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  • Inhibition
  • This review will discuss the potential reasons for the lack of clinical success of IKKβ inhibitors to date, the challenges associated with their therapeutic use, realistic opportunities for their future utilisation, and the alternative strategies to inhibit NF-κB signalling that may overcome some of the limitations associated with IKKβ inhibition. (babraham.ac.uk)
  • Since the result of EMT is loss of the normal HCEC phenotype, the inhibition of canonical Wnt-Smad2/3-Zeb1/2 signaling is necessary during the expansion of HCECs. (medsci.org)
  • receptors
  • Using an adaptation of our in vitro primary epithelial cell culture system, we found that prostaglandin E2 ( PGE 2 ) signaling through one of its receptors, Ptger4, was sufficient to drive a differentiation state morphologically and transcriptionally similar to in vivo WAE cells. (embopress.org)
  • cell
  • RAF-MEK-ERK signalling is normally thought to occur in the cytoplasm of the cell. (babraham.ac.uk)
  • Type I tumors develop from precursor lesions, are slow developing and in 65% display mutations in thebrafandkrasgenes, which play an essential part in the cell development signaling cascade . (researchreport-digital.com)
  • Among them, Wnt signaling is indispensable for orchestrating the complex cell behaviors that occur throughout development (reviewed by Croce and McClay, 2008 ). (biologists.org)
  • Wnt signaling controls cell proliferation, stem cell maintenance and cell fate decisions, as well as organized cell movements and the establishment of tissue polarity. (biologists.org)
  • The signal(s) triggering expression of the pluripotency genes are unknown, but we demonstrate that endothelial cell conditioned medium upregulates these genes in ex vivo fracture cultures, supporting histological evidence that transdifferentiation occurs adjacent to the vasculature. (biologists.org)
  • Roles
  • In this Commentary, we describe these recent findings and discuss the possible physiological roles of these diverse signals. (biologists.org)
  • interactions
  • However, it should be stressed that mutations targeting NDPK activity can preclude other enzymatic and signaling functions and interactions of NM23-H1 with its molecular partners. (aacrjournals.org)
  • Below, we consider this novel concept in more detail, focusing on the integration of signals at the level of Wnt-receptor interactions. (biologists.org)
  • basic
  • Consequently we translate our basic knowledge of signalling through collaborations with charities and pharmaceutical companies (e.g. (babraham.ac.uk)