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  • Wnts
  • This pathway involves the activation of several intermediary components by Wnts, including the cytoplasmic protein dishevelled, which interacts with conductin/axin ( 22 , 27 , 28 , 36 ). (asm.org)
  • Wnts are cysteine-rich secreted glycoproteins that exert their effects through auto- and paracrine signaling ( 39 ). (asm.org)
  • inhibits
  • Supporting the in vivo role of PTK7 in the localization of dsh, a PTK7 deletion construct deficient in dsh binding inhibits neural crest migration. (biologists.org)
  • Furthermore, the PTK7-mediated membrane localization of a dsh deletion mutant lacking PCP activity inhibits neural crest migration. (biologists.org)
  • activates
  • Wnt triggers Frizzled-mediated activation, triggering a cascade leading to Ca 2+ release, which activates effectors that control gene transcription relevant to cell fate and cell migration. (wikipedia.org)
  • Molecules
  • A combination of genetic and molecular studies has provided a biochemical model for how Wnt molecules act. (biologists.org)
  • molecular
  • This review summarizes our current understanding of the molecular mechanisms underlying the cross-regulation between the two pathways and discusses their involvement in inflammation and inflammation-associated diseases such as cancer. (frontiersin.org)
  • However, it should be stressed that mutations targeting NDPK activity can preclude other enzymatic and signaling functions and interactions of NM23-H1 with its molecular partners. (aacrjournals.org)
  • Several molecular pathways involved in the regulation of proliferation and cell death are implicated in the hepatocarcinogenesis. (biomedcentral.com)
  • Dkk1
  • One group, the focus of this paper, is based on antagonizing the functions of putative inhibitors of Wnt signaling, Dickkopf-1 (DKK1), and Sclerostin (SOST). (hindawi.com)
  • apoptosis
  • In fact, a well-recognized feature of MM is the presence of an intimate relationship between PC and bone marrow microenvironment where PC are hosted in special niches and receive multiple signals that maintain their long survival and exert a protective effect on drug-induced apoptosis. (hindawi.com)
  • tissues
  • Dsh relays complex Wnt signals in tissues and cells, in normal and abnormal contexts. (wikipedia.org)
  • Detects BMAL 1 / aryl hydrocarbon nuclear translocator 3 (ARNT 3) from hamster tissues as well as recombinant human BMAL 1. (abcam.com)
  • development
  • Both loss- and gain-of-function experiments of members of the Wnt signaling pathway were found to cause marked alterations of vascular development and endothelial cell specification. (ahajournals.org)
  • All of these signals importantly contribute to neural development. (frontiersin.org)
  • Thus, WISP2 is a novel secreted adipokine at the crossroad between WNT and BMP4 signaling that can play a critical role for the development of hypertrophic obesity and associated metabolic complications. (diabetesjournals.org)
  • We here review basic pathways regulating adipogenesis, focusing on the limited expandability of the subcutaneous adipose tissue and the development of hypertrophic obesity with a dysregulated adipose tissue and ectopic fat accumulation. (diabetesjournals.org)
  • We will first review the core components of the Wnt signaling pathway to put the development of these agents into a cellular context. (hindawi.com)
  • Piwi , a key component of the Piwi-interacting RNA (piRNA) pathway , plays an essential role in germline development. (sdbonline.org)
  • expression
  • MCME was found to upregulate the expression of Wnt-2 and affect the migratory and invasive ability of CL1 cells through suppressed MMP-2 and MMP-9 enzymatic activities. (hindawi.com)
  • Wnt-5a has been shown to influence the metastatic behavior of human breast cancer cells, and the loss of Wnt-5a expression is associated with metastatic disease. (asm.org)
  • TG2 expression and activity are increased in warfarin-treated cells, in contrast to canonical Wnt ligands. (ahajournals.org)