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  • pontine
  • In the cat and rat , carbachol is well known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. (wikipedia.org)
  • membrane
  • Our results show that carbachol produced a significant decrease in the spontaneous and evoked action potential (AP) firing frequency of RA projection neurons, accompanying a hyperpolarization of the membrane potential, an increase in the evoked AP latency, afterhyperpolarization (AHP) peak amplitude, and AHP time to peak, and a decrease in the membrane input resistance, membrane time constant, and membrane capacitance. (hindawi.com)
  • These results indicate that carbachol reduces the activity of RA projection neurons by hyperpolarizing the resting membrane potential and increasing the AHP and the membrane conductance, suggesting that the cholinergic modulation of RA may play an important role in song production. (hindawi.com)
  • These data confirm, by direct measurements of intracellular ion concentration changes, the contribution of the Na+, K+-pump to the post-carbachol membrane hyperpolarization and [K+]e-undershoot. (uni-muenchen.de)
  • intraocular
  • Carbachol is not easily metabolized by cholinesterase , it has a 2 to 5 minute onset of action and its duration of action is 4 to 8 hours with topical administration and 24 hours for intraocular administration. (wikipedia.org)
  • doses
  • Lower doses of carbachol injected near the supraoptic nuleus produced an increase in drinking without an increase in eating. (sciencemag.org)
  • The resultant response in respiratory impedence was investigated in nine normal volunteers, and compared with the response to increasing doses of inhaled carbachol. (ersjournals.com)
  • drops
  • Many studies have used carbachol iontophoresis (CARB-ionto) or topical pilocarpine eye drops to pharmacologically stimulate accommodation in Rhesus monkeys. (arvojournals.org)
  • sodium
  • Infusions of angiotensin II (AII) or carbachol (CBC) into the lateral ventricles of rats which had been depleted of sodium 4 h previously with either furosemide or polyethylene glycol produced significant changes in salt appetite and sodium and water balances relative to rats infused with saline vehicle. (semanticscholar.org)
  • 1993
  • Journal of Neuroscience 1993-06-01 C-fos expression in the pons and medulla of the cat during carbachol-induced active sleep . (acronymattic.com)
  • kinase
  • Selective inhibitorsof Rho kinase, ERK1/2, CaMKK/AMPK, and CaMKII each reduced carbachol-induced contractionin the innervated muscle strips. (nih.gov)
  • Previous studies from this confluence, they were presented with OS suspended in laboratory have investigated the possible role of the Krebs-Henseleit buffer in the presence or absence of protein kinase C pathway4 as well as of the protein carbachol and LiCl. (tripod.com)
  • detrusor
  • To test if carbachol (CCh)‐evoked Ca 2+ oscillations in freshly isolated murine detrusor myocytes are affected by β3‐adrenoceptor (β‐AR) modulators. (bjuinternational.com)
  • pilocarpine
  • Intravenous administration of pilocarpine produces a 90 times faster accommodative response than carbachol iontophoresis with more consistent and stable accommodative changes as indicated by smaller standard deviations from multiple experiments. (arvojournals.org)
  • response
  • The percentage changes in R0 following pneumatic trouser inflation highly correlated those induced by inhalation of 125 micrograms carbachol (r = 0.98) Our data demonstrate that, even in normal subjects, pneumatic trouser inflation causes an increase in respiratory resistance, which can be predicted by the response to a low dose of carbachol. (ersjournals.com)