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  • cleavage
  • In eukaryotes, 3′ end cleavage of transcripts generated by RNA polymerase II (pol II) is a universal step of gene expression that proceeds through the recognition of cis -acting elements of the pre-messenger RNA (mRNA) [defined as the poly(A) signal] by a complex machinery. (pubmedcentralcanada.ca)
  • machinery
  • One of the prominent features of eukaryotic cells is the spatial separation of genetic materials from the translational machinery by the nuclear envelope ( 1 , 2 ). (jcancer.org)
  • Nuclear transport is highly controlled through coordination of expression of the transport machinery and dysregulation is implicated in many disease states. (virginia.edu)
  • gene
  • This phosphorylation event promotes STAT dimerization and nuclear entry, allowing STAT binding to specific promoter sequences and thus initiating gene transcription. (elifesciences.org)
  • It also participates in the quantitative and qualitative regulation of gene expression in a variety of biological processes through the selection of single or alternative poly(A) signals in transcription units. (pubmedcentralcanada.ca)
  • found
  • Nuclear localized EGFR has been found in regenerated hepatocytes, benign and cancerous tumors ( 9 , 11 , 13 , 14 , 15 ). (jcancer.org)
  • cell
  • Through differential expression of the Imp-α isoforms, the differences in NLS affinity between them functions to regulate the overall nuclear import capacity for a given cell. (virginia.edu)
  • mRNA
  • Messenger RNA (mRNA) 3′ end formation is a nuclear process through which all eukaryotic primary transcripts are endonucleolytically cleaved and most of them acquire a poly(A) tail. (pubmedcentralcanada.ca)
  • basic
  • Lessons Learned from the Accident at the Fukushima Dai-ichi Nuclear Power Plant-More than Basic Knowledge: Education and its Effects Improve the Preparedness and Response to Radiation Emergency. (pubfacts.com)
  • leaf
  • Classic experiments with photoperiod-sensitive plants have shown that exposure of a single leaf to inductive photoperiods can produce a graft-transmissible signal capable of promoting flowering at the shoot apex. (plantphysiol.org)