RetinopathyVesselsCerebralEndothelial cellsLeakageMicrovascularDiabetesVascularRetinalGlomerularARTERIOLESRetinaPathogenesisAtherosclerosisPeripheralGlucose levelsDamageCommonlyPatientsAdhesionBRAINComplicationsVesselOccurMicroangiopathyCoagulationFlowTreatmentHemostasisCellsClinicalLevelsCirculationEffects
Retinopathy14
- Thus, tissues which are very sensitive to oxygen levels, such as the retina, develop microangiopathy and may cause blindness (so-called proliferative diabetic retinopathy). (wikipedia.org)
- This extract also improved diabetic micro-angiopathy and retinopathy. (naturalon.com)
- Retinopathy is a type of vision loss, especially for diabetic patients, caused by hemorrhages and vascular lesions. (naturalon.com)
- A large body of evidence now implicates increased leukocyte-endothelial cell adhesion as a key early event in the development of diabetic retinopathy. (diabetesjournals.org)
- We recently reported that raised activity of the glycosylating enzyme core 2 β 1,6- N -acetylglucosaminyltransferase (GlcNAc-T) through protein kinase C (PKC)β2-dependent phosphorylation plays a fundamental role in increased leukocyte-endothelial cell adhesion and capillary occlusion in retinopathy. (diabetesjournals.org)
- Levels of enzyme activity in plasma-treated U937 cells were closely dependent on the severity of diabetic retinopathy, with the highest values observed upon treatment with plasma of patients affected by proliferative retinopathy. (diabetesjournals.org)
- Based on the prominent role of TNF-α in the development of diabetic retinopathy, these observations further validate the significance of core 2 GlcNAc-T in the pathogenesis of capillary occlusion, thereby enhancing the therapeutic potential of specific enzyme inhibitors. (diabetesjournals.org)
- Diabetic retinopathy is a progressive vision-threatening complication of diabetes, characterized by capillary occlusion, formation of microvascular lesions, and retinal neovascularization adjacent to ischemic areas of the retina ( 1 - 2 ). (diabetesjournals.org)
- Diabetic retinopathy in 2% of patients leads to complete blindness. (rv.ua)
- This publication is dedicated to the application of a complex of peptide bioregulators being highly effective in treatment of different retinal diseases (diabetic retinopathy, pigment retinitis, age-related macular degeneration etc. (antiaging-peptides.com)
- Among the most frequent retinal diseases there are age-related macular degeneration, hereditary retinal degenerations (including retinitis pigmentosa), complicated myopia, diabetic retinopathy. (antiaging-peptides.com)
- Although diabetic nephropathy, neuropathy and retinopathy are the most common microvascular complications of hyperglycemia, it also affects choroid plexus. (scialert.net)
- Patients with diabetic retinopathy (DR) comprised 68% of the group with CIMT ≥1.0 mm, while they were 28% of the group without CIMT thickening ( P =0.003). (e-enm.org)
- Vesselucida 360 software includes breakthrough quantitative analysis capabilities that empower researchers studying neurodegeneration, TBI, stroke, angiogenesis in cancer, diabetic retinopathy, and other conditions that affect microvasculature. (mbfbioscience.com)
Vessels16
- Angiopathy is the generic term for a disease of the blood vessels (arteries, veins, and capillaries). (wikipedia.org)
- citation needed] In macroangiopathy, atherosclerosis and a resultant blood clot forms on the large blood vessels, sticks to the vessel walls, and blocks the flow of blood. (wikipedia.org)
- In microangiopathy, the walls of the smaller blood vessels become so thick and weak that they bleed, leak protein, and slow the flow of blood through the body. (wikipedia.org)
- This pine bark extract encourages the production of nitric oxide, as well as improved dilation of blood vessels, and increased oxygen levels and blood flow. (naturalon.com)
- The constant inclusion of this ingredient in food allows you to cleanse the body of toxins, strengthen the walls of blood vessels, regulate the production of digestive enzymes, which makes it possible to improve appetite and speed up metabolism. (htgetrid.com)
- Changes in small blood vessels in DM is strictly specific and characterized by thickening and splitting of the basement membrane of capillaries, venules, arteries, deposition in her gialinopodobnyh substances, fats, proteins, increased permeability of the vascular wall. (rv.ua)
- It is characterized by the prominence of skin blood vessels, such as vascular spiders. (sdsu.edu)
- Acquired degenerative dilation or expansion (ectasia) of normal BLOOD VESSELS, often associated with aging. (ucdenver.edu)
- A condition with multiple tumor-like lesions caused either by congenital or developmental malformations of BLOOD VESSELS, or reactive vascular proliferations, such as in bacillary angiomatosis. (uchicago.edu)
- They play a role in damaging blood vessels, which can lead to diabetes complications. (diabetes.org)
- Any disease of the blood vessels (veins, arteries, capillaries) or lymphatic vessels. (diabetes.org)
- Hemostasis depends on the integrity of BLOOD VESSELS, blood fluidity, and BLOOD COAGULATION. (bvsalud.org)
- The rapidly expanding science of hemorheology concerns blood, its components and the blood vessels with which blood interacts. (semcs.net)
- Cardiovascular disease ( CVD ) is any disease involving the heart or blood vessels . (wikipedia.org)
- There are many cardiovascular diseases involving the blood vessels. (wikipedia.org)
- Oxidatively stressed RBC stall significantly and rapidly in cerebral vessels in mice, accompanied by decreased blood flow velocity which recovers at 5 days. (biomedcentral.com)
Cerebral8
- Hypertension and cerebral amyloid angiopathy (CAA) are the most common causes of primary ICH, but the mechanism of hemorrhage in both conditions is unclear. (nature.com)
- In primary ICH, hypertension is thought to be the underlying cause in 65% of cases, followed by cerebral amyloid angiopathy (CAA). (nature.com)
- Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice. (open.ac.uk)
- This may be due to the occlusion of a cerebral vessel, in which case the patient suffers an ischemic infarction, or due to the rupture of a blood vessel. (symptoma.mt)
- Both the occlusion of a blood vessel supplying the brain and the rupture of a cerebral vessel occur suddenly and mostly unexpectedly. (symptoma.mt)
- Our previous study shows that the interaction between oxidatively stressed red blood cells (RBC) and cerebral endothelium may underlie CMH development. (biomedcentral.com)
- Our in vivo and ex vivo findings show the stalling and clearance of oxidatively stressed RBC in cerebral capillaries, highlighting the significance of microglial responses and altered RBC-brain endothelial interactions in CMH development. (biomedcentral.com)
- Cerebral microhemorrhages (CMH), the pathological substrates of cerebral microbleeds (CMB), are microscopic accumulations of blood degradation products in the brain. (biomedcentral.com)
Endothelial cells5
- In the present study, we demonstrate that following exposure to plasma from diabetic patients, the human promonocytic cell line U937 exhibits a significant elevation in core 2 GlcNAc-T activity and increased adherence to cultured retinal capillary endothelial cells. (diabetesjournals.org)
- Adhesion proteins control leukocyte migration from the blood stream to the tissue and each step of this migration event is regulated by specific adhesion molecules both on leukocytes and endothelial cells, which increase during inflammation [ 17 ]. (biomedcentral.com)
- Under normal conditions VAP-1 is mainly intracellular, but under inflammatory stimulation it is expressed at the cell membrane of activated endothelial cells and is shed into the blood stream, increasing VAP-1 levels in the blood that can serve as a biomarker for inflammation [ 24 ]. (biomedcentral.com)
- Although all diabetic cells are exposed to elevated levels of plasma glucose, hyperglycemic damage is limited to those cell types that are unable to down regulate glucose transport into the cell (e.g., endothelial cells), leading to intra-cellular hyperglycemia ( Brownlee, 2001 ). (scialert.net)
- An In Vitro Blood-Brain Barrier Model to Study Firm Shear Stress-Resistant Leukocyte Adhesion to Human Brain Endothelial Cells. (open.ac.uk)
Leakage3
- Treating these problems with pine bark extract helped to strengthen capillaries and stop blood leakage into the retina. (naturalon.com)
- Consequently, capillaries exhibit increased leakage in some organs. (scialert.net)
- Furthermore, significant CMH develop in the absence of blood-brain barrier leakage after t-BHP-RBC injection. (biomedcentral.com)
Microvascular3
- Diabetic patients with SSNHL tended to have increased NLR, LMR, and PLR, which are reported to be associated with microvascular angiopathy. (ejao.org)
- Additionally, microvascular problems in diabetic patients can affect the delivery and efficacy of systemic steroid in the cochlea [ 6 , 7 ]. (ejao.org)
- Connective Tissue Growth Factor (CTGF) has recently been shown to be over-expressed in kidney, myocardium and aorta in diabetic animals, implicating CTGF role in the pathogenesis of both microvascular and macrovascular diabetic complications ( Brownlee, 2001 ). (scialert.net)
Diabetes5
- The best known and most prevalent angiopathy is diabetic angiopathy, a common complication of chronic diabetes. (wikipedia.org)
- It is not unusual for patients with type 1 diabetes to present with diabetic ketoacidosis (DKA). (medscape.com)
- All patients with type 1 diabetes should learn how to self-monitor and record their blood glucose levels with home analyzers and adjust their insulin doses accordingly. (medscape.com)
- Cardiac autonomic neuropathy (CAN) is one of the most common complications of diabetes, and represents a significant cause of morbidity and mortality in diabetic patients. (e-enm.org)
- [3] Treating risk factors, such as high blood pressure, blood lipids and diabetes is also beneficial. (wikipedia.org)
Vascular4
- Macroangiopathy may cause other complications, such as ischemic heart disease, stroke and peripheral vascular disease which contributes to the diabetic foot ulcers and the risk of amputation. (wikipedia.org)
- Prevention of vascular disorders in diabetic patients using dietary supplements ART LIFE. (rv.ua)
- 1986 and others), a beneficial effect on the state of the vascular wall, blood rheology. (rv.ua)
- Majority of the hemostatic disorders are caused by disruption of the normal interaction between the VASCULAR ENDOTHELIUM, the plasma proteins (including BLOOD COAGULATION FACTORS), and PLATELETS. (bvsalud.org)
Retinal1
- The exact pathogenic mechanism by which capillary nonperfusion, as demonstrated by fluorescein angiography, occurs is still unclear, but recent experimental animal studies ( 3 - 5 ) demonstrate that increased leukocyte entrapment in retinal capillaries of diabetic rats is an early event associated with areas of capillary nonperfusion and the development of endothelial cell damage. (diabetesjournals.org)
Glomerular2
- Although in all diabetic patients, GFR is initially normal or mildly elevated with no histological alterations, it progresses to produce thick glomerular basement membrane and expand to mesangial, followed by high glomerular capillary pressure and microalbuminuria. (scialert.net)
- Aassociations between carotid atherosclerosis and both urine albumin excretion (UAE) and glomerular filtration rate (GFR) in diabetic patients have been investigated, but these studies showed only inconsistent results [ 5 , 13 , 14 ]. (e-enm.org)
ARTERIOLES1
- In hypertension, the cause of hemorrhage is thought to be elevated blood pressure-induced degenerative changes in the penetrating arterioles leading to rupture [ 14 ]. (nature.com)
Retina1
- Position of the retina behind other optic structures, direct ingress of sun rays, peculiarities of the blood supply make it vulnerable to both external (sun rays, light striking, radiation) and internal factors. (antiaging-peptides.com)
Pathogenesis1
- Recent studies have shown that diabetic microangiopathies are associated with macroangiopathies and suggest that microangiopathies may have a prominent role in the pathogenesis of microangiopathy development [ 2 ]. (e-enm.org)
Atherosclerosis3
- Although the precise underlying mechanisms linking the diabetic microangiopathies and macroangiopathies are unclear, some evidence suggests that the effects of microangiopathies may be linked to subclinical atherosclerosis [ 3 - 5 ]. (e-enm.org)
- Carotid atherosclerosis as estimated by carotid intima-media thickness (CIMT) and plaques is considered to reflect an early stage of atherosclerotic disease and is therefore used as a surrogate marker for diabetic macroangiopathies [ 6 - 8 ]. (e-enm.org)
- So far, studies on the relationship between diabetic microangiopathies and carotid atherosclerosis have yielded inconsistent results. (e-enm.org)
Peripheral1
- Damage to nerve cells may cause peripheral neuropathy, and to kidney cells, diabetic kidney disease (Kimmelstiel-Wilson syndrome). (wikipedia.org)
Glucose levels3
- All fingerstick capillary glucose levels must be confirmed in serum or plasma to make the diagnosis. (medscape.com)
- Optimal diabetic control requires frequent self-monitoring of blood glucose levels, which allows rational adjustments in insulin doses. (medscape.com)
- Most require 2 or more injections of insulin daily, with doses adjusted on the basis of self-monitoring of blood glucose levels. (medscape.com)
Damage1
- Disease processes may be incited or exacerbated by a variety of external and internal influences, including trauma , infection , poisoning , loss of blood flow , autoimmunity , inherited or acquired genetic damage, or errors of development . (bionity.com)
Commonly1
- A cerebrovascular accident, more commonly known as a stroke, occurs when the blood supply to determined parts of the brain suddenly ceases. (symptoma.mt)
Patients11
- Another advantage of this product is that it is useful for diabetic patients, because it contains fructose and sucrose, which is not harmful to this group of patients. (htgetrid.com)
- This study aimed to evaluate the clinical features and the clinical factors associated with prognosis of sudden sensorineural hearing loss (SSNHL) in diabetic patients. (ejao.org)
- Simultaneous intratympanic dexamethasone (ITD) injections with systemic steroid did not confer an additional hearing gain or an earlier recovery rate in diabetic patients with SSNHL. (ejao.org)
- In the multivariate analysis, initial hearing thresholds of affected ear and timing of steroid treatment were significantly associated with hearing prognosis in diabetic patients with SSNHL. (ejao.org)
- Simultaneous ITD injections to improve hearing recovery in diabetic patients with SSNHL seems unnecessary. (ejao.org)
- Also, the use of systemic steroids can worsen glycemic control in diabetic patients. (ejao.org)
- Given this, systemic steroid use for SSNHL in diabetic patients may lead to poorer outcomes than are observed in those without DM [ 8 , 9 ]. (ejao.org)
- However, previous studies of SSNHL have seldom focused on diabetic patients. (ejao.org)
- Therefore, we conducted a retrospective review to evaluate the clinical factors associated with prognosis and compare the efficacy of simultaneous and sequential systemic steroid and ITD treatment in diabetic patients with SSNHL. (ejao.org)
- Also, we evaluated the clinical features of SSNHL in diabetic patients including the laboratory data which are known to be related to systemic inflammation and glycemic control. (ejao.org)
- We retrospectively reviewed the medical records of all diabetic patients who admitted to Dankook University Hospital for SSNHL between January 2014 and July 2018. (ejao.org)
Adhesion1
- These effects of diabetic plasma on enzyme activity and cell adhesion, mediated by PKCβ2-dependent phosphorylation of the core 2 GlcNAc-T protein, were found to be triggered by increased plasma levels of tumor necrosis factor (TNF)-α. (diabetesjournals.org)
BRAIN4
- One important factor is the influence of brain inflammation on the integrity of the neurovasculature generally and the blood-brain barrier (BBB) in particular [ 3 , 4 ]. (biomedcentral.com)
- A hydrogel model of the human blood-brain barrier using differentiated stem cells. (open.ac.uk)
- The Blood-Brain Barrier: Methods and Protocols. (open.ac.uk)
- Despite the fact that stroke therapy aims at recanalization and restoration of blood flow to affected brain regions, it can't currently be excluded that tissue reperfusion contributes to neuroinflammation and neuronal death. (symptoma.mt)
Complications1
- Diabetic microvasular complications, which are considered as an important group of hyperglycemia imperfections, caused by increased endothelial permeability and can progress to severe impairments in several organs. (scialert.net)
Vessel1
- A large blood vessel that carries blood with oxygen from the heart to all parts of the body. (diabetes.org)
Occur1
- They occur most often in mucosal capillaries of the GASTROINTESTINAL TRACT leading to GASTROINTESTINAL HEMORRHAGE and ANEMIA. (ucdenver.edu)
Microangiopathy1
- There are two types of angiopathy: macroangiopathy and microangiopathy. (wikipedia.org)
Coagulation1
- It is very important to maintain a normal level of activity indicators of the blood coagulation system. (rv.ua)
Flow3
- The decrease of blood flow through stenosis or clot formation impairs the flow of oxygen to cells and biological tissues (called ischemia) and leads to cellular death (necrosis and gangrene, which in turn may require amputation). (wikipedia.org)
- Clinical Hemorheology and Microcirculation , a peer-reviewed international scientific journal, serves as an aid to understanding the flow properties of blood and the relationship to normal and abnormal physiology. (semcs.net)
- The endeavour of the Editors-in-Chief and publishers of Clinical Hemorheology and Microcirculation is to bring together contributions from those working in various fields related to blood flow all over the world. (semcs.net)
Treatment2
- Tomsk and Voronezh have been studied biologically active food additives (BAA) MEMORY RISE (production company ARTLIFE ) for the prevention and treatment of diabetic angiopathies, including diabetic foot. (rv.ua)
- The influence of methodical parameters (like geometry of the glass capillary, sucking pressure) as well as results concerning experimentally altered RBC by heat treatment are briefly described and give evidence that the … parameters entry time te , passage time tp and amplitude A, derived from impulse-like changes of conductivity describe the deformability of an individual erythrocyte. (semcs.net)
Hemostasis1
- This pine bark extract was also noted in another study, published in the journal of Clinical and Applied Thrombosis and Hemostasis, which helped to improve overall blood circulation as well as minimize edema. (naturalon.com)
Cells3
- Hemoglobin (HEE-mo-glo-bin) is the part of a red blood cell that carries oxygen to the cells and sometimes joins with the glucose in the bloodstream. (diabetes.org)
- The body sends a signal to the alpha cells to make glucagon when blood glucose (blood sugar) falls too low. (diabetes.org)
- A condition in which the number of red blood cells is less than normal, resulting in less oxygen being carried to the body's cells. (diabetes.org)
Clinical1
- Pharmacologists, clinical laboratories, blood transfusion centres, manufacturing firms producing diagnostic instruments, and the pharmaceutical industry will also benefit. (semcs.net)
Levels1
- The main advantage of this vegetable is that regular consumption normalizes blood glucose and cholesterol levels. (htgetrid.com)
Circulation1
- Pathological processes involving the integrity of blood circulation. (bvsalud.org)
Effects1
- This paper highlights the underlying pharmacological mechanisms of the anti-diabetic effects of ginsenosides. (frontiersin.org)