Capecitabine. Medical search. Frequent questions

Capecitabine, sold under the brand name Xeloda among others, is a anticancer medication used to treat breast cancer, gastric cancer and colorectal cancer. (wikipedia.org)
Capecitabine is available as tablets of 150 and 500 mg generically and under the brand name Xeloda. (nih.gov)
It was announced today that the European Commission has approved the oral chemotherapy capecitabine (Xeloda) for the treatment of metastatic colorectal cancer in combination with any chemotherapy in all lines of treatment with or without Avastin. (ecancer.org)
In addition to 5-FU, oral fluoropyrimidines such as capecitabine (Xeloda) and, outside the United States, tegafur are used as monotherapy or in combination with oxaliplatin (Eloxatin). (medscape.com)
Capecitabine is most commonly sold under the brand name Xeloda and is administered orally. (kahkaham.net)
Xeloda is a brand-name medication containing the active ingredient Capecitabine. (rhghspace.com)
Each Xeloda tablet contains 500 mg of Capecitabine as its active ingredient. (rhghspace.com)
Capecitabine, the active ingredient in Xeloda, is a prodrug that is converted into an active form in the body. (rhghspace.com)
Xeloda should not be used in individuals with a known hypersensitivity or allergy to Capecitabine or any other component of the medication. (rhghspace.com)
Xeloda, containing Capecitabine 500 mg tablets, is a widely used medication for the treatment of various cancers, including breast cancer, colorectal cancer, and gastric cancer. (rhghspace.com)
Capecitabine (Xeloda) is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers by reducing or preventing the progression of cancer cells. (straitsresearch.com)
Capecitabine (Xeloda) was launched in 2005 by Roche. (straitsresearch.com)
For instant, Hikma Pharmaceuticals PLC (Hikma) one of the fast-growing multinational pharmaceutical group, launched Capecitabine Tablets, the generic equivalents to Xeloda Tablets. (straitsresearch.com)
4. Capecitabine (Xeloda) improves medical resource use compared with 5-fluorouracil plus leucovorin in a phase III trial conducted in patients with advanced colorectal carcinoma. (nih.gov)

This study aimed to assess the efficacy and safety of prolonged capecitabine chemotherapy following CAPOX chemotherapy for stage III CRC after radical surgery. (medscimonit.com)
Among those patients, 104 patients received prolonged capecitabine chemotherapy (prolonged group) following 8 cycles of CAPOX regimen chemotherapy, while the other 108 patients (control group) received no prolonged chemotherapy. (medscimonit.com)
The prolonged chemotherapy consisted of capecitabine (1000 mg/m² per day for 2 weeks) and was repeated every 3 weeks for 8 cycles at most. (medscimonit.com)
In further subgroup analyses, no benefit for 3-year DFS or 3-year OS of prolonged capecitabine chemotherapy was found in colon cancer or rectal cancer. (medscimonit.com)
Prolonged capecitabine chemotherapy following CAPOX regimen chemotherapy failed to improve the survival of patients with stage III CRC after radical surgery. (medscimonit.com)
Capecitabine , the super-drug we're talking about today, is an oral chemotherapy medication used primarily to treat breast and colorectal cancers. (ntpills.com)
Storing any medication, especially chemotherapy drugs like capecitabine, is crucial. (ntpills.com)
Capecitabine and mitomycin C may be an effective treatment option for third-line chemotherapy in advanced colorectal cancer. (gla.ac.uk)
Aims and Background: We evaluated the activity in terms of time to progression (TTP) of mitomycin C and capecitabine in patients with advanced colorectal cancer who progressed after 2 lines of chemotherapy. (gla.ac.uk)
Methods: Patients with advanced colorectal cancer undergoing third-line chemotherapy after failure of 5-FU with CPT-11 or oxaliplatin-based chemotherapy regimens were treated with capecitabine and mitomycin C. Results: Sixty-one patients were enrolled in this study. (gla.ac.uk)
Conclusions: The combination of capecitabine and mitomycin C could represent an effective and manageable treatment option for colorectal cancer patients failing previous chemotherapy regimens. (gla.ac.uk)
Capecitabine is a chemotherapy medication that is used in the treatment of various types of cancer, including breast cancer, colorectal cancer, and gastric cancer. (kahkaham.net)
Capecitabine has been approved as an advanced medication for metastatic breast cancer, and studies have shown that it is effective and well-tolerated in breast cancer patients when used in combination with other chemotherapy agents, such as docetaxel and paclitaxel. (kahkaham.net)
Capecitabine is an oral chemotherapy drug that is converted into an active form in the body. (rhghspace.com)
Paclitaxel has also been suggested as a partner for capecitabine-based chemotherapy because taxanes upregulate the activity of thymidine phosphorylase (TP) [ 10 ], which is an essential enzyme for the activation of capecitabine. (biomedcentral.com)
Hand-Foot syndrome (HFS) and diarrhoea are dose-limiting Adverse Drug Reactions (ADRs) of capecitabine-based chemotherapy. (unisa.it)
Objectives The combination chemotherapy regimen capecitabine/temozolomide (CAPTEM) is efficacious for metastatic well-differentiated pancreatic neuroendocrine tumors (PNETs), but its role in the neoadjuvant setting has not been established. (elsevierpure.com)
Capecitabine is a chemotherapy drug, which is used in treatment for combating, preventing and reducing the progression of cancer cells in cancer patients. (qyrconsulting.com)
6. Single-agent capecitabine in patients with metastatic colorectal cancer refractory to 5-fluorouracil/leucovorin chemotherapy. (nih.gov)

Capecitabine, inside the body, is converted to 5-fluorouracil (5-FU) through which it acts. (wikipedia.org)
The dihydropyrimidine dehydrogenase (DPD) enzyme is responsible for the detoxifying metabolism of fluoropyrimidines, a class of drugs that includes capecitabine, 5-fluorouracil and tegafur. (wikipedia.org)
Capecitabine is an oral prodrug of fluorouracil (5-FU), which is also a commonly used cytotoxic drug in this patient population. (medscape.com)
tell your doctor and pharmacist if you are allergic to capecitabine, fluorouracil (Adrucil, 5-FU), any other medications, or any of the ingredients in capecitabine tablets. (medlineplus.gov)
Capecitabine is a prodrug which is converted into fluorouracil and other active metabolites in body tissues (EMA 2018, Derissen 2016, Calzas 2003). (e-lactancia.org)
Since the last update we have not found published data on the excretion of capecitabine in breastmilk, but its active metabolite, fluorouracil, is excreted in breastmilk in undetectable, clinically insignificant amounts (Peccatori 2012) which can be explained by its pharmacokinetics: fast degradation to non-active metabolites and very low liposolubility (Pistilli 2013). (e-lactancia.org)
Capecitabine is a prodrug of 5-fluorouracil (5-FU) and is converted to this active metabolite intracellularly, where it acts by interfering with DNA, RNA and protein synthesis and inhibiting cell division. (nih.gov)
Capecitabine is converted into 5-fluorouracil (5-FU), and cells metabolize it into 5-fluoro-2'-deoxyuridine monophosphate and 5-fluorouridine triphosphate, which stops cell making and damage the repairing of DNA and cancer cells need to make DNA to grow and multiply. (ikrispharmanetwork.com)
Once inside the body, Capecitabine undergoes enzymatic conversion, primarily in tumor cells, where it is transformed into fluorouracil (5-FU), which is an anti-cancer drug. (rhghspace.com)
Capecitabine is an oral prodrug of 5-fluorouracil with a relevant role in the treatment of breast cancer. (uniroma1.it)
Genetic polymorphisms and the 5-fluorouracil degradation rate of breast cancer patients treated with capecitabine were retrospectively studied. (uniroma1.it)
The cardiac symptoms subsided after initiation of capecitabine, the oral formulation of 5-fluorouracil. (elsevierpure.com)
To our knowledge, this is only the second reported case where 5-fluorouracil was successfully replaced by capecitabine without recurrence of cardiac symptoms. (elsevierpure.com)
Capecitabine may be a viable option for patients who develop 5-fluorouracil-induced chest pain. (elsevierpure.com)
Saneeymehri, SS, Markey, KR & Mahipal, A 2016, ' Paradoxical effect of capecitabine in 5-fluorouracil-induced cardiotoxicity: A case vignette and literature review ', Journal of Oncology Pharmacy Practice , vol. 22, no. 3, pp. 552-555. (elsevierpure.com)
1. Capecitabine versus continuous-infusion 5-fluorouracil for colorectal cancer: a retrospective efficacy and safety comparison. (nih.gov)
2. Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer: results of a large phase III study. (nih.gov)
3. A randomised cross-over trial comparing patient preference for oral capecitabine and 5-fluorouracil/leucovorin regimens in patients with advanced colorectal cancer. (nih.gov)
5. Capecitabine Versus Continuous Infusion Fluorouracil for the Treatment of Advanced or Metastatic Colorectal Cancer: a Meta-analysis. (nih.gov)
7. First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin. (nih.gov)
11. Oral capecitabine vs intravenous 5-fluorouracil and leucovorin: integrated efficacy data and novel analyses from two large, randomised, phase III trials. (nih.gov)
20. Oral capecitabine as an alternative to i.v. 5-fluorouracil-based adjuvant therapy for colon cancer: safety results of a randomized, phase III trial. (nih.gov)

CAIRO2 assessed the efficacy and safety of capecitabine/oxaliplatin and bevacizumab with or without cetuximab. (hindawi.com)
To determine the efficacy and tolerability of combining oxaliplatin with capecitabine in the treatment of advanced nonpretreated and pretreated colorectal cancer. (edu.au)
Forty-three nonpretreated patients and 26 patients who had experienced one fluoropyrimidine-containing regimen for advanced colorectal cancer were treated with oxaliplatin 130 mg/m 2 on day 1 and capecitabine 1,250 mg/m 2 bid on days 1 to 14 every 3 weeks. (edu.au)
Combining capecitabine and oxaliplatin yields promising activity in advanced colorectal cancer. (edu.au)
On the basis of our toxicity experience, we recommend use of capecitabine in combination with oxaliplatin 130 mg/m 2 at an initial dose of 1,250 mg/m 2 bid in nonpretreated patients and at a dose of 1,000 mg/m 2 bid in pretreated patients. (edu.au)
To test a study drug (CDX-1140) combined 3 other drugs (capecitabine, oxaliplatin, Keytruda) in people with BTC. (nih.gov)

Through careful therapy recognition, we demonstrated that, unbeknownst to the oncologists, the patients were taking folic acid during the treatment with capecitabine at a dosage higher than 2000 mg/m(2), which is the maximum tolerated dose when folate is administered. (unisa.it)

Capecitabine maintenance is associated with a significant improvement in progression-free survival (PFS) and overall survival compared with active monitoring after first-line treatment for patients with metastatic colorectal cancer (CRC). (medscape.com)
This is a summary of a preprint research study, "Does Capecitabine Maintenance Therapy Versus Active Monitoring Confer a Survival Benefit After First-line Treatment of Metastatic Colorectal Cancer? (medscape.com)
Capecitabine is used in the treatment of Colorectal Cancer, Breast Cancer and Gastric Cancer (off-label in the USA). (ikrispharmanetwork.com)
Several new oral chemotherapeutic agents, including capecitabine, have recently been introduced for the treatment of colorectal cancer. (e-crt.org)
10. Capecitabine: the new generation of fluoropyrimidines in colorectal cancer. (nih.gov)
14. Update on capecitabine alone and in combination regimens in colorectal cancer patients. (nih.gov)
16. Capecitabine as first-line treatment in colorectal cancer. (nih.gov)
18. Clinical and cost-effectiveness of capecitabine and tegafur with uracil for the treatment of metastatic colorectal cancer: systematic review and economic evaluation. (nih.gov)

Our product range includes a wide range of cacit capecitabine 500mg tablets. (hardikoncocare.in)
Uses: CAPECITABINE TABLETS CAP 500MG is used alone or in combination with other cancer treatments in patients with colon cancer that has spread (Stage III) to help prevent colon cancer from coming back after surgery. (oceanpharmaproducts.com)

Capecitabine is also used to treat colon or rectal cancer (cancer that begins in the large intestine) that has gotten worse or spread to other parts of the body. (medlineplus.gov)
USP Capecitabine 3-O-BDR Impurity product with CAS: 1262133-64-1 is also known as USP Capecitabine Impurity G. Capecitabine is used to treat breast, colon, or rectal cancer. (synthinkchemicals.com)
This study was performed to evaluate the efficacy and toxicity of preoperative chemoradiation therapy, when used with oral capecitabine, for locally advanced rectal cancer. (e-crt.org)

The aim of this study was to assess the efficacy and safety of a combination regimen of capecitabine plus cisplatin (CC) or capecitabine plus paclitaxel (CP) as a first-line treatment in patients with metastatic esophageal squamous cell carcinoma. (biomedcentral.com)
Patients were assigned to either the CC arm (days [D]1-14 capecitabine 1000 mg/m 2 twice daily + D1 cisplatin 75 mg/m 2 , every 3 weeks) or the CP arm (D1-14 capecitabine 1000 mg/m 2 twice daily + D1, 8 paclitaxel 80 mg/m 2 , every 3 weeks). (biomedcentral.com)
Meta-analysis of three randomized trials of capecitabine plus cisplatin (XP) versus S-1 plus cisplatin (SP) as first-line treatment for advanced gastric cancer. (bvsalud.org)
S-1 plus cisplatin (SP) and capecitabine plus cisplatin (XP) are standard first-line regimens for advanced gastric cancer (AGC) worldwide. (bvsalud.org)

Findings from an Asian subgroup of patients with previously-treated HER2-positive metastatic breast cancer presented at the ESMO Asia Virtual Congress 2020 (20 to 22 November 2020) showed these patients achieved prolonged survival and improved responses following combination treatment with neratinib plus capecitabine, as compared to lapatinib plus capecitabine. (esmo.org)
Findings from the Asian cohort were consistent with previous reports for neratinib plus capecitabine compared with lapatinib plus capecitabine in patients with metastatic HER2-positive breast cancer, according to the study authors. (esmo.org)
In this trial, we compared lapatinib plus capecitabine with capecitabine alone in such patients. (houstonmethodist.org)
CONCLUSIONS: Lapatinib plus capecitabine is superior to capecitabine alone in women with HER2-positive advanced breast cancer that has progressed after treatment with regimens that included an anthracycline, a taxane, and trastuzumab. (houstonmethodist.org)

Tucatinib with capecitabine and trastuzumab in advanced HER2-positive metastatic breast cancer with and without brain metastases: a non-randomised, open-label, phase 1b study. (nih.gov)

1oCentro de Refer&ncia da Mulher, Oncology, S&o Paulo, Brazil Background: The oral fluoropyrimidine capecitabine is highly active and well tolerated as single-agent therapy in patients with anthracycline- and/or taxane-pretreated MBC and extends survival when added to docetaxel in MBC. (coek.info)

The investigators performed a meta-analysis of five trials of capecitabine vs active monitoring after first-line treatment. (medscape.com)

00001). The addition of tucatinib reduced the risk of death by 34% compared to trastuzumab and capecitabine alone (HR = 0.66, 95% C = 0.50-0.87, P = .0048). (ascopost.com)
Tucatinib Plus Trastuzumab and Capecitabine for ERBB2 (HER2)-Positive Metastatic Breast Cancer With Brain Metastases. (qxmd.com)

What are the Procedures to buy Capecitabine from Ikris Pharma? (ikrispharmanetwork.com)
Get contract manufacturing for Capecitabine Tablets, Find best price for Capecitabine Tablets generic drug and Capecitabine Tablets generic version available at best price from GMP approved manufacturer Taj Pharma is WHO-GMP Certified Pharmaceutical Wholesaler of Capecitabine Tablets, Capecitabine Tablets Supplier, Capecitabine Tablets Exporters from India. (tajgenerics.com)
Taj Pharma holds excellent record in manufacturing of Capecitabine Tablets from India. (tajgenerics.com)

although capecitabine has been shown to improve PFS, some studies have found that the benefit comes at the cost of ongoing toxicity. (medscape.com)
Moreover, capecitabine-related toxicity may worsen due to drug-drug and drug-supplement interactions. (unisa.it)
Genetic and environmental factors should be considered good predictors of severe capecitabine-related toxicity. (unisa.it)
We retrospectively evaluated acute toxicity in 88 patients that were treated with capecitabine and concurrent radiotherapy to the upper abdomen. (biomedcentral.com)
Capecitabine was interrupted, discontinued or given at an adjusted dose in 13 (15%) patients because of acute toxicity. (biomedcentral.com)
We retrospectively evaluated acute toxicity in 88 patients treated with concurrent capecitabine and radiation therapy to the upper abdomen, at the University of Texas M.D. Anderson Cancer Center, between June 2000 and July 2003. (biomedcentral.com)
Preoperative chemoradiation therapy with capecitabine achieved encouraging rates of tumor downstaging and sphincter preservation, with a low toxicity profile. (e-crt.org)

These results suggest that the combination of capecitabine and temozolomide should be included as a standard treatment option for patients with advanced pancreatic NETs and is a reasonable comparator arm in future randomized studies. (medpagetoday.com)
It represents the first randomized clinical trial of temozolomide and capecitabine in advanced pancreatic NETs. (medpagetoday.com)

The market has a considerable presence of substitutes of Capecitabine such as leucovorin and raltitrexed, which is restraining the growth of the market. (qyrconsulting.com)

In NALA, patients with centrally confirmed HER2-positive metastatic breast cancer who had received ≥2 prior HER2-directed regimens were randomised equally to treatment with neratinib at 240 mg daily plus capecitabine at 750 mg/m 2 twice daily on days 1-14 or to receive lapatinib at 1250 mg daily plus capecitabine at 1000 mg/m 2 twice daily on days 1-14 in 21-day cycles. (esmo.org)

The global capecitabine market has been steadily growing, and this trend is expected to continue in the coming years. (kahkaham.net)
One of the primary drivers of the global capecitabine market is the growing use of the drug in the treatment of breast cancer. (kahkaham.net)
The breast cancer segment is expected to account for the largest revenue share in the global capecitabine market over the forecast period. (kahkaham.net)
In 2017, the global capecitabine market was approximately USD 1,652 Million. (straitsresearch.com)
The report includes depth research study on the global Capecitabine Market. (straitsresearch.com)
According to a study published in the report, the global Capecitabine market was valued at US$ 1047 Mn, in 2018 and is expected to drop to US$ 1024 by the end of 2025. (qyrconsulting.com)

Furthermore, capecitabine is converted to 5-FU in a three step process, the first of which takes place in the liver and the last two predominantly in tumor cells, which may account for why it is better tolerated than 5-FU. (nih.gov)
Capecitabine is an attractive oral chemotherapeutic agent that has a radiosensitizing effect and tumor-selectivity. (e-crt.org)

Now, results from a randomized phase II trial show significantly improved progression-free survival (PFS) and a clinically meaningful improvement in overall survival (OS) with combined capecitabine-temozolomide compared with temozolomide alone. (medpagetoday.com)

Capecitabine is used in combination with other medications to treat breast cancer that has come back after treatment with other medications. (medlineplus.gov)
Our findings that the combination of temozolomide and capecitabine is more effective confirmed our hypothesis and reinforced findings from retrospective studies. (medpagetoday.com)
Capecitabine is a pyrimidine analogue used as an antineoplastic agent to treat metastatic and advanced forms of breast and colon cancer, often in combination with other agents. (nih.gov)
On April 17, the U.S. Food and Drug Administration (FDA) granted approval to tucatinib (Tukysa) in combination with trastuzumab/capecitabine for adult patients with advanced unresectable or metastatic HER2-positive breast cancer, including patients with brain metastases, who have received one or more prior anti-HER2-based regimens in the metastatic setting. (ascopost.com)
In addition to the possible synergistic effect of a capecitabine and paclitaxel (CP) combination, these agents have non-overlapping toxicities and therefore can be combined with reasonable tolerability. (biomedcentral.com)
BACKGROUND: Lapatinib, a tyrosine kinase inhibitor of human epidermal growth factor receptor type 2 (HER2, also referred to as HER2/neu) and epidermal growth factor receptor (EGFR), is active in combination with capecitabine in women with HER2-positive metastatic breast cancer that has progressed after trastuzumab-based therapy. (houstonmethodist.org)

Compared with active monitoring, capecitabine maintenance therapy was associated with a significant improvement in PFS (hazard ratio [HR], 0.59) and overall survival (HR, 0.85). (medscape.com)

Four polymorphisms in the dihydropyrimidine dehydrogenase (DPYD) gene, encoding the DPD enzyme responsible for the metabolism of fluoropyrimidines, such as capecitabine, are strongly associated with severe ADRs, and their screening should be performed before starting treatment. (unisa.it)

A 47-year-old woman with metastatic breast cancer developed acute pancreatitis while receiving capecitabine. (medscape.com)
Capecitabine is approved by the Food and Drug Administration (FDA) for patients with anthracycline- and taxane-resistant metastatic breast cancer. (medscape.com)
Previously reported results from NALA demonstrating significantly extended progression-free survival (PFS) and time to intervention for central nervous system (CNS) disease with neratinib/capecitabine over lapatinib/capecitabine in these patients formed the basis for the US Food and Drug Administration approval of treatment with neratinib plus capecitabine for metastatic HER2-positive breast cancer. (esmo.org)
Neratinib + Capecitabine (N+C) vs Lapatinib + Capecitabine (L+C) in Asians with HER2+ Metastatic Breast Cancer (MBC) Previously Treated with Two or More HER2-Directed Regimens: A Pan-Asian Analysis of the Phase III NALA Trial. (esmo.org)
Due to higher usage of Capecitabine in various sub-segments of application segment such as breast cancer and others is expected to create a positive impact on the entire application segment. (qyrconsulting.com)
Thirty-seven patients with a median age of 58 years old treated with capecitabine for stages II-IV breast cancer were included in this study. (uniroma1.it)

Clinicians should be aware of this potential adverse effect, particularly in patients with preexisting risk factors for pancreatitis who are prescribed capecitabine. (medscape.com)
As the team reported in the Journal of Clinical Oncology , the final analysis of data from the 133 predominantly white, male, non-Hispanic patients enrolled in the ECOG-ACRIN E2211 trial showed that median progression-free survival (PFS) was 23.2 months in the capecitabine-temozolomide arm, and 15.1 months in the temozolomide-only arm. (medpagetoday.com)
Mild serum bilirubin elevations are also common during capecitabine therapy, occurring in up to 40% of patients. (nih.gov)
The current study showed that among patients who received capecitabine maintenance in the second line, survival was improved, and the adverse events were manageable. (medscape.com)
In a subgroup analysis, patients with BRAF/RAS wild-type mutations benefited significantly from capecitabine maintenance, but those with BRAF or RAS mutations did not. (medscape.com)
Severe mucocutaneous reactions, some with fatal outcomes, such as Stevens-Johnson syndrome and Toxic Epidermal Necrolysis (TEN) can occur in patients treated with Capecitabine. (ikrispharmanetwork.com)
Patients receiving therapy with Capecitabine should be monitored under the experienced physician. (ikrispharmanetwork.com)
Patients who are allergic to the ingredients of the medicine should not take Capecitabine. (ikrispharmanetwork.com)
Here we investigated factors responsible for severe HFS and diarrhoea presented by two patients, non-carriers of the recommended DPYD single nucleotide polymorphisms (SNPs) but carriers of other genetic variants suggested to increase the risk of capecitabine-related ADRs. (unisa.it)
Patients who received a second concurrent chemotherapeutic agent along with capecitabine were excluded. (biomedcentral.com)
The current study represents the largest reported series of patients treated with concurrent capecitabine and upper abdominal radiation therapy. (biomedcentral.com)
Sixty-eight (77%) patients received capecitabine at 800-900 mg/m 2 twice daily. (biomedcentral.com)
There was clear documentation that capecitabine was given 5 days a week (Monday-Friday) in 47 (53%) patients, 6 days a week in 2 (2%) and 7 days a week in 3 (3%) patients. (biomedcentral.com)
The frequency of capecitabine administration could not be reliably ascertained for the remaining 36 (41%) patients. (biomedcentral.com)
It was a retrospective study in the population of patients with diagnosed grade 3 neuroendocrine neoplasms of different origin treated with capecitabine and temozolomide. (viamedica.pl)
The study included 32 patients with grade 3 neuroendocrine tumours treated with capecitabine and temozolomide. (viamedica.pl)
Capecitabine dose reductions were necessary in 26% of the nonpretreated and 45% of the pretreated patients in the second treatment cycle. (edu.au)

However, this trend did not reach statistical significance in the final analysis, which showed a median OS of 53.8 months in the temozolomide arm and 58.7 months in the capecitabine-temozolomide arm. (medpagetoday.com)
The response rate (RR) with capecitabine/temozolomide was 39.7% -- higher than that reported with other available therapies. (medpagetoday.com)
Many retrospective studies have confirmed that capecitabine combined with temozolomide is effective in neuroendocrine neoplasms. (viamedica.pl)
There are limited data regarding the efficacy capecitabine with temozolomide in grade 3 neuroendocrine tumours. (viamedica.pl)

Your doctor may adjust your dose of capecitabine or stop your treatment for a period of time depending on your response to treatment and any side effects that you experience. (medlineplus.gov)
In one case, dose reduction of capecitabine and discontinuation of lipid-lowering agents were carried out. (unisa.it)
The median dose of capecitabine was 850 mg/m 2 twice daily, with 77% receiving 800-900 mg/m 2 twice daily. (biomedcentral.com)
The median dose of capecitabine was 850 mg/m 2 (range 400-900 mg/m 2 ) twice daily. (biomedcentral.com)
A radiation dose of 50 Gy over five weeks and a daily dose of 1650 mg/m 2 capecitabine in two potions was administered during the entire course of radiation therapy. (e-crt.org)
The present research was to formulate and optimize capecitabine-loaded microspheres for CRC targeting to enhance bioavailability, reduce dose, minimize side effect, and sustain drug release for 24 h. (asiapharmaceutics.info)

Aims: Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of advanced stage of colorectal cancers (CRC). (asiapharmaceutics.info)

Cite this: Survival Benefit With Capecitabine Maintenance in Metastatic CRC - Medscape - Dec 07, 2022. (medscape.com)
The costliest agents were and sex distribution, which would result in higher either anti-neoplastic agents, such as capecitabine, or apparent survival. (nih.gov)

You should use a reliable method of birth control to prevent pregnancy in yourself or your partner during your treatment with capecitabine. (medlineplus.gov)
Today I am starting a new treatment -- radiation + oral chemo (Capecitabine pills). (cancer.org)
Capecitabine is now widely used as an alternative to 5-FU for the treatment of gastrointestinal cancers. (biomedcentral.com)

The report will also include detailed pipeline analysis, recent market scenario, and cost effective analysis of the Capecitabine Vs other available drugs. (straitsresearch.com)

In the end, the report introduced Capecitabine market competitive share analysis, company profiles and analyst conclusion for the market. (straitsresearch.com)
Conclusion: Capecitabine-loaded microspheres can be prepared using chitosan and Eudragit S100 as sustained release with mucoadhesion and pH sensitive polymer, respectively, for CRC targeting. (asiapharmaceutics.info)

Capecitabine comes as a tablet to take by mouth. (medlineplus.gov)
Capecitabine 500 mg tablet should be swallowed whole with water. (ikrispharmanetwork.com)
Capecitabine 500 mg tablet should not be opened or crushed. (ikrispharmanetwork.com)
What are the uses of Capecitabine 500 mg tablet? (ikrispharmanetwork.com)

Severe and unexpected toxicities related to capecitabine are not rare, and the identification of biomarkers is challenging. (uniroma1.it)

folic acid might increase the side effects of capecitabine , especially stomach problems like diarrhea and vomiting. (nih.gov)
In the other case, discontinuation of capecitabine and folic acid and capecitabine re-administration were performed after a month. (unisa.it)

Please also find out process impurities, degradation impurities, potential impurities of Capecitabine developed by our R&D. (synthinkchemicals.com)

Therefore, capecitabine and concurrent radiotherapy to the upper abdomen appears to be well tolerated. (biomedcentral.com)

Capecitabine is the active ingredient and other inactive ingredients: anhydrous lactose, croscarmellose sodium, hydroxypropyl methylcellulose, microcrystalline cellulose, magnesium stearate. (ikrispharmanetwork.com)

Capecitabine was patented in 1992 and approved for medical use in 1998. (wikipedia.org)

The overall cumulative incidence of intervention for CNS disease was lower (27.9%) with neratinib/capecitabine compared to 33.8% with lapatinib/capecitabine (p = 0.039). (esmo.org)

Calcium folinate may enhance the therapeutic effects of capecitabine by means of synergising with its metabolite, 5-FU. (wikipedia.org)

As per the research, in 2016, U.S. Capecitabine Tablets Market were over USD 472 million. (straitsresearch.com)

Many adverse effects are known to occur with capecitabine, including diarrhea, palmar-plantar erythrodysesthesia (hand-foot syndrome), and nausea. (medscape.com)

Capecitabine is associated with a low rate of transient serum aminotransferase elevations during therapy but has been only rarely implicated in cases of clinically apparent acute liver injury. (nih.gov)
Capecitabine has not been linked to cases of acute liver failure, chronic hepatitis or vanishing bile duct syndrome. (nih.gov)

Anatomy4

Organisms1

Diseases61

Chemicals and Drugs64

Analytical, Diagnostic and Therapeutic Techniques and Equipment65

Phenomena and Processes14

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science3

Health Care38

Geographicals4

Xeloda14

Chemotherapy19

Fluorouracil22

Oxaliplatin6

2000 mg1

Colorectal cancer8

500mg2

Rectal cancer3

Cisplatin4

Lapatinib plus capecitabine4

Advanced HER2-positive metastatic breast cancer1

Fluoropyrimidine1

Trials of capecitabine1

Trastuzumab and capecitabine2

Pharma3

Toxicity7

Pancreatic2

Leucovorin1

1000 mg1

Global capecitabine6

Tumor2

Compared with temozolomide1

Combination6

Hazard ratio1

Metabolism of fluoropyrimidines1

Breast cancer6

Patients17

Temozolomide4

Dose6

Chemotherapeutic agent1

Survival2

Treatment3

Drugs1

Conclusion2

Tablet4

Severe1

Folic acid2

Impurities1

Radiotherapy1

Active ingredient1

Medical use in 19981

Neratinib1

Therapeutic1

20161

Diarrhea1

Acute2