• It is not known exactly how cantharidin works to treat molluscum contagiosum. (medlineplus.gov)
  • Cantharidin, Cantharone is officially indicated for the removal of warts, molluscum contagiosum and periungal warts. (ziprx.ca)
  • YCANTH (cantharidin) topical solution, 0.7% is indicated for the topical treatment of molluscum contagiosum in adult and pediatric patients 2 years of age and older. (ycanthpro.com)
  • In a recent announcement, Verrica Pharmaceuticals announced that the U.S. Food and Drug Administration (FDA) has approved cantharidin (YCANTH™) for the treatment of molluscum contagiosum in pediatric and adult patients. (livderm.org)
  • Verrica is the first company to develop a proprietary applicator and GMP-formulation of cantharidin that allows a safe, effective, and precise topical administration, and the first company to successfully gain FDA approval after conducting rigorous clinical trials to evaluate the safe and effective use of a cantharidin-based product for the treatment of molluscum. (livderm.org)
  • Vakharia PP, Chopra R, Silverberg NB, Silverberg J. Efficacy and safety of topical cantharidin treatment for molluscum contagiosum and warts: a systematic review [published online August 10, 2018]. (dermatologyadvisor.com)
  • Safety and efficacy of topical cantharidin for the treatment of pediatric molluscum contagiosum: a prospective, randomized, double-blind, placebo-controlled pilot trial. (harvard.edu)
  • Cantharidin 0.7% could be an emerging standard for molluscum treatment. (dermatologytimes.com)
  • Introduction however, mechanical removal (via curettage, cryotherapy, or laser treatment) and various topical therapies (including tretinoin, Molluscum contagiosum (MC) is a superficial infection of the cantharidin, Imiquimod, cidofovir) are sometimes utilized to dermis caused by a virus in the family Poxviridae. (cdc.gov)
  • Cantharidin is an odorless, colorless fatty substance of the terpenoid class, which is secreted by many species of blister beetles. (wikipedia.org)
  • The level of cantharidin in blister beetles can be quite variable. (wikipedia.org)
  • However, oil beetles do not bite or sting, and their primary defense mechanism is the release of cantharidin. (whatsthatbug.com)
  • Some 1500 species of cantharidin-producing beetles can be found around the world. (mcgill.ca)
  • Blister beetles (Coleoptera: Meloidae) get their name from the cantharidin toxin in their body fluids, which can cause blisters on people's skin if handled and life-threatening inflammations in horses and livestock. (ndsu.edu)
  • Blister Beetles naturally contain and secrete a chemical substance called cantharidin, which is extremely toxic to horses. (thehorse.com)
  • The largely herbivorous spur-wing goose of Africa sometimes has poison in its body, perhaps from eating blister beetles, which contain the potent toxins cantharidin. (juneauempire.com)
  • The chemical these beetles produce is cantharidin. (ggapest.com)
  • Topical cantharidin showed high efficacy and safety for the treatment of warts, especially when used with podophyllotoxin and salicylic acid, according to research published in the American Journal of Clinical Dermatology . (dermatologyadvisor.com)
  • Study investigators performed a systematic review of the available literature and research in regard to the treatment of MC or warts with topical cantharidin. (dermatologyadvisor.com)
  • Treatment for warts demonstrated significant clearance and maintenance of clearance with use of topical cantharidin monotherapy. (dermatologyadvisor.com)
  • Investigators conclude that topical treatment for warts with cantharidin is effective, safe, and well tolerated among patients. (dermatologyadvisor.com)
  • Topical treatment of plantar warts with compounds that include cantharidin and podophyllotoxin and salicylic acid consistently demonstrated 100% clearance rates across studies. (dermatologyadvisor.com)
  • Another common method for removal of warts is to apply the chemical cantharidin on the affected area. (targetwoman.com)
  • For example, when squeezed or distressed, the cantharidin in the excreted oil may cause skin irritation and blisters for people who have sensitive skin or allergies. (whatsthatbug.com)
  • This fluid contains a chemical called cantharidin, which can cause blisters on the skin. (whatsthatbug.com)
  • Cantharidin causes terribly painful blisters. (mcgill.ca)
  • Cantharidin can cause large blisters. (keepkidshealthy.com)
  • This secretion contains cantharidin, an irritating substance that can cause blistering on human skin. (whatsthatbug.com)
  • This oil contains cantharidin, an irritating chemical that can cause blistering in many people. (whatsthatbug.com)
  • The extract contains cantharidin, a substance that supposedly increases sexual desire. (mcgill.ca)
  • The FDA's approval of cantharidin comes after two identical Phase 3 randomized, double-blind trials, CAMP-1 and CAMP-2, evaluated the safety and efficacy of VP-102 (YCANTH™) compared to placebo. (livderm.org)
  • Other options for topical therapy include iodine and salicylic acid, potassium hydroxide, tretinoin, cantharidin (a blistering agent usually applied in an office setting), and imiquimod (T cell modifier). (cdc.gov)
  • Wart removal is performed by applying medications like salicylic acid or cantharidin onto the wart. (whatclinic.com)
  • Externally, cantharidin is a potent vesicant (blistering agent), exposure to which can cause severe chemical burns. (wikipedia.org)
  • Similar products include cryotherapy, cantharidin compounded solution, and Allergan Pharmaceuticals' Condylox ® (podofilox). (primetherapeutics.com)
  • In its natural form, cantharidin is secreted by the male blister beetle, and given to the female as a copulatory gift during mating. (wikipedia.org)
  • Cantharidin, from the Greek kantharis, for beetle, is an odorless, colorless natural product with solubility in various organic solvents,[specify] but only slight solubility in water. (wikipedia.org)
  • Males of Berberomeloe majalis have higher level of cantharidin per beetle: 64.22 ± 51.28 mg/g (dry weight) and 9.10 ± 12.64 mg/g (d. w. (wikipedia.org)
  • Cantharidin is synthesized by the male beetle and is given as a nuptial gift to the female during copulation for the purpose of protecting her eggs. (mcgill.ca)
  • Pure cantharidin was first isolated by the French chemist Pierre Robiquet in 1810 who identified it as the substance being responsible for the blistering properties of the beetle eggs. (mcgill.ca)
  • Topical treatment of MC with cantharidin as a monotherapy demonstrated variable efficacy but was well tolerated and had good treatment satisfaction among patients. (dermatologyadvisor.com)
  • Cantharidin is classified as an extremely hazardous substance in the United States, and is subject to strict reporting requirements by facilities that produce, store, or use it in significant quantities. (wikipedia.org)
  • Poisoning from cantharidin is a significant veterinary concern, especially in horses, but it can also be poisonous to humans if taken internally (where the source is usually experimental self-exposure). (wikipedia.org)
  • As in humans, cantharidin can produce an erection in males prompting the animal to try to resolve the situation through mating. (mcgill.ca)
  • There are also accounts of Louis XIV's lust for women being aided by cantharidin, but the most famous proponent of "Spanish Fly" as a sexual stimulant was the notorious Marquis de Sade who is said to have given prostitutes cantharidin-laced pastilles to "set them on fire. (mcgill.ca)
  • Whether Spanish Fly was a component of "Aqua Tofana" is contentious but there certainly was a belief that cantharidin was being used as a poison. (mcgill.ca)
  • Spanish Fly, Cantharidin, Canth. (abchomeopathy.com)
  • Given that systemic exposure to cantharidin following topical administration is low, maternal use is not expected to result in fetal exposure to the drug. (ycanthpro.com)
  • If topical cantharidin comes in contact with your or your child's eyes, flush the eye for at least 15 minutes and get emergency medical treatment. (medlineplus.gov)
  • Talk to you doctor if you have any questions about your treatment with topical cantharidin. (medlineplus.gov)
  • In Germany, homeopathic remedies based on cantharidin are available for the treatment of urinary tract infections. (mcgill.ca)
  • Cantharidin is in a class of medications called vesicants. (medlineplus.gov)
  • tell your doctor and pharmacist if you are allergic to cantharidin, any other medications, or any of the ingredients in cantharidin topical solution. (medlineplus.gov)
  • Cantharidin comes as a solution (liquid) to apply to the skin by a healthcare professional at a doctor's office or clinic. (medlineplus.gov)
  • Topical cantharidin may cause severe eye injury if it comes in contact with your or your child's eyes, including scarring and ulcers in your eyes and permanent loss of vision. (medlineplus.gov)
  • Topical cantharidin may cause blistering or severe pain at the application site. (medlineplus.gov)
  • If you have a severe reaction at the application site sooner than 24 hours after topical cantharidin was applied, wash the medication off of your skin with soap and water and call your doctor. (medlineplus.gov)
  • Oral ingestion of cantharidin has resulted in renal failure, blistering and severe damage to the gastrointestinal tract, coagulopathy, seizures, and flaccid paralysis. (ycanthpro.com)
  • Topical cantharidin should only be applied to skin and should not be applied to the mouth, nose, eyes, or genital areas. (medlineplus.gov)
  • Do not touch the treated areas of your skin or allow topical cantharidin to come in contact with your eyes or mouth for 24 hours after the medication is applied or until after it has been washed off the skin. (medlineplus.gov)
  • Topical cantharidin is flammable, even after it has dried on the skin. (medlineplus.gov)
  • If you are breast-feeding, your doctor will avoid applying topical cantharidin to areas of your skin that your baby could come in contact with. (medlineplus.gov)
  • These local skin reactions are expected and related to the anticipated blistering response of the skin to cantharidin. (ycanthpro.com)
  • Cantharidin content in haemolymph is also higher in males (80.9 ± 106.5 µg/g) than in females (20.0 ± 41.5 µg/g). (wikipedia.org)
  • No studies evaluating the drug interaction potential of cantharidin have been conducted. (ycanthpro.com)
  • It is a proprietary drug-device combination product containing a GMP-controlled formulation of cantharidin (0.7% w/v) delivered via a single-use applicator which allows for precise topical dosing and targeted administration by a health care professional. (livderm.org)
  • The Pharmacy Compounding Advisory Committee of the US Food and Drug Administration (FDA) voted yesterday to add squaric acid dibutyl ester, diphenylcyclopropenone, and cantharidin to its bulk drug substances list but voted not to add piracetam to the list. (medscape.com)
  • Be the first to review Cantharidin and earn rewards! (tocris.com)
  • Cantharidin also resulted in a death sentence for an American fisherman, but in a different fashion. (mcgill.ca)