (B3C), bis(12)-hupyridone, and tacrine(10)-hupyridone might possess disease-modifying effects through the modulation of N-methyl-d-aspartic acid receptors, the activation of myocyte enhancer factor 2D gene transcription, and the promotion of neurotrophic factor secretion. (inrae.fr)
- Acetylcholinesterase inhibitors: pharmacology and toxicology. (springer.com)
- DEET is commonly used in combination with insecticides and can strengthen the toxicity of carbamate insecticides, which are also acetylcholinesterase inhibitors. (goddessofherbs.com)
Insecticides6
- Carbamate pesticides are derived from carbamic acid and kill insects in a similar fashion as organophosphate insecticides. (toxno.com.au)
- Detection of organophosphorus insecticides with immobilized acetylcholinesterase-comparative study of two enzyme sensors. (springer.com)
- An amperometric biosensor based on acetylcholinesterase immobilized onto iron oxide nanoparticles/multi-walled carbon nanotubes modified gold electrode for measurement of organophosphorus insecticides. (springer.com)
- Mechanism of action of organophosphorus and carbamate insecticides. (springer.com)
- 1983. Determination of octanol-water partitioning coefficients KOW61 organophosphorus and carbamate insecticides and their relationship to respective water solubility (S) values. (cdc.gov)
- The Ace1 substitution and duplications occur on a unique resistance haplotype that evolved in A. gambiae and introgressed into A. coluzzii, and is now common in West Africa primarily due to selection imposed by other organophosphate or carbamate insecticides. (unl.pt)
Pesticides3
- Quantitative screening and resolution of carbamic and organoposphate pesticides mixture in extra virgin olive oil by acetylcholinesterase-choline oxidase sensor. (springer.com)
- Detection of carbamic and organophosphorus pesticides in water samples using cholinesterase biosensor based on Prussian Blue modified screen printed electrode. (springer.com)
- The illegal practice of combining organophosphates (OPs) with other compounds such as carbamates and pyrethroids, creating 'street pesticides', is common in South Africa. (scielo.org.za)
Toxicity3
- We present a novel approach for assessing pesticide toxicity on mammalian cells, by measuring the response patterns of four cell lines (two neuroblastoma and two fibroblast) to three different pesticide groups (carbamates, organophosphates, pyrethroids) at a broad range of concentrations. (siftdesk.org)
- The symptoms of acute toxicity are typical of the other carbamates. (voldoramotors.com)
- Local reference values for acetyl and butyrylcholinesterase were determined in Aberdeen Angus bovine and cross bred cattle (n D 25), a requirement to be able to evaluate toxicity of commercial organophosphate and carbamate formulations. (umaza.edu.ar)
Pyrethroids1
- Pyrethroids, organochlorines, carbamates and organophosphates are the only four classes of insecticide approved for use in vector control [ 6 ]. (biomedcentral.com)
Carbaryl4
- The first carbamate, carbaryl, was introduced in 1956 and more of it has been used throughout the world than all other carbamates combined. (toxno.com.au)
- Determination of carbaryl in tomato "in natura" using an amperometric biosensor based on the inhibition of acetylcholinesterase activity. (springer.com)
- Carbaryl is a neurotoxic carbamate insecticide. (voldoramotors.com)
- It also suppresses several … Carbaryl is a reversible inhibitor of acetylcholinesterase. (voldoramotors.com)
Inhibitor1
- T-1123 is a carbamate-based acetylcholinesterase inhibitor. (wikipedia.org)
Enzyme2
- In the biomedical, environmental, and food quality control, agricultural, and pharmaceutical industries, enzyme-based biosensors have become an important tool for qualitative and quantitative measurement of a variety of target analytes. (jpionline.org)
- M. D. Luque de Castro and M. C. Herrera, "Enzyme_ Inhibition-Based Bio-sensors and Biosensing Systems: Questionable Analytical De-vices," Biosensors and Bioelectronics, Vol. 18, No. 2-3, 2003, pp. 279-294. (scirp.org)
Inhibition of acetylcholinesterase1
- Inhibition of acetylcholinesterase leads , thereby leading to an accumulation of acetylcholine in the central and peripheral nervous system. (cdc.gov)
Inhibit acetylcholinesterase1
- The term organophosphate poisoning only applies to those organophosphates that inhibit acetylcholinesterase. (bmj.com)
Cholinergic5
- As with organophosphates, the signs and symptoms are based on excessive cholinergic stimulation. (toxno.com.au)
- acetylcholinesterase, butyrylcholinesterase), preventing the hydrolysis of acetycholine, and thus leading to an increased concentration of acetylcholine at cholinergic synapses. (medeasy.health)
- A clinical diagnosis of a cholinergic toxidrome secondary to OP/carbamate poisoning was made. (scielo.org.za)
- Petreski T, Kit B, Strnad M, Grenc D, Svenšek F. Cholinergic syndrome: a case report of acute organophosphate and carbamate poisoning. (aaem.pl)
- Diagnosis is usually based on a history of exposure, with characteristic signs of cholinergic excess, but can be difficult when the patient is inadvertently exposed, unconscious, or confused. (bmj.com)
Physostigmine2
- Rivastigmine is a carbamate derivative that is structurally related to physostigmine, but not to donepezil and tacrine. (medeasy.health)
- Diagnosis may be confirmed by resolution or improvement of symptoms during a slow (over 2-5 minutes) IV injection of 0.5 to 1 mg of physostigmine salicylate , a carbamate that reversibly inhibits acetylcholinesterase. (empendium.com)
Nerve agents1
- Quantification of efficacy of monopyridinium isomers and homologs derived from clinically used Pralidoxime within reactivation of acetylcholinesterase inhibited with organophosphorus nerve agents. (nel.edu)
Compounds2
- For this reason, a monoenzymatic acetylcholinesterase impedimetric biosensor was developed in order to sensitively detect carbamate and organophosphate compounds with a very fast response. (springer.com)
- Goldfrank's Toxicologic Emergencies, Insectidices: organic phosphorous compounds and carbamates, 2019: 1409-1420. (aaem.pl)
Anticholinesterase1
- The anticholinesterase activity of rivastigmine is relatively specific for brain acetylcholinesterase and butyrylcholinesterase compared with those in peripheral tissues. (medeasy.health)
Phenyl1
- A phenyl carbamate ester is bonded in the meta position to the nitrogen on a diethylmethyl amine. (wikipedia.org)
Butyrylcholinesterase1
- Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase. (springer.com)
Pesticide1
- V. G. Andreou and Y. D. Clonis, "A Portable Fiber-Optic Pesticide Biosensor Based On Immobilized Cholinesterase and Sol-Gel Entrapped Bromocresol Purple for In-Field Use," Biosensors and Bioelectronics, Vol. 17, No. 1-2, 2002, pp. 61-69. (scirp.org)
Sarin1
- Efficacy of structural homoloques and isomers of pralidoxime in reactivation of immobilised acetylcholinesterase inhibited with sarin, cyclosarin and soman. (nel.edu)
Acetylcholine2
- Itopride increases acetylcholine concentrations by inhibiting dopamine D2 receptors and acetylcholinesterase. (wynardtage.de)
- H. C. Tsai and R. A. Doong, "Simultaneous Determina- tion of Ph, Urea, Acetylcholine and Heavy Metals Using Array-Based Enzymatic Optical Biosensor," Biosensors and Bioelectronics, Vol. 20, No. 9, 2005, pp. 1796-1804. (scirp.org)
Resistance5
- To date, however, these cases of multiple-insecticide resistance have been restricted by the relatively low prevalence of organophosphate/carbamate resistance and the limited effect that kdr mutations alone have on pyrethroid-based interventions ( 6 ). (cdc.gov)
- Insecticide-based malaria vector control is increasingly undermined due to the development of insecticide resistance in mosquitoes. (biomedcentral.com)
- Given that DDT and pyrethroid resistance is widespread, interest in the carbamates and organophosphates for IRS is growing (see Refs. (biomedcentral.com)
- A combination of copy number variation and a single non-synonymous substitution in the acetylcholinesterase gene, Ace1, provides the key resistance diagnostic in an A. coluzzii population from Côte d'Ivoire that we used for sequence-based association mapping, with replication in other West African populations. (unl.pt)
- Our findings highlight the predictive value of this complex resistance haplotype for phenotypic resistance and clarify its evolutionary history, providing tools to for molecular surveillance of the current and future effectiveness of pirimiphos-methyl based interventions. (unl.pt)
Carbofuran1
- Carbofuran, ein Pestizid aus der Wirkstoffgruppe der Carbamate, kam auf einer kleinen Wiese am Luganersee zwecks Bekämpfung von Bodenschädlingen zum Einsatz. (uzh.ch)
Pyrethroid1
- Improved esterase activity was documented in carbamate and pyrethroid resistant adults through the Tihuquine area in Mozambique [19], as well as with specimens through the Chikwawa area in Malawi that have been resistant to permethrin, deltamethrin, dDT and bendiocarb [20]. (research-in-field.com)
Derivatives1
- The use of this medicinal product is contraindicated in patients with hypersensitivity to the active substance or other carbamate derivatives. (medeasy.health)
Biosensor1
- Acetylcholinesterase biosensor based on self-assembled monolayer-modified gold-screen printed electrodes for organophosphorus insecticide detection. (springer.com)
Exposures2
Biosensors2
- In a broader sense, higher eukaryotic cells have been recruited as biorecognition elements either in advanced cell-based biosensors (CBBs) or in cell-based assays (CBAs) [1]. (siftdesk.org)
- Optical, electrochemical and piezoelectric biosensors have been reported based on the detection method. (scirp.org)
Stimulation1
- Durch Hemmung der enzymatischen Spaltung des Neurotransmitters Acetylcholin führen die Carbamate zu einer exzessiven Stimulation des Parasympathicus. (uzh.ch)
Toxic4
- Most of the carbamates are extremely toxic to Hymenoptera, and precautions must be taken to avoid exposure to foraging bees or parasitic wasps. (toxno.com.au)
- Whichever the case, the final output of any cell-based test system is the measurement of the deviation of a predetermined cellular function from control, "baseline" levels as a result of exposure to a toxic compound. (siftdesk.org)
- A sufficiently high speed of measurement, low cost and ease-of-use, to satisfy high throughput requirements: most currently available methods for measuring toxic effects on mammalian and other cell types are associated with either optical (dye-based) [2] or electric (impedance spectrometry) [3] working principles implemented in multi-step processes, which demand several hours before enough data are collected. (siftdesk.org)
- This toxic syndrome description is based on CDC's best current information. (cdc.gov)
Cholinesterase activity1
- That is based on the usage of organophosphates to inhibit carboxylesterase activity, eserine and organophosphates sulphate to inhibit cholinesterase activity and sulphydryl reagents to inhibit arylesterase activity. (research-in-field.com)
Activity1
- In this work, various imidazo[1,2-a]pyridines linked to carbamate moiety were designed, synthesized, and evaluated for their α-glucosidase inhibitory activity. (researchgate.net)
Findings1
- Findings warrant further work to validate ivermectin's impact on M. sorbens reproduction through controlled lab and field-based studies. (bvsalud.org)
Mammalian1
- Bioelectric assay methods based on mammalian cells have gained considerably in popularity over the past few years. (siftdesk.org)
Detection2
Biochemical1
- Glucose is an important diagnostic biochemical marker of diabetes but also for organophosphates, carbamates, acetaminophens or salicylates poisoning. (nel.edu)
Determination1
- C. La Rosa, F. Pariente, L. Hernandez and E. Lorenzo, "Determination of Organophosphorus and Carbamic Pes- ticides with an Acetylcholinesterase Amperometric Bio-sensor Using 4-Aminophenyl Acetate as Substrate," Analytica Chimica Acta, Vol. 295, No. 3, 1994, pp. 273-282. (scirp.org)
Sensor Based1
- Glucose sensor based on magnetic particles (MPs) with immobilized enzymes glucose oxidase (GOx) and horseradish peroxidase (HRP) was developed and the GOx catalyzed reaction was visualized by a smart-phone-integrated camera. (nel.edu)
Enzymes1
- The presented assay showed complying results with reference method (standard spectrophotometry based on enzymes glucose oxidase and peroxidase inside plastic cuvettes) with linear dependence and correlation coefficient 0.999 in concentration range between 0 and 4 mmol/l. (nel.edu)
Description1
- Dans le cadre d'un essai contrôlé randomisé, nous avons pour objectifs de fournir une description actualisée de la transmission du paludisme dans la zone de Korhogo, au nord de la Côte d'Ivoire, et de collecter les données de base pour l'essai. (parasite-journal.org)